scholarly journals Influence of combined treatment with mianserin and simvastatin on selected biochemical serum parameters of liver and kidney function in rats

2013 ◽  
Vol 26 (3) ◽  
pp. 263-266
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Day Treatment ◽  
Combined Treatment ◽  
Creatinine Concentration ◽  
Serum Parameters ◽  
Combined Administration ◽  
Liver And Kidney ◽  
The Impact

The aim of the present study was to assess the impact of combined 14-day treatment with mianserin (10 mg/kg) and simvastatin (1 or 10 mg/kg) on selected biochemical liver and kidney parameters in rats (AST and ALT activities and the concentrations of AFP, total protein, urea, creatinine and ß2-M). The results showed the increase in both transaminases activities, creatinine concentration and the decrease of AFP, total protein and ß2-M concentrations. The results indicate that 14-day combined administration of mianserin with simvastatin negatively affects the liver functioning. The observed changes in kidney biochemical parameters may suggest a risk of renal dysfunction during long-term combined treatment with these drugs.

Changes of biochemical parameters in blood serum rats under chronic light desynchronosis

2020 ◽  
Vol 66 (6) ◽  
pp. 450-455
Author(s):  
E.G. Batotsyrenova ◽  
E.A. Zolotoverkhaja ◽  
V.A. Kashuro ◽  
A.V. Sharabanov
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Physical Factor ◽  
Toxicity Tests ◽  
Constant Darkness ◽  
Serum Total Protein ◽  
Modified Model ◽  
Medicinal Substances ◽  
Light Mode

Ten biochemical parameters total protein, albumin, glucose, cholesterol, urea, creatinine, total bilirubin, ALT, AST, APh were determined during long-term light mode changes in serum of rats. Changing the light mode, a number of parameters revealed unreliable 24-hour rhythms. An ultradian 12-hour reliable rhythm has been for serum total protein of rats exposed to constant darkness during 1 month. The light-modified model can be used to study the effects of the chemical factor in combination with the physical factor of the external environment, as well as in preclinical toxicity tests of medicinal substances in different light modes.

scholarly journals Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus

2013 ◽  
Vol 53 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Hany Kamal Abd-Elhady ◽  
Gamal Elsayed Abou-Elghar
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Corn Oil ◽  
Male Rats ◽  
Streptomyces Avermitilis ◽  
Sublethal Dose ◽  
Histopathological Changes ◽  
Albino Rat ◽  
Liver And Kidney ◽  
Sublethal Doses

Abstract Abamectin (Avermectin B1a), is a natural fermentation product derived from the soil bacterium Streptomyces avermitilis. Abamectin (Avermectin B1a) is widely used as an insecticide, acaricide, and anthelmintic. The present study assessed the effects of repeated subacute and subchronic exposure to the commercial formulation of abamectin (Vertemic, 1.8% EC) in albino male rats. The toxic effects of abamectin were studied. The various biochemical parameters and histopathological changes were noted. A stomach tube was used to orally administer sublethal doses of abamectin suspended in corn oil to the rats. The animals were divided into four groups. Rats of the group T1 were orally administered a sublethal dose of 30 mg/kg body weight (b.wt.) (1/10 LD50) three times a week for 30 days and the animals in group T2 were exposed to 10 mg/kg b.wt. (1/30 LD50) for 210 days, once a week. Two control groups (C1 and C2) were used in parallel studies, where animals were administered a corn oil vehicle. At the end of the study period, blood samples were collected from all groups to measure plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, and the levels of creatinine and urea. Also, total protein and RNA contents were determined in the liver and kidney tissues. Changes in biochemical parameters were more intense in male rats from group T2 than those reported in group T1. The levels of ALT, AST, urea and creatinine were significantly elevated in rats from group T2 when compared to the control. In group T2, a significant decrease in the levels of total protein and RNA in both the liver and kidneys was observed. Fertility was also significantly reduced in male rats ingesting abamectin in group T2. The number of offspring was significantly reduced. Histopathological changes were more intense in male rats from group T2 than those from group T1. In conclusion, the results of this study demonstrate that subchronic oral administration of abamectin altered some biochemical parameters which correlated with histopathological changes

scholarly journals Pentoxifylline with metformin treatment improves biochemical parameters in patients with nonalcoholic steatohepatitis

