scholarly journals Prevalence of thyroid dysfunction in patients with polycystic ovarian syndrome: a cross sectional study

2018 ◽  
Vol 7 (8) ◽  
pp. 3055 ◽  
Author(s):  
Deepa Shanmugham ◽  
Sindhu Natarajan ◽  
Arun Karthik
Keyword(s):  
Thyroid Dysfunction ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Thyroid Stimulating Hormone ◽  
Endocrine Disorders ◽  
Free T4 ◽  
Cross Sectional ◽  
The Mean ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) and thyroid disorders are two of the most common endocrine disorders in the general population. Both of these endocrine disorders share common predisposing factors, gynaecological features and have profound effect on reproductive function in women. The aim of this study is to study the prevalence of thyroid dysfunction in patients with polycystic ovarian syndrome and to evaluate the relationship between polycystic ovarian syndrome and thyroid dysfunction.Methods: This is a cross sectional observational study done on 100 patients with Poly Cystic Ovarian Syndrome based on Rotterdam’s criteria. The exclusion criteria was hyperprolactinemia, congenital adrenal hyperplasia and virilising tumour. Thyroid function was evaluated by measurement of fasting serum thyroid stimulating hormone (TSH), free thyroxine levels (free T3 and free T4).Results: The mean age of the study patients was 26±4.2 years. Among the study patients, 11% of them had goitre. 18% of the patients with presented with subclinical hypothyroidism. The mean TSH levels in the study patients was 4.62±2.12 mIU/ml. The overall prevalence of thyroid dysfunction was 33% in the study patients with PCOS.Conclusions: This study concludes that the prevalence of hypothyroidism is increased in women with PCOS patients.

Magnitude of thyroid dysfunction among antenatal women attending tertiary care centre

2019 ◽  
Vol 8 (11) ◽  
pp. 4371
Author(s):  
Deepa Shanmugham ◽  
Deepak Kannan Saravanan ◽  
Priyanka Shah
Keyword(s):  
Thyroid Dysfunction ◽  
Tertiary Care ◽  
Thyroid Function Test ◽  
First Trimester ◽  
Endocrine Disorders ◽  
Tertiary Care Centre ◽  
Free T4 ◽  
Cross Sectional ◽  
High Prevalence ◽  
The Mean

Background: Thyroid disorders constitute one of the most common endocrine disorders in pregnancy. However, there is no universal guidelines to screen every Pregnant Woman for Thyroid dysfunction in India. This study was conducted to evaluate the magnitude of thyroid dysfunction among ante natal mothers in a tertiary care centre.Methods: This was a cross sectional observational study conducted on ante natal mothers for a period of 6 months. All consecutive ante natal mothers in their first trimester were included in this study. Exclusion criteria was pre-gestational thyroid dysfunction, hypertension and diabetes mellitus. After obstetric examination and investigation, thyroid function test (Free T4 and TSH) was done in all patients.Results: Mean age of the patients enrolled was 26.2±3.54 years. Mean gestational age at which they underwent screening was 9±2 weeks. The mean BMI of the study patients was 21.7±4. The prevalence of hypothyroidism in antenatal mothers was 14.5%. 5 patients (5.5%) had hyperthyroidism. The calculated mean TSH value was 4.26 mIU/L.Conclusions: Universal screening for thyroid dysfunction during pregnancy should be made mandatory in India due to high prevalence, in order to prevent maternal and foetal complications.

scholarly journals Correlation of serum thyroid stimulating hormone with body mass index in healthy adults

2019 ◽  
Vol 2 (3) ◽  
pp. 116-120
Author(s):  
Bishow Raj Baral ◽  
Manoj Koirala ◽  
Buddhi Sagar Lamichhane ◽  
Suresh Raj Paudel ◽  
Laxman Banstola ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Stimulating Hormone ◽  
Function Evaluation ◽  
Free T4 ◽  
Cross Sectional ◽  
The Mean ◽  
Stimulating Hormone

Background: Obesity, a chronic disease that is increasing in prevalence in adults, adolescents and children, is now considered a global epidemic. Thyroid dysfunction contributes to the pathogenesis of obesity. Many clinical studies raise the questions of whether thyroid-stimulating hormone (TSH) changes in physiological limits is associated with obesity and whether there is a link between adipose tissue and hypothalamo-thyroidal axis. Materials and Method: This was a cross-sectional study. All clinically euthyroid patients and healthy volunteer adults of age 18 to 60 years of either gender were included in the study. Fasting blood sample was taken for thyroid function evaluation, which included Free T3, Free T4 and thyroid stimulating hormone. Height, weight, waist circumference and hip circumference were measured. The results were compared with calculated Body Mass Index (BMI). Results: 61 patients who met the inclusion criteria were studied. Among 61 patients 16 had subclinical hypothyroidism, 2 patients had hypothyroidism and 43 were euthyroid. Similarly, 2 underweight patients were observed, 7 had normal weight, 13 were over weight and 39 were obese. The mean TSH according to BMI were 3.8, 4.04, 3.88 and 6.19 respectively. Conclusion: The result in this study showed that the mean TSH increased as BMI increased with significant relationship between serum TSH and BMI (p <0.001). Thus thyroid dysfunction mainly subclinical hypothyroidism and hypothyroidism could be found in association with increased body weight.

