GENETIC MODERATORS OF THE IMPACT OF PHYSICAL ACTIVITY ON DEPRESSIVE SYMPTOMS

Background: Converging evidence suggests that physical activity is an effective intervention for both clinical depression and sub-threshold depressive symptoms; however, findings are not always consistent. These mixed results might reflect heterogeneity in response to physical activity, with some subgroups of individuals responding positively, but not others. Objectives: 1) To examine the impact of genetic variation and sex on changes in depressive symptoms in older adults after a physical activity (PA) intervention, and 2) to determine if PA differentially improves particular symptom dimensions of depression. Design: Randomized controlled trial. Setting: Four field centers (Cooper Institute, Stanford University, University of Pittsburgh, and Wake Forest University). Participants: 396 community-dwelling adults aged 70–89 years who participated in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). Intervention: 12-month PA intervention compared to an education control. Measurements: Polymorphisms in the serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF), and apolipoprotein E (APOE) genes; 12-month change in the Center for Epidemiologic Studies Depression Scale total score, as well as scores on the depressed affect, somatic symptoms, and lack of positive affect subscales. Results: Men randomized to the PA arm showed the greatest decreases in somatic symptoms, with a preferential benefit in male carriers of the BDNF Met allele. Symptoms of lack of positive affect decreased more in men compared to women, particularly in those possessing the 5-HTT L allele, but the effect did not differ by intervention arm. APOE status did not affect change in depressive symptoms. Conclusions: Results of this study suggest that the impact of PA on depressive symptoms varies by genotype and sex, and that PA may mitigate somatic symptoms of depression more than other symptoms. The results suggest that a targeted approach to recommending PA therapy for treatment of depression is viable.

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The Relationship Between Perceived Barriers for Physical Activity and Depression in Low Active Community-Dwelling Women

10.21203/rs.3.rs-135211/v1 ◽

2021 ◽

Author(s):

Caroline Figueroa ◽

Adrian Aguilera ◽

Thomas Hoffmann ◽

Yoshimi Fukuoka

Keyword(s):

Physical Activity ◽

Depressive Symptoms ◽

Social Influence ◽

Controlled Trial ◽

Depression Scale ◽

Community Dwelling ◽

Perceived Barriers ◽

Effect Estimate ◽

Cross Sectional ◽

The Relationship

Abstract Background: Women are less physically active, report greater perceived barriers for exercise and show higher levels of depression. This contributes to high global disability. The relationship between perceived barriers for physical activity and depressive symptoms in women remains largely unexplored. The aims of this cross-sectional analysis were to examine the association between physical activity barriers and depressive symptoms, and identify types of barriers in low active community dwelling women. Methods: 318 physically inactive women aged 25-65 years completed the Barriers to Being Active Quiz (BBAQ) developed by the Centers for Disease Control and Prevention, and the Center for Epidemiological Studies Depression Scale (CES-D) at the baseline visit of the mobile phone based physical activity education (mPED) trial. The BBAQ consists of 6 subscales (lack of time, social influence, lack of energy, lack of willpower, fear of injury, lack of skill, and lack of resources). We used multivariate regression analyses, correcting for sociodemographics. Results: Higher physical activity barriers were associated with greater depression scores (linear effect, estimate=0.75, 95% CI: 0.39 – 1.12, p<0.001). This effect appeared to taper off for the higher barrier scores (quadratic effect, estimate: -0.02, 95% CI: -0.03 – -0.01, p=0.002). Exploratory analyses indicated that score differences were most driven by the social influence (p=0.027) and lack of energy subscales (p=0.017).Conclusions: Higher depression scores were associated with higher physical activity barriers. Social influence and lack of energy were particularly important barriers. Thus, addressing these barriers may improve the efficacy of physical activity interventions in women with higher depressive symptoms. However, a randomized controlled trial is warranted. Trial Registration ClinicalTrials.gov#: NCTO1280812 registered January 21, 2011

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Validation of the Japanese Version of the Center for Epidemiologic Studies Depression Scale—Revised: A Preliminary Analysis

Behavioral Sciences ◽

10.3390/bs11080107 ◽

2021 ◽

Vol 11 (8) ◽

pp. 107

Author(s):

Hirohito Tsuboi ◽

Yui Takakura ◽

Hiromasa Tsujiguchi ◽

Sakae Miyagi ◽

Keita Suzuki ◽

...

