scholarly journals Vessel-Associated Transforming Growth Factor-Beta1 (TGF-β1) Is Increased in the Bronchial Reticular Basement Membrane in COPD and Normal Smokers

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39736 ◽  
Author(s):  
Amir Soltani ◽  
Sukhwinder Singh Sohal ◽  
David Reid ◽  
Steve Weston ◽  
Richard Wood-Baker ◽  
...  
Keyword(s):  
Growth Factor ◽  
Basement Membrane ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Beta1 ◽  
Tgf Β1

Significance of Increased Accumulation of Type VI Collagen and Transforming Growth Factor βi in Tubulointerstitial Damage in Hypertensive Nephrosclerosis: An Immunohistochemical Study

1996 ◽  
Vol 24 (2) ◽  
pp. 199-208 ◽  
Author(s):  
M S Razzaque ◽  
T Harada ◽  
T Taguchi
Keyword(s):  
Growth Factor ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Transforming Growth Factor ◽  
Tubulointerstitial Injury ◽  
Tubular Basement Membrane ◽  
Type Vi Collagen ◽  
Hypertensive Nephrosclerosis ◽  
Tubulointerstitial Damage ◽  
Tgf Β1

The distribution of type VI collagen and transforming growth factor β1 (TGF β1) was studied by immunohistochemistry in 12 renal biopsy specimens of hypertensive nephrosclerosis and five control cases. In control kidneys, the immunostaining of type VI collagen was found in the mesangium, glomerular basement membrane and tubular basement membrane. For TGF β, mesangium, glomerular basement membrane, tubular basement membrane and tubular epithelial cells stained positively in the control kidneys. In contrast to the control cases, markedly increased immunostaining for both type VI collagen and TGF β1 was consistently observed in tubulointerstitial damage in hypertensive nephrosclerosis. These immunohistochemical findings provide the evidence for a parallel increase of both type VI collagen and TGF β1 during the process of tubulointerstitial injury in hypertensive nephrosclerosis. From the results of the present study, it is speculated that TGF β1 may contribute to the tubulointerstitial injury by stimulating increased synthesis of various extracellular matrix including type VI collagen.

scholarly journals Age-Dependent Decrease in Serum Transforming Growth Factor (TGF)-Beta 1 in Healthy Japanese Individuals; Population Study of Serum TGF-Beta 1 Level in Japanese

2005 ◽  
Vol 21 (2) ◽  
pp. 71-74 ◽  
Author(s):  
Yoshihiro Okamoto ◽  
Yoshimitsu Gotoh ◽  
Osamu Uemura ◽  
Soichi Tanaka ◽  
Tsunesaburo Ando ◽  
...  
Keyword(s):  
Growth Factor ◽  
Pediatric Patients ◽  
Transforming Growth Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tgf Beta ◽  
Japanese Children ◽  
Transforming Growth Factor Beta1 ◽  
Control Value ◽  
Age Dependent ◽  
Tgf Β1

Transforming growth factor-beta1 (TGF-β1), a multi-functional cytokine, is involved in regulating a variety of cellular activities and the serum/plasma TGF-β1 level is altered with various diseases. However, most published reports have described adult patients, and so we investigated the clinical significance of serum TGF-β1 level in pediatric patients. The diagnostic application of the measurement of serum TGF-β1 level depends critically on the control value, however, there is no information on the control value of serum TGF-β1 for children.In the present study, we determined the serum TGF-β1 level of healthy Japanese children as a control value with enzyme-linked immunosorbent assay (ELISA). The serum TGF-β1 level of children (0–14 years old) was significantly higher than that of adults (over 15 years old) (p< 0.01). Thus, it is recommended that when the serum TGF-β1 levels of patients are evaluated, they should be compared with those of age-matched controls.

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