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Milica Culafic ◽  
Sandra Vezmar Kovacevic ◽  
Violeta Dopsaj ◽  
Branislav Oluic ◽  
Nemanja Bidzic ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Biochemical Parameters ◽  
Liver Enzymes ◽  
Low Cost ◽  
Combined Treatment ◽  
Prospective Trial ◽  
Nonalcoholic Fatty Liver ◽  
Blood Tests ◽  
Nash Group ◽  
The Impact

Summary Background The progression of the nonalcoholic fatty liver disease to nonalcoholic steatohepatitis (NASH) is multifactorial, and there is still a lack of approved medications for its treatment. The study aimed to evaluate the impact of combined treatment with Pentoxifylline and Metformin on biochemical parameters in patients with NASH. Setting: Outpatient hepatology clinic. Methods A prospective trial was conducted. The first cohort included patients with biopsy-proven NASH, while the second cohort consisted of patients with biopsy-confirmed NAFLD. Blood tests were checked at baseline and every three months. Pentoxifylline at a dosage of 400 mg t.i.d. and Metformin at the dosage of 500 mg t.i.d. were introduced for six months in NASH group. The impact of the treatment was assessed based on biochemical results after combined treatment with low-cost medications. Results All 33 NASH patients completed 24 weeks of treatment. We observed significant improvement (p<0.05) of median values after treatment for the following parameters: serum uric acid levels decreased by 51.0 micromol/L, calcium decreased for 0.27 mmoL/L, magnesium showed an increase of 0.11 mmoL/L. Insulin resistance improved as a reduction of HOMA – IR by 1.3 was detected. A significant decrease of median in liver enzymes, alanine aminotransferase, aspartate aminotransferase and gammaglutamyltransferase by 24.0 IU/L, 9.1 IU/L, 10.8 IU/L respectively, was noted. Conclusions Pentoxifylline and Metformin may provide possible treatment option in NASH. Some new potential benefit of the therapy in improving liver function whilst decreasing cardiovascular risk was perceived.

scholarly journals Impact des extraits éthyliques des feuilles de Hexalobus Monopétalus sur lemétabolisme protéiques des rats Wistar

2018 ◽  
Vol 6 (01) ◽  
Author(s):  
Akotegnon Rodrigue ◽  
Michodjehoun Loetitia ◽  
Behanzin Justin ◽  
Houeze Elisabeth ◽  
Sezan Alphonse
Keyword(s):  
Uric Acid ◽  
Total Protein ◽  
Wistar Rats ◽  
Polyphenolic Compounds ◽  
Blood Levels ◽  
Phytochemical Screening ◽  
Duration Of Treatment ◽  
Anthracene Derivatives ◽  
The Impact

The aim of this study was to evaluate the impact of the ethyl extract of dried leaves of Hexalobus monopetalus on protein metabolism in Wistar rats. After a phytochemical screening of extracts, total protein, urea, uric acid and creatinine were measured spectrophotometrically at six (06) sets of three (03) Wistar rats each. Batches 2 to 6 were given with orally administered respectively the daily doses of: 0.25 mg / kg, 0.5mg / kg, 1mg / kg, 1.5mg / kg and 2.5mg kg body weight of the extracts (for 14 days). The lot1 witness received distilled water instead of the extract. The results of the phytochemical screening revealed the presence polyphenolic compounds (gallic tannins, catechin tannin or condensed, anthocyanins, and leuco anthocyanins), flavonoids, mucilages reducing compounds, alkaloids, certain anthracene derivatives ( free anthracene, the O-glycosides), Steroids, and quinone derivatives. It was observed a significant increase (p ˂ 0.05) blood levels of total protein and uric acid and a significant (p ˂ 0.05) blood urea and creatinine levels in treated plots to extracts. These observed variations did not depend on the administered dose of the extracts but were depending on the duration of treatment; they were outstanding from the 7th day of treatment. The long term use of ethyl extract of dried leaves of Hexalobus monopetalus could compromise the liver function and the kidneys and may inhibit apoptosis in Wistar rats.

