Assessment of serum amylase, lipase and associated factors among patients with visceral leishmaniasis treated with sodium stibogluconate/paromomycin at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Background Visceral leishmaniasis (VL) is a life-threatening parasitic disease next to malaria, which is responsible for the death of 50,000 patients annually. It has three major clinical stages, including visceral, cutaneous, and mucocutaneous leishmaniasis. Ethiopia is one of the east African countries commonly affected with leishmanisis disease. There are many drugs for leishmaniasis, including sodium stibogluconate and paromomycin combined therapy. However, the adverse effect of those combined drugs is not well-defined. Therefore, the purpose of this study was to assess serum amylase, lipase, and associated factors among patients with VL treatment with those combined drugs. Methods Hospital-based cross-sectional study was conducted at the University of Gondar Comprehensive Specialized Hospital Leishmaniasis Research and Treatment Center from February to September 2020 G.C. Simple random sampling technique was utilized to select study participants. The study participants who fulfill the inclusion criteria were included in the study with written informed consent. 5 ml of blood was withdrawn by an experienced health professional to analyze serum amylase and lipase level. Descriptive data was presented by tables, charts and graphs. Data was cleared, entered by Epi-data version 3.1 then transfer to STATA 14.1 SE version and for analysis paired t-test was used, for factors correlation and regression was used. Those factor variable who have p-value <0.25 was filtered and goes to multivariate regression and p-value <0.05 was considered as significant variables. Results The result of this study showed that there was a significant mean difference between serum pancreatic amylase and lipase before and after treatment. The mean ± SD level of serum amylase after treatment showed a statistically significant elevation (P<0.001) as compared to its level before treatment. Similarly, the mean ± SD level of serum lipase after treatment showed a statistically significant elevation (P<0.001) as compared to its level before treatment. There was also significant association between age and baseline serum amylase as compared to serum amylase after treatment. Similarly, there was also significant relation of age and serum lipase with serum lipase after treatment. Conclusion In this study, the level of serum amylase and lipase at treatment of cure was higher and there was an increase in mean serum amylase and lipase after a patient taking sodium stibogluconate and paromomycin combined drugs. Consequently, the elevated result of these biochemical profiles mainly associated with drug induced adverse effect and associated risk factors in VL patients.

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Level of physical activity and its correlates among health care workers in Ethiopia, 2019

10.21203/rs.2.19544/v1 ◽

2019 ◽

Author(s):

Tigist Demssew Adane ◽

Birhan Gebresillassie Gebregiorgis ◽

Elda Mekonnen Nigussie ◽

Abate Dargie Wubetu

Keyword(s):

Physical Activity ◽

Health Care ◽

Health Care Providers ◽

Health Care Workers ◽

Health Professionals ◽

Associated Factors ◽

P Value ◽

Care Providers ◽

Care Workers ◽

Study Participants

Abstract Background These days, engaging at sufficient regular physical activity strongly recommended for good health and physical functioning. Physical activity can increase the self-confidence of the health professionals and they would become fit for daily activities with patients. Knowing the level of physical activity can help health care professionals to plan for physical activity programs. This study aimed to measure the level of physical activity and associated factors among adult health professionals at Tirunesh Beijing general hospital.Objective The aim of this study was to assess the level of physical activity and associated factors among health care workers in Ethiopia, 2019.Methods Institution based cross-sectional study conducted level of physical activity and associated factors among health care workers in Ethiopia, 2019. Two hundred nighty seven adult health professionals were participated, which was a 97.4% response rate. The global physical activity questionnaire used to measure the level of physical activity. Descriptive statistics and binary logistic regression analyses was done to affirm the variables characteristics. A predictor variable with a p-value of less than 0.2 exported to multivariate analysis. During multivariate analysis, statistical significance declared at a p-value of < 0.05.Results In general, the majority of the study participants, 89.2% (95% CI: 85.9-92.6) were achieved recommended levels of physical activity. Regarding the intensity of the physical activity, the overall mean time score was 518.4 mints per week or 2352.6 MET/week. For moderate-intensity physical activity, 83.5% of the study participants were physically active, (≥150 minutes/week). In the case of vigorous activity, about 32.7% of the study participants were physically active and engaged in vigorous physical activity (≥75 minutes /week). The study participants, who had self-motivation for physical activity, had a BMI of less than 25 kg/m2 and aged < 40 years were physically active.Conclusions Health care providers’ habit of physical activity improved as compared with the previous studies. However, the current level of physical activity of health professionals is not adequate. Health care providers’ age, body mass index and self-motivation attribute to physical activity. The level of physical activity can increase by enhancing staff motivation towards physical activity.

