scholarly journals STATE OF LIPID SYNTHESIS FUNCTION OF LIVER AT MODERATE CEREBRAL ISCHEMIA IN NEWBORNS FROM MOTHERS WITH CYTOMEGALOVIRUS INFECTION

2017 ◽  
Vol 1 (65) ◽  
pp. 65-70
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Михаил Луценко ◽  
Mikhail Lutsenko ◽  
Наталия Ишутина ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Total Cholesterol ◽  
Cytomegalovirus Infection ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Igg Antibodies ◽  
Avidity Index ◽  
Igg Antibody ◽  
Igm Antibodies ◽  
Antibody Titers

The contents of total cholesterol, high-density lipoproteins, low-density lipoproteins, and triglycerides in cord blood were studied at moderate cerebral ischemia in 230 mature newborns from mothers with chronic cytomegalovirus infection (CMVI) in the second trimester of gestation (main group). The first group (control group) consisted of 30 newborns from mothers with physiological pregnancy. Depending on the activity of chronic CMVI, 4 groups were distinguished, in each of which there were 2 subgroups. Subgroup A included newborns from mothers with pregnancy and an uncomplicated threat of miscarriage, and in subgroup B there were the patients whose mothers suffered the threat of miscarriage at 16-21st week of gestation. The second group was represented by 50 newborns whose mothers had a latent course of chronic CMVI. The third group included 50 children from mothers with reactivation of chronic CMVI (titers of IgM antibodies to CMV were 1:200-1:400, IgG antibody titers to CMVI were 1:200-1:400, avidity index of IgG antibodies to CMVI was more than 65%). The fourth group included 50 newborns whose mothers suffered an acute phase of chronic CMVI (titers of IgM antibodies to CMV were 1:200-1:400, IgG antibody titers to CMV were 1:200-1: 800, avidity index of IgG antibodies to CMV was more than 65%), and in the fifth group there were 50 patients with antenatal history with reactivation of chronic CMVI (IgM antibody titers to CMV were 1:200-1:400, IgG antibody titers to CMV were 1:400-1:1600, avidity index of IgG antibodies to CMV was more than 65%). When comparing 2A and 2B subgroups with the first group, there were no significant changes in total cholesterol of high and low density lipoproteins and triglycerides. In children in 3A subgroup, the concentration of low density lipoproteins decreased to 0.34±0.02 mmol/L, and in 3B subgroup to 0.32±0.02 mmol/L with simultaneous increase in the triglyceride level to 0.51±0.03 mmol/L (in the first group, it was 0.53±0.03 mmol/L, p<0.001 and 0.43±0.03 mmol/L, p<0.05, respectively). In comparison with the first group in 5B subgroup, the lowest total cholesterol values (1.82±0.05 mmol/L, p<0,05), low-density lipoproteins (0.21±0.05 mmol/L, p<0.001), as well as high triglycerides (0.59±0.03, p<0.001) were registered. These can weaken the compensatory-adaptive reactions of the hormonal system that regulates the immune response, vascular permeability and the blood-brain barrier, as well as disrupt the blood supply to the brain in newborns with moderate cerebral ischemia.

scholarly journals LIPID SYNTHESIS FUNCTION OF LIVER IN PREGNANT WOMEN WITH CYTOMEGALOVIRUS INFECTION

2017 ◽  
Vol 1 (66) ◽  
pp. 54-59
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Наталия Ишутина ◽  
Nataliya Ishutina
Keyword(s):  
Total Cholesterol ◽  
Cytomegalovirus Infection ◽  
Lipid Synthesis ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Igg Antibodies ◽  
Avidity Index ◽  
Pregnancy And Delivery ◽  
Antibody Titers