Combined treatment and survival of medullary thyroid carcinoma patients

Open Medicine ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. 426-430
Author(s):  
Zenonas Baranauskas ◽  
Konstantinas Valuckas ◽  
Giedre Smailyte
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
External Beam Radiotherapy ◽  
Combined Treatment ◽  
Term Survival ◽  
Long Term Survival ◽  
Medullary Thyroid ◽  
The Impact

AbstractThe aim of this study is to analyze the impact of combined treatment (thyroidectomy and radiotherapy and radioactive iodine treatment) on patients’ long-term survival with medullary thyroid carcinoma. This is a retrospective study of 59 patients treated from 1977 to 2006 for medullary carcinoma at the Institute of Oncology in Vilnius, Lithuania. Survival was estimated by the Kaplan-Meier method. Univariate and multivariate Cox proportional hazard models were used to explore the association of prognostic factors with long-term survival. The survival of MTC patients was 88.0% (95% CI 68.0–88.9), 67.9% (95% CI 52.3–79.4) and 60.5% (95% CI 43.2–74.0), respectively, 5, 10 and 15 years after diagnosis. In survival analysis, only the type of surgery and lymph node involvement were found to be significant prognostic factors. The results of this study suggest that treatment with radioiodine and external beam radiotherapy do not improve significantly the long-term survival of surgically treated MTC patients.

scholarly journals Impact of regular consumption of the main Ivorian traditional foods on blood biochemical parameters and certain nutrition regulators: cases in growing rats (Rattus norvegicus)

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Adou Koffi Lunindjani ◽  
Vincent Kadjo ◽  
Jean Brice Gbakayoro ◽  
Abou Joel Ladry Okon ◽  
Kouakou Brou
Keyword(s):  
Rattus Norvegicus ◽  
Biochemical Parameters ◽  
Traditional Foods ◽  
Growing Rats ◽  
Blood Biochemical ◽  
Cholesterol Levels ◽  
Regular Consumption ◽  
Liver And Kidney ◽  
Sugar Levels ◽  
The Impact

The aim of this work was to assess the impact of regular consumption of Ivorian traditional foods on growing wistar rats. Thus, a nutrition test was carried out with 40 rats divided into 5 groups of 8 rats. The rats in one batch were fed with an Ivorian traditional dish and the control rats ingested the control dish for 22 days. At the end of the experiment, biological examinations allowed us to assess the state of the body's functioning. The histopathology of the liver and kidney of the rats was performed. The blood sugar levels of the rats who consumed the Ivorian traditional dishes varied between 0.79 g / l (FFB / SC) and 0.89 g / l (FI / SNA) while that of the rats who consumed the reference dish was 0.87 g / l. The urea contents of the blood of the rats were between 0.22 and 0.26 g / l. They were identical to that of the control rats (0.26 g / l). The rats which consumed the traditional dishes had creatinine contents between 6.83 (FFB / SC) and 8 mg / l (FI / SNA) while the controls had a creatinine content of 7.83 mg / l. The uric acid contents of the rats fed with the Ivorian dishes varied between 22.5 and 26.0 mg / l while that of the control rats was 23.83 mg / l. The total cholesterol levels in the rats accustomed to Ivorian dishes were between 1.51 and 1.75 g / l while that of the rats having ingested the control dish was 1.69 g / l. The triglyceride values (0.84 to 1.02 g / l) were lower than that of the rats fed with the reference dish (1.05 g / l). Analysis of histopathological sections of the liver and of the kidney showed no organizational abnormalities of the tissues. The regular consumption of Ivorian local dishes ensures the proper functioning of the consumer's body.

scholarly journals Assessment of Some Biochemical Changes in Wistar Rats Following Administration of Three Polyherbal Preparations Repurposed for COVID-19

2020 ◽  
pp. 54-60
Author(s):  
Kennedy Iliya Amagon ◽  
Bukata Bayero Bukar ◽  
Jacob Adegboyega Kolawole ◽  
Kakjing Dadul Falang ◽  
Ukpe Ajima ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Specific Treatment ◽  
Laboratory Animals ◽  
Total Serum Protein ◽  
Total Serum ◽  
Creatinine Concentration ◽  
Mean Values ◽  
Significant Public Health ◽  
Liver And Kidney ◽  
The Mean

