scholarly journals The level of thyroid-stimulating hormone in newborns in conditions of goiter endemicity and radiation pollution

1997 ◽  
Vol 43 (5) ◽  
pp. 8-12
Author(s):  
E. P. Kasatkina ◽  
D. E. Shilin ◽  
V. P. Fedotov ◽  
T. M. Belosludtseva
Keyword(s):  
Iodine Deficiency ◽  
Thyroid Dysfunction ◽  
Low Dose ◽  
Thyroid Stimulating Hormone ◽  
Normal Range ◽  
Radiation Factor ◽  
Neonatal Adaptation ◽  
Radiation Contamination ◽  
The Mean ◽  
The Relationship

The findings of five-year screening for hypothyrosis, carried out in 1242 newborns 6 to 10 years after the Chernobyl accident, are analyzed in order to assess the patterns of thyroid dysfunction in the neonatal period in regions endemic for goiter and evaluate the relationship between this condition and iodine deficiency and radiation contamination of the environment. The incidence of increased level of TTH in the blood (>5 iU/liter) is 3-4 times increased in two controlled districts contaminated with 137Cs at a density of 1-5 and 5-15 Ci/km2 in comparison with the reference (free from radiation) district. The incidence of neonatal thyroid hypofunction directly correlated with the radiation factor and its intensity and negatively with the severity of iodine deficiency. In addition, the mean TTH values (<5 iU/liter) in the newborns, although within the normal range, were 79 and 187%) higher, respectively, than in controls. Analysis of the results of screening for every year showed an outbreak of thyroid dysfunction in 1994, that is, 8 years after the atomic disaster. These data permit us to hypothesize that low-dose ionizing radiation is responsible for disorders of neonatal adaptation of the thyroid system to iodine deficit in the environment and hence, adequate iodine therapy is to be started from the earliest terms of gestation.

scholarly journals The Relationship between Thyroid Function and Depressive Symptoms—the FIN-D2D Population-Based Study

2015 ◽  
Vol 8 ◽  
pp. CMED.S24111 ◽  
Author(s):  
Juha Saltevo ◽  
Hannu Kautiainen ◽  
Pekka Mäntyselkä ◽  
Antti Jula ◽  
Sirkka Keinänen-Kiukaanniemi ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Depressive Symptoms ◽  
Thyroid Function ◽  
Participation Rate ◽  
Population Based ◽  
Thyroid Stimulating Hormone ◽  
Free Triiodothyronine ◽  
Population Based Study ◽  
The Mean ◽  
The Relationship

The association between thyroid function and depression is controversial. Both conditions express many similar symptoms, but the studies done give conflicting results. This study draws on a random, population-based sample of 4500 subjects aged 45–75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depressive symptoms were 1.92/1.97 mU/L, 13.1/13.1 pmol/L, and 3.91/3.87 pmol/L (NS), respectively. In men, the levels were 1.87/1.94 mU/L, 13.5/13.7 pmol/L, and 4.18/4.12 pmol/L (NS), respectively. In multiple regression analysis, TSH had no relationship to BDI-21 total score. We found no association between depressive symptoms and thyroid values.

scholarly journals Increased left atrial pressure in non-heart failure patients with subclinical hypothyroidism and atrial fibrillation

2016 ◽  
Vol 5 (3) ◽  
pp. 101-106 ◽  
Author(s):  
Akinori Sairaku ◽  
Yukiko Nakano ◽  
Yuko Uchimura ◽  
Takehito Tokuyama ◽  
Hiroshi Kawazoe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Subclinical Hypothyroidism ◽  
Left Atrial ◽  
Structural Heart Disease ◽  
Thyroid Stimulating Hormone ◽  
The Mean ◽  
V Wave ◽  
The Impact ◽  
The Relationship

Background The impact of subclinical hypothyroidism on the cardiovascular risk is still debated. We aimed to measure the relationship between subclinical hypothyroidism and the left atrial (LA) pressure. Methods The LA pressures and thyroid function were measured in consecutive patients undergoing atrial fibrillation (AF) ablation, who did not have any known heart failure, structural heart disease, or overt thyroid disease. Results Subclinical hypothyroidism (4.5≤ thyroid-stimulating hormone <19.9 mIU/L) was present in 61 (13.0%) of the 471 patients included. More subclinical hypothyroidism patients than euthyroid patients (55.7% vs 40.2%; P=0.04).’euthyroid patients had persistent or long-standing persistent AF (55.7% vs 40.2%; P = 0.04). The mean LA pressure (10.9 ± 4.7 vs 9.1 ± 4.3 mmHg; P = 0.002) and LA V-wave pressure (17.4 ± 6.5 vs 14.3 ± 5.9 mmHg; P < 0.001) were, respectively, higher in the patients with subclinical hypothyroidism than in the euthyroid patients. After an adjustment for potential confounders, the LA pressures remained significantly higher in the subclinical hypothyroidism patients. A multiple logistic regression model showed that subclinical hypothyroidism was independently associated with a mean LA pressure of >18 mmHg (odds ratio 3.94, 95% CI 1.28 11.2; P = 0.02). Conclusions Subclinical hypothyroidism may increase the LA pressure in AF patients.