Lipid synthesis function of the liver was studied by the contents of total cholesterol, lipoproteins of high density, lipoproteins of low density and triglycerides in 270 women in the second trimester of pregnancy. The first group (control) included 30 women with a physiological course of pregnancy. The main group consisted of the patients of the second, third, fourth and fifth groups with chronic cytomegalovirus infection (CMVI). Each of them were divided into two subgroups: subgroup A included the women with progressing pregnancy which terminated with the delivery in term; subgroup B - the patients with miscarriage threat whose treatment led to prolongation of the pregnancy and delivery at the 38-40th weeks of gestation. The second group included 60 women with latent chronic CMVI. The third group included patients with reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:400, avidity index of IgG antibodies was more than 65%). The fourth group included 60 patients with acute phase of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:800, avidity index of IgG to CMV was more than 65%), the fifth group had 60 patients with reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:400-1:1600, avidity index of IgG antibodies was more than 65%). When comparing the parameters of the first group with such-like ones of 2A and 2B subgroups there were not found any changes in the contents of total cholesterol, lipoproteins of high density and lipoproteins of low density and triglycerides; whereas in 3A subgroup there were revealed lower values of lipoproteins of low density (3.55±0.09 mmole/L; p<0.01), and in subgroup 3B there was a decrease of concentration of total cholesterol till 6.33±0.14 mmole/L (in control it was 6.7±0.09 mmole/L; p<0.05) and lipoproteins of low density till 3.43±0.10 mmole/L (in control it was 3.93±0.09 mmole/L; p<0.001). In the patients of subgroup 4B in comparison with the first group there were registered lower values of total cholesterol (6.20±0.15 mmole/L; p<0.01) and there was a growth of lipoproteins of high density till 2.04±0.13 mmole/L (p<0.05). In subgroup 5B there was a drop of concentration of total cholesterol till 5.93±0.14 mmole/L (p<0.001 in comparison with the first group; p<0.05 in comparison with subgroup 2B); there was a decrease of lipoproteins of low density in comparison with the first group till 2.73±0.09 mmole/L (p<0.001), as well as the increase of concentration of lipoproteins of high density till 2.06±0.10 mmole/L (p<0.01) and triglycerides till 1.96±0.05 mmole/L (p<0.01). The changes in the concentration of lipids in the serum of peripheral blood proved a very important role of the acute virus infection with 4-time growth of antibodies of IgG to CMVI in the suppression of lipid synthesis function of the liver and development of miscarriage.

scholarly journals THE CONTENTS OF TOTAL CHOLESTEROL AND TRIGLYCERIDES IN NASOPHARYNGEAL ASPIRATE UNDER MODERATE CEREBRAL ISHEMIA IN NEWBORNS FROM MOTHERS WITH CYTOMEGALOVIRUS INFECTION DURING PREGNANCY

2017 ◽  
Vol 1 (65) ◽  
pp. 59-64
Author(s):  
Михаил Луценко ◽  
Mikhail Lutsenko ◽  
Игорь Гориков ◽  
Igor Gorikov ◽  
Наталия Ишутина ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Total Cholesterol ◽  
Cytomegalovirus Infection ◽  
Control Group ◽  
Healthy Children ◽  
Nasopharyngeal Aspirate ◽  
Second Trimester ◽  
Igg Antibodies ◽  
Avidity Index ◽  
Antibody Titers

