scholarly journals Equilibrium, DNA Cleavage and Antimicrobial Studies of Cu(II) and Zn(II) Complexes with Novel 1-Propionyl-4-methyl-3-thiosemicarbazide

2019 ◽  
Vol 32 (1) ◽  
pp. 142-146
Author(s):  
P. Nirmala Jyothi ◽  
B. Sireesha
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Formation Constants ◽  
Molar Conductance ◽  
Water Medium ◽  
Hydrolytic Cleavage ◽  
Antimicrobial Studies ◽  
Pbr322 Dna ◽  
Visible Spectra ◽  
Titration Technique

Cu(II) and Zn(II) metal complexes with novel Schiff base 1-propionyl-4-methyl-3-thiosemicarbazide (PMTSC) were synthesized and characterized by LC-MS, IR, 1H NMR (D2O exchangeable), 13C NMR and UV-visible spectra, ESR, TGA, molar conductance and magnetic susceptibility measurements. The spectro-analytical studies revealed the composition of complexes as ML2 for Cu(II)-PMTSC and Zn(II)-PMTSC complex. The proton-ligand dissociation constant and metal-ligand formation constants of PMTSC with Zn(II) have been determined in 70 % (v/v) DMF-water medium at 0.1M (KNO3) ionic strength and 303 K using potentiometric Irving-Rossotti titration technique. The results revealed that PMTSC acts as monobasic ligand by releasing proton from amide via enol form and forms 1:2 (Zn-L) complex in solution. The cleavage of plasmid pBR322 DNA without any additives was monitored by gel electrophoresis and these complexes exhibited hydrolytic cleavage of plasmid DNA. The antibacterial activity of the Schiff base and its Cu(II) and Zn(II) complexes were tested against Gram-positive and Gram-negative bacteria.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

scholarly journals Microwave Synthesis, Spectral, Thermal and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Aminothiazole Moiety

2012 ◽  
Vol 9 (4) ◽  
pp. 1655-1666 ◽  
Author(s):  
A. P. Mishra ◽  
H. Purwar ◽  
Rajendra K. Jain ◽  
S. K. Gupta
Keyword(s):  
Electrical Conductivity ◽  
Schiff Base ◽  
Solid State ◽  
Metal Complexes ◽  
Analytical Data ◽  
Xrd Analysis ◽  
Lattice Parameter ◽  
Molar Conductance ◽  
Unit Cell ◽  
Antimicrobial Studies

Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 4-chlorobenzylidene-2-aminothiazole (CAT) and 2-nitrobenzylidene-2-aminothiazole (NAT) have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR, magnetic susceptibility, thermal, electrical conductivity and XRD analysis. The complexes are coloured and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal:ligand) ratio with coordination number 4 or 6. FAB-mass and thermal data show degradation pattern of the complexes. The thermal behavior of metal complexes shows that the hydrated complexes loses water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. The crystal system, lattice parameter, unit cell volume and number of molecules in unit cell in the lattice of complexes have been determined by XRD analysis. XRD patterns indicate crystalline nature for the complexes. The solid state electrical conductivity of the metal complexes has also been measured. Solid state electrical conductivity studies reflect semiconducting nature of the complexes. The Schiff base and metal complexes show a good activity against the Gram-positive bacteria;Staphylococcus aureusand Gram-negative bacteria;Escherichia coliand fungiAspergillus nigerandCandida albicans.

scholarly journals Coordination Modes of a Schiff Base Derived from Substituted 2-Aminothiazole with Chromium(III), Manganese(II), Iron(II), Cobalt(II), Nickel(II) and Copper(II) Metal Ions: Synthesis, Spectroscopic and Antimicrobial Studies

2011 ◽  
Vol 8 (4) ◽  
pp. 1750-1764 ◽  
Author(s):  
Ambit Thakar ◽  
Krishnakant Joshi ◽  
Kishor Pandya ◽  
Arvind Pancholi
Keyword(s):  
Schiff Base ◽  
Metal Ions ◽  
Transition Metal Complexes ◽  
Mass Spectra ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Techniques ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
C Nmr

