Effect of tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with erectile dysfunction

Objective: To evaluate the effect and clinical significance of tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with Erectile dysfunction (ED). Methods: Eighty patients with hyperlipidemia complicated with ED who were treated at The Second Hospital of Hebei Medical University from January 2019 to June 2020 were selected. Using a completely randomized design experimental method, these 80 patients were randomly divided into two groups: the experimental group and the control group, with 40 cases in each group. The control group was treated with a single drug, atorvastatin calcium, while the experimental group was given tadalafil orally on the basis of the control group for 3 months. Changes in the levels of inflammatory factors such as IL-6, TNF and CRP, adverse drug reactions, changes in hemodynamic indicators such as HSV, LSV, PSV, HCT and ESR before and after treatment, as well as changes in sexual function after treatment were compared and analyzed between the two groups. Results: TNF-a, CRP and IL-6 in the experimental group were significantly lower than those in the control group after treatment, with statistically significant differences (p<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (p=0.18). After treatment, hemodynamic indexes and sexual function indexes of the experimental group were significantly improved compared with those in the control group, with statistically significant differences (p<0.05). Conclusion: A significant improvement effect can be achieved by tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with ED. At the same time, the combination of the two has synergism on inflammatory factors and blood rheology, and the incidence of adverse reactions is not significantly increased. Abbreviations: ED: Erectile dysfunction, PDE-5: Phosphodiesterase-5, IL-6: Interleukin- 6, CRP: C-reactionprotein, HSV: High shear viscosity, LSV: Low cut viscosity of whole blood, PSV: The plasma viscosity, HCT: Hematocrit, ESR: Erythrocyte sedimentation rate, IIEF-5: International Index of Erectile Function Questionnaire – 5, HMG-CoA: Hydroxy-methylglutaryl coenzyme A, cGMP: cyclic Guanosinc monophosphate, TNF-α: Tumor necrosis factor-α, IFN-γ: Interferon-γ, TC: Total cholesterol, TG: Triglycerides, HDL-C: High density lipoprotein cholesterol. doi: https://doi.org/10.12669/pjms.37.7.4257 How to cite this:Du L, Jia J, Xue W, Qi J. Effect of tadalafil combined with atorvastatin on hemodynamics and sexual function in middle-aged and elderly patients with hyperlipidemia complicated with erectile dysfunction. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4257 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Clinical Effect of Qibai Landslide on Jellyfish Injuries in Qinhuangdao City

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v3i6.866 ◽

2019 ◽

Vol 3 (6) ◽

Author(s):

Huaian Li

Keyword(s):

Magnesium Sulfate ◽

Adverse Drug Reactions ◽

Sea Lice ◽

Inflammatory Factors ◽

Control Group ◽

Clinical Effects ◽

Observation Group ◽

Drug Reactions ◽

Significant Difference ◽

Skin Loss

Objective: To investigate the clinical effects of phlegm and phlegm and magnesium sulfate combined with magnesium sulfate in sea lice in Qinhuangdao City. Methods: A total of 78 patients with sea lice in Qinhuangdao City from June to May 2018 were enrolled. They were randomly divided into control group (n=39 cases) and observation group (n=39 cases). The control group was treated with magnesium sulfate. The observation group was treated with Qibai Colshi Decoction on the basisof the control group. The effect of the patients was evaluated after 5 days of treatment. The disappearance time of symptoms, inflammatory factors and adverse drug reactions were compared. Results: After treatment, the onset, pain time, skin loss, swelling time and course of treatment were shorter in the observation group than in the control group (P<0.05). The levels of inflammatory factors were lower than those before treatment (P<5). The levels of TNF-a, IL-6, HIS and 5-HT in the observation group were lower than those in the control group (P<0.05). The rash, itching, drug allergy, liver and kidney were observed in the observation group and the control group. There was no significant difference in the incidence of dysfunction and blood pressure (P>0.05). Conclusion: The combination of magnesium sulfate and magnesium sulfate in the treatment of sea lice in Qinhuangdao City can shorten the disappearance of symptoms, reduce the level of inflammatory factors, and increase the incidence of adverse drug reactions. It is worthy of popularization and application.