Keyword(s):

Factor Analysis ◽

Depressive Symptoms ◽

Native Speakers ◽

Depression Scale ◽

Japanese Version ◽

Population Based ◽

Epidemiologic Studies ◽

Community Dwelling ◽

Two Factors ◽

Study Population

To make the Japanese version of the CESD-R—a revised version of the Center for Epidemiologic Studies depression scale (CES-D)—in the assessment of depressive symptoms in a general population. The English version of CESD-R was translated into Japanese, and back-translated into English by three native speakers of Japanese and English; then, we selected the version most completely consistent with the original items. The CESD-R was applied to 398 community-dwelling people (191 men: 48.0%, and 207 women: 52.0%) who were over 40 years old. The Japanese version of the CES-D was also carried out in the same population. Factor analysis was performed. Additionally, the correlations between the CESD-R and CES-D results were identified. The CESD-R scores showed a significantly positive correlation with CES-D scores (r = 0.74, p < 0.0005). Analysis of the CESD-R yielded a Cronbach’s alpha result of 0.90. Factor analysis revealed one principal factor in the CESD-R, whereas the original CES-D had two factors because of reversed items. The Japanese version of the CESD-R appears to have the reliability to be applicable for assessing depressive symptoms in population-based samples. However, because the Japanese expressions for some items might be unusual, our study population was also limited; further studies on other populations and on incorporating improved Japanese terminology will be needed.

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Assessing the Impact of a Hilly Environment on Depressive Symptoms among Community-Dwelling Older Adults in Japan: A Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094520 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4520

Author(s):

Takafumi Abe ◽

Kenta Okuyama ◽

Tsuyoshi Hamano ◽

Miwako Takeda ◽

Masayuki Yamasaki ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Depression Scale ◽

Cross Sectional Study ◽

Community Dwelling ◽

Rural Setting ◽

Sectional Study ◽

Cross Sectional ◽

The Impact ◽

Community Dwelling Older Adults

Although some neighborhood environmental factors have been found to affect depressive symptoms, few studies have focused on the impact of living in a hilly environment, i.e., land slope, on depressive symptoms among rural older adults. This cross-sectional study aimed to investigate whether a land slope is associated with depressive symptoms among older adults living in rural areas. Data were collected from 935 participants, aged 65 years and older, who lived in Shimane prefecture, Japan. Depressive symptoms were assessed using the Zung Self-Rating Depression Scale (SDS) and defined on the basis of an SDS score ≥ 40. Land slopes within a 400 m network buffer were assessed using geographic information systems. Odds ratios (ORs) with 95% confidence intervals (CIs) of depressive symptoms were estimated using logistic regression. A total of 215 (23.0%) participants reported depressive symptoms. The land slope was positively associated with depressive symptoms (OR = 1.04; 95% CI = 1.01–1.08) after adjusting for all confounders. In a rural setting, living in a hillier environment was associated with depressive symptoms among community-dwelling older adults in Japan.

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Physical activity and depressive symptoms in community-dwelling elders from southern Brazil

Brazilian Journal of Psychiatry ◽

10.1590/s1516-44462011005000006 ◽

2011 ◽

Vol 33 (2) ◽

pp. 165-170 ◽

Cited By ~ 16

Author(s):

César L. Reichert ◽

César L. Diogo ◽

José L. Vieira ◽

Roberta R. Dalacorte

Keyword(s):

Physical Activity ◽

Depressive Symptoms ◽

Linear Trend ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Population Based ◽

