The place of nonsteroidal anti-inflammatory drugs in the current osteoarthritis guidelines

The paper provides a review of the data available in the literature on the relationship of pain to the risk of OA progression. Network analyses and numerous studies, including those conducted at the V.A. Nasonova Research Institute of Rheumatology, have confirmed that pain syndrome is one of the significant predictors of knee OA progression. The major class of medications for OA pain includes nonsteroidal anti-inflammatory drugs. The paper gives data on the efficacy of meloxicam in OA patients, which is widely used in both Russia and other countries of the world. Meloxicam is characterized by a good safety profile in the gastrointestinal tract, cardiovascular and renal systems. It is the drug of choice in patients with musculoskeletal diseases, in particular OA. Good results in severe pain syndrome have been shown by a step-by-step regimen of meloxicam when the injection formulation of the drug is used in the first days of treatment, and then, to consolidate what has been gained from therapy, its oral dosage form is administered in terms of concomitant diseases.

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The Chemopreventive Efficacies of Nonsteroidal Anti-inflammatory Drugs: The Relationship of Short-term Biomarkers to Long-term Skin Tumor Outcome

Cancer Prevention Research ◽

10.1158/1940-6207.capr-13-0064 ◽

2013 ◽

Vol 6 (7) ◽

pp. 675-685 ◽

Cited By ~ 20

Author(s):

Carol D. Mikulec ◽

Joyce E. Rundhaug ◽

Melissa S. Simper ◽

Ronald A. Lubet ◽

Susan M. Fischer

Keyword(s):

Skin Tumor ◽

Short Term ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Relationship Of ◽

The Relationship

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The positive and negative effects of using transdermal nonsteroidal anti-inflammatory drugs: chemoreactome analysis

Neurology neuropsychiatry Psychosomatics ◽

10.14412/2074-2711-2020-5-123-129 ◽

2020 ◽

Vol 12 (5) ◽

pp. 123-129

Author(s):

I. Yu. Torshin ◽

O. A. Gromova ◽

T. R. Grishina ◽

V. A. Semenov

Keyword(s):

Side Effects ◽

Sports Injuries ◽

Musculoskeletal Diseases ◽

Pain Syndrome ◽

Combinatorial Theory ◽

Negative Effects ◽

Transdermal Administration ◽

Drug Concentrations ◽

Inflammatory Drugs ◽

Anti Inflammatory

Transdermal nonsteroidal anti-inflammatory drugs (NSAIDs) are actively used for mild and moderate pain syndrome, muscle contusions and sprains, sports injuries, and the widest range of musculoskeletal diseases. The transdermal administration of NSAIDs aims to create sufficiently high drug concentrations in the lesion focus, provided that the side effects associated with its systemic action are maximally reduced.Objective: to comparatively simulate the effects of transdermal NSAIDs.Material and methods. Chemoreactome profiling of six NSAIDs (meloxicam, diclofenac, ibuprofen, ketoprofen, nimesulide, and dexketoprofen) was performed. The pharmacological capabilities of molecules were analyzed within the framework of a chemoreactome methodology, by comparing the chemical structure of the studied molecule with those of millions of other molecules, the pharmacological properties of which had already been studied in experimental and clinical studies. Training the artificial intelligence algorithms based on the big data available in in the databases PubChem/PHARMGKB, HMDB, STRING, and others was done with multi-level training quality control in the cross validation framework according to the combinatorial theory of solvability and the theory of feature value classification.Results and discussion. Meloxicam versus other NSAIDs accumulates primarily in the muscles and skin and, to a much lesser extent, in heart tissues, lymphocytes, gonads, and cartilage. This drug showed the greatest dose-dependent decongestant effect in the model of edema induced by croton oil. Analysis of the systemic effects of NSAIDs indicated that meloxicam might affect the metabolism of vitamins A, D, PP, and B6 to a lesser extent than other NSAIDs.Conclusion. The chemoreactomе analysis has demonstrated that meloxicam as a gel causing minimal side effects can be used effectively and long.

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Can Ultrasound Therapy Be an Environmental-Friendly Alternative to Non-Steroidal Anti-Inflammatory Drugs in Knee Osteoarthritis Treatment?

Materials ◽

10.3390/ma14112715 ◽

2021 ◽

Vol 14 (11) ◽

pp. 2715

Author(s):

Rodica Ana Ungur ◽

Viorela Mihaela Ciortea ◽

Laszlo Irsay ◽

Alina Deniza Ciubean ◽

Bogdana Adriana Năsui ◽

...

Keyword(s):

Ultrasound Therapy ◽

Negative Effects ◽

Beneficial Effects ◽

Knee Oa ◽

Environmental Friendly ◽

Chemical Pollutants ◽

Osteoarthritis Treatment ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

And Function

The non-steroidal anti-inflammatory drugs (NSAIDs) are the most used drugs in knee OA (osteoarthritis) treatment. Despite their efficiency in pain and inflammation alleviation, NSAIDs accumulate in the environment as chemical pollutants and have numerous genetic, morphologic, and functional negative effects on plants and animals. Ultrasound (US) therapy can improve pain, inflammation, and function in knee OA, without impact on environment, and with supplementary metabolic beneficial effects on cartilage compared to NSAIDs. These features recommend US therapy as alternative for NSAIDs use in knee OA treatment.

