scholarly journals Evaluation of Some Toxic and Essential Trace Elements in Children Foods and Infant Formulae by Using ICP-OES

2020 ◽  
Vol 32 (6) ◽  
pp. 1273-1278
Author(s):  
Malik A. Elsheikh ◽  
Dafaalla M.H. Ali ◽  
Saad H. Alotaibi
Keyword(s):  
Trace Elements ◽  
Limit Of Detection ◽  
Daily Intake ◽  
High Concentration ◽  
Limit Of Quantification ◽  
Toxic Trace Elements ◽  
Tolerable Weekly Intake ◽  
Infant Formulae ◽  
Accuracy And Precision ◽  
Essential Trace Elements

In Turabah province of Saudi Arabia, infant formula and children′s food products were investigated to determine the concentrations of essential trace elements, namely Mn, Ni, V and Si, and toxic trace elements, namely Al, Ba, Pb, Cd, and As, present in them. Their daily intake amounts were calculated and compared with provisional tolerable daily intake (PTDI), which was calculated based on the provisional tolerable weekly intake (PTWI), which was recommended by joint FAO/WHO. The results obtained were found to be below the PTDI levels. Some samples exhibited a large amount of Al. The PTWI of Si and V is not established; however, their concentrations were compared with those reported in other studies. In some samples, a high concentration of Si was observed. The method employed for evaluation was based on the limit of quantification (LOQ), limit of detection (LOD), and recovery percent of 92.3–101.6%. Accuracy and precision were employed for evaluating the results

scholarly journals Development and Validation of a Rapid RP-HPLC Method for the Estimation of Esmolol Hydrochloride in Bulk and Pharmaceutical Dosage Forms

2010 ◽  
Vol 7 (3) ◽  
pp. 807-812 ◽  
Author(s):  
Vanita Somasekhar ◽  
D. Gowri Sankar
Keyword(s):  
Limit Of Detection ◽  
Hplc Method ◽  
Detector Response ◽  
Reverse Phase Hplc ◽  
Limit Of Quantification ◽  
Pharmaceutical Dosage Forms ◽  
Rp Hplc ◽  
Accuracy And Precision ◽  
Development And Validation

A reverse phase HPLC method is described for the determination of esmolol hydrochloride in bulk and injections. Chromatography was carried on a C18column using a mixture of acetonitrile, 0.05 M sodium acetate buffer and glacial acetic acid (35:65:3 v/v/v) as the mobile phase at a flow rate of 1 mL/min with detection at 275 nm. The retention time of the drug was 4.76 min. The detector response was linear in the concentration of 1-50 μg/mL. The limit of detection and limit of quantification was 0.614 and 1.86 μg/mL respectively. The method was validated by determining its sensitivity, linearity, accuracy and precision. The proposed method is simple, economical, fast, accurate and precise and hence can be applied for routine quality control of esmolol hydrochloride in bulk and injections.

Trace Element Deficiency and Cot Deaths

1981 ◽  
Vol 21 (1) ◽  
pp. 41-46 ◽  
Author(s):  
R. M. Raie ◽  
H. Smith
Keyword(s):  
Trace Elements ◽  
Human Milk ◽  
Trace Element ◽  
Normal Adult ◽  
Toxic Trace Elements ◽  
Essential Trace Elements ◽  
Trace Element Deficiency

The level of 10 trace elements (As, Br, Co, Cu, Fe, Hg, Mg, Mn, Se, Zn) in infant tissues (5 cot deaths, 4 other causes) are presented. These levels are compared with the normal adult levels for the same area or with the levels presented in the literature. The concentrations of 5 trace elements (As, Cu, Hg, Mn, Se) in human milk and 4 brands of artificial milks are also given and the intake of these trace elements from human and artificial milk for infants up to the age of 6 months is calculated. It is concluded that some artificial milks contain less of some essential trace elements (e.g. Cu and Se) and are richer in toxic trace elements (e.g. Hg and As). The suggestion of deficiency of the reported trace elements as a cause of cot deaths is rejected.