The contents of total cholesterol (TC) and triglycerides (TG) in nasopharyngeal aspirate were studied in 233 mature newborns from mothers with normal pregnancy and complicated with cytomegalovirus infection (CMVI). The first (control) group included 30 babies of 38-40 weeks from mothers with physiological course of pregnancy. Among the newborns with moderate cerebral ischemia and antenatal history complicated with chronic CMVI in their mothers in the second trimester of pregnancy, four groups were distinguished and each of them was divided into two subgroups. Subgroup A had patients whose mothers did not have the threat of miscarriage during pregnancy and subgroup B had children from mothers who had the threat of miscarriage in the second trimester of gestation. The second group included 50 newborns whose mothers had a latent course of chronic CMVI; the third group included 50 children from mothers with reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:400, the avidity index of IgG antibodies to CMV was more than 65%); the fourth group consisted of 51 newborns whose mothers suffered an acute form of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:800, avidity index of IgG antibodies to CMV was more than 65%); and the fifth group had 52 children from mothers who suffered a reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:400-1:600, avidity index of IgG antibodies to CMV was more than 65%). The children of 2A, 3A and 4A subgroups, in comparison with the first group, in nasopharyngeal aspirate did not have any significant changes in the contents of TC and TG. In 5A subgroup against the absence of reliable differences of TG concentration there was registered a fall of TC level till 0.189±0.015 mmole/L (in control and 2A subgroup it was 0.250±0.016 mmole/L, p<0.01 and 0.246±0.015 mmole/L, p<0.01, respectively). When comparing the lipid composition of nasopharyngeal aspirate in newborns of 2B and 3B subgroups with the one taken from healthy children there were not found any significant differences in TC and TG. But in 4B and 5B subgroups there was a fall of TC till 0.191±0.014 mmol/L (p<0.01) and till 0.146±0.010 mmole/L (p<0.001), while the values of TG grew till 0.169±0.009 mmole/L (p<0.05) and till 0.198±0.009 mmole/L (p<0.001); at the same time the contents of TG in the first group was only 0.142±0.008 mmole/L. Thus in newborns with moderate cerebral ischemia and antenatal history complicated with 4 times growth of antibody titers of IgG to CMV and the threat of miscarriage in the second trimester of gestation, the decrease of TC can lead to less expressed compensatory-adaptive reactions, and the increase of TG, including fatty acids peroxides, results in the starting of mechanisms of intrauterine degradation of pulmonary surfactant and membrane-destructive processes in central nervous system.

Adsorption of Lipoprotein Containing Apolipoprotein-B through Plasma Separation for Treatment of Familial Hypercholesterolemia

1986 ◽  
Vol 9 (5) ◽  
pp. 343-348 ◽  
Author(s):  
M. Odaka ◽  
H. Kobayashi ◽  
K. Soeda ◽  
N. Murotani ◽  
Y. Saito ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Adsorption Capacity ◽  
Familial Hypercholesterolemia ◽  
Apolipoprotein B ◽  
Clinical Results ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Affinity Adsorbent ◽  
Excellent Selectivity

For the treatment of familial hypercholesterolemia, Liposorber LA-40 was clinically applied. The Liposorber is a commercially developed affinity adsorbent for plasma perfusion which selectivily adsorbs low density lipoproteins and very low density lipoproteins and is specially designed for plasmapheretic treatment of hypercholesterolemia. The Liposorber column, containing activated cellulose beads having an affinity for liporpotein containing apolipoprotein-B, has an excellent adsorption capacity, excellent selectivity, minimum albumin loss. This new apheresis system was applied to 2 clinical cases. After seven months of trial perfusion every 2 weeks, patient condition was good, with a level of total cholesterol under 300 mg/dl. No replacement fluids were given during or after treatment. In this paper, clinical results of these patients were shown and the mechanism of adsorption of this specific adsorbent was discussed.

Hypocholesterolemic effects of watermelon fruit rind on rats

2018 ◽  
Vol 48 (5) ◽  
pp. 836-845 ◽  
Author(s):  
Hind Abu-Hiamed
Keyword(s):  
Total Cholesterol ◽  
Normal Control ◽  
Citrullus Lanatus ◽  
Control Diet ◽  
Low Density Lipoproteins ◽  
Hepatic Tissue ◽  
Low Density ◽  
Hypocholesterolemic Effect ◽  
Content Type ◽  
Fruit Rind