scholarly journals Prevalence of thyroid dysfunction in patients with polycystic ovarian syndrome: a cross sectional study

2018 ◽  
Vol 7 (8) ◽  
pp. 3055 ◽  
Author(s):  
Deepa Shanmugham ◽  
Sindhu Natarajan ◽  
Arun Karthik
Keyword(s):  
Thyroid Dysfunction ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Thyroid Stimulating Hormone ◽  
Endocrine Disorders ◽  
Free T4 ◽  
Cross Sectional ◽  
The Mean ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) and thyroid disorders are two of the most common endocrine disorders in the general population. Both of these endocrine disorders share common predisposing factors, gynaecological features and have profound effect on reproductive function in women. The aim of this study is to study the prevalence of thyroid dysfunction in patients with polycystic ovarian syndrome and to evaluate the relationship between polycystic ovarian syndrome and thyroid dysfunction.Methods: This is a cross sectional observational study done on 100 patients with Poly Cystic Ovarian Syndrome based on Rotterdam’s criteria. The exclusion criteria was hyperprolactinemia, congenital adrenal hyperplasia and virilising tumour. Thyroid function was evaluated by measurement of fasting serum thyroid stimulating hormone (TSH), free thyroxine levels (free T3 and free T4).Results: The mean age of the study patients was 26±4.2 years. Among the study patients, 11% of them had goitre. 18% of the patients with presented with subclinical hypothyroidism. The mean TSH levels in the study patients was 4.62±2.12 mIU/ml. The overall prevalence of thyroid dysfunction was 33% in the study patients with PCOS.Conclusions: This study concludes that the prevalence of hypothyroidism is increased in women with PCOS patients.

scholarly journals Thyroid function in preterm infants and neurodevelopment at 2 years

2020 ◽  
Vol 105 (5) ◽  
pp. 504-509 ◽  
Author(s):  
Fiona L R Williams ◽  
Alice Lindgren ◽  
Jennifer Watson ◽  
Anita Boelen ◽  
Timothy Cheetham
Keyword(s):  
Preterm Infants ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Cohort Analysis ◽  
Dried Blood Spots ◽  
Thyroid Stimulating Hormone ◽  
Composite Score ◽  
Fine Motor ◽  
The Relationship ◽  
Stimulating Hormone

ObjectivesPostnatal thyroid dysfunction is common in preterm infants but the relationship between mild dysfunction and neurodevelopment is unclear. Our aim is to describe the relationship between thyroid function and neurodevelopment.DesignCohort analysis.Patients1275 infants born under 31 weeks’ gestation; there were no exclusion criteria.SettingThe infants were part of a UK daily iodine supplementation trial.Main outcomesThyroid-stimulating hormone, thyroid-binding globulin and total thyroxine levels were measured in dried blood spots on postnatal days 7, 14, 28 and the equivalent of 34 weeks’ gestation. Neurodevelopment was measured using the Bayley-III Scales of infant development at 2 years of age.ResultsNo infant was identified as hypothyroid through routine screening. The 3% of infants consistently in the top decile of gestationally age-adjusted thyroid-stimulating hormone levels had a reduction in cognitive score of 7 Bayley units when compared with those not in the top decile (95% CI –13 to –1). A reduction in motor composite score of 6 units (95% CI −12 to <−0.1) and fine motor score of 1 unit (95% CI –2 to –0.1) was also identified. The 0.7% of infants consistently in the bottom decile of age-adjusted thyroxine levels had a reduction in motor composite score of 14 units (95% CI –25 to –2) and its two subset scores, fine and gross motor, of 2 units (95% CI respectively −4.5 to <−0.1 and –4.3 to –0.3).ConclusionsPreterm infants with consistent ‘mild’ thyroid dysfunction score less on neurodevelopmental tests at 2 years of age. Many of these infants will not be detected by current clinical protocols or screening programmes.

scholarly journals Obesity and hypothyroidism

2013 ◽  
Vol 10 (2) ◽  
pp. 54-58 ◽  
Author(s):  
S M Zakharova ◽  
L V Savelieva ◽  
M I Fadeeva
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Thyroid Stimulating Hormone ◽  
Overt Hypothyroidism ◽  
Obese Patients ◽  
Common Diseases ◽  
The Relationship ◽  
Stimulating Hormone

