scholarly journals Convolutional neural network model based on radiological images to support COVID-19 diagnosis: Evaluating database biases

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247839
Author(s):  
Caio B. S. Maior ◽  
João M. M. Santana ◽  
Isis D. Lins ◽  
Márcio J. C. Moura
Keyword(s):  
Neural Network ◽  
Scientific Community ◽  
Binary Classification ◽  
Low Cost ◽  
X Ray ◽  
Radiological Data ◽  
Radiological Images ◽  
The World ◽  
Chest X Ray ◽  
Open Datasets

As SARS-CoV-2 has spread quickly throughout the world, the scientific community has spent major efforts on better understanding the characteristics of the virus and possible means to prevent, diagnose, and treat COVID-19. A valid approach presented in the literature is to develop an image-based method to support COVID-19 diagnosis using convolutional neural networks (CNN). Because the availability of radiological data is rather limited due to the novelty of COVID-19, several methodologies consider reduced datasets, which may be inadequate, biasing the model. Here, we performed an analysis combining six different databases using chest X-ray images from open datasets to distinguish images of infected patients while differentiating COVID-19 and pneumonia from ‘no-findings’ images. In addition, the performance of models created from fewer databases, which may imperceptibly overestimate their results, is discussed. Two CNN-based architectures were created to process images of different sizes (512 × 512, 768 × 768, 1024 × 1024, and 1536 × 1536). Our best model achieved a balanced accuracy (BA) of 87.7% in predicting one of the three classes (‘no-findings’, ‘COVID-19’, and ‘pneumonia’) and a specific balanced precision of 97.0% for ‘COVID-19’ class. We also provided binary classification with a precision of 91.0% for detection of sick patients (i.e., with COVID-19 or pneumonia) and 98.4% for COVID-19 detection (i.e., differentiating from ‘no-findings’ or ‘pneumonia’). Indeed, despite we achieved an unrealistic 97.2% BA performance for one specific case, the proposed methodology of using multiple databases achieved better and less inflated results than from models with specific image datasets for training. Thus, this framework is promising for a low-cost, fast, and noninvasive means to support the diagnosis of COVID-19.

Entropy estimation of the fragments of chest X-ray images

2021 ◽  
pp. 20-26
Author(s):  
Aleksei Aleksandrovich Rumyantsev ◽  
Farkhad Mansurovich Bikmuratov ◽  
Nikolai Pavlovich Pashin
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Binary Classification ◽  
Statistical Characteristics ◽  
Type I ◽  
Deep Convolutional Neural Networks ◽  
Preliminary Calculation ◽  
X Ray ◽  
The Matrix ◽  
Chest X Ray

The subject of this research is medical chest X-ray images. After fundamental pre-processing, the accumulated database of such images can be used for training deep convolutional neural networks that have become one of the most significant innovations in recent years. The trained network carries out preliminary binary classification of the incoming images and serve as an assistant to the radiotherapist. For this purpose, it is necessary to train the neural network to carefully minimize type I and type II errors. Possible approach towards improving the effectiveness of application of neural networks, by the criteria of reducing computational complexity and quality of image classification, is the auxiliary approaches: image pre-processing and preliminary calculation of entropy of the fragments. The article provides the algorithm for X-ray image pre-processing, its fragmentation, and calculation of the entropy of separate fragments. In the course of pre-processing, the region of lungs and spine is selected, which comprises approximately 30-40% of the entire image. Then the image is divided into the matrix of fragments, calculating the entropy of separate fragments in accordance with Shannon’s formula based pm the analysis of individual pixels. Determination of the rate of occurrence of each of the 255 colors allows calculating the total entropy. The use of entropy for detecting pathologies is based on the assumption that its values differ for separate fragments and overall picture of its distribution between the images with the norm and pathologies. The article analyzes the statistical values: standard deviation of error, dispersion. A fully connected neural network is used for determining the patterns in distribution of entropy and its statistical characteristics on various fragments of the chest X-ray image.