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Prevalence and associated factors of antenatal depression among women attending antenatal care follow up at Michu Clinic in Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia 2019.

10.21203/rs.3.rs-22003/v1 ◽

2020 ◽

Author(s):

Birhane Gebrehiwot Beyene ◽

Gebrewahd Bezabhy Gebremichael ◽

Abreha Tsegay Gebreselassie

Keyword(s):

Antenatal Care ◽

Associated Factors ◽

Depressive Disorders ◽

Sampling Technique ◽

Antenatal Depression ◽

Cross Sectional Study ◽

Limited Attention ◽

P Value ◽

Cross Sectional ◽

Specialized Hospital

Abstract Background Antenatal depression is a serious mental health problem that can negatively affect the lives of women. Depressive disorders are not only common and chronic among women throughout the world but also the principal source of disability. The scarce information and limited attention to the problem might aggravate the consequence of the problem and can limit the intervention to be taken. So the purpose of the study is to determine the prevalence and associated factors of antenatal depression among women. Methods An institutional based cross sectional study was conducted by systemic random sampling technique among 203 pregnant women following Antenatal care at Michu clinic in Ayder Comprehensive Specialized Hospital from March to June 2019. An interviewer administered Beck Depression Inventory (II) questionnaire was used to assess individual’s depression condition after consent obtained from participants. Data was entered and analyzed by using statically package for social science version 22. Then bivariate regression with p-value ≤0.25 was entered in to multivariate regression with p-value

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Awareness of Colorectal Cancer and Associated Factors Among Adult Patients in Jimma, South-West Ethiopia.

10.21203/rs.3.rs-111807/v1 ◽

2020 ◽

Author(s):

Abdulmenan Hamza ◽

Zeleke Argaw ◽

Debela Gela

Keyword(s):

Colorectal Cancer ◽

Associated Factors ◽

Adult Patients ◽

P Value ◽

Bloody Stool ◽

Cancer Awareness ◽

Awareness Campaigns ◽

South West ◽

Study Participants ◽

South West Ethiopia

Abstract Background: Colorectal cancer (CRC) is the first commonest diagnosed cancer in men and the fourth commonest in women in Ethiopia. The most significant factors that may increase the risk of having CRC were modifiable. However, little is known about the awareness of CRC and associated factors among adult patients in study area. Therefore, the study aimed to assess the awareness of CRC and associated factors among adult patients in Jimma, South-West Ethiopia, 2020. Methods: The institution-based quantitative cross-sectional study design was conducted among 422 patients from March 8 to April 30, 2020. The study participants were recruited by a systematic random sampling method and data was collected semi-structured interviewer-administered questionnaires. Descriptive, bivariate, and multivariate logistic regression was implemented. The statistical level of significance was stated at p-value < 0.05. Result: A 100% response rate in this study was recorded. More than half (57.6%) of the study participants had low awareness of colorectal cancer. Smoking (78.2%) and bloody stool (49.3%) were the most known risk factors and symptoms. There is a significant association between awareness of colorectal cancer with gender, residency, monthly income, level of education, information sources, and heard about CRC. Conclusion: Overall awareness of patients towards CRC was inadequate. Participants with high levels of education and females had better awareness, however; the overall awareness of them was insufficient. Therefore, there is a need for awareness campaigns and health education for promoting colorectal cancer awareness.

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Nurses’ knowledge of pressure ulcer and its associated factors at Hawassa University Comprehensive Specialized Hospital Hawassa, Ethiopia, 2018.

