Haemostatic functions and metabolic profile of subclinical hypothyroid and hypothyroid patients.

Objectives: Both hypercoagulable and hypocoagulable states have been proposed for hypothyroidism, whether in overt or subclinical spectrum. The status of haemostatic functions, metabolic profile and their relationship in hypothyroid disorders need to be evaluated.Methods and Material: This prospective case control study was undertaken in 30- 50 years old female subclinical and hypothyroid patients. Haemostatic functions like bleeding time (BT), clotting time (CT), prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count and metabolic parameters like plasma glucose and lipid levels and clinical variables like blood pressure and body mass index were noted and compared. In addition the strength of correlation of TSH, T4, T3, lipid profile with the haemostatic functions was evaluated.Results: Both groups of patients were obese, normotensive with normal haemostatic parameters. The platelet count correlated with TSH in subclinical hypothyroid patients and with T4 levels in hypothyroid patients. Although within normal range, total cholesterol and LDL cholesterol levels were higher and postprandial plasma glucose (PPPG) levels lower in hypothyroid patients compared to subclinical hypothyroid patients. A positive correlation was seen between TSH and LDL, PPPG levels, between fT3 and BMI, and also of antiTPO with total cholesterol, LDL, Fasting plasma glucose (FPG) in hypothyroid patients. The BMI was negatively associated with fT3 levels in subclinical hypothyroid patients.Conclusion: This study found normal haemostatic and metabolic functions in both subclinical and hypothyroid patients. Although within normal range, hypothyroid patients had higher total and LDL cholesterol. TSH and antiTPO levels correlated with LDL levels in these patients. Correlation of platelet count with TSH in subclinical hypothyroid and T4 levels in hypothyroid patients advocate a difference in mechanism involved. Therefore it can be connoted that thyroid status influences metabolic profile, and platelet count.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.532-536

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Hypercortisolaemia and dyslipidaemia in a selected diabetic population

International Journal of Biomedical Research ◽

10.7439/ijbr.v9i4.4538 ◽

2018 ◽

Vol 9 (4) ◽

pp. 143

Author(s):

Adediji Isaac Oluwole ◽

Ayodele Ademola Adelakun ◽

Afolabi Joy Oluwaseyifunmi ◽

Akinleye Waheed A ◽

Taiwo Timilehin Darasimi

Keyword(s):

Total Cholesterol ◽

Plasma Glucose ◽

Type Ii Diabetes ◽

Ldl Cholesterol ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Serum Cortisol ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Obese Subjects

Background: Type II DM and obesity are metabolic disorders characterized by insulin resistance, dyslipidaemia, and metabolic stress. These features were assessed in patients using fasting plasma glucose, fasting lipid profile and serum cortisol as their markers.Materials and methods: Ninety participants were recruited and classified into 3 groups of thirty each – Obese with type II DM, Non-obese with type II DM, non-obese and non-diabetics who served as controls. Anthropometric measures of weight and height were taken using standard procedures and body mass index was calculated thereafter. Blood samples were collected after an overnight fast for the in vitro assay of serum cortisol, plasma glucose, triglycerides, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol using enzyme linked immunosorbent assay and colorimetry as appropriate. Data obtained were analyzed statistically using ANOVA and post hoc test for comparison of variables between groups. Pearson’s correlation was performed to assess the relationship between variables and p<0.05 was considered significant.Results: Serum cortisol, plasma glucose, total cholesterol, triglycerides and LDL-cholesterol were elevated while HDL-cholesterol was reduced in both obese and non-obese subjects with type II diabetes mellitus when compared with controls. Cortisol had a significant positive association with plasma glucose, total cholesterol, triglycerides and LDL-cholesterol in obese subjects with type II diabetes mellitus while cortisol had a significant inverse relationship with HDL-cholesterol in both obese and non-obese subjects with type II diabetes mellitus.Conclusion: From this study, we conclude that elevated serum cortisol, a consequence of type II DM, accompanies dyslipidaemia in both obese and non-obese type II DM patients. It could therefore be inferred that ‘diabetic stress’ is the underlying factor of elevated cortisol in this group.

