scholarly journals Association of the Q141K polymorphism of the ABCG2 gene with the effectiveness of urate-lowering therapy in patients with gout (a pilot study)

2021 ◽  
Vol 15 (6) ◽  
pp. 55-60
Author(s):  
M. S. Eliseev ◽  
M. N. Chikina ◽  
I. A. Guseva ◽  
O. V. Zhelyabina ◽  
E. Yu. Samarkina ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Pilot Study ◽  
Filtration Rate ◽  
Mean Values ◽  
Lowering Therapy ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship ◽  
Abcg2 Gene

Achieving the target serum uric acid (UA) level is a priority in the treatment of gout.Objective: to study the relationship of the ABCG2 gene polymorphism (rs2231142) with the efficacy of allopurinol and febuxostat in patients with gout.Patients and methods. The study included 82 patients with gout over 18 years of age with serum UA level >360 μmol/L who did not take uratelowering therapy.All patients were prescribed allopurinol 100 mg daily, followed by its titration until the target UA level was reached (<360 μmol/L or <300 μmol/L in patients with chronic tofus gout), up to a maximum of 900 mg/day, in patients with glomerular filtration rate <60 ml/min/1.73 m2 – up to 300 mg/day. Patients who did not reach the target UA level when using allopurinol were prescribed febuxostat 80 mg/day, which, if necessary, was increased to 120 mg/day. Monitoring of each patient was continued until the target serum UA level was reached.All patients underwent genotyping of the C>A polymorphism (rs2231142) of the ABCG2 gene. We compared the probability of achieving the target UA level, the mean values of a decrease in the serum UA level, and the mean doses of urate-lowering drugs in patients with different genotypes (CC, CA, AA) of the ABCG2 gene.Results and discussion. The target UA level in 45 (55%) of 82 patients was defined as <300 μmol/L, in the remaining 37 – as <360 μmol/L.In 26 patients, the dose of allopurinol did not exceed 300 mg/day. In 28 (34%) patients treated with allopurinol, the target UA level was achieved, in the remaining 54 (66%) patients, allopurinol was substituted by febuxostat, and in 22 (41%) of them the UA level decreased and was below the target.The CC genotype of the ABCG2 gene was detected in 51 (62%) patients, the CA genotype in 30 (37%) and the minor genotype AA in 1 (1%).The probability of achieving the target UA level during therapy with allopurinol in carriers of homozygous CC genotype and genotypes CA or AA did not differ: 17 (33%) and 11 (35%) cases, respectively, but patients with CA and AA genotypes required a significantly higher dose of allopurinol (365±102 mg/day) than patients with the CC genotype (290±85 mg/day), p=0.002. Of the 54 patients who took febuxostat and did not reach the target UA level, 30 (56%) had the CC genotype and 24 (44%) had the CA genotype, the probability of reaching the target UA level was also comparable (p=0.22).Conclusion. The probability of reaching the target serum UA level in patients with gout taking allopurinol is not associated with the C>A polymorphism of the ABCG2 gene, but the presence of CA and AA genotypes is identified with a higher dose of the drug. The C>A (rs2231142) polymorphism of the ABCG2 gene does not affect the ability to achieve the goal of therapy when using febuxostat in patients with allopurinol ineffectiveness.

The Relationship of Environmental Temperature to the Incidence and Outcome of Schizophrenia

1992 ◽  
Vol 160 (6) ◽  
pp. 788-792 ◽  
Author(s):  
Sunjai Gupta ◽  
Robin M. Murray
Keyword(s):  
Pilot Study ◽  
Environmental Temperature ◽  
Climatic Variables ◽  
Sociocultural Factors ◽  
Outcome Study ◽  
Daily Range ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

This paper presents new analyses of data from two multicentre studies carried out by the WHO. The morbid risk of developing schizophrenia, as broadly defined by the Determinants of Outcome Study, was positively related to the mean daily range of temperature. The outcome of schizophrenia, as determined by the International Pilot Study of Schizophrenia, was found to be positively related to mean environmental temperature. Further studies are needed to examine the relationship of geographical and climatic variables to schizophrenia in order to complement what is already known about the role of sociocultural factors.

scholarly journals The relationship of religious attitude with self-control andself-discrepancy in students

2019 ◽  
Vol 21 (3) ◽  
pp. 144-148
Author(s):  
Masoud Nikfarjam ◽  
Elham-Sadat Salehi ◽  
Ali Ahmadi
Keyword(s):  
Pearson Correlation ◽  
Self Control ◽  
Cross Sectional ◽  
Mean Values ◽  
Religious Attitude ◽  
Significant Difference ◽  
The Mean ◽  
Self Discrepancy ◽  
Relationship Of ◽  
The Relationship