Community Dwelling ◽

Active Group ◽

Lower Prevalence ◽

Cross Sectional

OBJECTIVE: To determine the existence of a relationship between physical activity and depressive symptoms in community-dwelling elders. METHOD: This is a cross-sectional, population-based study, which included 379 community-dwelling elders from Novo Hamburgo, state of RS, Brazil. The level of physical activity was estimated using the International Physical Activity Questionnaire and depressive symptoms were diagnosed according to the Yesavage Geriatric Depression Scale. The association between the level of physical activity and depressive symptoms was analyzed by logistic regression. RESULTS: A tendency towards a lower prevalence of depressive symptoms was observed in individuals with higher levels of physical activity, both in the sample as a whole as well as among men, but not among women (p for linear trend 0.04, 0.03 and 0.36, respectively). The odds ratio of the presence of depressive symptoms in the very active group, as compared against that of the insufficiently active group was 0.32 (95% CI: 0.12-0.86) for men and 0.76 (95% CI: 0.39-1.46) for women. CONCLUSION: In this population of aged individuals, more intense physical activity is related to a lower prevalence of depressive symptoms. As shown by gender stratification, physical activity is inversely related to depressive symptoms in men, albeit not in women.

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Depressive symptoms in community-dwelling persons aged ≥60 years in Inanda, Ntuzuma and KwaMashu in eThekwini, KwaZulu-Natal

South African Journal of Psychiatry ◽

10.4102/sajpsychiatry.v21i1.576 ◽

2015 ◽

Vol 21 (1) ◽

pp. 6 ◽

Cited By ~ 1

Author(s):

Jayalakshmi Narainsamy ◽

Jennifer Chipps ◽

Bilkish Cassim

Keyword(s):

Logistic Regression ◽

Depressive Symptoms ◽

Univariate Analysis ◽

Secondary Analysis ◽

Depression Scale ◽

The Elderly ◽

Epidemiologic Studies ◽

Household Size ◽

Community Dwelling ◽

Primary Study

Background. Physical and psychological ailments increase with age; while the physical ailments are well documented, mental health issues have received less attention. Objective. To determine the prevalence of depressive symptoms and associated risk factors in individuals aged ≥60 years living in a low-resource peri-urban area in South Africa. Methods. Secondary analysis was performed on data obtained from a primary study conducted to determine the influence of socioeconomic and environmental factors on the health status and quality of life in older persons living in the Inanda, Ntuzuma and KwaMashu (INK) area. The Center for Epidemiologic Studies Short Depression Scale (CES-D 10) was used to screen for depressive symptoms in the week preceding the interview, and respondents were categorised as having no (score <10), mild (10 - 14), or severe (>14) depressive symptoms. Risk factor associations were tested using Pearson’s χ2 tests and logistic regression. Results. There were 1 008 respondents (mean (standard deviation) age 68.9 (7.4) years), of whom 503 (49.1%) did not meet criteria for depressive symptoms. Of the 505 (50.1%) respondents who met the CES-D 10 criteria for depressive symptoms, 422 (41.9%) had mild and 83 (8.2%) had severe depressive symptoms. In the univariate analysis, significant associations were found with age (p=0.011), household size (p=0.007), income (p=0.033), disability (p=0.001), nutritional status (p≤0.001), the inability to count on family (p=0.008) and lack of mastery (p≤0.001). In direct binary logistic regression, there were significant associations with lack of mastery (p≤0.001), inability to count on family (p=0.027), malnutrition (p≤0.001) and household size (p=0.024).Conclusion. This study highlights the high prevalence of depressive symptoms in the elderly in the INK area, and the need to promote successful ageing of the elderly population in this area.

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Relationship Between Physical Activity, Depressive Symptoms and Low Back Pain Related Disability in Older Adults With Low Back Pain: A Cross-Sectional Mediation Analysis

Journal of Aging and Physical Activity ◽

10.1123/japa.2019-0077 ◽

2020 ◽

Vol 28 (5) ◽

pp. 686-691

Author(s):

Fabianna R. de Jesus-Moraleida ◽

Paulo H. Ferreira ◽

Juscelio P. Silva ◽

André G.P. Andrade ◽

Rosangela C. Dias ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Low Back Pain ◽

Back Pain ◽

Depressive Symptoms ◽

Depression Scale ◽

Epidemiologic Studies ◽

Short Version ◽

Low Back ◽

Cross Sectional

Low back pain (LBP) can be less disabling in those who are physically active. This study analyzed the association between physical activity (PA)- and LBP-related disability in older people with LBP, exploring if this association was mediated by depressive symptoms. The authors analyzed the relationship between PA levels and disability using the short version of the International Physical Activity Questionnaire and the Roland–Morris Disability Questionnaire, respectively, collected at baseline from the Brazilian Back Complaints in the Elders study. The authors investigated depressive symptoms as a mediator of this association using the Center of Epidemiologic Studies Depression scale. PA was inversely associated with disability. This association was smaller when considering the indirect effect through depressive symptoms. Thus, depressive symptoms partially mediated the association between PA and disability in older adults with LBP, and higher levels of PA were associated with less depressive symptoms and disability.