Transition metal complexes of Cr(III), Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) metal ions with general stoichiometry [ML2.2H2O] and [ML3], where M= Mn(II), Cr(III), Fe(II), Co(II), Ni(II) and Cu(II), L= Schiff base derived from the condensation of 2-amino-4(4’-phenyl/methylphenyl)-5-methyl-thiazole with 4-acetyl-1(3-chloro phenyl)-3-methyl-2-pyrazoline-5-ones, have been synthesized and structurally characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements and spectral techniques like IR, UV,1H NMR,13C NMR and Mass Spectra. All the complexes were found to be octahedral geometry. The ligand and its complexes have been screened for their antifungal and antibacterial activities against three fungi,i.e. Alternaria brassicae, Aspergillus nigerandFesarium oxysporumand two bacteria,i.e. Xanthomonas compestrisandPseudomonas aeruginosa.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of 3-[(2-Hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one and its Metal(II) Complexes

2008 ◽  
Vol 5 (1) ◽  
pp. 155-162 ◽  
Author(s):  
K. Siddappa ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML2 and M′L [where M=Cu(II), Co(II), and Ni(II) and M′= Zn(II), Cd(II) and Hg(II)]. L = 3-[(2-hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one, (HQMAPQ) Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HQMAPQ acts as doubly monodentate bridge for metal(II) ions and form mononuclear complexes. The complexes Ni(II), Co(II) and Cu(II) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal(II) complexes were screened for their antimicrobial activity.

scholarly journals Synthesis, characterization and antimicrobial studies of Mn(II) complexes of acetylthiophene and acetyl furan Schiff base derivatives

2020 ◽  
Vol 12 (1) ◽  
pp. 251-258
Author(s):  
S. Isyaku ◽  
H.N. Aliyu ◽  
E.C. Ozoro ◽  
T. Abubakar
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Salmonella Typhi ◽  
Decomposition Temperature ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Antimicrobial Studies

Manganese(II) complexes of Schiff bases; 2-acetylthiophene-4‑phenylthiosemi-carbazone (AT-PTSC) and 2-furylmethylketone-4-phenylthiosemi-carbazone  (AF‑PTSC) derived from condensation of 2-acetylthiophene and 2-furylmethylketone (2-acetylfuran) each with 4-phenylthiosemicarbazide in (1:1 molar ratio) ethanol, have been synthesized. The Schiff bases and the Mn(II) complexes were characterized on the basis of melting point/decomposition temperature, solubility, magnetic susceptibility, infrared spectra, molar conductance measurements,  elemental and gravimetric  analyses. The Mn(II) complexes show moderate values of decomposition temperatures. The Schiff bases and the complexes were soluble in some common organic solvents. Infrared spectral data of the Schiff bases and their complexes, indicate coordination of the Schiff bases to the metal(II) ion via azomethine nitrogen. The effective magnetic moment of the Mn(II) complexes suggested an octahedral geometry. The molar conductance values of the complexes show that the complexes are electrolytes. The results of the elemental analysis of the ligands and their complexes are in good agreement with the calculated values, suggesting a 1:2 (metal-ligand) ratio. Antimicrobial screenings of the ligands and their complexes were conducted against gram-positive (Staphylococcus aureus,) and two gram-negative (Salmonella typhi, and Escherichia coli) bacteria specie. Also three fungi mainly (Candida albicans, Mucus indicus and Aspergillus flavus) were tested. The results showed that both the ligands and the complexes are active against the bacteria and the fungi specie. Keywords: Ligand, Schiff base, 4-phenylthiosemicarbazide, 2-acetylthiophene, 2-acetylfuran molar conductivity, magnetic susceptibility, elemental analysis.

