scholarly journals Positive Effects of Diphlorethohydroxycarmalol (DPHC) on the Stability of the Integument Structure in Diet-Induced Obese Female Mice

2015 ◽  
Vol 19 (3) ◽  
pp. 145-152 ◽  
Author(s):  
Chae-lim Kim ◽  
Sun-yeong Cha ◽  
Min Young Chun ◽  
Bumsoo Kim ◽  
Min Young Choi ◽  
...  
Keyword(s):  
Female Mice ◽  
Positive Effects ◽  
Obese Female ◽  
The Stability

scholarly journals Increased Tumor Growth in Mice with Diet-Induced Obesity: Impact of Ovarian Hormones

Endocrinology ◽  
2006 ◽  
Vol 147 (12) ◽  
pp. 5826-5834 ◽  
Author(s):  
Shoshana Yakar ◽  
Nomeli P. Nunez ◽  
Patricia Pennisi ◽  
Pnina Brodt ◽  
Hui Sun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Tumor Growth ◽  
Glucose Intolerance ◽  
Tumor Development ◽  
Tumor Growth Rate ◽  
Obese Mice ◽  
Female Mice ◽  
Diet Induced Obesity ◽  
Body Adiposity ◽  
Obese Female

Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

Technology and Effectiveness of Cast Iron Treatment by Gas Injection

2010 ◽  
Vol 457 ◽  
pp. 459-464
Author(s):  
Edis B. Ten
Keyword(s):  
Cast Iron ◽  
Gas Injection ◽  
Small Diameter ◽  
Multiple Use ◽  
Positive Effects ◽  
Injection Treatment ◽  
The Stability ◽  
Injection Technology ◽  
Stability Regime ◽  
Structure Stabilization

In this work the development of the technology and equipment for gas injection treatment of cast iron by inert gas (nitrogen) is presented. The equipment includes the plunging lance as a lined steel pipe with nozzles. The nozzles are thin channels, which are lined by ceramic tubes with small-diameter. The lance has a multiple use, as it has calibrated channel sizes, and provide the stability regime of gas injection treatment. The characteristic of the gas injection technology consists of blowing of melt by gas, which is injected into the liquid cast iron through thin jet with a speed near to the velocity of sound. In this case, the dispersion of gas jets in small-sized bubbles is reached, therefore the refining effectiveness increases. The gas injection treatment shows the promotion of casting properties, improvement of homogeneity and fineness of structure, stabilization or increasing of mechanical properties, decreasing of casting defectiveness. The positive effects of the gas injection treatment is the result of complex action of the injecting gas into the cast iron melt. Together with refining and homogenizing action at specified conditions, it offers the modifying and alloying effects also.

scholarly journals Effects of aerobic exercise training on obese female mice: metabolic and autonomic evaluation

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Michelle Sartori ◽  
Leandro Eziquiel Souza ◽  
Pamella Ramona Souza ◽  
Fernando Santos ◽  
Kátia De Angelis ◽  
...  
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Female Mice ◽  
Obese Female

scholarly journals Competition Law and State Aid for Failing Banks in the EU and its Specific Implications for CEE Member States

2016 ◽  
Vol 9 (14) ◽  
pp. 145-157
Author(s):  
Virág Blazsek
Keyword(s):  
European Union ◽  
State Aid ◽  
Common Market ◽  
Competition Authority ◽  
The European Union ◽  
Member States ◽  
Positive Effects ◽  
The Stability ◽  
Bank Bailouts ◽  
The Eu

