scholarly journals Synthesis, Characterization and Cytotoxicity of Ni (II), Pd (II), Pt (II) Complexes with 6-Methoxy-2, 3, 4, 5-tetrahydropyridine (MTP)

2020 ◽  
Vol 36 (05) ◽  
pp. 903-907
Author(s):  
Hikmat Ali Mohamad ◽  
Widad Taha Al-Kattan ◽  
Zena Mashal Al-Daly ◽  
Ali Nafia Najim
Keyword(s):  
Magnetic Susceptibility ◽  
Divalent Metal ◽  
Molar Conductivity ◽  
The Other ◽  
Divalent Metal Ions ◽  
Square Planar ◽  
Ft Ir ◽  
Colored Complexes ◽  
Cytotoxicity Effects ◽  
Mcf 7

Reaction of 2 moles of (MTP) with one mole of MCl2 gave colored complexes with general formula; [M(MTP)2Cl2]. [M = Ni+2, Pd+2, and Pt+2]. All synthesized complexes are well-characterized using, FT-IR, 1HNMR, 13C NMR, UV-Vis. Spectra furthermore of magnetic susceptibility, C,H,N analysis, and molar conductivity. The results illustrated that divalent metal ions were coordinated with the ligands through nitrogen atoms in square planar spatial arrangements. The complexes were screened for their cytotoxicity effects versus MCF-7 cell line and showed that [Pt(MTP)2Cl2] complex has good cytotoxicity in comparison with the other complexes.

scholarly journals Preparation and Spectral Study of New Complexes of Some Metal Ions with 3,5-Dimethyl-1H-Pyrazol-1-yl Phenyl Methanone

2011 ◽  
Vol 8 (4) ◽  
pp. 1005-1011
Author(s):  
Baghdad Science Journal
Keyword(s):  
Magnetic Susceptibility ◽  
Elemental Analysis ◽  
Room Temperature ◽  
Molar Conductivity ◽  
The Other ◽  
Octahedral Structure ◽  
Tetrahedral Structure ◽  
Visible Spectra ◽  
Ft Ir ◽  
Uv Visible

Many complexes of 3,5-dimethyl-1H-pyrazol-1-yl phenyl methanone with Cr(III), Co(II), Ni(II), Cu(II) and Cd(II) were synthesized and characterized by FT-IR, UV/visible spectra, elemental analysis, room temperature magnetic susceptibility and molar conductivity. Cd(II) complex was expected to have tetrahedral structure while all the other complexes were expected to have an octahedral structure.

Inhibition of glycogen synthase (casein) kinase-1 by divalent metal ions

1988 ◽  
Vol 66 (3) ◽  
pp. 238-243 ◽  
Author(s):  
Toolsee J. Singh
Keyword(s):  
Metal Ions ◽  
Kinase Activity ◽  
Glycogen Synthase ◽  
Divalent Metal ◽  
Casein Kinase ◽  
The Other ◽  
Divalent Metal Ions ◽  
Casein Kinase 1 ◽  
Competitive Inhibitors ◽  
Noncompetitive Inhibitors

The specificity of glycogen synthase (casein) kinase-1 (CK-1) for different divalent metal ions was explored in this study. Of nine metal ions (Mg2+, Mn2+, Zn2+, Cu2+, Ca2+, Ba2+, Ni2+, Co2+, Fe2+) tested, only Mg2+ supported significant kinase activity. Several of the other metals, however, inhibited the Mg2+-stimulated kinase activity. Half-maximal inhibitions by Mn2+, Zn2+, Co2+, Fe2+, and Ni2+ were observed at 55, 65, 110, 125, and 284 μM, respectively. Kinetic analyses indicate that the metal ions are acting as competitive inhibitors of CK-1 with respect to the protein substrate (casein) and as noncompetitive inhibitors with respect to the nucleotide substrate (ATP). The inhibition of CK-1 by the different metal ions can be reversed by EGTA.