Purpose Watermelon (Citrullus lanatus) fruit and its rind are known to contain phytochemicals that may have health benefits. The aim of this paper is to investigate the potential hypocholesterolemic effect of watermelon fruit rind (WR) using rats who are fed a high-cholesterol diet. Design/methodology/approach Rats were divided into six groups and fed diets for eight weeks containing normal control diet or normal control diet with either 1% cholesterol, 5% WR, 10% WR, 1% cholesterol + 5% WR or 1% cholesterol + 10% WR. Triglycerides, total cholesterol and lipoprotein levels in serum and liver samples were determined, and histopathological examination of liver tissues was carried out. Findings Diets containing 1% cholesterol led to hypercholesterolemia, characterized by increased levels of total cholesterol and low-density lipoproteins in rat serum and liver samples. Incorporation of 10% WR into the diet of the otherwise hypercholesterolemic rats led to significant reduction in serum levels of total cholesterol (from 266.2 to 222.7 mg/dL) and low-density lipoproteins (from 159.5 to 94.4 mg/dL). In addition, these rats also exhibited improvements in hepatic tissue structure compared to the hypercholesterolemic rats. Originality/value These results support the potential use of WR as a hypocholesterolemic agent. Further research is needed to ascertain the hypocholesterolemic effect of WR in human.

The Effects of Exclusive Walking on Lipids and Lipoproteins in Women with Overweight and Obesity: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 089011712110481
Author(s):  
Anjulyn M. Ballard ◽  
Ashlee Davis ◽  
Brett Wong ◽  
Rodney Lyn ◽  
Walter R. Thompson
Keyword(s):  
Total Cholesterol ◽  
Data Extraction ◽  
Cochrane Review ◽  
Low Density Lipoproteins ◽  
Overweight And Obesity ◽  
Mean Difference ◽  
Lipid Lowering ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Lipids And Lipoproteins

Objective To evaluate the effects of walking, independent of diet and weight-loss, on lipids and lipoproteins in women with overweight and obesity. Data Source Academic Search Complete, Alternative Health Watch, Global Health, Health Source, CINAHL, MEDLINE, EMBASE, SportDiscus, and ProQuest. Study Inclusion and Exclusion Criteria (1) experiment-control design; (2) women with overweight or obesity; (3) walking as the experiment’s independent variable; (4) four or more weeks; and (5) pre- to post-assessment of lipids and/or lipoproteins. Excluded studies reported use of lipid-lowering medication, diet or other modes of physical activity, and alternative interventions as the control. Data Extraction Data extraction and study quality were completed by the first 2 authors using the Cochrane review protocol and risk of bias assessment. Data Synthesis Raw mean difference between the experiment and control groups using a random effects model. Results Meta-analyses of 21 interventions (N = 1129) demonstrated exclusive walking improves total cholesterol (raw mean difference = 6.67 mg/dL, P = .04) and low-density lipoproteins (raw mean difference = 7.38 mg/dL, P = .04). Greater improvement in total cholesterol, triglycerides, high-density lipoproteins, and low-density lipoproteins existed in women with obesity. Conclusions Exclusive walking aids in normalizing total cholesterol and LDLs in women with overweight and obesity. Exclusive walking can be used as a non-pharmacologic therapy, which may have positive clinical outcomes for individuals who especially struggle with diet and weight-reduction.

scholarly journals Reactivity features of cytokines and vasculoendothelial growth factor in patients with chronic cerebral ischemia and metabolic syndrome

2019 ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Cerebral Ischemia ◽  
Growth Factor ◽  
Waist Circumference ◽  
Interleukin 6 ◽  
Interleukin 10 ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Chronic Cerebral Ischemia ◽  
Very Low Density Lipoproteins