10.21203/rs.2.13562/v2 ◽

2019 ◽

Author(s):

Tarkie Abebe Walle ◽

Ezedin Molla Muhammed ◽

Berhanu Boru Bifftu ◽

Yemataw Zewdu Temachu

Keyword(s):

Pressure Ulcer ◽

Associated Factors ◽

Pressure Ulcers ◽

Sampling Technique ◽

Signs And Symptoms ◽

Cross Sectional ◽

Specialized Hospital ◽

The Mean ◽

Hawassa University ◽

Nurses Knowledge

Abstract Introduction Pressure ulcer is largely avoidable, but its prevalence rate increased more than 80% in a thirteen years study. Nurses have a great position to advance best practices towards the prevention of pressure ulcers. Therefore they should be knowledgeable of the signs and symptoms of pressure ulcers, and preventive strategies to reduce its incidence, but there is limited evidence on nurses’ knowledge and its associated factors to prevent pressure ulcer in Ethiopia.Objectives The study aimed to assess nurses' knowledge and associated factors towards pressure ulcer prevention at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia, 2018.Methods A hospital-based cross-sectional study was conducted from March 25 – April 23/ 2018. A total of 356 nurses were selected by stratification with a simple random sampling technique. Pretested structured questionnaire with closed and open-ended questions was used to collect data. Frequency distribution and percentage were computed to describe each variable. Bivariate and multivariable logistic regression with a 95% confidence interval was also carried out to see the effect of each independent variable on the dependent variable and declared statistical significant association with P< 0.05.Result The mean knowledge score of nurses was 25.22 out of 41 item questions. Fifty-two point five percent of nurses score above the mean. Males [AOR=0.44, 95% CI (0.26 – 0.73)], working a maximum of eight hours [AOR= 3.57, 95% CI (1.48 – 8.61), not having training [(AOR= 2.31, 95% CI (1.14 – 4.61)], Low salary [AOR= 3.47, 95% CI (1.03 – 11.67)] were significantly associated with inadequate knowledge.Conclusion Generally a nurse's knowledge of pressure ulcer was inadequate. Being female, working less than or equal to eight hours, not having the training and low working salary are contributors to a low level of knowledge for pressure ulcer.

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Insight and Associated Factors among Patients with Schizophrenia in Mental Specialized Hospital, Ethiopia, 2018

Psychiatry Journal ◽

10.1155/2019/2453862 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Mandaras Tariku ◽

Demeke Demilew ◽

Tolesa Fanta ◽

Meskerem Mekonnen ◽

Dessie Abebaw Angaw

Keyword(s):

Associated Factors ◽

Linear Regression Analysis ◽

Prognostic Indicator ◽

Multiple Linear Regression Analysis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Specialized Hospital ◽

First Onset ◽

The Mean ◽

Negative Syndrome

Background. Insight is the degree of the patient’s awareness and understanding of their attributions, feelings, behavior and disturbing symptoms. Majority of the patients with schizophrenia have poor insight and insight is an important prognostic indicator in schizophrenia to enhance treatment compliances and reducing the risks of clinical deterioration. The main objective of this study was to assess insight and its associated factors among patients with schizophrenia at mental specialized hospital in Ethiopia. Methods. Institutional based cross-sectional study was conducted from May to June 2018 Mental Specialized Hospital among 455 patients with schizophrenia. Insight was measured by an abridged version of Scale to assess unawareness of mental disorder. Positive and Negative Syndrome Scale, Calgary depressive scale, Oslo social support scale was used to identify factors associated with insight. Simple and multiple linear regression analysis were used to assess associated factors of insight in the participants. Results. The mean score of insight was 13.66 (95% CI 13.27, 14.04). Age at first onset of illness, duration of treatments, depressive symptoms were inversely associated with mean insight score; whereas unemployed, positive and negative syndrome, previous hospitalization, >=2 episodes were positively associated with mean insight score. Conclusion. Nearly half of the study participants were scored above the mean insight score so, the clinicians and psychotherapists should have to work together to improve insight among patients with schizophrenia.

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Coagulopathy and Its Associated Factors Among Bleeding Diathesis Patients Attending at University of Gondar Specialized Referral Hospital, Northwest Ethiopia.