In Methanolic Solvent Synthesis of New MnII, CoII, NiII and CuII Schiff Base of Aromatic β Amino Acids: Spectroscopic, Thermal, Molecular Docking and Antimicrobial Studies

2020 ◽  
Vol 12 (8) ◽  
pp. 1137-1148 ◽  
Author(s):  
Asma S. Al-Wasidi ◽  
Nawal M. Al-Jafshar ◽  
Amal M. Al-Anazi ◽  
Moamen S. Refat ◽  
Nashwa M. El-Metwaly ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Amino Acid ◽  
Benzoic Acid ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Proton Nuclear Magnetic Resonance ◽  
Antimicrobial Studies ◽  
Amino Benzoic Acid

In this article, four new Schiff base complexes of Mn(II), Co(II), Ni(II) and Cu(II) complexes have been synthesized with two different compositions as [M(L)2Cl2] · nH2O and [M(L)2(H2O)2]Cl2 · nH2O [where L1 = benzoin-o-amino benzoic acid (aromatic β amino acid) and L2 = benzoin bromo-o-amino benzoic acid (aromatic β amino acid); M = MnII, CoII, NiII and CuII; n = 1, 2 and 4]. These Schiff base complexes were discussed by many tool of analyses like elemental analysis, magnetic susceptibility, molar conductance, mass spectra, infrared spectra "IR," proton nuclear magnetic resonance "1H-NMR," electronic spectral and thermogravimetric analysis (TG/DTG). These complexes have an electrolytic nature within range of 78–174 Ω1 cm–1 mol –1 based on conductance measurements. Magnetic moment and electronic spectral results deduced that the geometry of Mn2+, Co2+ and Ni2+ and Cu2+ complexes has an octahedral configuration. The number of coordinated and uncoordinated water molecules for the synthesized complexes were calculated based on the thermal analysis technique. The kinetic thermodynamic data were estimated by using commonly integral equations of Horowitz-Metzger (HM) and Coats-Redfern (CR). In vitro the antimicrobial activity of both free L1 and L2 ligands in comparable with their metal complexes were evaluated. This study was strengthen by molecular docking against three protein receptors, which attributing to selected organisms already used in vitro study.

scholarly journals Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Amani S. Alturiqi ◽  
Abdel-Nasser M. A. Alaghaz ◽  
Reda A. Ammar ◽  
Mohamed E. Zayed
Keyword(s):  
Schiff Base ◽  
Analytical Data ◽  
Molar Conductance ◽  
Ligand Field ◽  
Cytotoxic Activities ◽  
Human Breast ◽  
Cytotoxicity Studies ◽  
Visible Spectra ◽  
Uv Visible ◽  
Mcf 7

Coordination compounds of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions were synthesized from the furan ligand [5-hydroxymethylfuran-2-yl-methyleneaminoquinolin-2-one] (H-MFMAQ) derived from the condensation of 5-hydroxymethylfuran-2-carbaldehyde and 1-aminoquinolin-2(1H)-one. Elemental analytical data, IR, NMR (1H, 13C, and 15N), EPR, XRD, SEM, TEM, EDX, TGA, mass, molar conductance, magnetic moment, and UV-Visible spectra techniques were used to confirm the structure of the synthesized chelates. According to the data obtained, the composition of the 1 : 1 metal ions : furan Schiff base ligand was found to be [M(MFMAQ)Cl2] (M = Cr(III) and Ru(III)) and [M(MFMAQ)Cl(H2O)]·nH2O in which (M = Mn(II); n=1, Co(II); n=0, Ni(II); n=2, Cu(II); n=0 and Zn(II); n=2.5). The measurements of magnetic susceptibility, ligand field parameter, and reflectance spectra suggested an octahedral geometry for the complexes. Central metals ions and furan Schiff base coordinated via O3 and N donor sites which was observed from IR spectra. The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.

scholarly journals Synthesis, Spectral and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Thiophenecarboxaldehyde Moiety

2012 ◽  
Vol 9 (3) ◽  
pp. 1113-1121 ◽  
Author(s):  
A. P. Mishra ◽  
A. Tiwari ◽  
S. K. Gupta ◽  
Rajendra Jain
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Antimicrobial Agents ◽  
Analytical Data ◽  
Molar Conductance ◽  
E Coli ◽  
Antimicrobial Studies ◽  
Degradation Pattern ◽  
Ft Ir ◽  
Schiff Base Metal Complexes

Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 3-chloro-4-fluoroaniline (HL1) and 4-fluoroaniline (HL2) with 2-thiophenecarboxaldehyde have been synthesized and characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR and magnetic susceptibility. The complexes exhibit coordination number 4 or 6. The complexes are colored and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal: ligand) ratio. FAB-mass data show degradation pattern of the complexes. The Schiff base and metal complexes show a good activity against the bacteria;B. subtilis,E. coliandS. aureusand fungiA. niger,A. flavusandC. albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases.

scholarly journals Spectral, NLO and antimicrobial studies of Co(II), Ni(II) and Cu(II) complexes of Schiff base ligands of 2-amino-6-nitrobenzothiazole

2019 ◽  
Vol 84 (3) ◽  
pp. 267-275 ◽  
Author(s):  
Chinnaraj Kanagavalli ◽  
Murugesan Sankarganesh ◽  
Raja Dhaveethu ◽  
Manivannan Kalanithi
Keyword(s):  
Schiff Base ◽  
Second Harmonic ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Spectroscopic Studies ◽  
Molar Conductance ◽  
Spectroscopic Techniques ◽  
Schiff Base Ligands ◽  
Tetrahedral Geometry ◽  
Antimicrobial Studies

Novel series of Co(II), Ni(II) and Cu(II) transition metal complexes were synthesized from the Schiff base ligands HL1?HL4 derived from 2-amino-6- nitrobenzothiazole with various aromatic aldehydes, i.e., 4-methylbenzaldehyde, 4- ethylbenzaldehyde, 2-hydroxybenzaldehyde and 4-hydroxybenzaldehyde, respectively. The ligands HL1?HL4 and their metal (II) complexes were characterized by atomic absorption spectroscopy (AAS), magnetic susceptibility and molar conductance measurements, and UV?Vis, FT-IR and NMR spectroscopic techniques. The spectroscopic studies revealed that the complexes of HL1?HL3 coordinated in an octahedral environment and L4 in square planar/tetrahedral geometry. The ligands HL1?HL4 and their metal(II) complexes were screened for their antimicrobial activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The results suggest that the complexes of HL4 possess greater inhibition activity towards C. albicans. The nonlinear optics (NLO) activities of ligands HL1?HL4 were determined. The obtained results showed that ligands HL1 and HL2 have greater second harmonic generation (SHG) efficiency than HL3and HL4.

scholarly journals Co(III) and VO(IV) complexes with a new bidentate Schiff base: Interaction with BSA and antimicrobial studies

2019 ◽  
Vol 9 (1) ◽  
pp. 3776-3782 ◽  
Keyword(s):  
Schiff Base ◽  
Analytical Techniques ◽  
Molar Conductance ◽  
Base Interaction ◽  
1H And 13C Nmr ◽  
Pyramidal Geometry ◽  
Antimicrobial Studies ◽  
Biological Studies ◽  
Bacteria And Fungi

A Schiff base ligand L was prepared from the condensation of 2-amino-3-benzyloxypyridine and 5-chlorosalicylaldehyde. The ligand forms complexes with Co(III) and VO(IV) in good yield. Design, synthesized and characterization of cobalt(III) and oxidovanadium(IV) with (E)-2-((3-(benzyloxypyridinylimino) methyl)-4-chlorophenol (L) are described. The prepared complexes were characterized by different analytical techniques elemental analysis, molar conductance, infrared spectra, 1H and 13C NMR, mass, electronic absorption and TGA. The coordination geometry is octahedral in C1 and C2, while complexes C3 and C4 show a square-pyramidal geometry. Numerous biological studies have been conducted on L and Co(III) and VO(IV) complexes. The results of antimicrobial studies indicated that all compounds had antimicrobial activity against bacteria and fungi. The binding of metal complexes with BSA (bovine serum albumin) was reported. The results of these indicated that Co(III) and VO(IV) are significantly quenching fluorescence intensity of BSA, that results in changing its conformation and results in a static quenching.

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