scholarly journals Ejaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutide

2021 ◽  
Vol 18 (3) ◽  
pp. 263-267
Author(s):  
D. N. Bobkov ◽  
R. V. Rozhivanov ◽  
I. I. Vityazeva
Keyword(s):  
Body Weight ◽  
Waist Circumference ◽  
Quality Indicators ◽  
Statistical Significance ◽  
Visceral Obesity ◽  
Reactive Oxygen ◽  
Obesity Treatment ◽  
The Body ◽  
Healthy Men ◽  
Reactive Oxygen Forms

Background: Considering the influence of visceral obesity on male infertility, the investigation of ejaculate quality indicators under obesity treatment is relevant.Objective: Evaluation of ejaculate quality indicators by obesity treatment with liraglutide in andrologically healthy men with infertility and post-pubertal visceral obesity.Methods: Infertile men with post-pubertal alimentary visceral obesity were included in a pilot observational prospective study. All patients were given recommendations for body weight loss (hypocaloric diet, daily aerobic physical activity) as well as an average daily dose of liraglutide 2.4 [2.4; 3.0] mg. Evaluation of waist circumference, antioxidant activity of ejaculate, spermogram was carried out initially and after 6 months. The differences were considered statistically significant at p <0.005.Results: The body weight decrease was -11.7 [12.4; 11.0]%, the waist circumference decrease was 8 [12; 7] cm. In dynamics, increased content of living sperm in ejaculate from 92 [90; 95]% to 95 [92; 98]%, morphologically normal forms from 5 [3; 6]% to 6 [3; 8]%, mobility of A + B from 25 [15; 36] to 35 [19; 52]%, seminal antioxidant capacity, a decrease in reactive oxygen forms in the neat ejaculate were statistically significant. Increasing the sperm count in 1 ml and decreasing reactive oxygen forms in the washed ejaculate did not reach statistical significance.Conclusion: Ejaculate quality indicators improved by the complex obesity therapy with liraglutide in young andrologically healthy men with postpubertal visceral obesity.

Efficacy and safety of drospirenone-containing microdosage combined oral contraceptive use with starting contraception

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 9-13
Author(s):  
A R Khachaturian ◽  
E V Misharina ◽  
M I Yarmolinskaya
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Oral Contraceptive ◽  
Waist Circumference ◽  
Young Women ◽  
Iron Metabolism ◽  
Serum Iron ◽  
The Body ◽  
Menstrual Bleeding ◽  
Combined Oral Contraceptive

Androgen-dependent dermopathy, as well as premenstrual syndrome of varying severity in young women, can cause emotional depression, difficulties in social adaptation and even depressive disorders. The aim of the study was to study the safety and efficacy of using a combined oral contraceptive (COC) Dimia® containing 20 μg ethinyl estradiol and 3 mg drospirenone in young women, as well as its therapeutic effects in androgen-dependent dermopathy. Materials and methods. The study included 57 young women aged 23.1±2.2 years with signs of androgen-dependent dermopathy. The evaluation of the change in the character of menstrual bleeding, the anthropometric parameters (body weight, waist circumference and hips), the therapeutic effect of the drug on the symptoms of androgen-dependent dermopathy, as well as the dynamics of arterial pressure, hemoglobin level, serum iron have been studied. The psycho-emotional state was assessed using the SAN questionnaire (well-being-activity-mood). Results. During 6 months of observation, there was no significant change in the body mass index, waist circumference, and hips, and the drug did not affect the blood pressure numbers. Against the background of taking the drug, there was an increase in the parameters of iron metabolism (hemoglobin content, serum iron). After 3 months of taking the contraceptive with drospirenone, the number of patients with a complaint about the abundance of menstruation decreased more than twofold (from 22.8 to 10.5%), and after 6 months of taking the drug no patient noted the profuse nature of menstruation. Before the start of taking COC with drospirenone, 57.9% of women reported painful menstrual bleeding. Against the background of taking the contraceptive within 3 months, this complaint was stopped in all patients. Sufficient efficacy of treatment of androgen dependent dermopathy in young women with the help of a microdosed drospirenone-containing combined oral contraceptive is estimated from the dermatological acne index. The analysis of the SAN questionnaire made it possible to reveal the improvement in the psychoemotional state of patients on the background of taking the drug. The conclusion. The results obtained proved the effectiveness and safety of the microclinized COC Dimia®. The drug has no significant effect on body weight, blood pressure, provides reliable control of the cycle and a decrease in menstrual bleeding, which results in stabilization of iron metabolism in the body. Dimia® is effective in the treatment of androgen-dependent dermopathy and can be recommended to young women for starting contraception.