Automated detection of pneumonia cases using deep transfer learning with paediatric chest X-ray images

2021 ◽  
pp. 20201263
Author(s):  
Mohammad Salehi ◽  
Reza Mohammadi ◽  
Hamed Ghaffari ◽  
Nahid Sadighi ◽  
Reza Reiazi
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Transfer Learning ◽  
Area Under Curve ◽  
Binary Classification ◽  
Classification Performance ◽  
Learning Approach ◽  
Insufficient Data ◽  
X Ray ◽  
Chest X Ray

Objective: Pneumonia is a lung infection and causes the inflammation of the small air sacs (Alveoli) in one or both lungs. Proper and faster diagnosis of pneumonia at an early stage is imperative for optimal patient care. Currently, chest X-ray is considered as the best imaging modality for diagnosing pneumonia. However, the interpretation of chest X-ray images is challenging. To this end, we aimed to use an automated convolutional neural network-based transfer-learning approach to detect pneumonia in paediatric chest radiographs. Methods: Herein, an automated convolutional neural network-based transfer-learning approach using four different pre-trained models (i.e. VGG19, DenseNet121, Xception, and ResNet50) was applied to detect pneumonia in children (1–5 years) chest X-ray images. The performance of different proposed models for testing data set was evaluated using five performances metrics, including accuracy, sensitivity/recall, Precision, area under curve, and F1 score. Results: All proposed models provide accuracy greater than 83.0% for binary classification. The pre-trained DenseNet121 model provides the highest classification performance of automated pneumonia classification with 86.8% accuracy, followed by Xception model with an accuracy of 86.0%. The sensitivity of the proposed models was greater than 91.0%. The Xception and DenseNet121 models achieve the highest classification performance with F1-score greater than 89.0%. The plotted area under curve of receiver operating characteristics of VGG19, Xception, ResNet50, and DenseNet121 models are 0.78, 0.81, 0.81, and 0.86, respectively. Conclusion: Our data showed that the proposed models achieve a high accuracy for binary classification. Transfer learning was used to accelerate training of the proposed models and resolve the problem associated with insufficient data. We hope that these proposed models can help radiologists for a quick diagnosis of pneumonia at radiology departments. Moreover, our proposed models may be useful to detect other chest-related diseases such as novel Coronavirus 2019. Advances in knowledge: Herein, we used transfer learning as a machine learning approach to accelerate training of the proposed models and resolve the problem associated with insufficient data. Our proposed models achieved accuracy greater than 83.0% for binary classification.

scholarly journals Identifying drug-resistant tuberculosis from chest X-ray images using a simple convolutional neural network

2021 ◽  
Vol 2071 (1) ◽  
pp. 012001
Author(s):  
J Ureta ◽  
A Shrestha
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Binary Classification ◽  
Health Concern ◽  
Drug Resistant ◽  
X Rays ◽  
Drug Resistant Tuberculosis ◽  
X Ray ◽  
Resistant Tuberculosis ◽  
Chest X Ray

Abstract Tuberculosis(TB) is one of the top 10 causes of death worldwide, and drug-resistant TB is a major public health concern especially in resource-constrained countries. In such countries, molecular diagnosis of drug-resistant TB remains a challenge; and imaging tools such as X-rays, which are cheaply and widely available, can be a valuable supplemental resource for early detection and screening. This study uses a specialized convolutional neural network to perform binary classification of chest X-ray images to classify drug-resistant and drug-sensitive TB. The models were trained and validated using the TBPortals dataset which contains 2,973 labeled X-ray images from TB patients. The classifiers were able to identify the presence or absence of drug-resistant Tuberculosis with an AUROC between 0.66–0.67, which is an improvement over previous attempts using deep learning networks.

scholarly journals An Effective Convolutional Neural Network Model for the Early Detection of COVID-19 Using Chest X-ray Images

2021 ◽  
Vol 11 (21) ◽  
pp. 10301
Author(s):  
Muhammad Shoaib Farooq ◽  
Attique Ur Rehman ◽  
Muhammad Idrees ◽  
Muhammad Ahsan Raza ◽  
Jehad Ali ◽  
...  
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Real World ◽  
Early Stage ◽  
Binary Classification ◽  
X Rays ◽  
X Ray ◽  
Proposed Model ◽  
Chest X Ray