10.21203/rs.3.rs-105077/v1 ◽

2020 ◽

Author(s):

Melak Aynalem ◽

Elias Shiferaw ◽

Yemataw Gelaw ◽

Bamlaku Enawgaw

Keyword(s):

Associated Factors ◽

Public Health Problem ◽

Test Tube ◽

Referral Hospital ◽

Stool Examination ◽

P Value ◽

Bleeding Diathesis ◽

Coagulation Test ◽

Factor Deficiency ◽

Study Participants

Abstract Background: Coagulopathy is the major cause of mortality and morbidity throughout the world. Globally, about 26 - 45% of healthy people have a history of bleeding symptoms, which may be a result of thrombocytopenia, factor deficiency, or pathological inhibitory.Objective: To assess coagulopathy and its associated factors among bleeding diathesis patients attending at University of Gondar Specialized Referral Hospital from January to May 2020.Method: A cross-sectional study was conducted on 384 study participants with bleeding diathesis recruited by using a convenient sampling technique. Socio-demographic and clinical characteristics were collected by using questioners. Then 6ml venous blood was collected with a needle and syringe method. About 3ml blood was transferred to EDTA test tube for platelet count and 2.7ml blood was transferred to a test tube containing 0.3ml of 3.2% sodium citrated anticoagulant for coagulation test. For those study participants with prolonged coagulation tests, a mixing test was done to differentiate the causes of coagulopathy whether factor deficiency or inhibitors. Blood film and stool examination were also done for malaria and intestinal parasite identification, respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS version-20 for analysis. Descriptive statistics were summarized as percentages, means, and standard deviations. Bivariate and multivariate logistic regression was used to identify the associated factors, and a P-value less than 0.05 was considered as statistically significant.Results: In this study, the prevalence of coagulopathy was 253/384 (65.9%; 95% CI: 61.16, 70.64). From them, 21.3% (54/253), 51.4% (130/253), and 27.3% (69/253) had only thrombocytopenia, only prolonged coagulation test, and mixed abnormality, respectively. Among participants with prolonged coagulation time, the prevalence of factor deficiency was 21.1% (42/199). Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy.Conclusion: Coagulopathy due to inhibitory was a public health problem. The participant with cardiac and other chronic disease was associated with coagulopathy. Therefore, mixing tests could done for all prolonged coagulation test and it could be considered as a routine laboratory test.

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Treatment Outcomes and Associated Factors among Hospitalized Stroke Patients at Shashemene Referral Hospital, Ethiopia

Stroke Research and Treatment ◽

10.1155/2018/8079578 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Tegegne Gobezie Temesgen ◽

Berhanu Teshome ◽

Peter Njogu

Keyword(s):

Ischemic Stroke ◽

Treatment Outcome ◽

Treatment Outcomes ◽

Associated Factors ◽

Common Type ◽

Referral Hospital ◽

P Value ◽

Stroke Patients ◽

Good Treatment Outcome ◽

Study Participants

Background. The 2013 Global Burden of Disease report indicated that 80% of stroke deaths occur in low- and middle-income regions. Although stroke has been consistently reported as one of the three leading causes of morbidity and mortality in the past years in Ethiopia, there is a paucity of data regarding treatment outcomes of stroke if sufficient. Hence, the present study aimed to assess patterns of treatment outcomes and associated factors among hospitalized stroke patients at Shashemene Referral Hospital. Methods. A retrospective cross-sectional study was conducted at the medical ward of Shashemene Referral Hospital. A total of 73 hospitalized stroke patients during the period 2012–2017 were included in the study. Demographic characteristics, risk factors, and stroke types and their hospital outcomes were reviewed from the medical records of the patients. The data were entered and analyzed using SPSS version 16.0. Descriptive statistics such as percent and frequency were used to summarize patients’ characteristics. Binary logistic regression was used to investigate the potential predictors of treatment outcome. A p-value ≤0.05 was considered statistically significant. Result. Ischemic stroke was the most common type of stroke (65.8%) diagnosed in our setting. Hypertension (52.05%) was the common comorbid condition. More than half (54.79%) of the stroke patients improved on treatment. Dyslipidemics were prescribed to 68.49% of patients and the most popular antiplatelet was aspirin, which was prescribed to 61.64% of the study participants. Age, sex, type of stroke, and type of comorbidity were not significant factors of stroke treatment outcome. Conclusion. Ischemic stroke was the most common type of stroke diagnosed among the study participants while aspirin and statins were the most frequently used drugs in the management of stroke. Approximately 50% of hospitalized stroke patients had good treatment outcome and none of the investigated variables were significantly associated with the treatment outcomes.