Obesity and hypothyroidism are common diseases, and consequently clinicians should be particularly alert to the possibility of thyroid dysfunction in obese patients. The relationship between thyroid function and obesity is likely to be bidirectional, with hypothyroidism affecting weight, but obesity also influencing thyroid function. Both serum thyroid-stimulating hormone and fT3 are typically increased in obese individuals, an effect likely mediated by leptin. Following L-T4 treatment for overt hypothyroidism, weight loss appears to be modest and mediated primarily by loss of water weight rather than fat. Selected thyroid analogs might be a means by which to improve weight loss by increasing energy expenditure in obese patients during continued caloric deprivation

scholarly journals Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death

2009 ◽  
Vol 160 (6) ◽  
pp. 985-991 ◽  
Author(s):  
N Benhadi ◽  
W M Wiersinga ◽  
J B Reitsma ◽  
T G M Vrijkotte ◽  
G J Bonsel
Keyword(s):  
Odds Ratio ◽  
Neonatal Death ◽  
Thyroid Dysfunction ◽  
Adjusted Odds Ratio ◽  
Thyroid Peroxidase ◽  
Child Loss ◽  
Increased Risk ◽  
The Mean ◽  
The Relationship ◽  
Tsh Levels

BackgroundTo examine the relationship between maternal TSH and free thyroxine (FT4) concentrations in early pregnancy and the risk of miscarriage, fetal or neonatal death.MethodCohort study of 2497 Dutch women. TSH, FT4, and thyroid peroxidase antibodies concentrations were determined at first booking. Child loss was operationalized as miscarriage, fetal or neonatal death. Women with overt thyroid dysfunction were excluded.ResultsTwenty-seven cases of child loss were observed. The mean TSH and FT4level in the women with child loss was 1.48 mU/l and 9.82 pmol/l compared with 1.11 mU/l and 9.58 pmol/l in women without child loss. The incidence of child loss increased by 60% (OR=1.60 (95% confidence interval (CI): 1.04–2.47)) for every doubling in TSH concentration. This association remained after adjustment for smoking, age, parity, diabetes mellitus, hypertension, previous preterm deliveries, and previous preterm stillbirth/miscarriage (adjusted odds ratio=1.80 (95% CI: 1.07–3.03)). This was not true for FT4concentrations (OR=1.41 (95% CI: 0.21–9.40);P=0.724).ConclusionIn a cohort of pregnant women without overt thyroid dysfunction, the risk of child loss increased with higher levels of maternal TSH. Maternal FT4concentrations and child loss were not associated.

scholarly journals Relation between vitamin D deficiency and osteoarthritis

2020 ◽  
Vol 4 (1) ◽  
pp. 1-4
Author(s):  
Ahmad Gharaibeh
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Calcium Level ◽  
Vitamin D Supplementation ◽  
University Hospital ◽  
Phosphorus Level ◽  
Normal Range ◽  
Health Records ◽  
The Mean ◽  
The Relationship

Purpose of the Work: The main objective of our work is to determine the relationship between osteoarthritis and deficiency of vitamin D in our region in central Europe and to make a database for further researches, to be effective in investigating, controlling, and preventing OA and vitamin D deficiency in our population. Methodology: We perform a retrospective study in adult patients≥25years with osteoarthritis big joints from their health records, which were seen at the osteology clinic of University Hospital Louise Pasteur during the year 2018. The authors analyse the blood tests of Vitamin D level, calcium level, phosphorus level, B ALP, glomerular filtration rate (GFR) levels in the serum of these patients. Results: There were 47 patients with osteoarthritis. All of these patients had Vitamin D deficiency. The mean age of our group is 71 years. 12.8% (7) are male and 87.2% (41)are female. The mean of vitamin D is 24mmol/l (normal range 75-200 nmol/l), Calcium level with in normal range, Phosphorus level mean was within normal range and B ALP level within normal. Conclusion: Osteoarthritis increased by deficiency of vitamin D level in blood serum and increasing with age. Vitamin D is a fat-soluble vitamin that regulates calcium and phosphorus metabolism, maintenance of the normal skeletal and muscular systems. Most of the patients show OA in hip and knee and in advanced age 71 years. Vitamin D supplementation may be a safe method to treat and prevent OA.

scholarly journals The relationship between ultrasound findings and thyroid function in children and adolescent autoimmune diffuse thyroid diseases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji Eun Park ◽  
Sook Min Hwang ◽  
Ji-Young Hwang ◽  
Jin Hee Moon ◽  
Ik Yang ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Diseases ◽  
Overt Hypothyroidism ◽  
Children And Adolescent ◽  
Ultrasound Findings ◽  
The Relationship ◽  
Overt Hyperthyroidism

