scholarly journals New Discovery of Covid-19 Natural-Based Antivirus Herbal Supplement Products from Pinang Yaki (Areca vestiaria) Extract by Untargeted Metabolomic Profiling

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1021
Author(s):  
Herny Emma Inonta Simbala ◽  
Fahrul Nurkolis ◽  
Nelly Mayulu ◽  
Linda Wilhelma Ancella Rotty
Keyword(s):  
Bioactive Compounds ◽  
Cinnamic Acid ◽  
Untargeted Metabolomics ◽  
Herbal Supplement ◽  
North Sulawesi ◽  
Metabolomic Profiling ◽  
Potential Benefits ◽  
Insight Into ◽  
Metabolomics Analysis ◽  
New Discovery

Background: Pinang yaki has bioactive compounds that have potential as a new herbal supplement. A better understanding of the bioactive compounds of pinang yaki using untargeted metabolomic profiling studies will provide clearer insight into the health benefits of pinang yaki and in particular its potential for the therapy and prevention of Covid-19.   Methods: Fresh samples of pinang yaki (Areca vestiaria) are obtained from forests in North Sulawesi Province, Indonesia. Samples were used for untargeted metabolomics analysis by UPLC-MS.   Results: Based on an untargeted metabolomic profiling study of pinang yaki, 2504 compounds in ESI- and 2645 compounds in ESI+ were successfully obtained. After the analysis, 356 compounds in ESI- and 543 compounds in ESI+ were identified successfully. Major compounds Alpha-Chlorohydrin (PubChem ID: 7290) and Tagatose (PubChem ID: 439312) were found in ESI+ and ESI-.   Discussion: The Top 10 metabolites from pinang yaki extract (ESI+) juga have been indicated in preventing SARS Cov2 infection and have exhibited good neuroprotective immunity. Benzothiazole (PubChem ID: 7222), L-Isoleucine (PubChem ID: 6306), D-Glucono-Delta-Lactone (PubChem ID: 736), Diethylpyrocarbonate (PubChem ID: 3051), Bis(2-Ethylhexyl) amine (PubChem ID: 7791), Cinnamic Acid (PubChem ID: 444539), and Trigonelline (PubChem ID: 5570) also had potential effects as an antiviral, anti-inflammatory, and anti-Covid19.   Conclusion: Untargeted metabolomic profiling showed many bioactive compounds contained in pinang yaki (Areca vestiaria) extract. The top 10 compounds have been identified and explored for their potential benefits as anti-Covid19 supplement products.

scholarly journals The European Green Capital Award—Is It a Dream or Reality for Belgrade (Serbia)?

2021 ◽  
Vol 13 (11) ◽  
pp. 6182
Author(s):  
Marijana Pantić ◽  
Saša Milijić
Keyword(s):  
Urban Transformation ◽  
The Other ◽  
Transmission Of Knowledge ◽  
Current State ◽  
Transitional Countries ◽  
Great Hope ◽  
Environmentally Responsible ◽  
Potential Benefits ◽  
The City ◽  
Insight Into

An agreement of cooperation and transmission of knowledge regarding the nomination for the European Green Capital Award (EGCA) was signed between the mayors of Belgrade and Ljubljana (EGCA 2016 winner) in September 2018. The candidacy of Belgrade was finally realized in October 2019. Great hope was placed in this endeavour because internationally recognized awards, such as the EGCA, represent enormous capital for both the city and the state. The EGCA requires serious preparation and significant fulfilment of preconditions. Many economically strong and environmentally responsible cities competed for the award, but did not win. On the other hand, the capital of Serbia does not appear to be an obvious winning candidate, especially as it is differentiated from the previous winners by being a non-EU city and by the fact that it is still undergoing an intense urban transformation, characteristic of transitional countries. Therefore, the main aim of this article is to present a review of the current state of Belgrade’s environmental qualities and its comparison with the EGCA criteria and with Grenoble as one of the winning competitors. The article gives a full overview of the EGCA requirements with certain details on required indicators, gives relevant insight into the procedure, which could be of use for any future candidacy, and discusses potential benefits for winners, losers and repeat candidacies.

scholarly journals Quick-start infrastructure for untargeted metabolomics analysis in GNPS

