Postprandial plasma glucose excursion is associated with an atherogenic lipid profile in individuals with type 2 diabetes mellitus: A cross-sectional study

Coronary heart disease (CHD) is a prevalent complication of type 2 diabetes mellitus (T2DM). The atherogenic low-density lipoprotein (LDL) cholesterol is an established risk factor of cardiovascular disease, and evidence also suggests that postprandial plasma glucose (PPG) levels closely delineate CHD mortality in diabetes. The investigators hypothesized that postprandial plasma glucose excursion (PPGE), defined as the difference between 2-hour PPG and fasting plasma glucose (FPG), may be associated with plasma LDL cholesterol levels in patients with T2DM. This study enrolled diabetic participants for whom FPG and lipid profile were sampled after a 12-hour fast, followed by PPG sampling two hours after consuming a standard meal with 75 grams of carbohydrates. The study enrolled 379 participants who were divided into PPGE tertiles according to the difference between their 2-hour PPG and FPG. Participants in the highest PPGE tertile had considerably greater plasma LDL cholesterol levels than patients in the lowest tertile (126.7 mg/dL vs. 99.5 mg/dL, P <0.001). Linear regression analysis also demonstrated that the PPGE was positively correlated with plasma LDL cholesterol levels (β coefficient: 0.165, P < 0.001). Postprandial glucose excursion positively correlated with plasma LDL cholesterol levels in individuals with T2DM. Participants with raised PPGE harbored greater LDL cholesterol levels than those with lower postprandial glucose fluctuations. Therefore, postprandial glucose excursion is associated with an atherogenic lipid profile and may be a modifiable risk factor of diabetic CHD.

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Comparative effects of insulin glulisine and lispro on postprandial plasma glucose and lipid profile in Japanese patients with type 2 diabetes mellitus

Diabetology International ◽

10.1007/s13340-020-00475-1 ◽

2020 ◽

Author(s):

Mika Yamada ◽

Jinya Suzuki ◽

Takahiro Nakaya ◽

Mai Ichikawa ◽

Katsushi Yamamoto ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Profile ◽

Plasma Glucose ◽

Japanese Patients ◽

Postprandial Plasma Glucose ◽

Insulin Glulisine

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Haemostatic functions and metabolic profile of subclinical hypothyroid and hypothyroid patients.

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v17i4.38312 ◽

2018 ◽

Vol 17 (4) ◽

pp. 532-536

Author(s):

Aarti Sood Mahajan ◽

R Mahaur ◽

T Singh ◽

AK Jain ◽

DK Dhanwal ◽

...

Keyword(s):

Platelet Count ◽

Total Cholesterol ◽

Plasma Glucose ◽

Metabolic Profile ◽

Ldl Cholesterol ◽

Medical Science ◽

Normal Range ◽

Postprandial Plasma Glucose ◽

The Status ◽

Hypothyroid Patients

Objectives: Both hypercoagulable and hypocoagulable states have been proposed for hypothyroidism, whether in overt or subclinical spectrum. The status of haemostatic functions, metabolic profile and their relationship in hypothyroid disorders need to be evaluated.Methods and Material: This prospective case control study was undertaken in 30- 50 years old female subclinical and hypothyroid patients. Haemostatic functions like bleeding time (BT), clotting time (CT), prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count and metabolic parameters like plasma glucose and lipid levels and clinical variables like blood pressure and body mass index were noted and compared. In addition the strength of correlation of TSH, T4, T3, lipid profile with the haemostatic functions was evaluated.Results: Both groups of patients were obese, normotensive with normal haemostatic parameters. The platelet count correlated with TSH in subclinical hypothyroid patients and with T4 levels in hypothyroid patients. Although within normal range, total cholesterol and LDL cholesterol levels were higher and postprandial plasma glucose (PPPG) levels lower in hypothyroid patients compared to subclinical hypothyroid patients. A positive correlation was seen between TSH and LDL, PPPG levels, between fT3 and BMI, and also of antiTPO with total cholesterol, LDL, Fasting plasma glucose (FPG) in hypothyroid patients. The BMI was negatively associated with fT3 levels in subclinical hypothyroid patients.Conclusion: This study found normal haemostatic and metabolic functions in both subclinical and hypothyroid patients. Although within normal range, hypothyroid patients had higher total and LDL cholesterol. TSH and antiTPO levels correlated with LDL levels in these patients. Correlation of platelet count with TSH in subclinical hypothyroid and T4 levels in hypothyroid patients advocate a difference in mechanism involved. Therefore it can be connoted that thyroid status influences metabolic profile, and platelet count.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.532-536