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Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v2i6.671 ◽

2018 ◽

Vol 2 (6) ◽

Author(s):

Xiaoye Wang

Keyword(s):

Blood Pressure ◽

Coronary Heart Disease ◽

Heart Disease ◽

Elderly Patients ◽

Adverse Reactions ◽

Effective Rate ◽

Control Group ◽

Significant Difference ◽

Pre Treatment ◽

Experimental Group

ã€Abstractã€‘Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

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Effects of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.38.1.4451 ◽

2021 ◽

Vol 38 (1) ◽

Author(s):

Dan Zhang ◽

Hongli Li ◽

Xiang Tian ◽

Sujuan Zhang

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Enteral Nutrition ◽

Elderly Patients ◽

Immune Function ◽

Inflammatory Markers ◽

Heart Function ◽

Inflammatory Factors ◽

Control Group ◽

Experimental Group

Objectives: To evaluate the effect of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure and its clinical significance. Methods: Eighty patients with moderate and severe heart failure admitted to the Cardiology Intensive Care Unit (CCU) of Baoding First Central Hospital from May 2019 to May 2020 were included in this study and randomly divided into two groups: the experimental group and the control group, with 40 patients in each group. The experimental group was given enteral nutrition support therapy on the basis of conventional therapy for one month, while the control group was given restricted salt and water intake on the basis of conventional therapy, and patients were given free diet according to their wishes. The changes in heart function before and after treatment, changes in inflammatory factors such as TNF-a, CRP, IL-6, changes in levels of immunoglobulins such as IgA, IgM, and IgG, and the improvement of the performance status of the two groups were compared and analyzed. Results: After treatment, indicators such as BNP, LVEDD, LVEF and 6min walking distance in the experimental group were significantly improved compared with the control group, with statistically significant differences (p<0.05), and the levels of inflammatory factors such as TNF-a, CRP and IL-6 in the experimental group were significantly reduced compared with those in the control group (p=0.00). The levels of IgG, IgA, IgM and other immunoglobulins in the experimental group improved more significantly after treatment than those in the control group, with statistically significant differences (IgG, IgA, p=0.00; IgM, p=0.01). Moreover, the experimental group was significantly superior to the control group in the improvement rate of performance status score (ECOG) after treatment (p=0.04); The incidence of gastrointestinal adverse reactions in the experimental group was 20%, and that in the control group was 15%. No statistically significant difference can be observed in the gastrointestinal tolerance of both groups (p=0.56). Conclusions: Reasonable enteral nutrition boasts a variety of benefits for the recovery of elderly patients with chronic heart failure. With reasonable enteral nutrition, the heart function of elderly patients with chronic heart failure can be significantly improved, inflammatory factors can be reduced, immunity and performance status can be enhanced, and gastrointestinal tolerance can be ameliorated without obvious gastrointestinal reactions. doi: https://doi.org/10.12669/pjms.38.1.4451 How to cite this:Zhang D, Li H, Tian X, Zhang S. Effects of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4451 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Clinical Observation of Huagai Pingchuan Decoction Combined with Seretide in the Treatment of Asthma

Proceedings of Anticancer Research ◽

10.26689/par.v4i5.1521 ◽

2020 ◽

Vol 4 (5) ◽

Author(s):

Rong He

Keyword(s):

Lung Function ◽

Clinical Effect ◽

Clinical Observation ◽

Inflammatory Factors ◽

Control Group ◽

Significant Difference ◽

Asthma Patients ◽

Experimental Group ◽

Better Than

Objective: To study the clinical effect of the Huagai Pingchuan decoction combined with Seretide in the treatment of asthma. Methods: 138 cases of asthma patients in our hospital were separated into the control group and the experimental group. The control group was given Seretide alone, while the experimental group was treated with Huagai Pingchuan decoction combined with Seretide. Results: After treatment, the wheezing symptoms remission time of the experimental group was shorter than control group, the performance of serum inflammatory factors and lung function indexes were better than control group, P<0.05 with significant difference. Conclusion: Huagai Pingchuan decoction combined with Seretide is more effective in the treatment of asthma.