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A simple formula based on postprandial plasma glucose prediction using 5,640 meals data via GH-Method: math-physical medicine (No. 301)

Journal of Clinical & Experimental Immunology ◽

10.33140/jcei.05.05.004 ◽

2020 ◽

Vol 5 (5) ◽

Keyword(s):

Plasma Glucose ◽

Research Work ◽

The Other ◽

Diabetes Research ◽

Physical Medicine ◽

Postprandial Plasma Glucose ◽

Sugar Intake ◽

Glucose Testing ◽

The Status ◽

Food Nutrition

This article is based on the continuation of the author’s research work, a simple and practical, yet highly accurate postprandial plasma glucose (PPG) prediction formula for type 2 diabetes (T2D) patients. His methodology is the developed GH-Method: math-physical medicine (MPM) which has been utilized repeatedly in the past decade. The predicted PPG formula-based on the status of fasting plasma glucose (FPG), carbs/sugar intake amount, and postmeal walking steps are as follows: Predicted PPG = 0.97 * FPG + (carbs/sugar grams * 1.8) - (post-meal walking steps in thousand * 5) The conclusive results have the order of values m1 / m2 /m3 / prediction accuracy %. Case A: 1.8 / 5.0 / 0.97 / 99.8% Case B: 2.0 / 5.0 / 0.945 / 99.9% Case C: 2.2 / 5.0 / 0.92 / 99.9% Exercise is important, contributing ~3% higher than food, is easily achieved compared to the required knowledge of diet. As a result, the author spent four years to study food nutrition. Most T2D patients are seniors; therefore, he suggests that walking is the best form of exercise. However, the most difficult part of exercise is the behavior psychology related to the issue of “discipline and persistence”. T2D patients need to walk between 2,000 to 4,000 steps after each meal. The author walks an average of 4,300 steps after each meal. On the other hand, diet (carbs/sugar amount and nutritional balance) requires much more and deeper knowledge of food nutrition in order to control diabetes. Therefore, the author developed an AI-based tool to assist T2D patients. For non-tech patients, the following simple guidelines can assist with meal intake: Starchy food: Eat an amount half of your fist or hand at most Colorful vegetables: Eat an amount limited to one fist or hand. Green vegetables: Eat an amount limited to 2.5 fists or hands. Please note: you must combine two types of vegetable together in order to get the total intake limitation. The author highly recommends the patients to measure their FPG at least several times a quarter, in order to get a quarterly average FPG value. The other three PPG values can then utilize the formula-based predicted PPG to control their overall diabetes conditions. The described method mentioned above in regard to the predicted PPG formula along with the post-meal walking exercise and carbs/sugar intake amount can help patients control their diabetes without painful and troublesome fingerpiercing glucose measurements. The author has been measuring his glucoses for 8.5 years (3,126 days) with fingerpiercing glucose testing combined with his 10-years of diabetes research work. He hopes this article can provide useful guidelines to other diabetes patients to take back their lives from this dreadful chronic disease.

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Craniopharyngioma, Chronotypes and Metabolic Risk Profile

Nutrients ◽

10.3390/nu13103444 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3444

Author(s):

Carolina Di Somma ◽

Elisabetta Scarano ◽

Luigi Barrea ◽

Domenico Solari ◽

Enrico Riccio ◽

...

Keyword(s):

Blood Pressure ◽

Total Cholesterol ◽

Plasma Glucose ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Risk Profile ◽

Metabolic Parameters ◽

Metabolic Risk ◽

Significant Difference ◽

The Mean

Aim: To investigate the potential association among Craniopharyngioma (CP), chronotypes and metabolic risk profile. Subjects and Methods: The study population included 28 patients (46.4% males; 42.6 ± 15.8 years) and 28 controls, age, gender and BMI matched (46.4% males; 46.5 ± 12.9 years). In this study sample, we evaluated: anthropometric measurements (waist circumference, WC; BMI), plasma glucose, lipid profile, and systolic (SBP) and diastolic (DBP) blood pressure. Morningness-Eveningness was measured with the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ), which included 19 questions about preferred sleep time and daily performance. Results: in both patients and controls grade I obesity was detected in 15 subjects (53.6%), grade II obesity in 13 subjects (46.4%). In the patient group, the mean score of chronotype was 47.8 ± 12.6. In particular, 9 patients (32.1%) exhibited the morning chronotype, 6 (21.4%) the intermediate chronotype and 13 (46.4.%) the evening chronotype. No significant difference was found in gender and age among the chronotype categories. Patients with the evening chronotype had higher blood pressure values and worse metabolic parameters than those with the morning chronotype. In the control group, the mean score of the chronotype was 57.6 ± 9.5. In particular, 16 (57.1%) subjects exhibited the morning chronotype, 10 (35.7%) the intermediate chronotype and only 2 (7.1.%) the evening chronotype. The prevalence of intermediate and evening chronotypes was higher in females than males (p = 0.021), while males have a higher prevalence of the morning chronotype. Subjects with intermediate and evening chronotypes had worse metabolic parameters than those with the morning chronotype. In patients, the chronotype score was inversely correlated to WC, BMI, SBP, DBP, plasma glucose, total cholesterol, triglycerides, LDL cholesterol and positively correlated with HDL cholesterol. No correlation was found between age and chronotype. In controls, the chronotype score was inversely correlated to WC, BMI, plasma glucose, total cholesterol, LDL cholesterol. No correlation was found among chronotype and age, blood pressure, triglycerides, HDL cholesterol. Considering the whole population of the study (patients and controls), at logistic regression the chronotype score was significantly associated with the presence of CP. Conclusions: for the first time thus far, our study puts the light on the association of the CP with chronotypes and metabolic alterations in this disease, which are the main determinants of the reduced quality of life, higher morbidity and mortality in this setting of patients. This finding suggests that alterations of chronotype might represent an adjunctive risk for CP patients and a possible target for their integrate management.