Trace-Element Analysis in Clinical Chemistry

1971 ◽  
Vol 17 (6) ◽  
pp. 461-474 ◽  
Author(s):  
Henry A Schroeder ◽  
Alexis P Nason
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Clinical Chemistry ◽  
Trace Element Analysis ◽  
Present Knowledge ◽  
Human Metabolism ◽  
Element Analysis ◽  
Toxic Trace Elements ◽  
Essential Trace Elements ◽  
Clinical Conditions

Abstract Present knowledge of human bodily contents and concentrations in blood, urine, and hair of 11 essential trace elements and 17-22 nonessential inert or toxic trace elements is reviewed and summarized. Analyses of trace elements are applicable as diagnostic aids and indices for therapy in a number of clinical conditions. Techniques are not difficult, and analyses will probably become more or less routine for many diseases in which primary or secondary abnormalities are manifest. Trace elements play fundamental roles in human metabolism.

scholarly journals Toxic Metals (Al, Cd, Pb) and Trace Element (B, Ba, Co, Cu, Cr, Fe, Li, Mn, Mo, Ni, Sr, V, Zn) Levels in Sarpa Salpa from the North-Eastern Atlantic Ocean Region

2020 ◽  
Vol 17 (19) ◽  
pp. 7212
Author(s):  
Alberto Gutiérrez-Ravelo ◽  
Ángel J. Gutiérrez ◽  
Soraya Paz ◽  
Conrado Carrascosa-Iruzubieta ◽  
Dailos González-Weller ◽  
...  
Keyword(s):  
Trace Elements ◽  
Health Risk ◽  
Toxic Metals ◽  
Daily Intake ◽  
The North ◽  
Tolerable Weekly Intake ◽  
Eastern Atlantic Ocean ◽  
Ocean Region ◽  
Sarpa Salpa ◽  
Almost All

Sarpa salpa is a fish belonging to the Sparidae family and is usually found in local markets. Toxic metals such as aluminum (Al), cadmium (Cd), lead (Pb) and trace elements such as boron (B), barium (Ba), cobalt (Co), copper (Cu), chromium (Cr), iron (Fe), lithium (Li), manganese (Mn), molybdenum (Mo), nickel (Ni), strontium (Sr), vanadium (V) and zinc (Zn) are incorporated into fish tissues and remain there. The liver has the highest concentrations of all the analyzed toxic metals and almost all the analyzed trace elements. The consumption of 100 g/day of S. salpa muscle tissue does not pose a health risk. However, 100 g/day of liver consumption may pose a serious health risk due to the intake of Cd (572% of the tolerable weekly intake for adults with a body weight of 68.48 kg) and Pb (117% of the tolerable daily intake for adults weighing 68.48 kg). The consumption of liver of this species is not recommended due to its possible harmful effects on health.

Simultaneous Determination of Cholecalciferol and 25- Hydroxycholecalceferol in Lipid-based Self-nanoemulsifying formulations and Marketed Product Vi-de 3® by UHPLC-UV

2019 ◽  
Vol 16 (1) ◽  
pp. 100-109
Author(s):  
Ibrahim Aljuffali ◽  
Fahad Almarri ◽  
A. F. M. Motiur Rahman ◽  
Fars Kaed Alanazi ◽  
Musaed Alkholief ◽  
...  
Keyword(s):  
High Performance ◽  
Limit Of Detection ◽  
Simultaneous Estimation ◽  
Limit Of Quantification ◽  
Column Temperature ◽  
Related Substances ◽  
Accuracy And Precision ◽  
Regulatory Guidelines ◽  
25 Hydroxycholecalciferol