AbstractTo evaluate the association between thyroid echogenicity and heterogeneity seen on ultrasonography (US) and thyroid function in pediatric and adolescent populations with autoimmune diffuse thyroid diseases (AITD). From 2000 to 2020, we reviewed thyroid ultrasound (US) images and thyroid function statuses in 133 children and adolescent AITD patients. Our review of the images focused on decreased echogenicity and heterogeneity, which were classified into four grades. Among patients with overt hypothyroidism or overt hyperthyroidism, 94.2% (65/69) showed a US grade of 3 or 4. In patients with subclinical hyper/hypothyroidism or euthyroidism, 45.3% (29/64) showed grades 1 or 2. There were no overt hyper/hypothyroidism patients with US grade 1. When we compared US grades according to thyroid status, more severe thyroid dysfunction was significantly associated with higher US grade (p = 0.047). Thyroid stimulating hormone (TSH) level differed significantly according to US grades when we evaluated hyperthyroid (p = 0.035) and hypothyroid (p = 0.027) states independently. 11 patients showed both US grade and thyroid function status changes on follow-up US. In children and adolescent AITD patients, there was an association between decreased echogenicity and heterogeneity on US and thyroid dysfunction.

scholarly journals Increased prevalence of hyperthyroidism as an early and transient side-effect of implementing iodine prophylaxis

2007 ◽  
Vol 10 (8) ◽  
pp. 799-802 ◽  
Author(s):  
Filip Gołkowski ◽  
Monika Buziak-Bereza ◽  
Małgorzata Trofimiuk ◽  
Agata Bałdys-Waligórska ◽  
Zbigniew Szybiński ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Thyroid Dysfunction ◽  
Thyroid Autoimmunity ◽  
Final Analysis ◽  
Iodine Intake ◽  
Thyroid Stimulating Hormone ◽  
Iodine Prophylaxis ◽  
Sudden Rise ◽  
Epidemiological Surveys ◽  
Thyroid Microsomal Antibodies

AbstractObjectiveTo assess the prevalence of hyperthyroidism just after implementation of iodine prophylaxis among adults from an area with iodine deficiency.Study design and subjectsA total of 1648 adults (age 16 years and older) were sampled from an area of southern Poland during two nationwide epidemiological surveys. Of these, 1424 adults with negative medical history for thyroid disorders qualified for final analysis. The authors compared thyroid dysfunction in participants prior to (1989–1990) and after implementation of iodine prophylaxis (1997–1999).SettingThe southern part of Poland.ResultsWe found an increase in the serum concentration of anti-thyroid microsomal antibodies from 4.9% in the years 1989–1990 to 12.1% after introduction of iodised household salt (P < 0.0001). The prevalence of hyperthyroidism (defined as thyroid-stimulating hormone < 0.4 μU ml− 1) significantly increased in the equivalent period from 4.8 to 6.5% (P = 0.009).ConclusionsWe concluded that a sudden rise in iodine intake after implementation of iodine prophylaxis among adults from the area with iodine deficiency may lead to an increase in thyroid autoimmunity and prevalence of hyperthyroidism. Those possible early side-effects appear to be only temporary and are acceptable when compared with the evident benefits of adequate iodine intake.

scholarly journals Correlation of serum thyroid stimulating hormone with body mass index in healthy adults

2019 ◽  
Vol 2 (3) ◽  
pp. 116-120
Author(s):  
Bishow Raj Baral ◽  
Manoj Koirala ◽  
Buddhi Sagar Lamichhane ◽  
Suresh Raj Paudel ◽  
Laxman Banstola ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Stimulating Hormone ◽  
Function Evaluation ◽  
Free T4 ◽  
Cross Sectional ◽  
The Mean ◽  
Stimulating Hormone

Background: Obesity, a chronic disease that is increasing in prevalence in adults, adolescents and children, is now considered a global epidemic. Thyroid dysfunction contributes to the pathogenesis of obesity. Many clinical studies raise the questions of whether thyroid-stimulating hormone (TSH) changes in physiological limits is associated with obesity and whether there is a link between adipose tissue and hypothalamo-thyroidal axis. Materials and Method: This was a cross-sectional study. All clinically euthyroid patients and healthy volunteer adults of age 18 to 60 years of either gender were included in the study. Fasting blood sample was taken for thyroid function evaluation, which included Free T3, Free T4 and thyroid stimulating hormone. Height, weight, waist circumference and hip circumference were measured. The results were compared with calculated Body Mass Index (BMI). Results: 61 patients who met the inclusion criteria were studied. Among 61 patients 16 had subclinical hypothyroidism, 2 patients had hypothyroidism and 43 were euthyroid. Similarly, 2 underweight patients were observed, 7 had normal weight, 13 were over weight and 39 were obese. The mean TSH according to BMI were 3.8, 4.04, 3.88 and 6.19 respectively. Conclusion: The result in this study showed that the mean TSH increased as BMI increased with significant relationship between serum TSH and BMI (p <0.001). Thus thyroid dysfunction mainly subclinical hypothyroidism and hypothyroidism could be found in association with increased body weight.

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