The Principles of Differentiated Immunotherapy of Pro-Inflammatory Diseases of Different Genesis

2015 ◽  
Vol 22 (2) ◽  
pp. 82-85
Author(s):  
Золоедов ◽  
V. Zoloedov ◽  
Земсков ◽  
M. Zemskov ◽  
Земскова ◽  
...  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Inflammatory Diseases ◽  
Hematological Parameters ◽  
Clinical Effectiveness ◽  
Immune Reactivity ◽  
Immune Disorders ◽  
Systemic Mechanism ◽  
Erythrocyte Sedimentation ◽  
Lymphoid System

The pathogenesis of various inflammatory diseases - deep pyodermia (DP), purulent soft tissue infection (PSTI), chronic pyelonephritis (SP) and chronic oophoritis (CO) is basis in the formation of diagnostically significant changes in routine hematological parameters and indicators of immune reactivity that can be represented in the form of specific formulas. So, the typical response of routine hematological tests on inflammation in patients from 4 groups was qualitatively universal standard, leukocytosis, neutrophilia, eosinophiles, monocytosis, lymphopenia, accelerated eryt-hrocyte sedimentation rate. In quantitative terms the differences were insignificant. When DP is relatively SP recorded higher leukocytosis and neutrophilia, relatively CO significantly less monocytosis and the value of the erythrocyte sedimentation rate, patients with CO had an advantage over SP by the number of neutrophils and monocytes, patients with PSTI relative to women with CO had reduced values of leukocyte, lymphocyte, granulocyte, erythrocyte sedimentation rate, relative to DP - monocytosis. In qualitative terms, the accumulation of hematological parameters for DP was minimal, with CO - maximum, when PSTI, SP - dynamics was average. One traditional treatment is not optimal, because it is not fully correct immune disorders. Additional administration to patients with monomodulators, metabolic agents, antioxidants, combinations of different origin, regional and systemic mechanism of action, with a differentiated focus on the basic parts of the lymphoid system (Roncoleukin, isoprinozine, gabriglobine, thymogen, nucleinate sodium, Derinat, polyoxidonium, licopid, superlymph, lipoxen, zygapan), in general, increases clinical effectiveness of conventional treatment, but requires a preliminary assessment of the effectiveness of these pharmacological effects on the clinical models. Mathematical formalization of the effects of immune disorders in the form of model formulas targets of action on lymphoid system allows you to set specific laboratory evidence to select individual options.

scholarly journals Effects of selected vitamins and minerals on growth rate and hematological parameters in broilers

2016 ◽  
Vol 1 (3) ◽  
pp. 487-494 ◽  
Author(s):  
Mohammad Harun Ar Rashid ◽  
Nazim Ahmad ◽  
Mohammad Rohul Amin ◽  
Mohammad Lalmoddin Mollah
Keyword(s):  
Body Weight ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Hematological Parameters ◽  
Haemoglobin Concentration ◽  
Erythrocyte Sedimentation ◽  
Group A ◽  
Group B ◽  
Group D ◽  
Standard Ration

The present study was designed with a view to study the body weight and hematological parameters; total erythrocyte count, haemoglobin concentration, packed cell volume and erythrocyte sedimentation rate of growing broilers fed with standard poultry ration. Broilers were kept under close observation for a period of 14 days and body weight was measured at each 7 days interval up to the end of the 35 days of experimental period. A total of 20 (7 days old) broiler chicks were reared throughout the entire period of study. These chicks were randomly divided into four equal groups (n=5). Group A considered as control, fed only standard ration. Group B, C and D was considered as treated group. Group B with vitamin AD3E 1 ml/5 liter drinking water. Group C treated with mineral 1 ml/5 liter dirking water and Group D treated with vitamin (AD3E) 1 ml/5liter and mineral 1 ml/5 liter dirking water with standard ration. It was observed that body weight of broiler increased significantly (p<0.01) in group D compare to group A, B, & C. Total erythrocyte count, haemoglobin concentration and erythrocyte sedimentation rate values were significant (p<0.01) in the treated groups as compared to that of control group A. So it is concluded that vitamin (AD3E) and mineral supplementation with standard ration is beneficial for broiler production and economically profitable.Asian J. Med. Biol. Res. December 2015, 1(3): 487-494

scholarly journals A Descriptive Study on Hematological Changes in Brucellosis Infected Individuals