Background and Aim: Spiritual attitude is one of the factors affecting mental health of students. The purpose of this study was to determine the relationship of religious attitudes with self-control and self-discrepancy (S-D) in students of Shahrekord University of Medical Sciences (SKUMS) in 2017. Methods: In this cross-sectional study, 328 students of the SKUMS were studied. The participants completed Tangney Self-control Survey, Higgins Self-discrepancy Questionnaire, a religious attitude questionnaire, and a checklist of demographic information. For data analysis, in addition to descriptive statistics, independent t-test, Pearson correlation coefficient, and one-way ANOVA were used. Stata software was used to analyze the data. Results: The mean values of religious attitude, self-control, and self-discrepancy were higher in women in comparison with men (P< 0.05). There was a significant difference between self-control religious beliefs, actual-self minus actual-self (S-D2), and self-discrepancy in terms of total monthly income of all family members (P< 0.05). Academic discipline was significantly associated with religious attitude, ideal-self minus actual-self (S-D1), S-D2, and S-D (P< 0.05), but self-control difference was not significant (P= 0.84). There was a linear relationship, significant correlation of religious attitude with the mean values of self-control, required self, actual-self, idea-self, self-discrepancy, and S-D1 and S-D2 (P< 0.05). Conclusion: According to the results of this study, religious attitude was associated with self-control, self-discrepancy, and their dimensions.

scholarly journals Relationships Between Hybrid Performance and Genetic Distance Revealed by Morphological and AFLP Marker in Cucumber

2014 ◽  
Vol 65 (1) ◽  
pp. 87-97
Author(s):  
J.A. Olfati ◽  
H. Samizadeh ◽  
Gh. Peyvast ◽  
B. Rabiei ◽  
S.A. Khodaparast
Keyword(s):  
Genetic Distance ◽  
Aflp Marker ◽  
Molecular Genetic ◽  
Yield Component ◽  
Fruit Color ◽  
Hybrid Performance ◽  
Mean Values ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

AbstractThis study investigated the relationship of morphological and molecular genetic distance with hybrid performance and heterosis in cucumber in an attempt to make use of genetic distance in predicting hybrid performance. The results of this study showed that GD, in general, correlated poorly with heterosis and SCA. Results showed that the mean values of the hybrids were significantly larger or smaller for many traits when compared with the mean of parental lines, indicating that heterosis was present for these traits. In next step we compare inter group hybrids versus intra group hybrids. This test showed that intra group hybridization although increased the yield and yield component but decrease some fruit quality such as fruit color and shape.

Overjet Stability after Treatment of Class II Division 1 Malocclusions

1975 ◽  
Vol 2 (4) ◽  
pp. 239-246 ◽  
Author(s):  
T. G. Bennett ◽  
J. F. Camilla Tulloch ◽  
Katherine W. L. Vig ◽  
W. G. Webb
Keyword(s):  
Class Ii ◽  
Lower Lip ◽  
Mean Values ◽  
Division 1 ◽  
Skeletal Pattern ◽  
Treatment Changes ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship ◽  
Class Ii Division 1

The results of an analysis of treatment and post-treatment changes in 48 unselected Class II Division 1 malocclusions are presented. All the cases were at least 1 year out of retention (mean 34·7 months). Mean values have been given for several features. In particular, the mean overjet reduction during treatment was 7·0 mm, the mean relapse 1·1 mm and the mean net overjet reduction 5·9 mm. The relationship of “final” overjet to overbite, overjet, skeletal pattern and lower lip height at different stages of treatment is described. There is wide variation in “final” overjet in relation to any of the single factors investigated but five significant correlations were found.

scholarly journals The relationship of shortening and strength of eggshell to some egg quality indicators and egg production in hens of different initial laying lines*

2002 ◽  
Vol 45 (3) ◽  
pp. 287-296 ◽  
Author(s):  
L. Máchal ◽  
J. Simeonovová
Keyword(s):  
Rhode Island ◽  
Egg Production ◽  
Egg Quality ◽  
Mean Values ◽  
Time Period ◽  
The Mean ◽  
Positive Correlations ◽  
Shape Ratio ◽  
Relationship Of ◽  
The Relationship

