scholarly journals The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0212321 ◽  
Author(s):  
Cecilia Arriagada ◽  
Charlotte Luchsinger ◽  
Alexis E. González ◽  
Tomás Schwenke ◽  
Gloria Arriagada ◽  
...  
Keyword(s):  
Cell Migration ◽  
Glioblastoma Multiforme ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Dependent Manner

scholarly journals Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1545
Author(s):  
Laura Ordas ◽  
Luca Costa ◽  
Anthony Lozano ◽  
Christopher Chevillard ◽  
Alexia Calovoulos ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Surface ◽  
Focal Adhesion ◽  
Nuclear Translocation ◽  
Single Cells ◽  
Integral Membrane Protein ◽  
Metastasis Suppressor ◽  
Dependent Manner ◽  
Strong Inhibitor ◽  
Caveolin 1

The plasma membrane is a key actor of cell migration. For instance, its tension controls persistent cell migration and cell surface caveolae integrity. Then, caveolae constituents such as caveolin-1 can initiate a mechanotransduction loop that involves actin- and focal adhesion-dependent control of the mechanosensor YAP to finely tune cell migration. Tetraspanin CD82 (also named KAI-1) is an integral membrane protein and a metastasis suppressor. Its expression is lost in many cancers including breast cancer. It is a strong inhibitor of cell migration by a little-known mechanism. We demonstrated here that CD82 controls persistent 2D migration of EGF-induced single cells, stress fibers and focal adhesion sizes and dynamics. Mechanistically, we found that CD82 regulates membrane tension, cell surface caveolae abundance and YAP nuclear translocation in a caveolin-1-dependent manner. Altogether, our data show that CD82 controls 2D cell migration using membrane-driven mechanics involving caveolin and the YAP pathway.

New concepts regarding focal adhesion kinase promotion of cell migration and proliferation

2006 ◽  
Vol 99 (1) ◽  
pp. 35-52 ◽  
Author(s):  
Braden D. Cox ◽  
Meera Natarajan ◽  
Michelle R. Stettner ◽  
Candece L. Gladson
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
New Concepts ◽  
Cell Migration And Proliferation

scholarly journals JSAP1/JIP3 Cooperates with Focal Adhesion Kinase to Regulate c-Jun N-terminal Kinase and Cell Migration

2005 ◽  
Vol 280 (45) ◽  
pp. 37772-37781 ◽  
Author(s):  
Takahisa Takino ◽  
Mitsutoshi Nakada ◽  
Hisashi Miyamori ◽  
Yumi Watanabe ◽  
Tokiharu Sato ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion

scholarly journals The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

2021 ◽  
Vol 15 (1) ◽  
pp. 58-73
Author(s):  
Andrea A. Villanueva ◽  
Pilar Sanchez-Gomez ◽  
Ernesto Muñoz-Palma ◽  
Sofía Puvogel ◽  
Bárbara S. Casas ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Neuroblastoma Cell ◽  
Integrin Β1 ◽  
Kinase Activation ◽  
Signaling Axis
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