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Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms

Behavioral Sciences ◽

10.3390/bs8110102 ◽

2018 ◽

Vol 8 (11) ◽

pp. 102 ◽

Cited By ~ 6

Author(s):

Hirohito Tsuboi ◽

Hiroyuki Sakakibara ◽

Yuuki Minamida ◽

Hiromasa Tsujiguchi ◽

Masahiro Matsunaga ◽

...

Keyword(s):

Depressive Symptoms ◽

Depression Scale ◽

Japanese Version ◽

Epidemiologic Studies ◽

Community Dwelling ◽

Tnf Alpha ◽

Serum Samples ◽

Female Community ◽

Cytokine Levels ◽

Community Dwellers

Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with high and low depressive symptoms of a general population. The participants comprised 20 female community-dwellers aged 40 years or older who contributed to a Shika study in Ishikawa, Japan. Ten participants who showed higher and ten who showed lower depressive symptoms among 208 females assessed by the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D) were selected for this study. Serum samples were analyzed for TNF-alpha, IL-6, IL-10, IL-12, and IL-17A using a multiplex Luminex analysis. For the comparison between the high and low depressive groups statistically, linear regression analyses were applied. The serum level of IL-17A was significantly higher among the high depressive participants (p < 0.05) even after controlling possible confounders, whereas there were no differences in TNF-alpha, IL-6, IL-10, or IL-12 between the high and low depressive groups. Our findings supported an association between serum IL-17A levels and depressive symptoms. Peripheral IL-17A immune response may be a preventive and treatment target for depression.

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Relationship between Depressive Symptoms and Cognitive, Psychological, and Physical Performance in Community-Dwelling Older People with Cognitive Impairment

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000520853 ◽

2021 ◽

pp. 1-9

Author(s):

Isabella Khoo ◽

Jacqueline C.T. Close ◽

Stephen R. Lord ◽

Kim Delbaere ◽

Morag E. Taylor

Keyword(s):

Cognitive Impairment ◽

Depressive Symptoms ◽

Physical Performance ◽

Sex Education ◽

Depressive Symptomatology ◽

Controlled Trial ◽

Depression Scale ◽

Community Dwelling ◽

Future Research ◽

The Relationship

Introduction: Dementia and depression often coexist. Understanding how concomitant comorbidities affect function can improve assessment and management strategies. We examined the relationship between cognitive, psychological, and physical function and depressive symptoms in people with cognitive impairment. Methods: Cross-sectional study using baseline data from the iFOCIS randomized controlled trial involving 309 participants with mild-moderate cognitive impairment. The association between cognitive (Addenbrooke’s Cognitive Examination-III [ACE-III], Frontal Assessment Battery), psychological (Goldberg Anxiety Scale; Iconographical Falls Efficacy Scale), and physical (Physiological Profile Assessment; Short Physical Performance Battery [SPPB]) function, and quality of life (QoL), physical activity levels and activities of daily living, and depressive symptoms (15-item Geriatric Depression Scale [GDS]) were assessed (adjusted for age, sex, education, and ACE-III as appropriate). Results: Participants with depressive symptoms (GDS ≥4) had significantly more falls in the previous year and a higher number of comorbidities than people without depressive symptoms (GDS <4). Each point increase in the GDS was associated with better memory, higher levels of anxiety and concern about falling, poorer balance, slower gait speed, and reduced QoL. The relationship between the GDS and poor balance and QoL withstood additional adjustment for comorbidity tertiles. The relationship between GDS and concern about falls withstood additional adjustment for previous falls (12 months) and SPPB scores. Conclusions: Depressive symptomatology is associated with poorer physical and psychological function and reduced QoL in people with cognitive impairment. These factors should be considered when assessing and intervening in this group. Future research could examine these relationships longitudinally to establish causality and examine intervention efficacy in this group.