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Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Beni-Suef University Journal of Basic and Applied Sciences ◽

10.1186/s43088-019-0025-9 ◽

2019 ◽

Vol 8 (1) ◽

Author(s):

Ayat S. Rashwan ◽

Marwa A. El-Beltagy ◽

Sherif Y. Saleh ◽

Ibrahim A. Ibrahim

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Superoxide Dismutase ◽

Uric Acid ◽

Total Cholesterol ◽

Plasma Glucose ◽

Ldl Cholesterol ◽

Reduced Glutathione ◽

Sesquiterpene Lactones ◽

Glycosylated Hemoglobin

Abstract Background One of the serious public health problems in the world is metabolic syndrome. It includes visceral obesity, dyslipidemia, insulin resistance, hyperglycemia, and hypertension. As a contributor to almost all the classic signs of metabolic syndrome, fructose was the ideal choice. There are certain shortcomings with existing drugs for insulin-resistant treatment. Plants still represent the main source of most available medicines. Cinnamaldehyde (CNA) is an active principle of Cinnamomum zeylanicum. Costunolide (CE) is natural sesquiterpene lactones, which is the main bioactive constituent of Saussurea lappa. The main aim of the present study is to investigate the effect of the synthetic antidiabetic agent (metformin) in comparison with natural constituents (cinnamaldehyde, costunolide) after developing a reliable model for insulin resistance by using high fructose diet (HFD). Results It was found that HFD increased plasma glucose, insulin, glycosylated hemoglobin, HbA1c, serum total cholesterol, LDL-cholesterol, triglyceride, ALT, AST, creatinine, and uric acid. Moreover, HFD decreased hepatic reduced glutathione and superoxide dismutase levels. While oral administration of cinnamaldehyde and costunolide significantly decreased plasma glucose, HbA1c, total cholesterol, LDL-cholesterol, triglyceride, and increased level of hepatic reduced glutathione and superoxide dismutase activity. Also, cinnamaldehyde and costunolide restored the altered plasma levels of ALT, AST, creatinine, and uric acid to normal. Conclusions The results of this experimental study showed that cinnamaldehyde and costunolide could be used as safe drugs for treating different abnormalities of metabolic syndrome.

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Postprandial plasma glucose excursion is associated with an atherogenic lipid profile in individuals with type 2 diabetes mellitus: A cross-sectional study

PLoS ONE ◽

10.1371/journal.pone.0258771 ◽

2021 ◽

Vol 16 (10) ◽

pp. e0258771

Author(s):

Po-Chung Cheng ◽

Chia-Hung Kao

Keyword(s):

Lipid Profile ◽

Plasma Glucose ◽

Ldl Cholesterol ◽

Postprandial Glucose ◽

Glucose Excursion ◽

Postprandial Plasma Glucose ◽

Cholesterol Levels ◽

Atherogenic Lipid Profile ◽

The Difference ◽

Postprandial Glucose Excursion

Coronary heart disease (CHD) is a prevalent complication of type 2 diabetes mellitus (T2DM). The atherogenic low-density lipoprotein (LDL) cholesterol is an established risk factor of cardiovascular disease, and evidence also suggests that postprandial plasma glucose (PPG) levels closely delineate CHD mortality in diabetes. The investigators hypothesized that postprandial plasma glucose excursion (PPGE), defined as the difference between 2-hour PPG and fasting plasma glucose (FPG), may be associated with plasma LDL cholesterol levels in patients with T2DM. This study enrolled diabetic participants for whom FPG and lipid profile were sampled after a 12-hour fast, followed by PPG sampling two hours after consuming a standard meal with 75 grams of carbohydrates. The study enrolled 379 participants who were divided into PPGE tertiles according to the difference between their 2-hour PPG and FPG. Participants in the highest PPGE tertile had considerably greater plasma LDL cholesterol levels than patients in the lowest tertile (126.7 mg/dL vs. 99.5 mg/dL, P <0.001). Linear regression analysis also demonstrated that the PPGE was positively correlated with plasma LDL cholesterol levels (β coefficient: 0.165, P < 0.001). Postprandial glucose excursion positively correlated with plasma LDL cholesterol levels in individuals with T2DM. Participants with raised PPGE harbored greater LDL cholesterol levels than those with lower postprandial glucose fluctuations. Therefore, postprandial glucose excursion is associated with an atherogenic lipid profile and may be a modifiable risk factor of diabetic CHD.