Background and Aims: The current pandemic known as Coronavirus Disease-19 (COVID-19) is a significant public health menace. Currently, there is no specific treatment for this disease, although some medicinal agents are under investigation. Some published articles have reported Severe Acute Respiratory Distress Syndrome Coronavirus-2 (SARS CoV-2) involvement in other organs, including the liver and kidneys, which can impair the metabolism and excretion of the medications taken to treat the disease. This study evaluated the effects of 3 herbal mixtures on some biochemical parameters of the liver and kidney of laboratory animals. Methods: Liver enzymes such as serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin and total serum protein were quantified. Urea, creatinine and bilirubin (total and direct) were also evaluated. These parameters were determined for all three polyherbal combinations (CoV Pla-1, CoV Pla-2, CoV Pla-3). Results: The extracts did not produce any mortality up to 5000 mg/kg per oral. Results showed that the polyherbal extracts (CoV Pla-1, CoV Pla-2 CoV Pla-3) did not cause any significant changes in ALT, AST, ALP, compared to control. The mean values of urea showed an insignificant (P>0.05) decrease across all test doses in the three extracts, compared to the control. In the current   study, the mean creatinine concentration showed slight decrease across all three extracts. Total protein was observed to be lower in CoV Pla-1 and CoV Pla-2, and increased in CoV Pla-3,    though these changes were not statistically significant. Serum albumin decreased at the low   and intermediate doses for the three polyherbal extracts in an insignificant manner compared to control. Conclusion: The results obtained in this study indicate that the extracts did not cause  significant changes in biochemical parameters evaluated and support their use in the treatment of Covid-19.

scholarly journals Days-in-Milk and Parity Affected Serum Biochemical Parameters and Hormone Profiles in Mid-Lactation Holstein Cows

Animals ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 230
Author(s):  
Xuehui Wu ◽  
Hui-Zeng Sun ◽  
Mingyuan Xue ◽  
Diming Wang ◽  
Leluo Guan ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Biochemical Parameters ◽  
Milk Protein ◽  
Dairy Farm ◽  
Serum Biochemical Parameters ◽  
Serum Parameters ◽  
Management Regime ◽  
Milk Protein Content ◽  
Liver And Kidney ◽  
Serum Biochemical

It is well known that serum biochemical parameters and hormones contribute greatly to the physiological and metabolic status of dairy cows. However, few studies have focused on the variation of these serum parameters in multiparous mid-lactation cows without the interference of diet and management. A total of 287 Holstein dairy cows fed the same diet and maintained under the same management regime were selected from a commercial dairy farm to evaluate the effects of days-in-milk (DIM) and parity on serum biochemical parameters and hormone profiles. Milk yield and milk protein content were affected by DIM and parity (p < 0.05). Milk protein yield showed a numerically decreasing trend with parity, and it was relatively constant in cows with parities between 2 and 4 but lower in cows with parity 6 (p = 0.020). Ten and five serum biochemical parameters related to protein status, energy metabolism, liver and kidney function, and oxidative stress were affected by DIM and parity, respectively (p < 0.05). Glucagon, insulin-like growth factor 1 concentration, and the revised quantitative insulin sensitivity check index were significantly different (p < 0.05) among cows with different DIM. Parity had no effect on hormone concentrations. An interaction between DIM and parity effect was only detected for glucagon concentration (p = 0.015), which showed a significantly increasing trend with DIM and overall decreasing trend with parity. In summary, DIM and parity played an important role in affecting the serum biochemical parameters and/or hormones of dairy cows, with serum parameters affected more by DIM than parity.

scholarly journals Recent Advances in the Application of Antibacterial Complexes Using Essential Oils

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1752
Author(s):  
Tae Jin Cho ◽  
Sun Min Park ◽  
Hary Yu ◽  
Go Hun Seo ◽  
Hye Won Kim ◽  
...  
Keyword(s):  
Essential Oils ◽  
Synergistic Effects ◽  
Combined Treatment ◽  
Antibacterial Effects ◽  
High Concentration ◽  
Short Term Exposure ◽  
Treatment Technologies ◽  
The Impact ◽  
Antibacterial Spectrum