scholarly journals Synthesis and spectral characterization of 1,2-bis(5-methyl/chloro-1H-benzimidazol-2-yl)ethanols and their Co(II), Pd(II) and Zn(II) complexes

2018 ◽  
Vol 83 (10) ◽  
pp. 1099-1112
Author(s):  
Aydin Tavman ◽  
Demet Gurbuz ◽  
Adem Cinarli
Keyword(s):  
Nmr Spectroscopy ◽  
13C Nmr Spectroscopy ◽  
Molar Conductance ◽  
Molar Conductivity ◽  
The Other ◽  
Chelating Ligands ◽  
Fluorescence Characteristics ◽  
Ft Ir ◽  
Ft Raman

1,2-Bis(5-methyl/chloro-1H-benzimidazol-2-yl)ethanols (1 and 2), asymmetric bis-benzimidazoles, and their complexes with CoCl2, PdCl2 and ZnCl2 were synthesized and characterized by elemental analysis, molar conductivity, magnetic moment, TGA, FT-IR (mid- and far-IR), FT-Raman, 1Hand 13C-NMR spectroscopy, ESI-MS and fluorescence spectroscopy. The spectral data suggest that the chiral chelating ligands acted as tridentate through both the C=N nitrogen and OH oxygen atoms. According to the molar conductance, the Zn(II) complexes are non-electrolyte whereas the Co(II) complexes are 1:2 and the Pd(II) complexes are 1:1 electrolytes. The ligands and most of the complexes show triple fluorescence in ethanol. In addition, the Zn(II) complex of 1 (1c) shows significant fluorescence characteristics compared to the other complexes.

scholarly journals Synthesis and Characterization of some Mixed Ligand Complexes Containing (8-hydroxyquinoline) and (2 - picoline) with some Metal Ions

2013 ◽  
Vol 10 (2) ◽  
pp. 396-404
Author(s):  
Baghdad Science Journal
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Ions ◽  
Molar Conductivity ◽  
Mixed Ligand ◽  
Synthesis And Characterization ◽  
Conductivity Measurements ◽  
Visible Spectroscopy ◽  
Ft Ir ◽  
Uv Visible

Complexes of some metal ions ( Mn(I? ) , Co(??) , Ni(??) ,Cu (??) , Zn(I?) , Cd (??) , and Hg(??) ) with 8-hydroxyquinoline (Oxine) and 2- Picoline (2-pic ) have been synthesized and characterized on the basis of their FT-IR. and Uv-visible spectroscopy ,atomic absorption molar conductivity measurements and magnetic susceptibility ,from the results obtained the following general formula has been given for prepared complexes [M (oxine)2 (2-pic)2]where M = M(??) = Mn , Co , Ni , Cu , Zn , Cd , Hg(oxine)- = ionic ligand 8-hydroxyquinolin (oxinato)(2- pic) = 2- picoline

scholarly journals Metal-Specificity Divergence between Metallothioneins of Nerita peloronta (Neritimorpha, Gastropoda) Sets the Starting Point for a Novel Chemical MT Classification Proposal

2021 ◽  
Vol 22 (23) ◽  
pp. 13114
Author(s):  
Mario García-Risco ◽  
Sara Calatayud ◽  
Veronika Pedrini-Martha ◽  
Ricard Albalat ◽  
Reinhard Dallinger ◽  
...  
Keyword(s):  
Metal Binding ◽  
High Selectivity ◽  
Biological Function ◽  
Divalent Metal ◽  
The Other ◽  
Divalent Metal Ions ◽  
Specific Group ◽  
Metal Specificity ◽  
Starting Point ◽  
New Perspective