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Decrease in Mobility during the COVID-19 Pandemic and Its Association with Increase in Depression among Older Adults: A Longitudinal Remote Mobility Monitoring Using a Wearable Sensor

Sensors ◽

10.3390/s21093090 ◽

2021 ◽

Vol 21 (9) ◽

pp. 3090

Author(s):

Ramkinker Mishra ◽

Catherine Park ◽

Michele K. York ◽

Mark E. Kunik ◽

Shu-Fen Wung ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Adverse Effect ◽

Depression Scale ◽

Epidemiologic Studies ◽

Community Dwelling ◽

Depression Symptoms ◽

Wearable Sensor ◽

Physical Activity Monitoring ◽

Community Dwelling Older Adults

Background: Social isolation during COVID-19 may negatively impact older adults’ wellbeing. To assess its impact, we measured changes in physical activity and sleep among community-dwelling older adults, from pre-to post-pandemic declaration. Method: Physical activity and sleep in older adults (n = 10, age = 77.3 ± 1.9 years, female = 40%) were remotely assessed within 3-month pre-to 6-month post-pandemic declaration using a pendant-wearable system. Depression was assessed pre-and post-pandemic declaration using the Center for Epidemiologic Studies Depression scale and was compared with 48 h continuous physical activity monitoring data before and during pandemic. Results: Compared to pre-pandemic, post-pandemic time spent in standing declined by 32.7% (Cohen’s d = 0.78, p < 0.01), walking by 52.2% (d = 1.1, p < 0.01), step-counts by 55.1% (d = 1.0, p = 0.016), and postural transitions by 44.6% (d = 0.82, p = 0.017) with increase in sitting duration by 20.5% (d = 0.5, p = 0.049). Depression symptoms increased by 150% (d = 0.8, p = 0.046). Interestingly, increase in depression was significantly correlated with unbroken-prolong sitting bout (ρ = 0.677, p = 0.032), cadence (ρ = −0.70, p = 0.024), and sleep duration (ρ = −0.72, p = 0.019). Conclusion: This is one of the early longitudinal studies highlighting adverse effect of the pandemic on objectively assessed physical activity and sleep in older adults. Our observations showed need for timely intervention to mitigate hard to reverse consequences of decreased physical activity such as depression.

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The Impact of Transitions in Caregiving Status on Depressive Symptoms among Older Family Caregivers: Findings from the Korean Longitudinal Study of Aging

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010042 ◽

2020 ◽

Vol 18 (1) ◽

pp. 42

Author(s):

Kyungduk Hurh ◽

Hin Moi Youn ◽

Yoon Sik Park ◽

Eun-Cheol Park ◽

Sung-In Jang

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Longitudinal Study ◽

Family Caregivers ◽

Depression Scale ◽

Estimating Equation ◽

Epidemiologic Studies ◽

Equation Model ◽

Significant Difference ◽

The Impact

This study identifies the effects of transitions in caregiving status on depressive symptoms among middle-aged or older adults who care for family members with limitations in activities of daily living (ADL). Data were collected from the 2006–2018 Korean Longitudinal Study of Aging. A total of 7817 subjects were included. On the basis of their caregiving status transition, participants were categorized into four groups: started caregiving, continued caregiving, stopped caregiving, and noncaregivers. Depressive symptoms were measured using the 10 item Center for Epidemiologic Studies Depression Scale. Analysis using a generalized estimating equation model and subgroup analyses were conducted. Compared to noncaregivers, women who started caregiving showed more depressive symptoms in the following year (β 0.761, p < 0.0001). Regardless of sex, older adults who continued caregiving had more depressive symptoms than noncaregivers did (β 0.616, p < 0.0277 in men, and β 1.091, p < 0.0001 in women). After relinquishing caregiving responsibilities to other caregivers, participants’ depressive symptoms in the following year showed no statistically significant difference from that of noncaregivers. Thus, starting or continuing caregiving was associated with increased depressive symptoms, and those symptoms could be normalized by stopping caregiving. Intervention strategies to reduce family caregivers’ depressive symptoms are needed.

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