scholarly journals Impact of Liver Functions by Repurposed Drugs for COVID-19 Treatment

2022 ◽  
Vol 000 (000) ◽  
pp. 000-000
Author(s):  
Rongzhi Zhang ◽  
Qiang Wang ◽  
Jianshe Yang
Keyword(s):  
Liver Functions ◽  
Repurposed Drugs

Effects of Hypophysectomy on the Fine Structure of Rat Liver Cells

1967 ◽  
Vol 25 ◽  
pp. 156-157
Author(s):  
Robert R. Cardell
Keyword(s):  
Electron Microscopy ◽  
Fine Structure ◽  
Rat Liver ◽  
Liver Cell ◽  
Anterior Pituitary ◽  
Liver Cells ◽  
Biochemical Studies ◽  
Liver Functions ◽  
Rat Liver Cells ◽  
And Control

Hypophysectomy of the rat renders this animal deficient in the hormones of the anterior pituitary gland, thus causing many primary and secondary hormonal effects on basic liver functions. Biochemical studies of these alterations in the rat liver cell are quite extensive; however, relatively few morphological observations on such cells have been recorded. Because the available biochemical information was derived mostly from disrupted and fractionated liver cells, it seemed desirable to examine the problem with the techniques of electron microscopy in order to see what changes are apparent in the intact liver cell after hypophysectomy. Accordingly, liver cells from rats which had been hypophysectomized 5-120 days before sacrifice were studied. Sham-operated rats served as controls and both hypophysectomized and control rats were fasted 15 hours before sacrifice.

STEROIDSTRUKTUR UND LEBERTOXIZITÄT

1967 ◽  
Vol 54 (1) ◽  
pp. 73-84 ◽  
Author(s):  
H. L. Krüskemper ◽  
G. Noell
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Blood Coagulation ◽  
Electrophoretic Pattern ◽  
Coagulation Factors ◽  
Blood Coagulation Factors ◽  
Methyl Group ◽  
Liver Functions ◽  
Male Subjects ◽  
Androstane Derivatives

ABSTRACT In male subjects investigations have been carried out regarding the effect of C1- and C17-methylated androstane derivatives (20 mg per day, orally, two weeks) on liver functions (parameters: activities of GPT, GOT, alkaline phosphatase and cholinesterase in serum; electrophoretic pattern; blood coagulation factors V, VII, X and prothrombin; BSP-retention). In addition to the well known hepatotropic action of 17α-alkylated C-19-steroids a quasi-axial 1α-methyl configuration (in 1α-methylandrost-2-en-17β-ol) definitely increased BSP-retention and several coagulation factors. These steroid effects decreased gradually when a methyl group was introduced in C1 equatorially (1-methylandrost-1-en-17β-ol-3-one) or quasi-equatorially (1β-methylandrost-2-en-17β-ol), the latter compound completely lacking from any influence on parameters of liver function under investigation.

Evaluation of Renal and Liver Functions Tests in Car Paint Sprayers

2016 ◽  
Vol 2 (6) ◽  
Author(s):  
Sumit Arora ◽  
Yogesh Tripathi ◽  
Varun Malhotra ◽  
Kavita Singh ◽  
Shivani Gupta
Keyword(s):  
Liver Functions

Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease

2020 ◽  
Vol 26 (30) ◽  
pp. 3733-3747 ◽  
Author(s):  
Mariana Ferreira-Duarte ◽  
Joana Beatriz Sousa ◽  
Carmen Diniz ◽  
Teresa Sousa ◽  
Margarida Duarte-Araújo ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Endothelial Dysfunction ◽  
Bowel Disease ◽  
Clinical Evidence ◽  
High Cardiovascular Risk ◽  
Considerable Evidence ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel ◽  
Repurposed Drugs ◽  
Main Effects

The endothelium has a crucial role in proper hemodynamics. Inflammatory bowel disease (IBD) is mainly a chronic inflammatory condition of the gastrointestinal tract. However, considerable evidence points to high cardiovascular risk in patients with IBD. This review positions the basic mechanisms of endothelial dysfunction in the IBD setting (both clinical and experimental). Furthermore, we review the main effects of drugs used to treat IBD in endothelial (dys)function. Moreover, we leave challenging points for enlarging the therapeutic arsenal for IBD with new or repurposed drugs that target endothelial dysfunction besides inflammation.

Possible Targets and Therapies of SARS-CoV-2 Infection

2020 ◽  
Vol 20 (18) ◽  
pp. 1900-1907
Author(s):  
Kasturi Sarkar ◽  
Parames C. Sil ◽  
Seyed Fazel Nabavi ◽  
Ioana Berindan-Neagoe ◽  
Cosmin Andrei Cismaru ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Viral Replication ◽  
Viral Infection ◽  
Human Activity ◽  
Viral Proteins ◽  
Therapeutic Agents ◽  
Effective Control ◽  
Human Society ◽  
Global Spread ◽  
Repurposed Drugs

The global spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes COVID-19 has become a source of grave medical and socioeconomic concern to human society. Since its first appearance in the Wuhan region of China in December 2019, the most effective measures of managing the spread of SARS-CoV-2 infection have been social distancing and lockdown of human activity; the level of which has not been seen in our generations. Effective control of the viral infection and COVID-19 will ultimately depend on the development of either a vaccine or therapeutic agents. This article highlights the progresses made so far in these strategies by assessing key targets associated with the viral replication cycle. The key viral proteins and enzymes that could be targeted by new and repurposed drugs are discussed.