2021 ◽  
Author(s):  
Tiago F. Leao ◽  
Chase M. Clark ◽  
Anelize Bauermeister ◽  
Emmanuel O. Elijah ◽  
Emily C. Gentry ◽  
...  
Keyword(s):  
Untargeted Metabolomics ◽  
Metabolomics Analysis

Nanomaterials for the delivery of Herbal Bioactive Compounds

2021 ◽  
Vol 17 ◽  
Author(s):  
Shadma Wahab ◽  
Md. Parwez Ahmad ◽  
Arshad Hussain ◽  
Shaik Fayazuddin Abdul Qadir
Keyword(s):  
Drug Delivery ◽  
Bioactive Compounds ◽  
Targeted Drug Delivery ◽  
Herbal Medicines ◽  
Herbal Drugs ◽  
Herbal Extracts ◽  
Significant Component ◽  
Pharmaceutical Application ◽  
Low Solubility ◽  
Insight Into

: Nanotechnology is a multidisciplinary domain that involves overlapping of areas such as nonanomaterials, nanoelectronics, and nanobiotechnology. Herbal medicine is a significant component of traditional medicine and has been a treatment part of many diseases. Asian peoples are using these herbal medicines for decades. Still, herbal extracts' therapeutic efficacy and pharmaceutical application are associated with many factors such as poor bioavailability, low solubility, permeability, and lack of targeting potential. In the present work, we have reviewed thriving strategies for the targeted drug delivery of phytoconstituents and critically explain the most recent progressions on emerging novel nanophytomedicine-based materials as herbal medicines carriers. Nanotechnology-based clinical trial studies targeting herbal bioactive compounds were discussed. Advancements in nanotechnology-based drug delivery systems intended to enhance cellular uptake, improved pharmacokinetics and effectiveness of herbal drugs have facilitated the powerful targeting of specific agents against diseases. This review provides insight into current progress and future opportunities for nanomedicines as potential curative targets for the delivery of herbal bioactive compounds. This information could be used as platforms for the future expansion of multi-functional nano constructs for the advanced detection of diseases and functional drug delivery of phytoconstituents.

scholarly journals Social Nurses’ Descriptions of Nursing: A Qualitative Study of What Social Nursing is and Does?

2019 ◽  
Vol 13 (1) ◽  
pp. 228-236
Author(s):  
Tine Louise Dideriksen ◽  
Marianne Lisby ◽  
Nina Brünés ◽  
Pia Dreyer
Keyword(s):  
Qualitative Study ◽  
Health Inequalities ◽  
Common Goal ◽  
Structured Interviews ◽  
Holistic Nursing ◽  
Encounter Complex ◽  
The Social ◽  
Potential Benefits ◽  
Female Nurses ◽  
Insight Into

Background: In the meeting between socially marginalised patients and somatic hospitals, healthcare systems often encounter complex challenges related to health inequalities that are difficult to resolve. To help reduce these challenges, a nursing approach employing a nurse (RN) with in-depth knowledge of socially marginalised patients and competences in rehabilitation (“social nurse”) has contributed to diminish health inequalities. However, further insight into the potential benefits of social nursing is required. Aim: To examine how social nurses describe and experience the social nursing approach situated at somatic hospitals. Methods: A qualitative study of social nurses’ descriptions and experiences with a social nurse approach included eight Danish hospitals. One male and 12 female nurses (n=13) employed as social nurses at somatic hospitals participated. Thirteen semi structured interviews were conducted using the methodological frameworks of phenomenology and hermeneutics. The interviews were analysed employing a method inspired by the French philosopher Paul Ricoeur’s theory of interpretation. Results: Four themes emerged from the analysis: 1) A unique expertise encompassing experience and evidence-based knowledge 2) coordination towards a common goal to reduce patients’ vulnerability, 3) to see and understand patients as whole persons, thereby assuring successful treatment and 4) working with the system to avoid losing the patients. The themes describe a unique expertise emerging from focusing healthcare efforts on the socially marginalised patients and the system in charge. Conclusion: The study indicated that the social nurse approach is a holistic nursing approach. Applying this approach allows for optimised treatment that fosters a more equal outcome across the spectrum of socially marginalised patients. The social nurse approach may contribute to diminishing health inequalities.

scholarly journals KEKAYAAN DAN POTENSI SENYAWA BIOAKTIF MAKROALGA DI PESISIR ATEP OKI, KABUPATEN MINAHASA, SULAWESI UTARA