scholarly journals Correlation of serum androgen and gonadotropin with anti-mullerian hormone in polycystic ovarian syndrome in Eastern Indian population

2019 ◽  
Vol 8 (1) ◽  
pp. 256
Author(s):  
Somnath Singh Raghuvanshi ◽  
Anirban Sinha ◽  
Animesh Maiti ◽  
Partha Pratim Chakraborty ◽  
Asish Kumar Basu ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Pulse Generator ◽  
Polycystic Ovary ◽  
Serum Testosterone ◽  
Pulse Frequency ◽  
Strong Positive Correlation ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Ovarian Syndrome

Background: Ovarian steroidogenesis requires gonadotropin stimulation, Luteinizing Hormone (LH) is a key factor in the hyperandrogenaemia of the polycystic ovary syndrome. Progesterone is the primary regulator of Gonadotropin-Releasing Hormone (GnRH) pulse frequency; however, in the polycystic ovary syndrome, the GnRH pulse generator is relatively resistant to the negative feedback effects of progesterone.  Study aims to evaluate the association of Anti-mullerian hormone with serum androgen and gonadotropin level in adolescents and young women of Polycystic Ovary Syndrome (PCOS).Methods: This was a single centre observational Cross-sectional study carried out in the department of Endocrinology and metabolism, Medical College, Kolkata from March 2017 to January 2019. Total number of study subjects were 207 out of which 138 were cases.Results: The AMH had strong positive correlation with serum testosterone in both case and control groups (r 0.542, p<0.001 and r 0.57, p<0.001) respectively .After the adjustment of age and BMI , the AMH moderately positive  but extremely significant correlation with serum testosterone as compare to control.Conclusions: Hyperandrogenaemia and higher ratio of LH and FSH associated with higher serum AMH level is associated with the higher serum AMH in polycystic ovarian syndrome.

scholarly journals POLYCYSTIC OVARIAN SYNDROME(PCOS), AWARENESS AMONG FEMALE STUDENTS, QASSIM UNIVERSITY, QASSIM REGION, SAUDI ARABIA

2018 ◽  
Vol 6 (9) ◽  
pp. 395-406
Author(s):  
Noura Mohammed Al Bassam ◽  
Sarah Ali ◽  
Syed Raziur Rahman
Keyword(s):  
University Students ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Data Entry ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Online Questionnaire ◽  
Voice Change ◽  
Cross Sectional ◽  
Ovarian Syndrome

Introduction: Polycystic Ovarian Syndrome (PCOS) is a condition that affects a woman’s hormone levels and it is said to be the most common female syndrome. Affects between 4-8% of reproductive-aged women and is associated with reproductive, metabolic and psychological dysfunction. Methods: A Quantitative observational cross-sectional study, we recruited 350 students of Qassim University selected using random sampling according to the inclusive criteria (age between 18-25 years). An online questionnaire designed in Arabic to facilitate the data collection, and university students, participated voluntarily. Statistical data entry and analysis of results was performed using Microsoft Excel. Results: Our sample size was 350 Qassim University students whose ages were between 18-25 years. 71% (n=248) Students heard about the PCOS, 49% of them heard about the symptoms from other people (mother, sister, cousin, etc.).  The presence of the symptoms of PCOS among these students was as, the most common symptoms were Hair loss 74%, Mood swing 67%, Acne 61%, and the least common symptom was Voice change 8%.  The prevalence of the syndrome among the university students was found to be 12% of these 350 students suffer from PCOS (diagnosed). Conclusion: 71% of studens were aware about the Polycystic Ovary Syndrome. 12% of students suffered from PCOS. Most common symptoms reported was Irregular menstrual cycle, 87%, and the least common symptom was Voice change 13%. 62 % of the students who suffered from PCOS were taking treatments based on hormonal therapy and surgical intervention. Attitude and Practices showed misconceptions about PCOS, and a need for awareness.

scholarly journals Thyroid dysfunction in patients of metabolic syndrome: A study from a tertiary care center in India

2021 ◽  
Vol 12 (10) ◽  
pp. 47-50
Author(s):  
Ritu Gupta ◽  
Akhil K Vijayan ◽  
Sushma Choudhary
Keyword(s):  
Metabolic Syndrome ◽  
Thyroid Dysfunction ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
P Value ◽  
Overt Hypothyroidism ◽  
Free T4 ◽  
Cross Sectional