COVID-19 has been difficult to diagnose and treat at an early stage all over the world. The numbers of patients showing symptoms for COVID-19 have caused medical facilities at hospitals to become unavailable or overcrowded, which is a major challenge. Studies have recently allowed us to determine that COVID-19 can be diagnosed with the aid of chest X-ray images. To combat the COVID-19 outbreak, developing a deep learning (DL) based model for automated COVID-19 diagnosis on chest X-ray is beneficial. In this research, we have proposed a customized convolutional neural network (CNN) model to detect COVID-19 from chest X-ray images. The model is based on nine layers which uses a binary classification method to differentiate between COVID-19 and normal chest X-rays. It provides COVID-19 detection early so the patients can be admitted in a timely fashion. The proposed model was trained and tested on two publicly available datasets. Cross-dataset studies are used to assess the robustness in a real-world context. Six hundred X-ray images were used for training and two hundred X-rays were used for validation of the model. The X-ray images of the dataset were preprocessed to improve the results and visualized for better analysis. The developed algorithm reached 98% precision, recall and f1-score. The cross-dataset studies also demonstrate the resilience of deep learning algorithms in a real-world context with 98.5 percent accuracy. Furthermore, a comparison table was created which shows that our proposed model outperforms other relative models in terms of accuracy. The quick and high-performance of our proposed DL-based customized model identifies COVID-19 patients quickly, which is helpful in controlling the COVID-19 outbreak.

scholarly journals COVID-Net CXR-S: Deep Convolutional Neural Network for Severity Assessment of COVID-19 Cases from Chest X-ray Images

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 25
Author(s):  
Hossein Aboutalebi ◽  
Maya Pavlova ◽  
Mohammad Javad Shafiee ◽  
Ali Sabri ◽  
Amer Alaref ◽  
...  
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Network Architecture ◽  
Clinical Decision ◽  
Severity Assessment ◽  
Clinical Workflow ◽  
X Ray ◽  
Number Of Patients ◽  
The World ◽  
Chest X Ray

The world is still struggling in controlling and containing the spread of the COVID-19 pandemic caused by the SARS-CoV-2 virus. The medical conditions associated with SARS-CoV-2 infections have resulted in a surge in the number of patients at clinics and hospitals, leading to a significantly increased strain on healthcare resources. As such, an important part of managing and handling patients with SARS-CoV-2 infections within the clinical workflow is severity assessment, which is often conducted with the use of chest X-ray (CXR) images. In this work, we introduce COVID-Net CXR-S, a convolutional neural network for predicting the airspace severity of a SARS-CoV-2 positive patient based on a CXR image of the patient’s chest. More specifically, we leveraged transfer learning to transfer representational knowledge gained from over 16,000 CXR images from a multinational cohort of over 15,000 SARS-CoV-2 positive and negative patient cases into a custom network architecture for severity assessment. Experimental results using the RSNA RICORD dataset showed that the proposed COVID-Net CXR-S has potential to be a powerful tool for computer-aided severity assessment of CXR images of COVID-19 positive patients. Furthermore, radiologist validation on select cases by two board-certified radiologists with over 10 and 19 years of experience, respectively, showed consistency between radiologist interpretation and critical factors leveraged by COVID-Net CXR-S for severity assessment. While not a production-ready solution, the ultimate goal for the open source release of COVID-Net CXR-S is to act as a catalyst for clinical scientists, machine learning researchers, as well as citizen scientists to develop innovative new clinical decision support solutions for helping clinicians around the world manage the continuing pandemic.

scholarly journals COVID-Net CXR-S: Deep Convolutional Neural Network for Severity Assessment of COVID-19 Cases from Chest X-ray Images

2021 ◽  
Author(s):  
Hossein Aboutalebi ◽  
Maya Pavlova ◽  
Mohammad Javad Shafiee ◽  
Ali Sabri ◽  
Amer Alaref ◽  
...  
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Network Architecture ◽  
Clinical Decision ◽  
Severity Assessment ◽  
Clinical Workflow ◽  
X Ray ◽  
Number Of Patients ◽  
The World ◽  
Chest X Ray