The purpose of the research is to determine the correlation between cytokines (interleukin-6, interleukin-10), vasculoendothelial growth factor, biochemical and anthropometric parameters in patients with chronic cerebral ischemia and metabolic syndrome. We examined 77 patients with chronic cerebral ischemia divided into 2 groups: with metabolic syndrome and without metabolic syndrome. In addition to neuroimaging, anthropometric and biochemical research we determined serum concentrations of interleukin-6, interleukin-10 and vasculoendothelial growth factor. It was found that patients with chronic cerebral ischemia and metabolic syndrome had significantly higher concentrations of interleukin-6, vasculoendothelial growth factor, indicators of weight, body mass index, waist circumference, glucose concentration, triglycerides, very low density lipoproteins, and high density lipoproteins was lower compared with the group without metabolic syndrome. During the comparing process of the biomarkers concentrations depending on gender, it was found that in patients with chronic cerebral ischemia and metabolic syndrome, the concentration of interleukin-6 was significantly higher in women than in men. Examination of all patients with chronic cerebral ischemia showed a direct correlation between the concentrations of interleukin-6 and glucose, the concentrations of interleukin-6 and weight, the concentrations of interleukin-6 and the waist circumference and between the concentration of vasculoendothelial growth factor and the waist circumference, in the group with metabolic syndrome - between the concentrations of interleukin-6 and interleukin-10, and in the group without metabolic syndrome - between the waist circumference and the atherogenic coefficient, between the concentrations of low density lipoproteins and β-lipoproteids, between the concentrations of low density lipoproteins and very low density lipoproteins. Thereby, metabolic syndrome is an additional complicating factor that comprehensively affects the reactivity of cytokines and vasculoendothelial growth factor in the pathogenesis of chronic cerebral ischemia.

scholarly journals DISTURBANCE OF 20α-HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN VILLOUS CHORION SYNCIOTHYTHROPHOBLAST AT REACTIVATION OF CYTOMEGALOVIRUS INFECTION DURING PREGNANCY

2017 ◽  
Vol 1 (65) ◽  
pp. 50-53
Author(s):  
Инна Довжикова ◽  
Inna Dovzhikova ◽  
Михаил Луценко ◽  
Mikhail Lutsenko ◽  
Ксения Петрова ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Dehydrogenase Activity ◽  
Cytomegalovirus Infection ◽  
Hydroxysteroid Dehydrogenase ◽  
First Trimester ◽  
Main Group ◽  
Control Group ◽  
Reaction Products ◽  
Igg Antibody ◽  
Antibody Titers

The aim of the work is to assess the effects of cytomegalovirus infection on the 20α-hydroxysteroid dehydrogenase activity in the villous chorion syncytiotrophoblast in the first trimester of pregnancy. The materials for the study included 48 villous chorions samples taken during spontaneous abortions at 8th–10th weeks of gestation from women with reactivation of cytomegalovirus infection (the main group). The control group included 35 villous chorions samples from pregnant women with chronic cytomegalovirus infection in the latent stage taken at medical abortions at the same stage of gestation. The results of women’s examination were studied taken into account the activity of cytomegalovirus infection by immunoassay by detection of IgM antibodies or by 4 times and more increase of IgG antibody titers in the paired serums in dynamics in 10 days. The activity of 20α-hydroxysteroid dehydrogenase was assessed by the histochemical method. Quantitative evaluation of the reaction products was carried out on sections under the microscope MT (Japan) connected to software-hardware complex «SCION Corporation» (USA). At histochemical specimen of villous chorion of pregnant women who had a reactivation of cytomegalovirus infection during pregnancy (main group), there was a decrease of cytophotometric parameter of 20α-hydroxysteroid dehydrogenase activity till 30.1±2.12 pixels/μm2 (p<0.001) compared with the control group. The decrease in the reaction activity in syncytiotrophoblast indicated a decrease in the contents of 20α-dihydroprogesterone in placenta, which contributed, in our opinion, to spontaneous abortion.

scholarly journals The Diabetes Prevention Program: A Worksite Experience

AAOHN Journal ◽  
2005 ◽  
Vol 53 (11) ◽  
pp. 499-505 ◽  
Author(s):  
Steven G. Aldana ◽  
Marilyn Barlow ◽  
Rebecca Smith ◽  
Frank G. Yanowitz ◽  
Ted Adams ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Total Cholesterol ◽  
Prevention Program ◽  
Diabetes Prevention ◽  
Diabetes Prevention Program ◽  
Low Density Lipoproteins ◽  
High Density Lipoproteins ◽  
Oral Glucose ◽  
Low Density ◽  
Very Low Density Lipoproteins