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Application of Dexmedetomidine combined with Propofol Intravenous Anesthesia in Laparoscopic Day Surgery in Pediatric Urology

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.38.1.4378 ◽

2021 ◽

Vol 38 (1) ◽

Author(s):

Xiao-dan Wang ◽

Bin Yang ◽

Lin-lin Fan ◽

Na Guo ◽

Hao-bin Song

Keyword(s):

Inflammatory Cytokines ◽

Analgesic Effect ◽

Day Surgery ◽

Pediatric Urology ◽

Control Group ◽

Drug Reactions ◽

Intravenous Anesthesia ◽

Extubation Time ◽

Significant Difference ◽

Experimental Group

Objectives: To evaluate the sedative and analgesic effects of dexmedetomidine combined with propofol intravenous anesthesia in laparoscopic day surgery in pediatric urology. Methods: Eighty male children with cryptorchidism and hydrocele who underwent laparoscopic daytime surgery in our hospital from January 2019 to January 2021 were selected and randomly divided into two groups: the experimental group and the control group. Children in the experimental group ranged in age from 5.7 to 11.3, with an average of 8.52±2.17 years old, while those in the control group ranged in age from 5.3 to 12.0, with an average of 8.60±2.07 years old. There were 12 cases of cryptorchidism and 28 cases of hydrocele in the experimental group, and 14 cases of cryptorchidism and 26 cases of hydrocele in the control group. Children in the control group received conventional propofol intravenous combined anesthesia, while those in the experimental group were given dexmedetomidine (2-5 ug/kg) intranasally on the basis of conventional propofol intravenous anesthesia. The anesthetic effect, analgesic effect, serum levels of inflammatory cytokines before and after surgery and adverse drug reactions in the two groups were compared and analyzed. Results: The awakening time, extubation time and retention time in the resuscitation room of the experimental group were shorter than those of the control group, with a statistically significant difference (P<0.05); The VAS pain scores of the experimental group were significantly lower than those of the control group at 15minutes, 12hour and 24hour after awakening, with a statistically significant difference (P<0.05). In addition, the levels of TNF-a, CRP, IL-6 and other inflammatory factors in the control group were significantly higher compared with those in the experimental group 24h after surgery, with a statistical significance (TNF-a, P=0.02; CRP, P=0.00; IL-6, P=0.03); The incidence of adverse drug reactions in the experimental group was 17.5%, while that in the control group was 12.5%, which was not statistically significant (P=0.53). Conclusion: Dexmedetomidine combined with intravenous propofol anesthesia may be helpful to shorten the extubation time, the recovery time and the stay time in the anesthesia resuscative room, improve the analgesic effect, and may reduce the inflammatory response and the expression of serum inflammatory cytokines, with no significant increase in side effects. doi: https://doi.org/10.12669/pjms.38.1.4378 How to cite this:Wang X, Yang B, Fan L, Guo N, Song H. Application of Dexmedetomidine combined with Propofol Intravenous Anesthesia in Laparoscopic Day Surgery in Pediatric Urology. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4378 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Adverse Drug Reactions and Their Impact on the Treatment of Pulmonary Tuberculosis

10.47363/jprr/2021(3)112 ◽

2021 ◽

pp. 1-4

Author(s):

Takahiro Kaki ◽

◽

Yoshiaki Minakata ◽

Yoichi Nakanishi ◽

Seigo Sasaki ◽

...

Keyword(s):

Liver Injury ◽

Pulmonary Tuberculosis ◽

Elderly Patients ◽

Adverse Drug Reactions ◽

Age Groups ◽

Tuberculosis Treatment ◽

Drug Reactions ◽

Medication Discontinuation ◽

Significant Difference ◽

The Difference

Background: Although there have been some reports about adverse drug reactions (ADRs) in pulmonary tuberculosis treatment, there are few detailed data and the effect of age among elderly patients on ADRs and the period of medication discontinuation due to ADRs is unknown. Purpose: We evaluated the difference in the incidence of ADRs necessitating discontinuation or a change of medication (dADR) among the different age groups and the period of discontinuation in elderly patients undergoing pulmonary tuberculosis treatment. Subjects and Methods: We conducted a retrospective medical record survey of patients who started anti-tuberculosis medication at our hospital from April 1st, 2018 to March 31st, 2020. Results: A total of 120 patients were recruited. There was no significant difference in the incidence of dADR among the different age groups every 10 years in patients ≥50 years of age (p=0.78). The median period of discontinuation was approximately 4 weeks for fever (29.5 days), approximately 3 weeks for rash (18.5 days), approximately 2 weeks for gastrointestinal disorders (16 days), and hepatocellular liver injury (15.5 days), and approximately 1 week for cholestatic liver injury (8 days) and eosinophilia (7 days). Conclusion: The incidence of dADR was not different among the age groups when patients of ≥50 years of age were compared by age. The median times of onset were 1–3 weeks after the start of treatment. The median periods of discontinuation were 1–4 weeks, and the period of discontinuation due to allergic reactions tended to be the longest