Background: The purpose of the current study was to develop a selective, precise, fast economical and advanced reverse phase ultra-high-performance liquid chromatography (UHPLC UV) method and validate it for the simultaneous estimation of cholecalciferol and its analogue 25- hydroxycholecalciferol in lipid-based self-nano emulsifying formulation (SNEDDS). Methods: The chromatographic separation was simply performed on a Dionex® UHPLC systems (Ultimate 3000, Thermo scientific) by using HSS C18 (2.1x50 mm, 1.8 µm) analytical column. The elution was carried out isocratically with the mobile phase consisting of acetonitrile and methanol in the ratio of 50:50 %v/v with a flow rate of 0.4 ml/min, followed by the UV detection at 265 nm. The injection volume was 1µl and the column temperature was maintained at 45°C. FDA regulatory guidelines were used to develop and validate the method. Results: The current developed UHPLC-UV method was found to be rapid (run time 2 min), and selective with the high resolution of cholecalciferol and 25-hydroxycholecalciferol (RT=0.530 min & 1.360 min) from different lipid matrices. The method was highly sensitive (Limit of Detection and Lower Limit of Quantification were 0.13 ppm & 0.51ppm, and 0.15 ppm & 0.54 ppm, respectively). The linearity, accuracy and precision were determined as suitable over the concentration range of 0.5-50.0 ppm for both the analytes. Conclusion: The proposed UHPLC-UV method can be used for the determination of cholecalciferol and 25-hydroxycholecalciferol in SNEDDS and marketed Vi-De 3® as pure forms (intact) with no interference of excipients or drug-related substances.

scholarly journals Studies on perchlorate levels in powdered infant formulas available on the Polish market

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Przemyslaw Nizinski ◽  
Patrycja Wisniewska ◽  
Magdalena Kulinowska ◽  
Anna Blazewicz
Keyword(s):  
Limit Of Detection ◽  
Geometric Mean ◽  
Daily Intake ◽  
Vulnerable Groups ◽  
Cell Detection ◽  
Infant Formulas ◽  
Older Children ◽  
Limit Of Quantification ◽  
Chromatography Method ◽  
Perchlorate Concentration

Abstract Perchlorate has been acknowledged as a health threat due to its ability to interfere with iodine uptake by the thyroid gland. Infants and developing newborns have been considered as the most vulnerable groups to the perchlorate toxicity. A crucial source of perchlorate ingestion are powdered infant formulas. This study was designed to measure perchlorate content in thirty-one powdered infant formulas available on the Polish market. A rapid and sensitive ion chromatography method – conductivity cell detection – was applied to determine ClO4 – content. Limit of detection (0.150 µg/L) and limit of quantification (0.450 µg/L) were assessed. Collected samples were classified by the age of consumers: first stage, until the baby is six months old and follow-on formula for older children. Geometric mean of perchlorate concentration of 1.041 µg/L and 0.857 µg/L in the groups of the first stage and follow-on formulas were calculated, respectively. A health risk assessment revealed that the Tolerable Daily Intake (TDI) for perchlorate (0.3 µg/kg body weight/day) was exceeded only in a few milk samples. The findings suggest that perchlorate contamination of powdered infant formulas may not to be an immediate health issue, yet testing for ClO4 – should continuously be conducted. To the best of our knowledge, this is the first study concerning perchlorate content in infant formulas in Poland.

scholarly journals Assessment of Toxic and Essential Trace Metals in Unwana Borehole Water in Afikpo North, Ebonyi State

2020 ◽  
pp. 19-24
Author(s):  
M. K. Ndukwe ◽  
C. E. Igara ◽  
A. E. Idara
Keyword(s):  
Trace Elements ◽  
Trace Metals ◽  
Water Samples ◽  
Human Consumption ◽  
Slight Variation ◽  
Toxic Trace Elements ◽  
Essential Trace Elements ◽  
Borehole Water

Water samples labeled A, B, C, D and E from five different boreholes in Unwana were analyzed to assess the level of toxicity and essential trace elements present. The results obtained showed slight variation in temperature for all the samples, having sample B, recording the highest values of 28oC. As for pH, sample B recorded a pH of 6.58 which lies within the limits recommended by WHO. For the trace metals, Cd(II), Pb(II), Ni(II), Cr(III) and Zn(II) were present in all the five samples. Cd(II), Pb(II) and Cr(III) concentrations in mg.L-1 exceeded  the WHO maximum allowed contaminant limit in all the five samples except for Zn (II) that recorded values in all the five samples that were  within the maximum allowed contaminant limit proposed by WHO. From the results obtained therefore, it is evident that some toxic trace elements were present beyond acceptable limits making the borehole water unfit for human consumption and hence will require treatments.

