scholarly journals Artificial intelligence in human genomics and biomedicine

Author(s):  
Reinhard Heil ◽  
Nils B. Heyen ◽  
Martina Baumann ◽  
Bärbel Hüsing ◽  
Daniel Bachlechner ◽  
...  

The increasing availability of extensive and complex data has made human genomics and its applications in (bio)medicine an at­ tractive domain for artificial intelligence (AI) in the form of advanced machine learning (ML) methods. These methods are linked not only to the hope of improving diagnosis and drug development. Rather, they may also advance key issues in biomedicine, e. g. understanding how individual differences in the human genome may cause specific traits or diseases. We analyze the increasing convergence of AI and genom­ics, the emergence of a corresponding innovation system, and how these associative AI methods relate to the need for causal knowledge in biomedical research and development (R&D) and in medical prac­tice. Finally, we look at the opportunities and challenges for clinical practice and the implications for governance issues arising from this convergence.

2020 ◽  
Author(s):  
Oliver Maassen ◽  
Sebastian Fritsch ◽  
Julia Gantner ◽  
Saskia Deffge ◽  
Julian Kunze ◽  
...  

BACKGROUND The increasing development of artificial intelligence (AI) systems in medicine driven by researchers and entrepreneurs goes along with enormous expectations for medical care advancement. AI might change the clinical practice of physicians from almost all medical disciplines and in most areas of healthcare. While expectations for AI in medicine are high, practical implementations of AI for clinical practice are still scarce in Germany. Moreover, physicians’ requirements and expectations of AI in medicine and their opinion on the usage of anonymized patient data for clinical and biomedical research has not been investigated widely in German university hospitals. OBJECTIVE Evaluate physicians’ requirements and expectations of AI in medicine and their opinion on the secondary usage of patient data for (bio)medical research e.g. for the development of machine learning (ML) algorithms in university hospitals in Germany. METHODS A web-based survey was conducted addressing physicians of all medical disciplines in 8 German university hospitals. Answers were given on Likert scales and general demographic responses. Physicians were asked to participate locally via email in the respective hospitals. RESULTS 121 (39.9%) female and 173 (57.1%) male physicians (N=303) from a wide range of medical disciplines and work experience levels completed the online survey. The majority of respondents either had a positive (130/303, 42.9%) or a very positive attitude (82/303, 27.1%) towards AI in medicine. A vast majority of physicians expected the future of medicine to be a mix of human and artificial intelligence (273/303, 90.1%) but also requested a scientific evaluation before the routine implementation of AI-based systems (276/303, 91.1%). Physicians were most optimistic that AI applications would identify drug interactions (280/303, 92.4%) to improve patient care substantially but were quite reserved regarding AI-supported diagnosis of psychiatric diseases (62/303, 20.5%). 82.5% of respondents (250/303) agreed that there should be open access to anonymized patient databases for medical and biomedical research. CONCLUSIONS Physicians in stationary patient care in German university hospitals show a generally positive attitude towards using most AI applications in medicine. Along with this optimism, there come several expectations and hopes that AI will assist physicians in clinical decision making. Especially in fields of medicine where huge amounts of data are processed (e.g., imaging procedures in radiology and pathology) or data is collected continuously (e.g. cardiology and intensive care medicine), physicians’ expectations to substantially improve future patient care are high. However, for the practical usage of AI in healthcare regulatory and organizational challenges still have to be mastered.


2020 ◽  
pp. practneurol-2020-002688
Author(s):  
Stephen D Auger ◽  
Benjamin M Jacobs ◽  
Ruth Dobson ◽  
Charles R Marshall ◽  
Alastair J Noyce

Modern clinical practice requires the integration and interpretation of ever-expanding volumes of clinical data. There is, therefore, an imperative to develop efficient ways to process and understand these large amounts of data. Neurologists work to understand the function of biological neural networks, but artificial neural networks and other forms of machine learning algorithm are likely to be increasingly encountered in clinical practice. As their use increases, clinicians will need to understand the basic principles and common types of algorithm. We aim to provide a coherent introduction to this jargon-heavy subject and equip neurologists with the tools to understand, critically appraise and apply insights from this burgeoning field.