2021 ◽  
pp. 390-395
Author(s):  
Hameedullah Safi ◽  
Waheedullah Noori
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Rural Areas ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Salmonella Typhi ◽  
Presenting Symptoms ◽  
Human Contact ◽  
Erythrocyte Sedimentation ◽  
Hematological Changes

Background: Brucellosis is a zoonotic organism that causes diseases in both animals and humans. Human contact with infected domestic animals is often a transmission route of Brucellosis infection. This infection affects hematological parameters of the patients. We carried this study to determine the changes in various hematological parameters in our study subjects. Patients and Methodology: This study was carried out in Nangarhar regional hospital and safi medical complex on 45 Afghani people from December 2018 up to December 2020. The study design was prospective. A total of 45 patients (Cases) with confirmed diagnosis of Brucellosis on the basis of serology enrolled in the study. Complete blood count and Erythrocyte sedimentation rate studies are also performed. Considered hematological parameters includes Hemoglobin (Hb), White Blood Cell count (WBC), Platelet count (PLT) and ESR.  As well interview was done with each patient and a questionnaire was used. The collected data was analyzed with Microsoft excel program Autosum statistics. Results. A total of 45 patients were enrolled. The mean age±SD of the patients under the study were (28.74±15.22) years. The most common hematological changes observed were; anemia (57.7%), thrombocytopenia (24%), leucocytosis (13.3%), pancytopenia (24.4%), lymphocytopenia (31.1%), lymphocytosis (55.5%) & leucopenia (40%). Erythrocyte sedimentation rate were elevated in about 66% of patients. Fever and headache were the most common presenting symptoms (73%) and (82%) respectively. Night sweats in (40%), joint pain (53%), muscle pain (53%) and lymphadenopathy in 46% of patients. Conclusion: This result of this study shows that Brucellosis commonly affects people of low socioeconomical states, female sex, uneducated, those consuming contaminated dairy products, peoples living in rural areas and those having consuming or contact with animal. Salmonella typhi causes changes in the hematological parameters due to involvement of bone marrow.

CHANGES IN HEMATOLOGICAL PARAMETERS IN HENS DURING SHORT-TERM INFLUENCE OF NEGATIVE ENVIRONMENTAL FACTORS

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Yu. V. Osadcha
Keyword(s):  
Environmental Factors ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Blood System ◽  
Short Term ◽  
Blood Leukocytes ◽  
Erythrocyte Sedimentation ◽  
Short Term Exposure

Comparative analysis of changes in hematological parameters of hens under short-term exposure to various negative environmental factors was performed. For this purpose in the conditions of a modern complex on production of food eggs 3 groups of hens were formed, each of which was kept in a separate cage-analogue on the area and the equipment. In particular, the hens of the 2nd group were deprived of fodder, the 3rd group – of light, and the 4th group – were kept with a significant overcrowding. Exposure to the factor in all groups was 24 hours, after which hematological parameters were determined. Differences in the response of the blood system of hens to short-term exposure to adverse environmental factors depending on their nature were found. The smallest changes in the blood system of hens were observed under the influence of the lack of food, namely an increase, within the physiological norm, the content of leukocytes and ESR, decreased hemoglobin, hematocrit, erythrocytes, platelets, as well as violation of the ratio of different forms of leukocytes – an increase in the concentration of heterophiles (3.3% > normal) on the background of a decrease in the concentration of monocytes (1.6% < normal), lymphocytes and basophils. Whereas under the influence of the factor of lack of light, a higher content of leukocytes in the blood by 10.6%, a lower concentration of hemoglobin by 22.4%, hematocrit – by 4.2%, platelets – by 9.8%, as well as higher erythrocyte sedimentation rate by 9.8%, higher concentration of heterophiles by 5.9% and lower concentration of lymphocytes – by 4.6%, compared with the lack of food. The most significant changes in the blood system were observed under the influence of a factor of significant overcrowding of hens, namely higher blood leukocytes by 17.1 and 5.9%, lower hemoglobin concentration by 29.6 and 9.2%, hematocrit – by 5.9 and 1.7%, erythrocytes – by 10.3%, platelets – by 35.8 and 28.8%, as well as higher erythrocyte sedimentation rate by 4.9%, higher concentration of heterophiles by 11.3 and 5.4% and lower concentration monocytes – by 0.8 and 0.4%, lymphocytes – by 9.4 and 4.8% and eosinophils – by 0.7%, compared with the factor of lack of food and lack of light, respectively.