Background: Metabolic syndrome is characterized by hypertension, dyslipidemia, central obesity, glucose intolerance, insulin resistance. Thyroid hormone acts as general pacemaker, accelerating metabolic process and may be associated with metabolic syndrome. There is no information available in literature regarding the prevalence and association of thyroid dysfunction in metabolic syndrome in this central region of the country. Aims and Objective: To estimate the prevalence of thyroid dysfunction in patients of metabolic syndrome. Materials and Methods: It is a duration based prospective cross sectional study including 200 patients of metabolic syndrome. A detailed history, clinical examination and relevant investigations including serum Free T4 (FT4), Free T3 (FT3), Thyroid Stimulating Hormone (TSH) were done. Range, frequencies, percentage, mean, standard deviation and P value were calculated. P value of < 0.05 was taken as significant. Results: Prevalence of thyroid dysfunction in metabolic syndrome patients was 28.5%. Prevalence of subclinical and overt hypothyroidism was 18.5% and 8.5% respectively. In patients with both metabolic syndrome and thyroid dysfunction, most common components associated are diabetes mellitus and hypertriglyceridemia. Conclusion: Thyroid dysfunction is significantly common in metabolic syndrome patients. It should be aggressively detected and treated in these patients for better outcome.

COMPLICATIONS OF PREGNANCY IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

2011 ◽  
Vol 22 (3) ◽  
pp. 188-206
Author(s):  
MALLIKA AZIZIA ◽  
PAUL HARDIMAN
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Polycystic Ovaries ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting around 5–8% of women of reproductive age. It has a variable clinical spectrum including hyperandrogenism, menstrual abnormalities, polycystic ovaries and metabolic features like diabetes mellitus, obesity and dyslipidaemia. The manifestation of PCOS and its impact especially on reproductive function and pregnancy are profoundly affected by associated features of obesity/raised body mass index and metabolic syndrome.

scholarly journals Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients

2020 ◽  
Vol 27 (3) ◽  
pp. 191-194
Author(s):  
Rofida Abuobaida KAMIL ◽  
Nuha Eljailli ABUBAKER ◽  
Seifeldeen Ahmed MOHAMED ◽  
Mariam Abbas IBRAHIM ◽  
Ahmed Bakheet ABD ALLA
Keyword(s):  
Thyroid Hormones ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Controlled Study ◽  
Control Group ◽  
Endocrine Disorders ◽  
Thyroid Disorders ◽  
Thyroid Autoantibody ◽  
Thyroglobulin Antibodies ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) and thyroid disorders are the most common endocrine disorders in women. Evidently, the involvement of polycystic ovarian syndrome (PCOS) and thyroid autoimmunity triggering thyroid disorders has not yet occurred. Objective: The aim was to assess serum free tri-iodothyronine (FT3), free thyroxin (FT4) and anti-thyroglobulin antibodies among polycystic ovary syndrome Sudanese patients. Materials and methods: Fifty Sudanese patients diagnosed with PCOS and 50 healthy age matched females were recruited in this cross-sectional controlled study. Serum FT3 and FT4 were measured by an immunoassay analyzer and serum anti-thyroglobulin antibodies were measured using ELISA. The data was then analyzed using the SPSS. Results: The results showed a signifi cant increase in serum FT3 and anti-thyroglobulin antibodies and there was no statistical difference in PCOS serum FT4 levels compared to the control group. The results revealed no correlation between levels of FT3, FT4 and anti-thyroglobulin antibodies with age; also there were no correlation between levels of FT3 and FT4 with BMI while there was a positive correlation between anti-thyroglobulin antibodies levels and BMI. Conclusion: Patients with PCOS had elevated FT3 and antithyroglobulin. Therefore, the assessment of thyroid autoantibody with thyroid hormones in patients with PCOS should be investigated.

scholarly journals Clinical, ultrasonographical and hormonal correlation in women with polycystic ovarian syndrome