scholarly journals Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Wiraphol Phimarn ◽  
Bunleu Sungthong ◽  
Hiroyuki Itabe
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Mass ◽  
The Body ◽  
Current Evidence ◽  
Diabetic Patients ◽  
Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

scholarly journals Rock back phenomenon in 32 dogs that underwent tibial plateau levelling osteotomy

2021 ◽  
Vol 66 (No. 2) ◽  
pp. 58-65
Author(s):  
ES Souza ◽  
BW Minto ◽  
JP Sales Luis ◽  
M Nobile ◽  
BT Lins ◽  
...  
Keyword(s):  
Body Weight ◽  
Bone Healing ◽  
Tibial Plateau ◽  
Statistical Significance ◽  
Temporal Changes ◽  
The Body ◽  
Positive Correlation

The aim of this study was to evaluate the postoperative temporal changes in the tibial plateau angle (TPA) after a tibial plateau levelling osteotomy (TPLO) in dogs. The TPA of thirty-two dogs were measured before surgery (TPA<sub>1</sub>), immediately after the TPLO (TPA<sub>2</sub>), and later at the healing of the osteotomy site (TPA<sub>3</sub>). Three observers carried out three TPA measurements for each patient at the time of the evaluation. TPA changes were observed over the bone healing (2.05 ± 3.05°); however, no statistical significance was noted when comparing TPA<sub>3</sub> and TPA<sub>1</sub>. There were no statistical differences in the inter-observer measurements among TPA<sub>1</sub>, TPA<sub>2</sub>, and TPA<sub>3</sub> (P &gt; 0.05). The comparison between the preoperative TPA<sub>1</sub> and the rock back showed a low positive correlation (S = 4 735.9, P = 0.471 5, r = 0.131 976 9). There was also a low positive correlation between the body weight (kg) and the change in the TPA during the bone healing (S = 4 581.8, P = 0.381, r = 0.160 234 7). Although changes in the TPA have been observed over the time of the bone healing, they were not influenced by the preoperative and postoperative TPA, or by the body weight. The magnitude of the variation in the TPA is not determined by the previous inclination or by the degree of rotation in the plateau.

scholarly journals Latihan yoga terhadap berat badan, persen lemak tubuh, dan lingkar perut pada wanita dewasa overweight

2018 ◽  
Vol 14 (4) ◽  
pp. 131
Author(s):  
Putri Nur Fatimah ◽  
Fillah Fithra Dieny ◽  
Etisa Adi Murbawani ◽  
Ahmed Fahmy Arif Tsani
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Waist Circumference ◽  
Nutrition Education ◽  
Body Fat ◽  
The Body ◽  
Control Group ◽  
Weight Percentage ◽  
Percentage Of Body Fat ◽  
Significant Difference

Background: Obesity caused diabetes and cardiovascular disease. Yoga considered three aspects, physic, emotion and mental that helped in obesity therapy.Objective: This research aimed to explain the influence of yoga excercise on body weight, percent of body fat, waist circumference and waist to hip ratio (WHR) in overweight women.Method: This research applied quasi experiment design by using pre-post test with control group design. The subjects of research were 31 women aged 19-25 years old and divided into 2 groups, treatment group and control group. Treatment group was prepared to do yoga in 60 minutes for 10 times during 20 days and given nutrition education, whereas control group was given nutrition education only. Data body weight and percentage of body fat were measured by bioimpedance analysis; waist circumference and WHR were measured by tape measures; food intake were assessed by food recall and food frequency questionnaire. Data were analyzed using paired t-test and independent t-test.Results: There was a significant difference of body weight before and after intervention in both groups. The body weight on treatment group decreased by 0.81 ± 1.29 kg (p<0.05), while the body weight on the control group increased. Percentage of body fat and waist circumference decreased on both of groups, however treatment group decreased more than the control group. WHR no significant on both of groups. Yoga excercise resulted no significant influences on body weight, percentage of body fat, waist circumference and WHR in overweight women (p>0.05). Conclusion: Obesity women with 10 times yoga had no significant influences on body weight, percentage of body fat, waist circumference and WHR.

scholarly journals Effect of body weight of goats and lactation order on the growth rate of kids in the suckling period

2011 ◽  
Vol 27 (3) ◽  
pp. 1193-1200 ◽  
Author(s):  
M. Zujovic ◽  
N. Memisi ◽  
V. Bogdanovic ◽  
Z. Tomic ◽  
N. Maksimovic ◽  
...  
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Milk Yield ◽  
Growth Traits ◽  
Statistical Significance ◽  
The Body ◽  
Individual Growth ◽  
Positive Sign ◽  
Suckling Period ◽  
Final Body Weight