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A RANDOMIZED CONTROLLED TRIAL FOR THE EFFECTS OF SEXUAL BEHAVIOUR GUIDANCE ON SEXUAL FUNCTION AMONG YOUNG AND MIDDLE-AGED MALE PATIENTS WITH RECTAL CANCER AFTER MILES OPERATION

Journal of Men s Health ◽

10.22374/jomh.v15i2.100 ◽

2019 ◽

Vol 15 (2) ◽

pp. e20-e26

Author(s):

Li-Ying Zhang ◽

Hui-Juan Bian ◽

Ya-Fei Kuang ◽

Guo-Li Cao ◽

Tao-Hsin Tung

Keyword(s):

Rectal Cancer ◽

Sexual Behavior ◽

Sexual Function ◽

Sexual Life ◽

Control Group ◽

Middle Aged ◽

Male Patients ◽

Experimental Group ◽

Middle Aged Male

Purpose This study was conducted to explore the effect of intervention in the form of sexual behavior guidance on the quality of sexual life of young and middle-aged male patients with rectal cancer. Methods Twenty cases of young and middle-aged male patients with rectal cancer were randomly divided into experimental and control group in each group including 10 cases per group. The control group was given the traditional health education after the rectal cancer Miles operation. While the experimental group was given sexual behavior guidance and “sex focused training therapy” after the Miles operation and before sexual intercourse in order to overcome erectile dysfunction. The International Index of Erectile Function (IIEF-5) questionnaire was used to measure the sexual functionality of both groups upon admission, at the time of discharge and after 3, 6 and 9 months. Results In the experimental group, patients with normal sexual function at the 6th and 9th month after discharge were 7 cases and 9 cases respectively, which were significantly higher than the control group which included 5 cases and 6 cases (p-value < 0.05). Conclusion In conclusion, sexual health education not only could effectively improve the sexual function of young and middle-aged male patients with rectal cancer after Miles operation, but also could improve the quality of the sexual life of the patients. It is considered to be worthy to promotion and application on clinical practice.

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Evaluation of Light Specific Gravity Ropivacaine Combined with Sufentanil in Hip Arthroplasty at An Advanced Age

Journal of Advances in Medicine Science ◽

10.30564/jams.v4i1.2724 ◽

2021 ◽

Vol 4 (1) ◽

pp. 19

Author(s):

Daxu Peng ◽

Qingchen Liu ◽

Xiuyang Cao ◽

Guanwen Deng

Keyword(s):

Specific Gravity ◽

Elderly Patients ◽

Hip Arthroplasty ◽

Recovery Time ◽

Adverse Reactions ◽

Sensory Block ◽

Control Group ◽

Significant Difference ◽

Sensory Recovery ◽

Experimental Group

Objective: To observe the effect of light specific gravity ropivacaine combined with sufentanil in elderly patients undergoing hip replacement. Methods :89 elderly patients with hip arthroplasty from July 2019 to September 2020 were randomly divided into experimental group and control group. The experimental group was anesthetized with light specific gravity ropivacaine combined with sufentanil. The control group was anesthetized with equal specific gravity ropivacaine to compare the effect of anesthesia and the incidence of adverse reactions. Results: there was no significant difference in sensory recovery time and motor recovery time between the experimental group and the control group (P>0.05), and the incidence of adverse reactions between the two groups was low. The sensory block time in the experimental group was shorter than that in the control group (PP>0.05). Conclusion: ropivacaine combined with sufentanil subarachnoid anesthesia is more effective in elderly patients undergoing hip arthroplasty, and the safety of the anesthesia scheme is higher, which will not lead to serious adverse reactions during operation. Moreover, the application of the anesthesia scheme can effectively improve the analgesic effect during and after operation, and the clinical application value is high.