Abstract The world is still struggling in controlling and containing the spread of the COVID-19 pandemic caused by the SARS-CoV-2 virus. The medical conditions associated with SARS-CoV-2 infections have resulted in a surge in the number of patients at clinics and hospitals, leading to a significantly increased strain on healthcare resources. As such, an important part of managing patients with SARS-CoV-2 infections within the clinical workflow is severity assessment, which is often conducted with the use of chest x-ray (CXR) images. In this work, we introduce COVID-Net CXR-S, a convolutional neural network for predicting the airspace severity of a SARS-CoV-2 positive patient based on a CXR image of the patient's chest. More specifically, we leveraged transfer learning to transfer representational knowledge gained from over 16,000 CXR images from a multinational cohort of over 15,000 patient cases into a custom network architecture for severity assessment. Experimental results with a multi-national patient cohort curated by the Radiological Society of North America (RSNA) RICORD initiative showed that the proposed COVID-Net CXR-S has potential to be a powerful tool for computer-aided severity assessment of CXR images of COVID-19 positive patients. Furthermore, radiologist validation on select cases by two board-certified radiologists with over 10 and 19 years of experience, respectively, showed consistency between radiologist interpretation and critical factors leveraged by COVID-Net CXR-S for severity assessment. While not a production-ready solution, the ultimate goal for the open source release of COVID-Net CXR-S is to act as a catalyst for clinical scientists, machine learning researchers, as well as citizen scientists to develop innovative new clinical decision support solutions for helping clinicians around the world manage the continuing pandemic.

scholarly journals Automatic COVID-19 Detection from X-Ray images using Ensemble Learning with Convolutional Neural Network

2020 ◽  
Author(s):  
Amit Kumar Das ◽  
Sayantani Ghosh ◽  
Samiruddin Thunder ◽  
Rohit Dutta ◽  
Sachin Agarwal ◽  
...  
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Classification Accuracy ◽  
Medical Personnel ◽  
Human Beings ◽  
Test Set ◽  
X Ray ◽  
The World ◽  
Chest X Ray ◽  
Set Up

Abstract Covid-19 continues to have catastrophic effects on the lives of human beings throughout the world. To combat this disease it is necessary to screen the affected patients in a fast and inexpensive way. One of the most viable steps towards achieving this goal is through radiological examination, Chest X-Ray being the most easily available and least expensive option. In this paper we have proposed a Deep Convolutional Neural Network based solution which can detect the Covid-19 +ve patients using chest X-Ray images. To test the efficacy of the solution we have used publicly available chest X-ray images of Covid +ve and -ve cases. 538 images of Covid +ve patients and 468 images of Covid -ve patients have been divided into 771 trainable images and 235 testing images. Our solution gave a classification accuracy of 95.7% and sensitivity of 98% in the test set-up. We have developed a GUI application for public use. This application can be used on any computer by any medical personnel to detect Covid +ve patients using Chest X-Ray images within a very few seconds.

scholarly journals Chest X-ray scanning based detection of COVID-19 using deepconvolutional neural network

2020 ◽  
Author(s):  
Samir Yadav ◽  
Jasminder Kaur Sandhu ◽  
Yadunath Pathak ◽  
Shivajirao Jadhav
Keyword(s):  
Neural Network ◽  
Low Cost ◽  
Diagnostic System ◽  
Multiclass Classification ◽  
Expert Advice ◽  
X Rays ◽  
X Ray ◽  
Chest X Ray ◽  
Using Data ◽  
Life On Earth