The bank bailouts following the global financial crisis of 2008 have been subject to prior approval of the European Commission (EC), the competition authority of the European Union. The EC was reluctant to reject rescue efforts directed at failing banks and so it consistently approved all such requests submitted by Member States. Out of the top twenty European banks, the EC authorized State aid to at least twelve entities. In this context, the paper outlines the gradually changing interpretation of EU State aid rules, the “temporary and extraordinary rules” introduced starting from late 2008, and the extension of the “no-State aid” category. The above shifts show that the EC itself deflected from relevant EU laws in order to systemically rescue important banks in Europe and restore their financial stability. The paper argues that bank bailouts and bank rescue packages by the State have led to different effects on market structures and consumer welfare in the Eurozone and non-Eurozone areas, mostly the Eastern segments of the European Union. As such, it is argued that they are inconsistent with the European common market. Although the EC tried to minimize the distortion of competition created as a result of the aforementioned case law primarily through the application of the principle of exceptionality and different compensation measures, these efforts have been at least partially unsuccessful. Massive State aid packages, the preferential treatment of the largest, or systemically important, banks through EU State aid mechanisms – almost none of which are Central and Eastern European (CEE) – may have led to the distortion of competition on the common market. That is so mainly because of the prioritization of the stability of the financial sector and the Euro. The paper argues that State aid for failing banks may have had important positive effects in the short run, such as the promotion of the stability of the banking system and the Euro. In the longrun however, it has contributed to the unprecedented sovereign indebtedness in Europe, and contributed to an increased economic and political instability of the EU, particularly in its most vulnerable CEE segment.

scholarly journals Red Clover Isoflavones Influence Estradiol Concentration, Exercise Performance, and Gut Microbiota in Female Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Yi-Ming Chen ◽  
I-Lin Wang ◽  
Xin-Yi Zhu ◽  
Wan-Chun Chiu ◽  
Yen-Shuo Chiu
Keyword(s):  
Gut Microbiota ◽  
Exercise Performance ◽  
Red Clover ◽  
Intestinal Barrier Function ◽  
Vehicle Group ◽  
Microbiota Composition ◽  
Main Compound ◽  
Female Mice ◽  
Positive Effects ◽  
Gut Microbiota Composition

In red clover (Trifolium pratense L.; RC) the main compound is isoflavones, which are selective estrogen receptor modulators for maintaining female health. Isoflavones exert antifatigue effects during exercise in high-temperature environments. This study aimed to investigate the effect of RC supplementation on gut microbiota composition to determine whether it improves intestinal barrier function and exercise performance. Female ICR mice were divided into four groups (n = 8 per group) and orally administered RC once daily for 6 weeks at 0 (vehicle), 308 (RC-1X), 615 (RC-2X), and 1,538 (RC-5X) mg/kg. RC supplementation decreased the fat mass and increased exhaustive swimming time, grip strength, and muscle glycogen in female mice. In the RC supplementation group, serum levels of lactate, ammonia, and creatine kinase decreased after swimming. The estradiol and progesterone levels were higher in the RC group than in the vehicle group. Regarding gut microbiota composition, the RC-2X group may increase intestinal health related to the microorganisms Pseudobutyrivibrio and Parabacteroide. Thus, the use of RC supplements as nutraceuticals could have positive effects on athletes' gut and overall health.

Abstract P295: Endothelial Sodium Channel Activation Promotes Cardiac Stiffness in Obese Female Mice

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Javad Habibi ◽  
Annayya R Aroor ◽  
Lixin Ma ◽  
Guanghong Jia ◽  
Adam Whaley-Connell ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Low Dose ◽  
Interstitial Fibrosis ◽  
Diastolic Heart Failure ◽  
The United States ◽  
High Fat ◽  
Female Mice ◽  
Obese Female ◽  
High Fructose ◽  
Endothelial Stiffness