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Evaluation of Postprandial Glucose Excursion Using a Novel Minimally Invasive Glucose Area-Under-the-Curve Monitoring System

Journal of Healthcare Engineering ◽

10.1260/2040-2295.4.4.529 ◽

2013 ◽

Vol 4 (4) ◽

pp. 529-540 ◽

Cited By ~ 6

Author(s):

Sachi Kuranuki ◽

Toshiyuki Sato ◽

Seiki Okada ◽

Samiko Hosoya ◽

Akinobu Seko ◽

...

Keyword(s):

Minimally Invasive ◽

Monitoring System ◽

Area Under The Curve ◽

Postprandial Glucose ◽

Glucose Excursion ◽

Postprandial Glucose Excursion

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Effects of Red Pitaya (Hylocereus polyrhizus) on Lipid Profile of Male White Rats (Rattus norvegicus) Receiving High Fat Diet

Folia Medica Indonesiana ◽

10.20473/fmi.v54i1.8046 ◽

2018 ◽

Vol 54 (1) ◽

pp. 16 ◽

Cited By ~ 1

Author(s):

Wiwik Werdiningsih ◽

Suhartati Suhartati

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Fruit Peel ◽

Cholesterol Levels ◽

White Rats ◽

Wistar Strain ◽

Dragon Fruit ◽

Pap Method

Red dragon fruit (Hylocereus polyrhizus) peel contains anthocyanin, fiber and vitamin C, so it can be used to improve lipid profile in dyslipidemia. The peel of the dragon fruit is not durable, so in this study we used freeze-dried dragon fruit peel. The aim of this study was to prove that the administration of the red dragon fruit peel in a dose of 0.72 g/200 g BW, 1.08 g/200 g BW, and 1.44 g/200 g BW of rat per day for 28 days may improve lipid profile in male wistar strain white rats with high-fat diet. Lipid profiles were studied by examining of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. This was a pure experimental study using randomized post test only control group design. This study used experimental animal of 30 male wistar strain white rats which were divided into five groups. Measurements of total, LDL, and HDL cholesterol levels were done by CHOD-PAP method, while triglyceride level was measured with GPO-PAP method. Data were analyzed statistically by One Way Anova test. The results of this study indicated that giving the peel of red dragon fruit as much as 0.72 g lowered total cholesterol levels, 1.08 g lowered total and LDL cholesterol levels, and 1.44 g lowered total cholesterol, LDL cholesterol, triglyceride levels, and raised HDL cholesterol level. Red dragon fruit peel can be used alternatively to improve lipid profile in dyslipidemia.

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GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgz175 ◽

2020 ◽

Vol 105 (3) ◽

pp. e725-e738 ◽

Cited By ~ 7

Author(s):

Lærke S Gasbjerg ◽

Mads M Helsted ◽

Bolette Hartmann ◽

Alexander H Sparre-Ulrich ◽

Simon Veedfald ◽

...

Keyword(s):