scholarly journals Determination of the Contents of Antioxidants and Their Degradation Products in Sodium Chloride Injection for Blood Transfusion

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Bo Tao ◽  
Gang Wang ◽  
Zongning Yin ◽  
Xiaocong Pu ◽  
Yan Jiang ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Blood Transfusion ◽  
Limit Of Detection ◽  
Degradation Products ◽  
Daily Intake ◽  
Gradient Elution ◽  
Hplc Method ◽  
Polymer Materials ◽  
Limit Of Quantification ◽  
Column Temperature

The infusion bag is mainly made up of polyolefin polymer. Antioxidants are usually added to these polymer materials in the production process to prevent the materials from aging and enhance the stability of the materials. Because of the potential harm of antioxidants to human body, it is necessary to limit the amount of antioxidants migrating to the pharmaceutical solutions. In the present study, we developed and validated the HPLC method for the simultaneous quantification of antioxidants and their degradation products migrating to sodium chloride solution for injection. A total of six antioxidants and six their degradation products were separated and simultaneously determined by using a Waters Symmetry RP18 column (250 × 4.6 mm, 5 μm) and gradient elution of methanol/acetonitrile/acetic acid-water (1 : 99, v/v) at a flow rate of 1.0 mL/min. The detective wavelength was set at 277 nm, and the column temperature was maintained at 35°C. The method was validated in terms of limit of detection (LOD, 0.011–0.151 μg/mL), limit of quantification (LOQ, 0.031–0.393 μg/mL), intraday precision (0.25%–3.17%), interday precision (0.47%–3.48%), linearity (0.1–46.8 μg/mL, r > 0.9994), stability (0.35%–3.29%), and accuracy (80.39%–104.31%). In the extraction experiment, antioxidants, BHT, 1010, 1330, 1076, and 168, and their degradation products, 1310 and DBP, were detected in the packaging materials. Only 1310 was detected in the migration experiment. The maximum daily dosage of sodium chloride for blood transfusion is three bags, and the content of 1310 in long-term testing samples is from 0 to 12 months ranging from 37.44 μg/3 bags to 48.71 μg/3 bags. The daily intake of 1310 did not exceed 48.71 μg, which was much lower than its permitted daily exposure (PDE, 300 μg/day). Therefore, the antioxidants and their degradation products migrating into the drug solution would not cause drug safety risks.

scholarly journals Ochratoxin A in Beers Marketed in Portugal: Occurrence and Human Risk Assessment

Toxins ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 249 ◽  
Author(s):  
Liliana J. G. Silva ◽  
Ana C. Teixeira ◽  
André M. P. T. Pereira ◽  
Angelina Pena ◽  
Celeste M. Lino
Keyword(s):  
Risk Assessment ◽  
Ochratoxin A ◽  
High Concentration ◽  
Case Scenario ◽  
Limit Of Quantification ◽  
Analytical Methodology ◽  
Worst Case ◽  
Weekly Intake ◽  
Human Risk ◽  
Tolerable Weekly Intake

Ochratoxin A (OTA) is produced by fungi present in several agricultural products with much relevance to food safety. Since this mycotoxin is widely found in cereals, beer has a potential contamination risk. Therefore, it was deemed essential to quantify, for the first time, the levels of OTA in beer, a cereal-based product that is marketed in Portugal, as well as to calculate the human estimated weekly intake (EWI) and risk assessment. A total of 85 samples were analyzed through immunoaffinity clean-up, followed by liquid chromatography-fluorescence detection (LC-FD). This analytical methodology allowed a limit of quantification (LOQ) of 0.43 µg/L. The results showed that 10.6% were contaminated at levels ranging between <LOQ and 11.25 µg/L, with an average of 3.14 ± 4.09 µg/L. Samples of industrial production presented lower incidence and contamination levels than homemade and craft beers. On what concerns human risk, the calculated EWI was significantly lower than the tolerable weekly intake (TWI). However, in the worst case scenario, based on a high concentration, the rate EWI/TWI was 138.01%.

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