Although antibacterial spectrum of essential oils (EOs) has been analyzed along with consumers’ needs on natural biocides, singular treatments generally require high concentration of EOs and long-term exposures to eliminate target bacteria. To overcome these limitations, antibacterial complex has been developed and this review analyzed previous reports regarding the combined antibacterial effects of EOs. Since unexpectable combined effects (synergism or antagonism) can be derived from the treatment of antibacterial complex, synergistic and antagonistic combinations have been identified to improve the treatment efficiency and to avoid the overestimation of bactericidal efficacy, respectively. Although antibacterial mechanism of EOs is not yet clearly revealed, mode of action regarding synergistic effects especially for the elimination of pathogens by using low quantity of EOs with short-term exposure was reported. Whereas comprehensive analysis on previous literatures for EO-based disinfectant products implies that the composition of constituents in antibacterial complexes is variable and thus analyzing the impact of constituting substances (e.g., surfactant, emulsifier) on antibacterial effects is further needed. This review provides practical information regarding advances in the EO-based combined treatment technologies and highlights the importance of following researches on the interaction of constituents in antibacterial complex to clarify the mechanisms of antibacterial synergism and/or antagonism.

scholarly journals Changes in the spectrum of proteins and phospholipids in tissues of rats exposed to thiosulfonates

2018 ◽  
Vol 9 (4) ◽  
pp. 495-500 ◽  
Author(s):  
V. I. Lubenets ◽  
V. V. Havryliak ◽  
A. Z. Pylypets ◽  
A. V. Nakonechna
Keyword(s):  
Blood Plasma ◽  
Total Protein ◽  
Methyl Esters ◽  
Kidney Tissue ◽  
Total Content ◽  
Ethyl Esters ◽  
Short Term ◽  
Wide Range ◽  
Liver And Kidney ◽  
The Impact

Esters of thiosulfoacids demonstrate a wide range of biological activity. One of their effects is the influence on the metabolism of proteins and lipids in the body. Therefore, the purpose of our experiment was to study the impact of synthesized thiosulfonates on the total content of proteins and phospholipids, as well as their spectrum in the blood, liver, and kidney of rats. For the experiment, allyl, ethyl, and methyl esters of thiosulfoacid were used. The protein profile of rat tissues was investigated by electrophoresis, and the ratio of different fractions of phospholipids by thin-layer chromatography. Our results have shown that short-term administration of thiosulfonates in a dose of 300 mg/kg of body weight did not cause significant changes in the content of total protein and its fractions in liver tissue, whereas the effect of allyl and ethyl esters of thiosulfoacid was accompanied by an increase in the total protein and albumin in the blood plasma. The decrease in total protein was found in the kidney tissue of rats injected with allyl- and methyl thiosulfonates. The newly synthesized compounds did not lead to significant changes in the total content of phospholipids in blood plasma and tissues of rats, except for methyl thiosulfonate, the effect of which was accompanied by an increase in the total phospholipids in the liver of rats. These data may indicate an adaptive reaction of the rat’s organism. Tissue-specific features of the phospholipid spectrum were detected in rats after short-term exposure to thiosulfonates. The most significant effect on the phospholipid profile in the blood was shown for allyl- and ethyl esters of thiosulfoacid. Their action was accompanied by a decrease in the phosphatidylserine and phosphatidylinositol fractions, while phosphatidylethanolamine and phosphatidylcholine increased, respectively. Esters of thiosulfoacid significantly influenced the ratio of different fractions of phospholipids in the liver and kidney tissues. The phospholipid composition of the liver was more influenced by the allyl and methyl esters of thiosulfoacid, whereas for the kidney tissue a greater effect was observed for ethyl and methyl esters. Thus, the action of allyl ester of thiosulfoacid caused a decrease in the asymmetry coefficient of hepatocyte membranes, indicating an elevation of the lipid bilayer saturation and the increase of membrane microviscosity. Similar changes were found in the kidney of rats treated with allyl- and ethyl thiosulfonates.

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