The purpose of this study was to determine if the U.S. National Institutes of Health Diabetes Prevention Program (DPP) could be successfully implemented in a worksite setting. Thirty-seven adult employees of BD Medical Systems of Sandy, Utah were enrolled in a single-group time-series study using the DPP. Two-hour oral glucose tolerance tests (OGTT) and other outcomes were measured at baseline, 6 months, and 12 months. Weight, body mass index, waist circumference, 2-hour OGTT, very low density lipoproteins, triglycerides, and aerobic fitness were significantly improved at 6 and 12 months and showed overall significant improvement across time. Fasting blood insulin, total cholesterol, low density lipoproteins, and total cholesterol/high density lipoproteins ratio were significantly improved at 6 months, but not at 12 months. Eighteen of the program participants (51%) were no longer in the pre-diabetes and diabetes categories after 1 year. Existing worksite health promotion and occupational health professionals can successfully offer the DPP and help employees improve glucose tolerance.

scholarly journals Serum IgG Antibodies against Periodontal Microbes and Cancer Mortality

2019 ◽  
Vol 5 (2) ◽  
pp. 166-175
Author(s):  
Z. Zhong ◽  
Q. Jin ◽  
J. Zhang ◽  
Y.M. Park ◽  
D. Shrestha ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cancer Mortality ◽  
Igg Antibodies ◽  
Igg Antibody ◽  
Actinomyces Naeslundii ◽  
Hazard Ratios ◽  
Chronic Inflammatory Condition ◽  
Yellow Orange ◽  
Z Scores ◽  
Antibody Titers

Introduction: Periodontitis is a chronic inflammatory condition initiated by microorganisms and is positively linked to systemic conditions such as cancer, cardiovascular disease, and diabetes mellitus. Objectives: To prospectively investigate associations between empirically derived clusters of IgG antibodies against 19 selected periodontal microorganisms and cancer mortality in a representative sample of the US population. Methods: We evaluated 6,491 participants aged ≥40 y from the Third National Health and Nutrition Examination Survey (1988 to 1994), who had complete data on IgG antibody titers against 19 selected periodontal microorganisms and were free of cardiovascular disease and cancer. In a prior study, antibodies were categorized into 4 mutually exclusive groups via cluster analysis: red-green, orange-red, yellow-orange, and orange-blue. Cluster scores were estimated by summing z scores of the antibody titers making up each cluster. Participants were followed up to death until December 31, 2011. Cox proportional hazard models were applied to estimate hazard ratios (HRs) and 95% CIs for all-cancer mortality by tertiles of cluster scores. Results: During follow-up for a median of 15.9 y, there were 2,702 deaths (31.3%), including 631 cancer-related deaths (8.1%). After adjusting for multiple confounders, the orange-blue cluster was inversely associated with cancer mortality (tertile 2 vs. tertile 1: HR = 0.67, 95% CI = 0.54 to 0.84; tertile 3 vs tertile 1: HR = 0.62, 95% CI = 0.46 to 0.84). The association between the yellow-orange cluster and all-cancer mortality was also inverse but not significant, and the orange-red cluster and the red-green cluster were not associated with all-cancer mortality. Conclusions: Antibodies against Eubacterium nodatum and Actinomyces naeslundii may be novel predictors of cancer mortality. If further studies establish a causal relationship between these antibodies and cancer mortality, they could be targets to prevent possible systemic effects of periodontal disease with potential interventions to raise their levels. Knowledge Transfer Statement: Periodontal antibodies against Eubacterium nodatum and Actinomyces naeslundii were inversely associated with cancer mortality among adults followed up for an average of 16 y. Periodontal antibodies may predict cancer mortality.

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