The paper presents results of investigation of milk yield by lactation, by order, and mother's body weight on growth rate of kids of the domestic Balkan goat. Daily weight gains of 376 single kids (168 male and 208 female), in three monthly intervals, and their final body weight at 90 days of age were established. Variability of analyzed traits was presented using descriptive statistics parameters, and differences of growth traits for weight gain of kids resulting from the effect of milk yield of female goats by order of lactation were investigated by single analysis of variance. The effect of independent variables, mothers' milk yield and body weight, on body weight of kids was tested using multiple regression analysis. During the entire suckling period, established average values for kids body weight differed significantly (P<0.001), increasing from the 1st toward later lactations. At 90 days of age the lowest values were established in kids from the youngest mothers (11.86 kg), while for kids of mothers in the fourth or later lactations these values were higher (13.93 kg). Coefficients of determination indicate that the variability percentage for individual growth traits of kids was in the 0.08 - 0.17 interval, indicating its significance. Both "b" coefficients (b1 and b2) are positive and statistically highly significant, except for coefficient b2 in the analysis of body weight of kids at birth. The positive sign and high statistical significance indicate a pronounced effect of mother's milk yield and body weight on the body weight of kids up to 90 days of age.

scholarly journals Effect of mating method, sex and birth type on growth of lambs

2013 ◽  
Vol 29 (2) ◽  
pp. 277-286 ◽  
Author(s):  
Zoran Ilic ◽  
A. Jevtic-Vukmirovic ◽  
M.P. Petrovic ◽  
V. Caro-Petrovic ◽  
B. Milosevic ◽  
...  
Keyword(s):  
Body Weight ◽  
Statistical Analysis ◽  
Statistical Significance ◽  
Reproductive Traits ◽  
The Body ◽  
Estrus Synchronization ◽  
Body Weights ◽  
The Difference ◽  
Mating Method ◽  
Birth Type

Estrus synchronization methods was use to control the reproductive traits of sheep, as well as bringing more females at the same stage of estrus and ovulation. According to the points mentioned above, the aim of the present study was to investigate and compare mating method and influence of fixed factors on birth and weaning weight of lambs. Statistical analysis showed that exist difference in the body weights between genotypes of lambs. In the first group, the difference in weight of lambs at birth, regardless of mating method was not significant (P> 0.05), while in the second group, the difference was slightly significant (P <0.05). As for the birth type, sex and within the same genotype, there was a statistical significance (P <0.05) between singles obtained naturally, between the triplets obtained naturally and between triplets received hormonal method. All the differences between body weight at 30 days (mating method, sex and birth type under the same genotype) were statistically significant (P <0.05).The determined differences in the body weights at 60 days (sex, mating method and type of birth under the same genotype) were statistically significant (P <0.05). The results showed that the differences (mating method, sex and type of birth under the same genotype) were statistically significant (P <0.05), except in between body weight at 90 days in twins among two genotypes obtained by natural method, which were not statistically significant (P> 0.05).

scholarly journals The Effect of Sodium Channel Blocker, Mexiletine, on Body Weight in Type 2 Diabetes Patients with Visceral Obesity

2019 ◽  
Vol 12 ◽  
pp. 117955141882504
Author(s):  
Naohiko Ueno
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Uric Acid ◽  
Waist Circumference ◽  
Diabetic Neuropathy ◽  
Serum Uric Acid ◽  
Visceral Obesity ◽  
Control Group ◽  
Diabetes Patients

Objective: Mexiletine is an anti-arrhythmic agent also used for the treatment of painful diabetic neuropathy. In this study, the effect of mexiletine on body weight was evaluated in type 2 diabetes patients with diabetic neuropathy exhibiting visceral obesity. Methods: Type 2 diabetes patients with neuropathy exhibiting visceral obesity (n = 21) treated by mexiletine (300 mg/day) and a control group of type 2 diabetes patients with the same condition who received vitamin B12 (n = 12) were retrospectively evaluated. Body weight, waist circumference, hemoglobin A1c (HbA1c), blood pressure, liver function, serum lipids, and serum uric acid were assessed before and 6 months after the treatment. Results: Mexiletine significantly decreased body weight and waist circumference. The changes in body weight and waist circumference in 6 months in the mexiletine group were greater than in the control group. In metabolic parameters, there were significant decreases in triglyceride (TG) and serum uric acid. There were positive relationships between the change in body weight and the changes in TG, uric acid, alanine aminotransferase (ALT), and HbA1c. Conclusions: Mexiletine may affect body weight regulation. It ameliorated the metabolic parameters possibly by decreasing visceral fat. Further study should be performed to clarify the mechanism of the effect.