2021 ◽  
Author(s):  
Dillon Kessy ◽  
Jose Ignacio Sierra Castro ◽  
Jose Chirinos ◽  
Giorgio De Paola ◽  
Maria Jose Lopez Perez-Valiente

Abstract The application of Artificial Intelligence for planning has received increased attention in the energy industry in the past few years, particularly for the increased production efficiency requirements and environmental standards. The objective of this paper is to show the successful integration of production, completion, subsurface and spatial data using machine-learning algorithms to predict production performance for future development wells. The internal Marcellus Business Unit (MBU) well database, populated with data of 500+ historical wells, has been used in this study. Production data, treated as timeseries, has been processed using functional Principal Component Analysis (PCA) to allow removal of outliers and mode detection. Utilizing this data, a suite of machine-learning algorithms has been applied to reconstruct gas production from available and target well data. Uncertainty quantification has been provided for production curves to identify the quality of prediction. During the study, the sensitivity analysis on input variables has been performed iteratively to screen and rank the most important variables for prediction. The workflow, Unconventional Reservoir Assistant (URA), has been implemented in a proprietary cloud-based platform providing the necessary means for data upload, integration, pre-processing, and finally model training and deployment. This allows the user to focus on the evaluation of model output quality, data filter and workspace generation for continuous model testing and improvement. The full well dataset, split into trained and tested data, has been used for prediction as a preliminary guide to where the most prolific areas of development are located. Results were ranked based on production expected by pad and based on normalized performance. The information was then used to compare with type curves and original development order. In parallel, economic evaluation of break-even was performed to rank all future pads. Consequently, integration of the model prediction and breakeven ranking were used to generate the final development order for the MBU. The URA tool has shown preliminary success in predicting production performance for the pilot development area. Multiple case studies have been run achieving blind test results with high accuracy for historical prediction. Results show some dependency of predictor variable ranking on the field development area, providing insight on how subsurface may affect well dynamic behavior. This paper describes how the integration of URA can complement the development workflow for unconventional reservoirs and be used to predict performance based on complex data integration. The methodology used is superior to standard machine learning models providing only production indicators, as it gives the user the possibility to evaluate economics and completion design sensitivity for future well activities. The methodology can be further extended as a proxy model for well schedule optimization in planning or for better insight into well refrac selection.


Author(s):  
S. Matthew Liao

This introduction outlines in section I.1 some of the key issues in the study of the ethics of artificial intelligence (AI) and proposes ways to take these discussions further. Section I.2 discusses key concepts in AI, machine learning, and deep learning. Section I.3 considers ethical issues that arise because current machine learning is data hungry; is vulnerable to bad data and bad algorithms; is a black box that has problems with interpretability, explainability, and trust; and lacks a moral sense. Section I.4 discusses ethical issues that arise because current machine learning systems may be working too well and human beings can be vulnerable in the presence of these intelligent systems. Section I.5 examines ethical issues arising out of the long-term impact of superintelligence such as how the values of a superintelligent AI can be aligned with human values. Section I.6 presents an overview of the essays in this volume.


Author(s):  
Riemer H. J. A. Slart ◽  
Michelle C. Williams ◽  
Luis Eduardo Juarez-Orozco ◽  
Christoph Rischpler ◽  
Marc R. Dweck ◽  
...  

AbstractIn daily clinical practice, clinicians integrate available data to ascertain the diagnostic and prognostic probability of a disease or clinical outcome for their patients. For patients with suspected or known cardiovascular disease, several anatomical and functional imaging techniques are commonly performed to aid this endeavor, including coronary computed tomography angiography (CCTA) and nuclear cardiology imaging. Continuous improvement in positron emission tomography (PET), single-photon emission computed tomography (SPECT), and CT hardware and software has resulted in improved diagnostic performance and wide implementation of these imaging techniques in daily clinical practice. However, the human ability to interpret, quantify, and integrate these data sets is limited. The identification of novel markers and application of machine learning (ML) algorithms, including deep learning (DL) to cardiovascular imaging techniques will further improve diagnosis and prognostication for patients with cardiovascular diseases. The goal of this position paper of the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI) is to provide an overview of the general concepts behind modern machine learning-based artificial intelligence, highlights currently prefered methods, practices, and computational models, and proposes new strategies to support the clinical application of ML in the field of cardiovascular imaging using nuclear cardiology (hybrid) and CT techniques.


Author(s):  
Kijpokin Kasemsap

This chapter explains the Artificial Intelligence (AI) techniques in terms of Artificial Neural Networks (ANNs), fuzzy logic, expert systems, machine learning, Genetic Programming (GP), Evolutionary Polynomial Regression (EPR), and Support Vector Machine (SVM); the AI applications in modern education; the AI applications in software engineering development; the AI applications in Content-Based Image Retrieval (CBIR); and the multifaceted applications of AI in the digital age. AI is a branch of science which deals with helping machines find the suitable solutions to complex problems in a more human-like manner. AI technologies bring more complex data-analysis features to the existing applications in various industries and greatly contribute to management's organization, planning, and controlling operations, and will continue to do so with more frequency as programs are refined.