Abstract. The mean values of shortening force at fracture of egg found out during the five-month observation period ranged between 0.17 and 0.19 mm in 231 hens of seven initial laying lines and strength of eggshell ranged from 29.05 N to 36.46 N. The mean values of shortening force at fracture decreased with age of hens from 0.18–0.22 mm at 28 wk of age to 0.12–0.15 mm at 46 wk of age. Similarly, strength of eggshell decreased from 31.35–37.68 N to 27.91–34.50 N in same time period. Index of shape, ratio of eggshell and albumen to total egg weight also decreased with increasing age of hens. The highest ratio of abnormal eggs was found in both Bar Plymouth Rock lines (BPR A and BPR B) – 7.5% and 8.3% resp. The lowest ratio was found in lines Rhode Island Red (RIR C) – 2.1% and Susex Light (SU) – 2.4 %. The ratio of cracked eggs ranged from 0.9 % to 3.9 %, the ratio of double-yolked eggs was 0.5%–3.2% and the ratio of eggs without shell was 0.4 %–1.5 %. The calculated coefficients of correlation between shortening of egg and index of shape were mainly positive with rp = 0.41 (P < 0.05) and rp = 0.49 (P < 0.01). The correlations between shortening of egg and total number of eggs were mainly negative with rp = −0. 34 (P < 0.05) and rp = −0. 46 (P < 0.01). Similar correlations existed also between shortening of egg and ratio of cracked eggs, i.e. rp = −0. 44 (P < 0.05) and rp = −0. 46 (P < 0.01). The correlations between shortening and total number of abnormal eggs were mainly negative rp = −0. 39 (P < 0.05) and rp = −0. 53 (P < 0.01). The relationships between strength of eggshell and shortening of egg are characterized by positive correlations – rp = 0. 40 (P < 0.05) and rp = 0.55, (P < 0.01). Positive correlations existed also between strength of eggshell and index of shape (from rp = 0. 37 (P < 0.05) to rp = 0.59 (P < 0.01)). Correlations between strength of eggshell and ratio of eggshell ranged from rp = 0.44 (P < 0.01) to rp = 0.74 (P < 0.01). Mainly negative correlations were found out between strength of eggshell and number of eggs rp = −0. 34 (P<0.05) and rp = −0. 44 (P < 0.01), similarly between the strength of eggshell and cracked eggs rp = −0. 40 (P < 0.05) and rp = −0. 52 (P < 0.01). Negative correlations existed between strength of eggshell and total number of abnormal eggs (rp = −0.45 to rp = −0.53 (P < 0.01)). This means that both eggshell shortening and strength may be used when selecting lines for egg quality.

scholarly journals Hubungan Kejadian Anemia dengan Penyakit Ginjal Kronik pada Pasien yang Dirawat di Bagian Ilmu Penyakit Dalam RSUP dr M Djamil Padang Tahun 2010.

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Rahmat Hidayat ◽  
Syaiful Azmi ◽  
Dian Pertiwi
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Medical Record ◽  
Filtration Rate ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship

AbstrakAnemia merupakan salah satu masalah utama pada pasien penyakit ginjal kronik. Tinggi rendahnya laju filtrasi glomerulus mempengaruhi kejadian anemia pada penyakit ginjal kronik. Tujuan penelitian ini adalah mengidentifikasi hubungan kejadian anemia dengan penyakit ginjal kronik pada pasien yang dirawat di Bagian Penyakit Dalam tahun 2010. Penelitian yang dilakukan merupakan survei analitik dengan menggunakan design penelitian cross sectional study. Penelitian menggunakan data sekunder yang diambil dari sub bagian Rekam Medik (Medical Record) RSUP dr. M Djamil Padang dari Juni–Desember 2012 dengan jumlah sampel adalah 67 pasien penyakit ginjal kronik. Ditemukan angka kejadian anemia pada pasien penyakit ginjal kronik sebesar 98,5% dengan rata-rata kadar Hb sebesar 7,3 g/dl dan rata-rata laju filtrasi glomerulus adalah 8,81 ml/menit/1.73m2. Dari hasil uji korelasi Pearson diperoleh hasil adanya hubungan kejadian anemia dengan penyakit ginjal kronik di RSUP dr M Djamil Padang  dengan p = 0,00 (p < 0,05). Kesimpulan hasil penelitian ini adalah semakin rendah laju filtrasi glomerulus menunjukkan semakin rendah juga kadar hemoglobin pada pasien penyakit ginjal kronik.Kata kunci: anemia, penyakit ginjal kronik, laju filtrasi glomerulus AbstractAnemia is one of the major problems in patients with chronic kidney disease. High and low glomerular filtration rate affect the incidence of anemia in chronic kidney disease. The objective of this study was to identify the relationship  of anemia on patients with chronic kidney disease in the Internal Medicine. The type of this research was analytic studies using a cross sectional study research design from June–December 2012 . This study used secondary data taken from Medical Record department of dr. M. Djamil hospital  with  samples of the entire medical record is 67 persons chronic kidney disease patients in 2010. The result found the incidence of anemia in chronic kidney disease patients was 98.5%, with an average hemoglobin level at 7.3 g/dl and mean glomerular filtration rate was 8.81 ml /min/1.73m2. Pearson correlation of test results obtained by the result of the relationship of anemia on patients with chronic kidney disease at dr M Djamil Padang Hospital with p = 0.00 (p <0,05). The low rate of glomerular filtration rate also showed by the low level of hemoglobin in patients with chronic kidney disease    Keywords: anemia, chronic kidney disease, glomerular filtration rate

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