Energy Expenditure ◽

Receptor Antagonist ◽

Plasma Glucose ◽

Area Under The Curve ◽

Postprandial Glucose ◽

Gallbladder Motility ◽

Incretin Hormones ◽

Gallbladder Ejection Fraction ◽

Postprandial Plasma Glucose ◽

Postprandial Glycemia

Abstract Context The actions of both endogenous incretin hormones during a meal have not previously been characterized. Objective Using specific receptor antagonists, we investigated the individual and combined contributions of endogenous glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) to postprandial glucose metabolism, energy expenditure, and gallbladder motility. Design Randomized, double-blinded, placebo-controlled, crossover design. Setting On four separate days, four liquid mixed meal tests (1894 kJ) over 270 minutes (min). Patients or Other Participants Twelve healthy male volunteers. Interventions Infusions of the GIP receptor antagonist GIP(3–30)NH2 (800 pmol/kg/min), the GLP-1 receptor antagonist exendin(9–39)NH2 (0–20 min: 1000 pmol/kg/min; 20–270 min: 450 pmol/kg/min), GIP(3–30)NH2+exendin(9–39)NH2, or placebo/saline. Main Outcome Measure Baseline-subtracted area under the curve (bsAUC) of C-peptide. Results Infusion of GIP(3–30)NH2+exendin(9–39)NH2 significantly increased plasma glucose excursions (bsAUC: 261 ± 142 mmol/L × min) during the liquid mixed meals compared with GIP(3–30)NH2 (180 ± 141 mmol/L × min; P = 0.048), exendin(9–39)NH2 (171 ± 114 mmol/L × min; P = 0.046), and placebo (116 ± 154 mmol/L × min; P = 0.015). Correspondingly, C-peptide:glucose ratios during GIP(3–30)NH2+exendin(9–39)NH2 infusion were significantly lower than during GIP(3–30)NH2 (P = 0.0057), exendin(9–39)NH2 (P = 0.0038), and placebo infusion (P = 0.014). GIP(3–30)NH2 resulted in significantly lower AUCs for glucagon than exendin(9–39)NH2 (P = 0.0417). Gallbladder ejection fraction was higher during GIP(3–30)NH2 compared with placebo (P = 0.004). For all interventions, energy expenditure and respiratory quotient were similar. Conclusions Endogenous GIP and GLP-1 lower postprandial plasma glucose excursions and stimulate insulin secretion but only endogenous GIP affects gallbladder motility. The two incretin hormones potentiate each other’s effects in the control of postprandial glycemia in healthy men.

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Study of Lipid Profile in Shift Workers

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v2i0.982 ◽

1970 ◽

Vol 2 ◽

pp. 34-37

Author(s):

Md Abedur Rahman ◽

Md Ruhul Amin ◽

Momotaj Begum ◽

Firoza Khatun ◽

Montasir Islam ◽

...

Keyword(s):

Blood Pressure ◽

Circadian Rhythm ◽

Lipid Profile ◽

Serum Lipid ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Shift Workers ◽

Shift Worker ◽

Cholesterol Levels ◽

Apparently Healthy

Background: The present study was undertaken to evaluate the changes of serum lipid profile in apparently healthy shift workers and non shift workers to identify the possible high risk factors for developing atherosclerotic changes. Methods: Serum Total Cholesterol, Triglyceride, HDL-Cholesterol and LDL-Cholesterol levels were estimated and blood pressure was measured in apparently healthy adult shift worker and non shift worker participants. Total 60 subjects age ranged from 20-50 years were selected, of whom 30 were shift workers (Study) for at least one year and 30 were non shift workers (control). Height, weight and resting blood pressure of all the subjects were recorded before collection of blood. Blood samples were collected after over night fasting for estimation of serum lipid and lipoprotein levels and were measured by standard laboratory technique. Data were analyzed by unpaired ‘t' test. Results: The mean serum Total Cholesterol and LDL-Cholesterol levels were significantly higher in shift workers compared to those of non shift workers. Again mean serum Triglyceride and HDL-Cholesterol levels in the shift workers did not differ significantly from that of non shift workers. These changes may be related to internal desynchronization due to disruption of circadian rhythm. Conclusion: The changes in serum lipid and lipoprotein levels with the exception of HDL-Cholesterol and Triglyceride in the subjects engaged in shift work may put them at increased risk for coronary artery disease. Keywords: Circadian Rhythm; Lipid Profile; Shift-work DOI:10.3329/jbsp.v2i0.982 J Bangladesh Soc Physiol. 2007 Dec;(2): 34-37.

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The Cardiovascular Risk of Adult GH Deficiency (GHD) Improved after GH Replacement and Worsened in Untreated GHD: A 12-Month Prospective Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.87.3.8336 ◽

2002 ◽

Vol 87 (3) ◽

pp. 1088-1093 ◽

Cited By ~ 40

Author(s):

Annamaria Colao ◽

Carolina di Somma ◽

Rosario Pivonello ◽

Alberto Cuocolo ◽

Letizia Spinelli ◽

...