2020 ◽  
Vol 8 (3) ◽  
pp. 7
Author(s):  
Silsia Dorkas Winowoda ◽  
Marina Flora Oktavine Singkoh ◽  
Ratna Siahaan
Keyword(s):  
Green Algae ◽  
Bioactive Compounds ◽  
Red Algae ◽  
Brown Algae ◽  
North Sulawesi ◽  
Sampling Locations

This study aims to analyze the richness and potential of macroalgae bioactive compounds on the Atep Oki Coast, District of Minahasa, North Sulawesi Province. This research was conducted in October 2019 until January 2020. Sampling used the roaming method in a predetermined location that is Atep Oki tidal/ intertidal coast. Sampling locations are spread over six coordinate points. Macroalgae found on the Atep Oki Coast assessed ten species belonging to three phyla, namely Chlorophyta (green algae), Ochrophyta (brown algae) and Rhodophyta (red algae). Chlorophyta members mean six species. Ochrophyta has members of three species and members of Rhodophyta only one species. The types of macroalgae found on the Atep Oki Coast provide bioactive compounds. Keywords : Macroalgae, Bioactive Compounds, Atep Oki Minahasa CoastAbstrak Penelitian ini bertujuan untuk menganalisis kekayaan jenis dan potensi senyawa bioaktif makroalga di Pesisir Atep Oki, Kabupaten Minahasa, Provinsi Sulawesi Utara. Penelitian ini telah dilaksanakan pada bulan Oktober 2019 sampai Januari 2020. Pengambilan sampel menggunakan metode jelajah di lokasi yang telah ditentukan yaitu pesisir pasang surut/intertidal Atep Oki. Lokasi pengambilan sampel tersebar di enam titik-titik koordinat. Makroalga yang ditemukan di Pesisir Atep Oki berjumlah sepuluh species yang tergolong ke dalam tiga filum yaitu Chlorophyta (alga hijau), Ochrophyta (alga cokelat) dan Rhodophyta (alga merah). Anggota Chlorophyta berjumlah enam species. Ochrophyta memiliki anggota tiga species dan anggota Rhodophyta hanya satu species. Jenis-jenis makroalga yang ditemukan di Pesisir Atep Oki berpotensi menghasilkan senyawa bioaktif. Kata kunci : Makroalga, Senyawa Bioaktif, Pesisir Atep Oki Minahasa

Untargeted Metabolomics Analysis of ABCC6-Deficient Mice Discloses an Altered Metabolic Liver Profile

2016 ◽  
Vol 15 (12) ◽  
pp. 4591-4600 ◽  
Author(s):  
Mie R. Rasmussen ◽  
Kirstine L. Nielsen ◽  
Mia R. Laursen ◽  
Camilla B. Nielsen ◽  
Pia Svendsen ◽  
...  
Keyword(s):  
Untargeted Metabolomics ◽  
Deficient Mice ◽  
Metabolomics Analysis

Characterization by HPLC of p-Hydroxybenzyl Alcohol Biotransformation to Gastrodin In Vivo

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110350
Author(s):  
Lijun Cheng ◽  
Yang Deng
Keyword(s):  
Bioactive Compounds ◽  
High Performance ◽  
Array Detector ◽  
Gastrodia Elata ◽  
Chromatography Method ◽  
Liquid Chromatography Method ◽  
First Time ◽  
Insight Into ◽  
Hydroxybenzyl Alcohol

Gastrodin (GAS) and its aglycone, p-hydroxybenzyl alcohol (HBA), are both bioactive compounds extracted from Gastrodia elata Blume (GEB). In the current Chinese pharmacopoeia, they are regarded as quality control markers for GEB. In this study, we developed a high-performance liquid chromatography method coupled with a diode array detector to quantify GAS and HBA concentrations in plasma following oral ingestion by rats. For the first time, GAS was detected in vivo after HBA administration. GAS and HBA both had similar pharmacological effects, but the influence of the glucose moiety resulted in different pharmacokinetic characteristics. In this study, the effects of GAS and HBA at different administration durations were investigated in zebrafish larvae. These compounds were found to induce a sedative effect but had different onset times. In conclusion, a biotransformation of HBA to GAS could be observed in the rats. This may be a new insight into the pharmacokinetic characteristics of these bioactive compounds and also relates to the different ways in which they take effect.

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