Metallothioneins’ (MTs) biological function has been a matter of debate since their discovery. The importance to categorize these cysteine-rich proteins with high coordinating capacity into a specific group led to numerous classification proposals. We proposed a classification based on their metal-binding abilities, gradually sorting them from those with high selectivity towards Zn/Cd to those that are Cu-specific. However, the study of the NpeMT1 and NpeMT2isoforms of Nerita peloronta, has put a new perspective on this classification. N. peloronta has been chosen as a representative mollusk to elucidate the metal-binding abilities of Neritimorpha MTs, an order without any MTs characterized recently. Both isoforms have been recombinantly synthesized in cultures supplemented with ZnII, CdII, or CuII, and the purified metal–MT complexes have been thoroughly characterized by spectroscopic and spectrometric methods, leading to results that confirmed that Neritimorpha share Cd-selective MTs with Caenogastropoda and Heterobranchia, solving a so far unresolved question. NpeMTs show high coordinating preferences towards divalent metal ions, although one of them (NpeMT1) shares features with the so-called genuine Zn-thioneins, while the other (NpeMT2) exhibits a higher preference for Cd. The dissimilarities between the two isoforms let a window open to a new proposal of chemical MT classification.

scholarly journals Synthesis and characterization of ligands derived 2-hydroxy-1- naphthaldehyde and their complexes with divalent metal ions (Mn+2, Fe+2, Ni +2)

2018 ◽  
Vol 16 (37) ◽  
pp. 79-87
Author(s):  
Shahinaz A. Hamad Al-Dabbagh
Keyword(s):  
Metal Ions ◽  
Condensation Reaction ◽  
Divalent Metal ◽  
Octahedral Geometry ◽  
Synthesis And Characterization ◽  
Divalent Metal Ions ◽  
Schiff Base Ligands ◽  
Tetrahedral Geometry ◽  
Ft Ir

In this work, Schiff base ligands L1: N, N-bis (2-hydroxy-1-naphthaldehyde) hydrazine, L2: N, N-bis (salicylidene) hydrazine, and L3:N –salicylidene- hydrazine were synthesized by condensation reaction. The prepared ligands were reacted with specific divalent metal ions such as (Mn2+, Fe2+, Ni2+) to prepare their complexes. The ligands and complexes were characterized by C.H.N, FT-IR, UV-Vis, solubility, melting point and magnetic susceptibility measurements. The results show that the ligands of complexes (Mn2+, Fe2+) have octahedral geometry while the ligands of complexes (Ni2+) have tetrahedral geometry.

scholarly journals Synthesis, Characterization and Biological Activity of Some Mixed Ligand Complexes of 1, 10-Phenanthronline and [4-(2-hydroxy-1,2-diphenylethylideneamino)-N-pyrimidin-2-yl) benzene sulfonamide] with Divalent Metal Ions

2017 ◽  
Vol 27 (5) ◽  
pp. 55
Author(s):  
Rehab K. Al-Shemary ◽  
Inam H. Ibrahim ◽  
Nibras A. Al-marsomy
Keyword(s):  
Escherichia Coli ◽  
Metal Ions ◽  
Acidic Medium ◽  
Condensation Reaction ◽  
Divalent Metal ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Divalent Metal Ions ◽  
Ft Ir ◽  
And Staphylococcus Aureus

Schiff base ligand [4-(2-hydroxy-1, 2-diphenylethylideneamino)-N-pyrimidin-2-yl)benzene sulfonamide] (L) was prepared through a condensation reaction of  sulfadiazine and benzoin in acidic medium. The prepared ligand has been characterized with different techniques (C.H.N.S, FT-IR, UV-Vis and 1H&13C-N.M.R). Mixed ligand complexes of some divalent metal ions [Co(II), Mn(II), Ni(II),Cu(II) and Hg(II)] were prepared by the  reaction of [4-(2-hydroxy-1,2-diphenylethylidene amino)-N-pyrimidin-2-yl)benzene sulfonamide](L)  and 1,10-Phenanthronline with the metal ions in basic conditions. The prepared complexes were characterized and their astrochemical structures and geometries were suggested depending upon data of (UV-Vis, FT-IR, atomic absorption, micro elemental analysis The following general formula was achieved : [M(PHN)(L)2], where  M represent  (Co(II)- Cu(II)-Mn(II)- Ni(II) and Hg(II)). Electronic spectra supported by magnetic moment's revealed octahedral geometries for all the prepared complexes. The mixed complexes showed resistivity to different bacteria such as(Pseudomonas aeruginosa), (Bacillus subtilis), (Escherichia coli), and (staphylococcus aureus).