Abstract Everyone’s life on earth influenced by a global coronavirus outbreak COVID- 19. Two regular practices, pathology tests, and Computer Tomography (CT) scan used to diagnose COVID-19. Pathology tests produce a considerable amount of false-positives & are time-consuming, whereas CT scans tests are costly and require expert advice. Hence, the main aim of this work is to develop a fast, accurate, and low-cost diagnostic system for detection of COVID-19 using inexpensive chest X-rays and the modern Deep Convolutional Neural Network(CNN) approach to assist medical professionals. In this study, two pre-trained CNN models (VGG16 and InceptionV3) are evaluated by several experiments using data augmentations. The analysis is based on 2905 images of chest X-rays with 219 confirmed positive COVID-19 and 1345 positive pneumonia cases taken from the open-source database consisting of patients suffering from the COVID-19 disease. Since a database consists of multiple types of diseases, multiclass classification for diagnosis of COVID-19 is used. The InceptionV3 model provides the highest classification accuracy (99.35% and 98.29%) for two binary classifications (normal vs. COVID-19 and COVID- 19 vs. Pneumonia) compare to VGG16 model’s accuracy (97.71% and 96.27%). Whereas, VGG16 provides highest accuracy (98.84%)for multiclass-classification(normal vs COVID- 19 vs pneumonia) as compared to VGG16 model’s accuracy(96.35%).

scholarly journals Performance Result for Detection of COVID-19 using Deep Learning

2020 ◽  
Vol 9 (7) ◽  
pp. 699-703
Keyword(s):  
Neural Network ◽  
Classification Model ◽  
Classification Models ◽  
X Ray ◽  
The World ◽  
Rectified Linear Unit ◽  
Chest X Ray ◽  
Novel Coronavirus ◽  
The Masses ◽  
Fully Connected

The 2019 novel coronavirus (COVID-19), which has sprawled fleetly among masses residing in distant nations, had a prefatory juncture in China. From both a safeness and a lucrative outlook, it has staggered the world with its hasty diffusion with conjectural vicious generic repercussions for the masses. Consequent to the escalating cases daily, there is a constricted fraction of COVID-19 inspection kits acquirable in healthcare institutions. Ergo, to obviate COVID-19 propagating betwixt masses, it is imperative to enforce an instinctive unveiling network as a prompt jack legging diagnosis appendage. The contemplated method embroils a convolutional neural network- based model, namely ResNet50, concerted with a Fully Connected Layer (FCL), reinforced by Rectified Linear Unit (ReLU) for the unearthing of coronavirus pneumonia imparted sufferer by harnessing chest X-ray radiographs. The endorsed classification model, i.e. resnet50 affirmed by FCL and ReLU, compassed accuracy of 94% for unearthing COVID-19. When equated to diverse classification models, the purported model is preeminent. The aftereffect is premised on the attested X-ray images from the data appropriable in the arsenal of Kaggle

scholarly journals Fast COVID-19 and Pneumonia Classification Using Chest X-ray Images

Mathematics ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1423
Author(s):  
Juan Eduardo Luján-García ◽  
Marco Antonio Moreno-Ibarra ◽  
Yenny Villuendas-Rey ◽  
Cornelio Yáñez-Márquez
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Respiratory Diseases ◽  
X Ray ◽  
Aggressive Disease ◽  
Learning Techniques ◽  
The World ◽  
Chest X Ray ◽  
The Common ◽  
Deep Learning Model

As of the end of 2019, the world suffered from a disease caused by the SARS-CoV-2 virus, which has become the pandemic COVID-19. This aggressive disease deteriorates the human respiratory system. Patients with COVID-19 can develop symptoms that belong to the common flu, pneumonia, and other respiratory diseases in the first four to ten days after they have been infected. As a result, it can cause misdiagnosis between patients with COVID-19 and typical pneumonia. Some deep-learning techniques can help physicians to obtain an effective pre-diagnosis. The content of this article consists of a deep-learning model, specifically a convolutional neural network with pre-trained weights, which allows us to use transfer learning to obtain new retrained models to classify COVID-19, pneumonia, and healthy patients. One of the main findings of this article is that the following relevant result was obtained in the dataset that we used for the experiments: all the patients infected with SARS-CoV-2 and all the patients infected with pneumonia were correctly classified. These results allow us to conclude that the proposed method in this article may be useful to help physicians decide the diagnoses related to COVID-19 and typical pneumonia.

Sign in / Sign up

Export Citation Format

Share Document