Repurposed Drugs in Metabolic Disorders

2013 ◽  
Vol 13 (18) ◽  
pp. 2386-2394 ◽  
Author(s):  
Josef Finsterer ◽  
Marlies Frank
Keyword(s):  
Metabolic Disorders ◽  
Repurposed Drugs

Repurposed Drugs for the Treatment of Schizophrenia and Bipolar Disorders

2013 ◽  
Vol 13 (18) ◽  
pp. 2364-2385 ◽  
Author(s):  
J. Bumb ◽  
F. Enning ◽  
F. Leweke
Keyword(s):  
Bipolar Disorders ◽  
Repurposed Drugs

Arctium lappa and management of liver functions to detoxifying the bloodstream

2020 ◽  
Vol 10 ◽  
Author(s):  
Mohaddese Mahboubi
Keyword(s):  
Zinc Oxide ◽  
Carbon Tetrachloride ◽  
Animal Studies ◽  
Main Part ◽  
Liver Enzymes ◽  
Review Article ◽  
Northern Asia ◽  
Arctium Lappa ◽  
Perennial Plant ◽  
Liver Functions

: Arctium lappa or burdock (Compositae family) is a perennial plant, native to Europe, Northern Asia and North America. Burdock roots are known as detoxifying herb to clear toxins from the bloodstream. It seems that its effects are on the liver functions as the main part of body in detoxifying the bloodstream. The aim of this review article was to evaluate the potency of burdock in management of liver functions in detoxifying the bloodstream. The information was extracted from electronic resources (Google scholar, Science Direct, Springer, Magiran). The results of our investigation exhibited that the studies are limited to animal studies, but the results of investigations showed that burdock roots detoxify the liver against ethanol, carbon tetrachloride (CCL4), acetaminophen, cadmium and zinc oxide by improving the functions of liver enzymes. The antioxidant, anti-inflammatory and prebiotic effects of burdock roots may involve in its effects on liver enzymes and detoxifying the blood. The large clinical studies are required to confirm its efficacy on liver functions and detoxify the liver.

Recent developments and opportunities in fighting COVID-19

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Vikram Rao ◽  
Subrat Kumar Bhattamisra
Keyword(s):  
World Health ◽  
Diagnostic Tools ◽  
Extensive Literature ◽  
Angiotensin Converting Enzyme 2 ◽  
Recent Developments ◽  
Therapeutic Molecules ◽  
Discharged Patients ◽  
Extensive Literature Search ◽  
Repurposed Drugs ◽  
Health Organization

Background: COVID-19, a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) was first diagnosed in the patients from Wuhan, China in December 2019. Within couple of months of infection, it was declared as pandemic by World health organization. COVID-19 has become the most contagious infection with a serious threat to global health. In this review, we aimed to discuss the pathogenesis, diagnostics, current treatments and potential vaccines for COVID-19. Methods: An extensive literature search was conducted using keywords “COVID-19”; “Coronavirus”; “SARS-Cov-2”; “SARS” in public domains of Google, Google scholar, PubMed, and ScienceDirect. Selected articles were used to construct this review. Results: SARS-Cov-2 uses the Spike (S) protein on its surface to recognize the receptor on angiotensin-converting enzyme 2 (ACE2) and bind with 10-folds greater affinity than SARS-Cov-1. Molecular assays and immunoassays are the most frequently used tests whereas computed tomography (CT) scans, Artificial intelligence enabled diagnostic tools were also used in patients. In therapeutic treatment, few drugs were repurposed and there are 23 therapeutic molecules including the repurposed drugs are in different stages of clinical trial. Similarly, development of vaccines is also in the pipeline. Few countries have managed well to contain the spread by rapid testing and identifying the clusters. Conclusion: Till now, the acute complications and mortality of COVID-19 has been linked to the pre-existing comorbid conditions or age. Besides the development of therapeutic strategies that includes drugs and vaccine, the long term implication of COVID-19 infection in terms of the disorder/disability in the cured/discharged patients is a new area to investigate.

Combination of Hydroxychloroquine, Melatonin and Mercaptopurine as possible intervention for prophylaxis and treatment of Novel COVID-19 infection

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Gyan Vardhan ◽  
Vikas Kumar ◽  
Megha Agrawal ◽  
Puneet Dhamija
Keyword(s):  
Mechanism Of Action ◽  
Drug Combination ◽  
Treatment Strategies ◽  
Effective Drug ◽  
Effective Alternative ◽  
Potential Candidate ◽  
Potential Drug ◽  
Review Of Literature ◽  
Scientific Review ◽  
Repurposed Drugs

Background: COVID-19 has been declared as a pandemic recently and has caused many deaths worldwide. Till date no effective drug or vaccine is available against SARS-CoV-2. There is an urgent need to find effective alternative preventive and treatment strategies to deal with SARS-CoV-2 outbreak. Objective: This communication proposes a new potential drug combination (repurposed) for prophylaxis and treatment of SARS-CoV-2. Methods and Materials: We performed a brief review of literature on combination of Hydroxychloroquine, Melatonin and Mercaptopurine for prophylaxis and treatment of Novel COVID-19 infection and also assessed their possible mechanism of action against SARS-CoV-2. Observation: Proposed combination seems to be safe and target is unlikely to develop resistance to this combination. Conclusion: This scientific review proposes potential repurposed drugs and their combination targeting SARS-CoV-2. Conclusion: This scientific review proposes potential candidate repurposed drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.

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