Comparison of Dapaglifozin and Liraglutide in patients with poorly controlled type 2 Diabetes Mellitus: a 24-week, Open, Double-centered, Head to Head Trial

2020 ◽  
Vol 20 ◽  
Author(s):  
Jianjia Jiang ◽  
Lu Lin ◽  
Pin Chen
Keyword(s):  
Body Weight ◽  
Triple Therapy ◽  
Treatment Satisfaction ◽  
Hba1c Level ◽  
Statistical Significance ◽  
Blood Lipid ◽  
The Body ◽  
C Peptide

Objective: To evaluate the efficacy and treatment satisfaction of dapagliflozin and liraglutide in T2DM patients with glucose poorly controlled after triple therapy. Methods: In addition to the original therapeutic regimen, dapagliflozin (n=83) and liraglutide (n=89) once a day were added, respectively. Height, body weight, waist circumference, and blood pressure were recorded. FBG, 2hPBG, HbA1c, fasting C-peptide, HOMA-IR, blood lipid, eGFR, BUA and DTSQ were detected before the treatment and after 24 weeks of treatment. Results: At the end of 24 weeks of treatment, a follow-up visit was completed for 79 patients in the dapagliflozin group and 77 patients in the liraglutide group. The body weight of the patients in the dapagliflozin group and the liraglutide group decreased significantly (P< 0.05). The HbA1c level in the dapagliflozin group decreased from 8.96 ± 1.23% to 7.03 ±0.74% (P< 0.01), more than that in the liraglutide group, namely, from 8.99 ± 1.34% to 7.24 ±0.77% (P< 0.01). After 12 weeks of treatment, eGFR in the dapagliflozin group first decreased and then increased after 12 weeks of treatment. The percentages of patients achieving combined endpoints in the two groups were of no statistical significance (P=0.204). And there were mild adverse events in both groups. Conclusion: The add-on treatment of dapagliflozin and liraglutide had promising clinical outcomes in patients with T2DM and poorly controlled glucose after triple therapy, which include the improvement in blood glucose, insulin resistance, SBP, and renal function. However, the overall treatment satisfaction was higher in the dapagliflozin group.

scholarly journals Biological Impact of Exposure to Extremely Fine-Grained Volcanic Ash

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Cristina Aguilera ◽  
Marco Viteri ◽  
Rachid Seqqat ◽  
Ligia Ayala Navarrette ◽  
Theofilos Toulkeridis ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Body Weight ◽  
Volcanic Ash ◽  
Active Continental Margin ◽  
Reactive Oxygen ◽  
The Body ◽  
Oxygen Species ◽  
Biological Impact ◽  
Murine Lung ◽  
The Impact

At the northwestern edge of South America is located Ecuador. This place is a classical example of an active continental margin with widespread active volcanism. Detailed studies about the impact of volcanic ash on human health are still lacking. Therefore, the disease of exposed populations is unknown. The objective of the present investigation was to assess the biological impact of Pichincha volcanic ash on cell culture and inflammation in murine lung tissues that will contribute to the understanding of the hazards. In this study, the in vivo phase was performed in mice C57BL/6 exposed to several doses of volcanic ash (0.5, 1, and 3.75 mg/100 g mouse body weight). The body weight and survival were controlled during seven days of treatment. The expression of inflammation markers NRLP 3, caspase-1, pro-IL-1, IL-1β, IL-6, IL-8, and h-HPRT was analyzed. The in vitro phase was performed in lung cancer cells A549, peritoneal macrophages, and McCoy cells exposing them to different concentrations of volcanic ash (80, 320, and 1280 μg/cm3) to determine the cytotoxicity and the production of reactive oxygen species. The ash initiated activation of the inflammasome complex NRLP 3 and the initiation of a proinflammatory activity in the murine lung tissue depending on the concentration of this agent. The viability of A549 and McCoy cell decreased with the length of exposure and increased with the concentration of volcanic ash. The activity in superoxide dismutase decreased by about 60%, leading to the formation of reactive oxygen species. These results associated with compounds contained in Pichincha volcanic ash are considered hazardous elements which induce inflammation leading to activate inflammasome NRLP, releasing reactive oxygen species, and producing changes in cell morphology and density, all of which are expression of cytotoxicity.

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