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Reducing pain in certain forms of obstetric pathology: nonsteroidal anti-inflammatory drugs (Сlinical lecture)

HEALTH OF WOMAN ◽

10.15574/hw.2017.122.9 ◽

2017 ◽

pp. 9-14

Author(s):

L. Nazarenko ◽

Keyword(s):

Preterm Birth ◽

Side Effects ◽

Key Words ◽

Clinical Efficacy ◽

Premature Birth ◽

Pain Syndrome ◽

Inflammatory Drug ◽

Threatened Abortion ◽

Inflammatory Drugs ◽

Anti Inflammatory

The article discusses the pathogenetic basis for the use of non-steroidal anti-inflammatory drugs (NSPVP) in obstetric practice for the treatment of pain syndrome in women with threatened abortion and pathological preliminary period. Provided with modern views on the mechanisms of analgesic clinical efficacy, side effects NSPVP. Provides information about the place of NSPVP during pregnancy, the risks to the fetus, the positive aspects in the conduct of women at risk of preterm birth, the pathological preliminary period. Key words: nonsteroidal anti-inflammatory drug, pain, premature birth, preliminary period.

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Comparative analysis of different methods of anesthesia in patients with acute pancreatitis using pain scales

Kazan medical journal ◽

10.17750/kmj2016-217 ◽

2016 ◽

Vol 97 (2) ◽

pp. 217-221

Author(s):

V N Shilenok ◽

E V Nikitina

Keyword(s):

Acute Pancreatitis ◽

Comparative Analysis ◽

Visual Analogue Scale ◽

Pain Intensity ◽

Epidural Anesthesia ◽

Analogue Scale ◽

Pain Syndrome ◽

Opioid Analgesics ◽

Inflammatory Drugs ◽

Anti Inflammatory

Aim. To conduct a comparative analysis of used anesthesia methods in patients with acute pancreatitis in intensive care units settings using pain scales.Methods. Depending on the anesthesia type, 44 patients with acute pancreatitis were divided into three groups: the first group received intramuscular injections of nonsteroidal anti-inflammatory drugs and spasmolytics, the second group - intramuscular injections of non-steroidal anti-inflammatory drugs and opioid analgesics, the third group - epidural anesthesia with local anesthetics. Comparative analysis of pain character, intensity was conducted, its dynamics in patients of all groups amid anesthesia was evaluated using a visual analogue scale, verbal rating scale, verbal descriptor scale, McGill pain questionnaire.Results. Baseline pain intensity in patients of all groups was high. Patients estimated this pain as «very strong». The time and the level of pain intensity reduction for various anesthesia types had differences. Pain syndrome was eliminated slower in patients of the second group. By the end of the 1st day, patients of this group continued to complain of «strong» pain. Pain intensity decreased only on the 2nd day - patients reported «moderate» pain. Pain syndrome was not completely eliminated in these patients for 2 days of anesthesia. 97.7% of patients reported that the visual analogue scale is the most acceptable pain assessment scale for them.Conclusion. In patients with acute pancreatitis, the most optimal anesthesia types are intramuscular nonsteroidal anti-inflammatory drugs with spasmolytics and prolonged epidural anesthesia with local anesthetics; intramuscular administration of opioid analgesics with non-steroidal anti-inflammatory drugs is less effective in relieving pain.

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NUTRITION FOR CORRECTING METABOLISM DISORDERS OF THE JOINT-LIGAMENT SYSTEM IN PHYSICALLY ACTIVE PEOPLE

Human Sport Medicine ◽

10.14529/hsm190115 ◽

2019 ◽

Vol 19 (1) ◽

pp. 108-116

Author(s):

O Tolmachyov ◽

A Vekovtsev ◽

V Vovchenko ◽

A Bykov ◽

V Poznyakovsky

Keyword(s):

Nutritional Support ◽

Pain Syndrome ◽

Disease Recurrence ◽

Biologically Active ◽

Control Group ◽

Movement Activity ◽

Physically Active ◽

Daily Movement ◽

Inflammatory Drugs ◽

Anti Inflammatory

Aim. The article deals with developing and assessing the efficiency of a complex nutritional support program for the joint-ligament system in athletes and physically active people. Materials and methods. The clinical evidence of biologically active substance (BAS) efficiency and functional orientation was obtained from the representative group of people with knee-joint osteoarthrosis. The main group of participants received a BAS complex with synergistic properties in terms of metabolism correction during osteoarthrosis: BAS 1 – 2 pills, BAS 2 – 1 capsule (2 times per day, 12 weeks), and BAS 3 – 1 capsule (2 times per day, 8 weeks). Nonsteroidal anti-inflammatory drugs were also prescribed to participants from the main and control groups. We used the general and special methods for assessing the quality and functional properties of specialized products. Knee joints were studied by using the Lequesne index (scores) characterizing pain syndrome, maximal distance, and daily movement activity. The intensity of pain syndrome was assessed with the visual analog scale (VAS, in mm). Results. We provided a scientific justification for the qualitative and quantitative content of BAS recipes for complex nutritional support of the joint-ligament system: BAS 1 – chondroprotective orientation; BAS 2 – an optimal source of minerals and vitamins; BAS 3 – polyunsaturated fatty acids. The results obtained revealed that specialized products improve the movement activity of participants with osteoarthrosis and significantly decrease pain syndrome (36 %). Apart from a chondroprotective effect such nutrition provides an anti-inflammatory effect and allows decreasing the intake of Nonsteroidal anti-inflammatory drugs in the absence of side effects. We revealed an insignificant number of disease recurrence – 6.7% (in the control group – 36.5 %) and established the mechanisms of such an influence. Conclusion. The application of biologically active complexes could serve as a reliable means of preventing and treating the diseases of the joint-ligament system, providing physical performance, and preserving health in athletes and physically active people.

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