Cardiac diastolic dysfunction (DD) and diastolic heart failure is increasing in concert with obesity and aging population in the United States. In obese and diabetic women, DD is more common than in their male counterparts. This disproportionate increase in DD in obese females may partly explain their loss of sex-related cardiovascular (CV) disease protection. Recent studies have suggested a role for endothelial sodium channel (ENaC) activation in promotion of endothelial stiffness and suppression of flow- (nitric oxide) mediated vasodilation. Moreover, increased mineralocorticoid receptor (MR) activation mediated endothelial stiffness is promoted, in part, by ENaC activation. In this regard, we have recently reported increased plasma aldosterone levels, aortic and cardiac stiffness, and cardiac and vascular MR expression in female mice fed a high fat and high fructose diet (western diet [WD]). This increase in CV stiffness was prevented by very low dose MR antagonism. Accordingly, we hypothesized that inhibition of MR-mediated ENaC activation by using a very low dose of the ENaC inhibitor, amiloride would prevent cardiac stiffening (DD) in WD-fed female mice. Four week old C57BL6/J mice were fed a WD containing high fat (46%), sucrose (17.5%), and high fructose corn syrup (17.5%) with or without a very low dose of amiloride (1mg/kg/day) for 16 weeks. Amiloride significantly attenuated WD-induced impairment of cardiac relaxation in vivo as measured by high resolution magnetic resonance imaging (MRI) as well as cardiac interstitial fibrosis as measured by immunohistochemistry by picrosirius red staining. Moreover, amiloride prevented the development of DD in obese female mice without having effects on blood pressure. These observations support a role for ENaC activation in diet-induced cardiac stiffening (DD) in obese females.

scholarly journals Metal-Organic Decomposition-Mediated Nanoparticulate Vanadium Oxide Hole Transporting Buffer Layer for Polymer Bulk-Heterojunction Solar Cells

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1791
Author(s):  
Chengkai Xia ◽  
Won Tae Hong ◽  
Young Eun Kim ◽  
Woo-Seok Choe ◽  
Dong-Hwan Kim ◽  
...  
Keyword(s):  
Solar Cells ◽  
Vanadium Oxide ◽  
Bulk Heterojunction ◽  
Hole Transport ◽  
Positive Effects ◽  
Polymer Bulk ◽  
Ito Glass ◽  
Metal Organic ◽  
The Stability ◽  
Organic Decomposition

In this study, a solution-processable compact vanadium oxide (V2O5) film with a globular nanoparticulate structure is introduced to the hole transport layer (HTL) of polymer bulk-heterojunction based solar cells comprised of PTB7:PC70BM by using a facile metal-organic decomposition method to replace the conventionally utilized poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS). For this, a biocompatible structure-determining agent, polyethylene glycol (PEG, Mn 300), is used as an additive in the precursor to form the nanoparticulate compact V2O5 (hereafter referred to as NP-V2O5) film, which possesses an outstandingly smooth surface morphology. The introduction of NP-V2O5 HTL via the solution process with a neutral pH condition successfully improved the stability by preventing the decomposition of indium tin oxide (ITO) glass and the penetration of heavy-metal components and moisture, which are considered as the crucial drawbacks of using PEDOT:PSS. Over 1440 h (60 days) of the stability test, an organic solar cell (OSC) with NP-V2O5 showed a significant durability, maintaining 82% of its initial power conversion efficiency (PCE), whereas an OSC with PEDOT:PSS maintained 51% of its initial PCE. Furthermore, due to the positive effects of the modified surface properties of NP-V2O5, the PCE was slightly enhanced from 7.47% to 7.89% with a significant improvement in the short-circuit current density and fill factor.

scholarly journals Insulin Receptor Signaling in the GnRH Neuron Plays a Role in the Abnormal GnRH Pulsatility of Obese Female Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119995 ◽  
Author(s):  
Sara A. DiVall ◽  
Danny Herrera ◽  
Bonnie Sklar ◽  
Sheng Wu ◽  
Fredric Wondisford ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Signaling ◽  
Gnrh Neuron ◽  
Female Mice ◽  
Obese Female ◽  
Insulin Receptor Signaling

Hunger motivation in goldthioglucose-treated and genetically obese female mice.

1974 ◽  
Vol 86 (5) ◽  
pp. 890-897 ◽  
Author(s):  
Devendra Singh ◽  
John R. Lakey ◽  
Melanie K. Sanders
Keyword(s):  
Female Mice ◽  
Obese Female ◽  
Hunger Motivation
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