Keyword(s):

Cardiovascular Risk ◽

Lipid Profile ◽

Ldl Cholesterol ◽

Gh Deficiency ◽

Hdl Cholesterol ◽

Left Ventricular ◽

Peak Exercise ◽

Gh Replacement ◽

Cholesterol Levels ◽

Igf I

Increased cardiovascular morbidity and mortality were reported in GH deficiency (GHD), and GH replacement can ameliorate cardiac abnormalities of adult GHD patients. To test the potential progression of untreated GHD on the cardiovascular risk and cardiac function, cardiovascular risk factors, cardiac size, and performance were prospectively evaluated in 15 GHD patients (age, 18–56 yr) who were treated with recombinant GH at the dose of 0.15–1.0 mg/d, 15 GHD patients (age, 18–56 yr) who refused GH replacement, and 30 healthy subjects (age, 18–53 yr). Electrocardiogram, systolic and diastolic blood pressure, and heart rate measurement, serum IGF-I, total cholesterol, low- and high-density lipoprotein (LDL, HDL) cholesterol, triglycerides, and fibrinogen level assay, echocardiography, and equilibrium radionuclide angiography were performed basally and after 12 months. At study entry, low IGF-I levels, unfavorable lipid profile, and inadequate cardiac and physical performance were found in GHD patients compared with controls. After 12 months of GH treatment, IGF-I levels normalized; HDL-cholesterol levels, left ventricular (LV) mass index (LVMi), left ventricular ejection fraction (LVEF) at peak exercise, peak filling rate, exercise duration and capacity significantly increased; total- and LDL-cholesterol levels significantly decreased. After 12 months in GH-untreated GHD patients, IGF-I levels remained stable, and HDL-cholesterol levels, LVEF both at rest and at peak exercise, and exercise capacity were further reduced; total- and LDL-cholesterol levels increased slightly. LVEF at rest and its response at peak exercise normalized in 60 and 53.3%, respectively, of GH-treated patients and in none of the GH-untreated patients. In conclusion, 12 months of GH replacement normalized IGF-I and improved lipid profile and cardiac performance in adult GHD patients. A similar period of GH deprivation induced a further impairment of lipid profile and cardiac performance. This finding strongly supports the need of GH replacement in adult GHD patients.

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A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-1756 ◽

2008 ◽

Vol 93 (2) ◽

pp. 470-476 ◽

Cited By ~ 92

Author(s):

Olivier Valkenburg ◽

Regine P. M. Steegers-Theunissen ◽

Huberdina P. M. Smedts ◽

Geesje M. Dallinga-Thie ◽

Bart C. J. M. Fauser ◽

...

Keyword(s):

Lipid Profile ◽

Ldl Cholesterol ◽

Case Control Study ◽

Polycystic Ovary ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Ovary Syndrome ◽

Atherogenic Lipid Profile ◽

Control Study ◽

Atherogenic Lipid

Abstract Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. Design: This was a case-control study. Setting: The study was performed at a single referral center. Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values ≤ 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

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Pengaruh propolis terhadap profil lipid plasma tikus model hiperkolesterolemia

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.17600 ◽

2012 ◽

Vol 8 (3) ◽

pp. 106

Author(s):

Krisnansari Diah ◽

Ariadne Tiara Hapsari ◽

Evy Sulistyoningrum ◽

Agus Prastowo

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Ldl Cholesterol ◽

Plasma Cholesterol ◽

Hdl Cholesterol ◽

Sprague Dawley ◽

High Cholesterol ◽

Cholesterol Levels ◽

Group I ◽

Before And After

Background: Nowadays, cardiovascular disease caused by hypercholesterolemia has become the main cause of death. Propolis has been used widely to reduce plasma cholesterol levels.Objective: The aims of this research was to study the effect of propolis on lipid profile of hypercholesterolemic Sprague Dawley rats.Method: This was an experimental study with pre-post test. Twenty four (24) male Sprague Dawley rats aged 12-16 week old, weighing 125-200 g were allocated into 4 groups. Group I received standard meal + aquadest-gavage; group II received high cholesterol meal + PTU 0,01 + aquadest gavage; group III received high cholesterol meal + PTU 0,01 + 0,027 g propolis gavage; group IV received high cholesterol meal + PTU 0,01 + 0,054 g propolis gavage. Total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol levels before and after treatment were measured. The data were then analyzed with One Way Anova.Results: The study showed that there were no significant differences in changes of body weight. There were significant differences in total cholesterol levels between all groups of treatment. Triglyceride levels were significantly different among all groups, except between group I and IV. Furthermore, the HDL cholesterol levels of group I vs III and group I vs IV were significantly different. However, there were no differences found in LDL cholesterol levels among all groups of treatment.Conclusion: Provision of 0,027 g and 0,054 g propolis improve lipid profile (total cholesterol, triglyceride and HDL cholesterol levels) of hypercholesterolemic rats.

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