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Attitude towards Antipsychotic Medications in Patients Diagnosed with Schizophrenia: A Cross-Sectional Study at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia

Schizophrenia Research and Treatment ◽

10.1155/2019/5094017 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9

Author(s):

Tilahun Kassew ◽

Demeke Demilew ◽

Addis Birhanu ◽

Mesele Wonde ◽

Biks Liyew ◽

...

Keyword(s):

Side Effects ◽

Linear Regression ◽

Associated Factors ◽

First Generation ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Antipsychotic Medications ◽

Specialized Hospital ◽

The Mean

Background. Poor attitude towards antipsychotic drugs is high, and it is a factor for non-adherence to treatment. This increases the risk of relapse, associated healthcare utilization, and costs. This study aimed to assess attitude towards antipsychotic medication among patients with schizophrenia. Objectives. The aim of this institution based cross-sectional study was to assess attitude towards antipsychotic medications and associated factors among patients with schizophrenia who attend the outpatient clinics at Amanuel Mental Specialized Hospital, 2018. Methods. In a cross-sectional study, 393 schizophrenic patients from Amanuel Mental Specialized Hospital were recruited by a systematic random sampling technique. Drug Attitude Inventory (DAI-10) was used to assess attitude, experience, and belief about antipsychotics. Glasgow antipsychotic side effect scale modified version, positive and negative syndrome scale, and Birch wood’s insight scale for psychosis were the instruments used to assess the associated factors. Simple and multiple linear regression analysis models were fitted, and the adjusted unstandardized beta (β) coefficient at 95% confidence interval was used. Results. The mean score of attitude towards antipsychotic medications was 6.51 with standard deviation (SD) of 2.22. In multiple linear regression, positive symptoms (β= -0.07, 95% CI: (-0.09, -0.05)), negative symptoms (β= -0.04, 95% CI: (-0.06,-0.02)), shorter (≤5 years) duration of illness (β= -0.39, 95% CI: (-0.63, -0.15)), first generation antipsychotics (β = -0.35, 95% CI: (-0.55,-0.14)), having sedation (β= -0.28, 95% CI: (-0.52, -0.02)), and extra-pyramidal side effects (β= -0.34, 95% CI: (-0.59,-0.09)) were factors negatively associated with attitude towards antipsychotic medication treatment. Insight to illness (β= 0.24, 95% CI: (0.20, 0.27) was a factor positively associated with attitude towards antipsychotic medications. Conclusion. The result suggests that the mean score of participants’ attitude towards antipsychotic medications was good. Prevention of side effects particularly due to first generation antipsychotics is necessary.

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Dietary Diversity Practice and Associated Factors Among Infants and Young Children in Haramaya Town, Ethiopia

International Journal of Public Health Science (IJPHS) ◽

10.11591/ijphs.v6i3.9295 ◽

2017 ◽

Vol 6 (3) ◽

pp. 243 ◽

Cited By ~ 1

Author(s):

Berhe Gebremichael ◽

Gudina Egata ◽

Nega Assefa

Keyword(s):