BMC Medicine ◽  
2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Christopher J. Kelly ◽  
Alan Karthikesalingam ◽  
Mustafa Suleyman ◽  
Greg Corrado ◽  
Dominic King

Abstract Background Artificial intelligence (AI) research in healthcare is accelerating rapidly, with potential applications being demonstrated across various domains of medicine. However, there are currently limited examples of such techniques being successfully deployed into clinical practice. This article explores the main challenges and limitations of AI in healthcare, and considers the steps required to translate these potentially transformative technologies from research to clinical practice. Main body Key challenges for the translation of AI systems in healthcare include those intrinsic to the science of machine learning, logistical difficulties in implementation, and consideration of the barriers to adoption as well as of the necessary sociocultural or pathway changes. Robust peer-reviewed clinical evaluation as part of randomised controlled trials should be viewed as the gold standard for evidence generation, but conducting these in practice may not always be appropriate or feasible. Performance metrics should aim to capture real clinical applicability and be understandable to intended users. Regulation that balances the pace of innovation with the potential for harm, alongside thoughtful post-market surveillance, is required to ensure that patients are not exposed to dangerous interventions nor deprived of access to beneficial innovations. Mechanisms to enable direct comparisons of AI systems must be developed, including the use of independent, local and representative test sets. Developers of AI algorithms must be vigilant to potential dangers, including dataset shift, accidental fitting of confounders, unintended discriminatory bias, the challenges of generalisation to new populations, and the unintended negative consequences of new algorithms on health outcomes. Conclusion The safe and timely translation of AI research into clinically validated and appropriately regulated systems that can benefit everyone is challenging. Robust clinical evaluation, using metrics that are intuitive to clinicians and ideally go beyond measures of technical accuracy to include quality of care and patient outcomes, is essential. Further work is required (1) to identify themes of algorithmic bias and unfairness while developing mitigations to address these, (2) to reduce brittleness and improve generalisability, and (3) to develop methods for improved interpretability of machine learning predictions. If these goals can be achieved, the benefits for patients are likely to be transformational.


2020 ◽  
Vol 13 (8) ◽  
Author(s):  
Albert K. Feeny ◽  
Mina K. Chung ◽  
Anant Madabhushi ◽  
Zachi I. Attia ◽  
Maja Cikes ◽  
...  

Artificial intelligence (AI) and machine learning (ML) in medicine are currently areas of intense exploration, showing potential to automate human tasks and even perform tasks beyond human capabilities. Literacy and understanding of AI/ML methods are becoming increasingly important to researchers and clinicians. The first objective of this review is to provide the novice reader with literacy of AI/ML methods and provide a foundation for how one might conduct an ML study. We provide a technical overview of some of the most commonly used terms, techniques, and challenges in AI/ML studies, with reference to recent studies in cardiac electrophysiology to illustrate key points. The second objective of this review is to use examples from recent literature to discuss how AI and ML are changing clinical practice and research in cardiac electrophysiology, with emphasis on disease detection and diagnosis, prediction of patient outcomes, and novel characterization of disease. The final objective is to highlight important considerations and challenges for appropriate validation, adoption, and deployment of AI technologies into clinical practice.


Author(s):  
A. V. Gusev ◽  
R. E. Novitskiy ◽  
A. A. Ivshin ◽  
A. A. Alekseev

Objective: to review domestic and foreign literature on the issue of machine learning methods applied in medical information systems (MIS), to analyze the accuracy and efficiency of the technologies under study, their advantages and disadvantages, the possibilities of implementation in clinical practice.Material and methods. The literature search was performed in the PubMed/MEDLINE databases covering the period from 2000 to 2020 (using groups of keyphrases: "machine learning", "laboratory data", "clinical events", "prediction diseases"), CyberLeninka ("machine learning", "laboratory data", "clinical events", "prediction diseases" Russian keyphrases combinations) and Papers With Code ("clinical events", "prediction diseases", "electronic health record"). After reviewing the full text of 30 literature sources that met the selection criteria, the 19 most relevant articles were selected.Results. An analysis of sources that describe the application of artificial intelligence techniques to obtain predictive analytics, taking into account information about patients, such as demographic, anamnestic, and laboratory data, the data of instrumental studies, information about existing and former diseases available in MIS, was performed. The existing ways of predicting adverse medical outcomes using machine learning methods were considered. Information about the significance of the used laboratory data for constructing high-precision predictive mathematical models is presented.Conclusion. Implementation of machine learning algorithms in MIS seems to be a promising tool for effective prediction of adverse medical events for wide application in real clinical practice. It corresponds to the global trend in the development of personalized medicine based on the calculation of individual risk. There is an increase in the activity of research in the field of predicting noncommunicable diseases using artificial intelligence technologies.


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