2018 ◽  
Vol 7 (12) ◽  
pp. 5134
Author(s):  
Ashwini Sidhmalswamy G. ◽  
Jyoti S. Ghongdemath ◽  
Sreedhar Venkatesh
Keyword(s):  
Testosterone Level ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Cross Sectional Study ◽  
Obese Women ◽  
Cross Sectional ◽  
Ovarian Volume ◽  
The Mean ◽  
Free Testosterone Level ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of fertile age. The prevalence, time of onset and severity of clinical presentation vary among different ethnic and racial groups. Though there is significant reproductive, endocrine and metabolic morbidity of PCOS, very little is known about its different modes of presentation in Indian population. A cross sectional observational study. The objective To study the correlation between the clinical, ultrasonographical and hormonal features in women diagnosed as PCOS based on the revised diagnostic criteria, 2003.Methods: A cross-sectional study of 74 PCOS women who had oligo ovulatory cycles and polycystic ovarian morphology on ultrasound was done. Data about menstrual history and anthropometric measurements were collected. Clinical observations of acne and hirsutism were made.  Transvaginal ultrasonography and biochemical analysis for free testosterone was done.Results: In all, 74 PCOS women were studied and analyzed. The mean age was 24.884.03, mean BMI was 25.48 ±3.75 and mean free testosterone was 3.81±4.05. Among the PCOS women 39.8% were hirsute, 10.1% were obese, 2.3% had acne and 38% were hyperandrogenemic. Of the hyperandrogenemic women 61.2% were hirsute, 53.22% were obese and 36.54% had acne.  The association between BMI and free testosterone level was statistically significant (p=0.0023). BMI was moderately correlated with hyperandrogenemia (r=0.446). The mean left ovarian volume was higher in obese than in non-obese women, which was statistically significant (p=0.003). The mean left ovarian volume was high in hyperandrogenemic women which was statistically significant (p=0.00034).Conclusions: In the present study it was found that there is association between obesity and free testosterone level which was significant. There was statistically significant association between ovarian volume and obesity. Similarly, there was association between ovarian volume and hyperandrogenemia which was significant. Hirsutism and acne had no association with hyperandrogenemia.

scholarly journals A Cross Sectional Study on the Status of Inflammatory Markers in Polycystic Ovary Syndrome (Pcos) in Indian Population

2019 ◽  
Vol 12 (04) ◽  
pp. 1975-1983
Author(s):  
Senthurselvi Ramamoorthy ◽  
Bhuvaneswari K
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Statistical Significance ◽  
Newly Diagnosed ◽  
Duration Of Treatment ◽  
Ovary Syndrome ◽  
The Status ◽  
The Mean ◽  
Hs Crp ◽  
Ovarian Syndrome

Polycystic Ovarian Syndrome (PCOS) is a common disease exclusively seen in women of reproductive age group. World Health Organization reports that Polycystic Ovarian Syndrome approximately affects 5-10% of the reproductive female population worldwide. Women with PCOS have chronic inflammation. This in turn leads to increased incidence of non-communicable diseases like cardiovascular disease and diabetes2. Chronic inflammation in PCOS patients can be identified using serum markers such as C - reactive protein [CRP], Interleukin-6 [IL-6] and Interleukin-18 [IL-18].So the main objective of the study was to assess the status of inflammation in patients with Polycystic Ovary Syndrome (PCOS) and to assess the influence of drugs prescribed for PCOS on inflammation. Patients were divided into three groups as healthy volunteers, newly diagnosed PCOS patients, already on treatment patients for PCOS. High sensitivity CRP (hs-CRP), IL-6 and IL-18 were assessed. There was an increase in the hs-CRP, IL-6 and IL-18 compared to healthy volunteers in both newly diagnosed and already diagnosed groups. But there was no statistical significance (hs-CRP=0.975, IL-6=0.746, IL-18 = 0.148) between them. The mean value has decreased in the already on treatment group as duration of treatment increases. There was no statistical significance between them. There was an inversely proportional relationship between the mean values of inflammatory markers and duration of treatment.

scholarly journals Characteristics and Risk Factors for Polycystic Ovarian Syndrome Among Females

2020 ◽  
Vol 5 (1) ◽  
pp. 200-209
Author(s):  
Bakhtyar Kamal Muhammad
Keyword(s):  
Vaginal Discharge ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
P Value ◽  
Regular Exercise ◽  
Ovary Syndrome ◽  
Young Females ◽  
The Mean ◽  
Uncertain Etiology ◽  
Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is a major endocrinal syndrome may affect the female at adult ages. In polycystic ovary, the ovarian seen that are enlarged and the investigation may base on ultra-sonographic detection. Polycystic ovarian syndrome always represents a spectrum of syndrome rather than the diseases. Also clinically presented by polycystic on ovarian and generally demonstrated by reversible. 104 female patients were examined, 18 (17.3%) of females were diagnosed with polycystic ovarian syndrome. The mean age was 24.62 ± 7.32 years (ranged from 15 month to 50 years-old). 17 (94.4%) of women were less than 25 years-old p-value=0.03, hormonal abnormality was the most frequent symptoms in relation to polycystic ovarian syndrome 10 (55.5%) and p-value=0.001. 16 (88.9%) of women experienced vaginal discharge p-value=0.09. In conclusion, one from six females is expected to experience polycystic ovarian syndrome. Young females are probably to be at a high risk for developing polycystic ovarian syndrome. Despite uncertain etiology of polycystic ovarian syndrome, marital status, stress or anxiety, doing a regular exercise and pregnancy are all related parameters to the incidence of polycystic ovarian syndrome. Additionally, Cases with high hormonal abnormality and vaginal excretion could be considerable indicators of polycystic ovarian syndrome.

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