Young Children ◽

Low Income ◽

Associated Factors ◽

Dietary Diversity ◽

Statistical Significance ◽

P Value ◽

Healthy Children ◽

Eastern Ethiopia ◽

Study Participants ◽

Infants And Young Children

Optimum child feeding is crucial for growth, development, and better health in later life. Dietary diversity is a critical part of the feeding practices. However, there is limited evidence on dietary diversity practice in low-income countries, like Ethiopia. This study assessed dietary diversity practice and associated factors among mothers of infants and young children aged 6-23 months in Haramaya Town, Eastern Ethiopia<strong>. </strong>Community based cross-sectional study design was used and study participants were selected by simple random sampling. Data were collected using a pre-tested questionnaire by face-to-face interview. The collected data were entered to EpiData version 3.1 and exported to SPSS version 22.0 for analysis. Characteristics of the study participants were described by using frequencies, percentages, summary measures, and tables. Bi-variable and multi-variable analyses were used to identify the associated factors. Statistical significance was declared at p-value < 0.05. The study included 635 participants yielding to a response rate of 98.1%. The prevalence of dietary diversity practice was 25.2%. Mothers learned up to secondary level or above [(AOR=2.97, 95% CI: (1.26, 6.99)], mothers who had job [(AOR=3.21, 95% CI: (1.41, 7.29)], older children [(AOR=2.51, 95% CI: (1.45, 4.34)], male children [(AOR= 2.08, 95% CI: (1.29, 3.33)], healthy children [(AOR=2.65, 95% CI: 1.36, 5.16)] and richest households [(AOR=4.45, 95% CI: 1.94, 10.22)] were associated with dietary diversity practice. Generally, the dietary diversity practice was low. Therefore, attention should be given to mothers with no formal education and efforts should be done to improve the socioeconomic status of the households.

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Prevalence of common mental disorders and associated factors among adults with Glaucoma attending University of Gondar comprehensive specialized hospital tertiary eye care and training center, Northwest, Ethiopia 2020

PLoS ONE ◽

10.1371/journal.pone.0252064 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0252064

Author(s):

Mikias Mered Tilahun ◽

Betelhem Temesgen Yibekal ◽

Habtamu Kerebih ◽

Fisseha Ademassu Ayele

Keyword(s):

Mental Disorders ◽

Associated Factors ◽

Common Mental Disorders ◽

P Value ◽

Medical Illness ◽

Training Center ◽

Eye Care ◽

Factors Associated ◽

Specialized Hospital ◽

And Training

Purpose This study aimed to assess the prevalence of common mental disorders and associated factors among adults with glaucoma at Gondar university comprehensive specialized hospital tertiary eye care and training center. Glaucoma predisposes patients to common mental problems and leads to wasteful, costly and inefficient use of medical services and complications of the diagnoses. So, determining the level and factors associated with common mental disorders among glaucoma patient would help to improve and integrate comprehensive ophthalmic services which address common mental disorder in a follow-up visit. Methods An institution-based cross-sectional study was conducted on 495 glaucoma patients selected by using systematic random sampling. Data were collected through face-to-face interview and chart review. Self-reported questionnaire (SRQ-20) was used to assess the presence of common mental disorders. Binary logistic regression analysis was done to identify factors associated with common mental disorders. Variables with P<0.05 were considered as factors significantly associated with common mental disorders. Result Four hundred sixty-eight patients were included in this study with a response rate of 94.54%. The mean age of the participant was 58 ± 14.11 years. The prevalence of common mental disorders was found to be 29.5% (95% CI 25.4–33.3). Female sex (AOR = 3.79, 95% CI: 1.66–8.62) (p-value = 0.001), average monthly income of less than 1200 birr (AOR = 6.05 95% CI: 2.26–16.22) (p-value = 0.001), poor level of social support (AOR = 17.39 95% CI: 7.79–38.82) (p-value = 0.001), moderate and high risk of alcohol use (AOR = 10.42 95%CI: 2.74–39.54) (p-value = 0.001), presence of chronic medical illness (AOR = 3.85 95% CI: 2.07–7.16) (p-value = 0.001), receiving both drug and surgical treatment (AOR = 2.50, 95%CI: 1.30–4.83) (p-value = 0.006) and presence of systemic carbonic anhydrase inhibitors use (AOR = 3.16, 95%CI: 1.65–6.06) (p-value = 0.001) were significantly associated with increased level of common mental disorders. Conclusion Significant numbers of glaucoma patients have CMD and found significantly associated with socio-economic, ocular and systemic clinical factors. Therefore, the integration of psychosocial care into the current treatment of patients with glaucoma would have a significant advantage to help these patients.

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