Interaction of divalent metal ions with the NADP+-malic enzyme from maize leaves

1991 ◽  
Vol 81 (4) ◽  
pp. 462-466 ◽  
Author(s):  
Maria Fabiana Drincovich ◽  
Alberto A. Iglesias ◽  
Carlos S. Andreo
Keyword(s):  
Metal Ions ◽  
Malic Enzyme ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Maize Leaves

New Ferrocene Compounds as Selective Cyclooxygenase (COX-2) Inhibitors: Design, Synthesis, Cytotoxicity and Enzyme-inhibitory Activity

2018 ◽  
Vol 18 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Shabnam Farzaneh ◽  
Elnaz Zeinalzadeh ◽  
Bahram Daraei ◽  
Soraya Shahhosseini ◽  
Afshin Zarghi
Keyword(s):  
Cell Lines ◽  
Inhibitory Activity ◽  
Fibroblast Cell ◽  
Breast Cancer Cell Lines ◽  
Ferrocene Derivatives ◽  
Cox 2 ◽  
Cytotoxicity Effects ◽  
Cox 2 Inhibitors ◽  
Mcf 7

Background: Due to the astonishing properties of ferrocene and its derivatives, it has a broad application in diverse areas. Numerous ferrocene derivatives demonstrated anti-proliferative activity. Also COX-2, as a key isoenzyme for production of prostaglandins, is frequently overexpressed in various cancers. It is now recognized that COX-2 over expression promotes tumorigenic functions which can be suppressed by COX-2 inhibitors, a phenomenon useful for the preventing of tumor progression. The combination of COX-2 inhibitors with other anti-cancer or cancer prevention drugs may reduce their side effects in future cancer prevention and treatment. Objective: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities. Methods: Chalcones were synthesized via clasien-schmidt condensation of methylsulfonyl aldehyde and acetyl ferrocene. Further different amines with solvent free and ultra sound condition were reacted with chalcones to have different 1-ferrocenyl-3-amino carbonyl compounds. Docking study was carried out with Auto Dock vina software. All the newly-synthesized compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity using chemiluminescent enzyme assays as well as cytotoxicity activity against MCF-7 and T47D and fibroblast cell lines by MTT assay. Results: In vitro COX-1/COX-2 inhibition studies demonstrated that all compounds were selective inhibitors of the COX-2 isozyme with IC50 values in the highly potent 0.05-0.12 µM range, and COX-2 selectivity indexes (SI) in the 148.3-313.7 range. These results indicated that either potency or selectivity of COX-2 inhibitory activity was affected by the nature and size of the substituents on C-3 of propane-1-one. Also anti-proliferative and toxicity activities of synthesized compounds against breast cancer cell lines MCF-7 and T47D and fibroblast cell lines showed that the synthesized compounds had mild to moderate cytotoxicity against MCT7 and T47D breast cancer cell lines at 10 µM concentration. In vitro COX-1/COX-2 inhibition studies and anticancer activity against MCF-7, identified 1-ferrocenyl-3-(4-methylsulfonylphenyl) propen-1-one as a potent compound (IC50 COX-2 = 0.05 µM, MCF-7: % inhibition (at concentration of 10 µM) = 32.7%), and also 1-ferrocenyl-3- (propan-1-amine)-3-(4-methylsulfonylphenyl) propan-1-one showed the most selectivity on COX-2 inhibition (selectivity index= 313.7). Conclusion: A novel group of ferrocene compounds, possessing a methyl sulfonyl COX-2 pharmacophore were synthesized to investigate the effect of different substituents on selectivity and potency of COX-2 inhibitory activity and their cytotoxicity effects. This study indicates that 1-ferrocenyl-3-amino carbonyl compounds having ferrocene motif and methyl sulfonyl COX-2 pharmacophore is a suitable scaffold to design COX-2 inhibitors and anti-cancer agents.

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