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PENGARUH TERAPI RELAKSASI NAPAS DALAM TERHADAP PERUBAHAN TEKANAN DARAH PADA PASIEN LANSIA DENGAN HIPERTENSI DI PUSKESMAS PASUNDAN SAMARINDA

Jurnal Ilmu dan Teknologi Kesehatan ◽

10.32668/jitek.v5i2.2 ◽

2018 ◽

Vol 5 (2) ◽

pp. 119-128

Author(s):

Rusni Masnina ◽

Annaas Budi Setyawan

Keyword(s):

Blood Pressure ◽

Elderly Patients ◽

Health Center ◽

Diastolic Blood Pressure ◽

Control Group ◽

P Value ◽

Relaxation Therapy ◽

Significant Difference ◽

Before And After ◽

Experimental Group

The most common disease in the elderly are hypertension affected the heart and stroke. Treatment of hypertension a lifetime so it must be with non-pharmacological treatment, namely deep breathing relaxation. The aim of research to determine the effect of deep breath relaxation to changes in blood pressure of elderly patients with hypertension in the Health Center Pasundan. Using a quasi-experimental study, the design of two group pretest - posttest. The research sample of elderly hypertensive total of 32 people consisting of 16 samples dan16 experimental control samples. Data collection technique used purposive sampling. Univariate data using the mean value, median, standard deviation, maximum and minimum bivariate t test. Research resultthere are differences in systolic and diastolic blood pressure before and after the relaxation of airway in the experimental group and the control group (p value 0.001). There are differences in systolic and diastolic blood pressure before and after the relaxation of airway in the control group and the experimental group (p value 0.001). There is the influence of deep breaths relaxation therapy to changes in blood pressure where there is a significant difference (p value 0.001) and there was also a significant difference (p value 0.011).Conclusion No effect of relaxation therapy deep breath to changes in blood pressure of elderly patients with hypertension in the Health Center Pasundan Samarinda.

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Clinical efficacy evaluation of Erlotinib Combined with Concurrent Chemoradiotherapy in the treatment of locally advanced Pancreatic Cancer

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.38.1.4150 ◽

2021 ◽

Vol 38 (1) ◽

Author(s):

Ci Liu ◽

Haobin Wei ◽

Yue-hong Hou ◽

Zhen-lin Gao ◽

Ya-jing Zhang

Keyword(s):

Pancreatic Cancer ◽

Adverse Drug Reactions ◽

Concurrent Chemoradiotherapy ◽

Locally Advanced ◽

Advanced Pancreatic Cancer ◽

Locally Advanced Pancreatic Cancer ◽

Control Group ◽

Drug Reactions ◽

Efficacy Evaluation ◽

Experimental Group

Objective: To evaluate the clinical effects of erlotinib combined with concurrent chemoradiotherapy in the treatment of locally advanced pancreatic cancer. Methods: Eighty patients with locally advanced pancreatic cancer who attended Shijiazhuang People’s Hospital or Anhui Cancer Hospital between January 2018 and January 2020 were randomly divided into two groups, with 40 cases in each group. Patients in the control group were treated with concurrent chemoradiotherapy, while those in the experimental group were treated with erlotinib tablets based on the treatment regimen of the control group. Anti-tumor efficacy evaluation was conducted for all patients in both groups, and the adverse drug reactions, improvement of performance status after treatment were compared and analyzed between the two groups. Results: The overall response rate of the experimental group was 47.5%, which was significantly better than the 25% of the control group (p=0.03). The incidence of adverse drug reactions in the experimental group was 40%, while that in the control group was 30%. The incidence of adverse drug reactions in the experimental group was higher than that in the control group, but there was no statistical significance (p=0.34). Moreover, the improvement rate of performance status score in the experimental group was significantly higher than that in the control group (p=0.00). Conclusion: Erlotinib combined with concurrent chemoradiotherapy has been preliminarily proved to be safe and effective in the treatment of locally advanced pancreatic cancer, which can improve the physical condition of patients to a certain extent without significantly increasing adverse reactions. doi: https://doi.org/10.12669/pjms.38.1.4150 How to cite this:Liu C, Yu H, Hou Y, Gao Z, Zhang Y. Clinical efficacy evaluation of Erlotinib Combined with Concurrent Chemoradiotherapy in the treatment of locally advanced Pancreatic Cancer. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4150 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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