scholarly journals HEMATOLOGICAL INDIXES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANEMIA

2019 ◽  
Vol 19 (3) ◽  
pp. 71-74
Author(s):  
O.M. Radchenko ◽  
O.V. Fedyk ◽  
R.R. Guta
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Erythrocyte Sedimentation Rate ◽  
Pulmonary Disease ◽  
Sedimentation Rate ◽  
Chronic Obstructive ◽  
Immune Reactivity ◽  
Obstructive Pulmonary Disease ◽  
Hematological Indices ◽  
Erythrocyte Sedimentation ◽  
Endogenous Intoxication

A retrospective analysis of 470 patients with chronic obstructive pulmonary disease and anemia was conducted in order to determine hematological indices. 17 markers of inflammation activity, endogenous intoxication, adaptation, nonspecific and immune reactivity were calculated during this analysis. It was established that the course of chronic obstructive pulmonary disease with anemia was accompanied by a more pronounced inflammation syndrome with a significant increase in stab and segmented neutrophilic granulocytes, an acceleration of the erythrocyte sedimentation rate, and significantly higher integral hematological inflammation indixes (leukocyte shift index, indexes of correlation: -leukocytes to erythrocyte sedimentation rate, -neutrophils to erythrocyte sedimentation rate, -nonsegonuclear neutrophils to erythrocyte sedimentation rate, neutrophils to lymphocytes; inflammation activity index, integrated inflammation index), large endogenous intoxication (neutrophil reactive response index, leukocyte intoxication index), change in adaptation, nonspecific reactivity (decrease in adaptation index, immune reactivity and allergization, and increase in the ratio indices: lymphocytes to monocytes, - lymphocytes to eosinophils) with activation of the phagocytic link of nonspecific protection over cell-humoral. The determination of integral hematological indices is an important, informative and accessible method for assessing the general condition of a patient with chronic obstructive pulmonary disease and anemia.

Hematological values for adult free-ranging pronghorns

1977 ◽  
Vol 55 (2) ◽  
pp. 448-455 ◽  
Author(s):  
Morley W. Barrett ◽  
Gordon A. Chalmers
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Rectal Temperature ◽  
Sedimentation Rate ◽  
Hematological Parameters ◽  
Blood Sampling ◽  
Erythrocyte Sedimentation ◽  
Leukocyte Number ◽  
Sampling Duration ◽  
Free Ranging ◽  
Hematological Values

Hematological parameters for 112 free-ranging, adult pronghorns (Antilocapra amcricana) trapped in southeastern Alberta were obtained in 1973 and 1974. Mean erythrocyte, hematocrit, hemoglobin, and erythrocyte sedimentation rate values were 11.46 × 106/mm3. 51.66%, 18.32 g/dl. and 12.28 mm/24 h. respectively. Mean leukocyte number in pronghorns was 5.02 × 103/mm3. of which 65.8% were neutrophils; lymphocytes comprised 31.5% of while cells. Mean monocyte, eosinophil, and basophil numbers, collectively, represented less than 3% of total leukocytes. Hematocrit and hemoglobin values were significantly greater in females than in males. Significant (P < 0.05) differences in hematological values were associated with year of sampling, duration of capture time before blood sampling, and rectal temperature.

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