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A simple formula based on postprandial plasma glucose prediction using 5,640 meals data via GH-Method: math-physical medicine (No. 301)

Journal of Clinical & Experimental Immunology ◽

10.33140/jcei.05.05.04 ◽

2020 ◽

Vol 5 (5) ◽

Keyword(s):

Plasma Glucose ◽

Research Work ◽

Physical Medicine ◽

Prediction Formula ◽

Postprandial Plasma Glucose ◽

Sugar Intake ◽

The Past ◽

The Status ◽

Glucose Prediction

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Abstract #804945: Fasting and Postprandial Plasma Glucose Contribution to HBA1C in People with Type 2 Diabetes on Basalbolus Insulin Therapy: Results from a Meta-Analysis of Insulin Lispro Clinical Trials

Endocrine Practice ◽

10.1016/s1530-891x(20)39601-4 ◽

2020 ◽

Vol 26 ◽

pp. 114-115

Author(s):

Farai Chigutsa

Keyword(s):

Type 2 Diabetes ◽

Clinical Trials ◽

Insulin Therapy ◽

Plasma Glucose ◽

Insulin Lispro ◽

Meta Analysis ◽

Postprandial Plasma Glucose

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Thrombotic Thrombocytopenic Purpura: Mechanism for Effectiveness of Plasmapheresis

10.1055/s-0038-1665810 ◽

1979 ◽

Author(s):

J. G. Kelton ◽

P. B. Neame ◽

I. Walker ◽

A. G. Turpie ◽

J. McBride ◽

...

Keyword(s):

Platelet Count ◽

Thrombotic Thrombocytopenic Purpura ◽

The Other ◽

Unknown Etiology ◽

Normal Range ◽

Antiplatelet Antibody ◽

Thrombocytopenic Purpura ◽

Serious Illness ◽

Normal Platelet ◽

Very High

Thrombotic thrombocytopenic purpura (TTP) is a rare but serious illness of unknown etiology. Treatment by plasmapheresis has been reported to be effective but the mechanism for benefit is unknown. We have investigated the effect of plasmapheresis in 2 patients with TTP by quantitating platelet associated IgG (PAIgG) levels prior to and following plasmapheresis. Both patients had very high levels of PAIgG at presentation (90 and A8 fg IgG/platelet respectively, normal 0-5). in both, the PAIgG levels progressively fell to within the normal range and the platelet count rose following plasmapheresis. One patient remained in remission with normal platelet counts and PAIgG levels. The other relapsed after plasmapheresis and the PAIgG level rose prior to the fall in platelet count. Plasmapheresis was repeated and resulted in normalization of both the platelet count and PAIgG level. It is suggested that plasmapheresis removes antiplatelet antibody or immune complexes which may be of etiological importance in this illness.

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ASSESSMENT OF THE PLATELET COUNT IN THE PREGNANT WOMEN IN IGIMS, PATNA, BIHAR

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i2.1185 ◽

2020 ◽

Vol 4 (2) ◽

Author(s):

Tanwi Singh ◽

Anshuman Sinha

Keyword(s):

Platelet Count ◽

Pregnant Women ◽

Screening Test ◽

Low Cost ◽

Medical Science ◽

Cost Effective ◽

Platelet Indices ◽

Increased Risk ◽

Low Platelet Count ◽

Severity Of The Disease

The major risk associated with low platelet count in pregnancy is the increased risk of bleeding during the childbirth or post that. There is an increased blood supply to the uterus during pregnancy and the surgical procedure requires cutting of major blood vessels. Women with thrombocytopenia are at increased risk of losing excessive blood. The risk is more in case of caesarean delivery as compared to vaginal delivery. Hence based on above findings the present study was planned for Assessment of the Platelet Count in the Pregnant Women in IGIMS, Patna, Bihar. The present study was planned in Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India. The present study was planned from duration of January 2019 to June 2019. In the present study 200 pregnant females samples received for the platelet estimation were enrolled in the present study. Clinically platelet indices can be a useful screening test for early identification of preeclampsia and eclampsia. Also platelet indices can assess the prognosis of this disease in pregnant women and can be used as an effective prognostic marker because it correlates with severity of the disease. Platelet count is a simple, low cost, and rapid routine screening test. Hence the data generated from the present study concludes that platelet count can be used as a simple and cost effective tool to monitor the progression of preeclampsia, thereby preventing complications to develop during the gestational period. Keywords: Platelet Count, Pregnant Women, IGIMS, Patna, Bihar, etc.

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