scholarly journals Akurasi Diagnostik Prokalsitonin Sebagai Penanda Serologis Untuk Membedakan Antara Sepsis Bakterial dan Sepsis Virus

2017 ◽  
Vol 9 (3) ◽  
pp. 157
Author(s):  
Syafri Kamsul Arif ◽  
A. Muh. Farid Wahyuddin ◽  
A. Muh Takdir Musba
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Area Under The Curve ◽  
Chi Square ◽  
Cross Sectional ◽  
Roc Area ◽  
Receiver Operating

Prokalsitonin merupakan penandadiagnostik yang baik pada sepsis khususnya sepsis yang disebabkan oleh bakteri. Penelitian ini bertujuan mengetahui sensitivitas, spesifisitas dan akurasi diagnostik prokalsitonin sebagai penandaserologis untuk membedakan antara sepsis bakterial dan virus pada pasien yang dirawat di Intensive Care Unit  (ICU) dan Infection Center (IC) RSUP Dr. Wahidin Sudirohusodo.Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional menggunakan data sekunder rekam medik pasien sepsis yang dirawat di ICU dan IC RSUP Dr. Wahidin Sudirohusodo, periode 1 Januari 2014 sampai dengan 31 Agustus 2016. Data tersebut dianalisa dengan uji T Independent,  Mann Whitney and Chi-Square dimana terdapat 80 sampel yang memenuhi kriteria inklusi.Dari penelitian ini, terdapat perbedaan yang signifikan dari kadarprokalsitonin antara sepsis bacterial(60.89 ± 73.651 ng/ml) dan sepsis virus (1.12 ± 0.622 ng/ml). Berdasarkan analisis Receiver Operating Characteristic (ROC), area Under the Curve (AUC) dari prokalsitonin adalah 0.841 dengan interval 0.758–0.925 dan signifikansi 95%. Kadar ambang diagnostik terbaik prokalsitonin yang didapatkan pada penelitian ini adalah 1.60 sebagai cut off point (sensitivitas: 82,4%, spesifisitas: 65,2% dan akurasi: 88,7%) untuk membedakan sepsis bakterial dengan sepsis virus. Prokalsitonin memiliki sensitivitas, spesifisitas dan akurasi diagnostik yang baik sebagai pembeda anatar seosis bakterial dan sepsis virus.

scholarly journals MicroRNAs-1299, -126-3p and -30e-3p as Potential Diagnostic Biomarkers for Prediabetes

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 949
Author(s):  
Cecil J. Weale ◽  
Don M. Matshazi ◽  
Saarah F. G. Davids ◽  
Shanel Raghubeer ◽  
Rajiv T. Erasmus ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Predictive Ability ◽  
Roc Curves ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Oral Glucose ◽  
Cross Sectional ◽  
Receiver Operating

This cross-sectional study investigated the association of miR-1299, -126-3p and -30e-3p with and their diagnostic capability for dysglycaemia in 1273 (men, n = 345) South Africans, aged >20 years. Glycaemic status was assessed by oral glucose tolerance test (OGTT). Whole blood microRNA (miRNA) expressions were assessed using TaqMan-based reverse transcription quantitative-PCR (RT-qPCR). Receiver operating characteristic (ROC) curves assessed the ability of each miRNA to discriminate dysglycaemia, while multivariable logistic regression analyses linked expression with dysglycaemia. In all, 207 (16.2%) and 94 (7.4%) participants had prediabetes and type 2 diabetes mellitus (T2DM), respectively. All three miRNAs were significantly highly expressed in individuals with prediabetes compared to normotolerant patients, p < 0.001. miR-30e-3p and miR-126-3p were also significantly more expressed in T2DM versus normotolerant patients, p < 0.001. In multivariable logistic regressions, the three miRNAs were consistently and continuously associated with prediabetes, while only miR-126-3p was associated with T2DM. The ROC analysis indicated all three miRNAs had a significant overall predictive ability to diagnose prediabetes, diabetes and the combination of both (dysglycaemia), with the area under the receiver operating characteristic curve (AUC) being significantly higher for miR-126-3p in prediabetes. For prediabetes diagnosis, miR-126-3p (AUC = 0.760) outperformed HbA1c (AUC = 0.695), p = 0.042. These results suggest that miR-1299, -126-3p and -30e-3p are associated with prediabetes, and measuring miR-126-3p could potentially contribute to diabetes risk screening strategies.

scholarly journals Identification of an optimal prolactin threshold to determine prolactinoma size using receiver operating characteristic analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bianca M. Leca ◽  
Maria Mytilinaiou ◽  
Marina Tsoli ◽  
Andreea Epure ◽  
Simon J. B. Aylwin ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Tumour Size ◽  
Area Under The Curve ◽  
Serum Prolactin ◽  
Pituitary Neoplasms ◽  
Characteristic Analysis ◽  
Roc Curve Analysis ◽  
Baseline Serum ◽  
Receiver Operating

AbstractProlactinomas represent the most common type of secretory pituitary neoplasms, with a therapeutic management that varies considerably based on tumour size and degree of hyperprolactinemia. The aim of the current study was to evaluate the relationship between serum prolactin (PRL) concentrations and prolactinoma size, and to determine a cut-off PRL value that could differentiate micro- from macro-prolactinomas. A retrospective cohort study of 114 patients diagnosed with prolactinomas between 2007 and 2017 was conducted. All patients underwent gadolinium enhanced pituitary MRI and receiver operating characteristic (ROC) analyses were performed. 51.8% of patients in this study were men, with a mean age at the time of diagnosis of 42.32 ± 15.04 years. 48.2% of the total cohort were found to have microadenomas. Baseline serum PRL concentrations were strongly correlated to tumour dimension (r = 0.750, p = 0.001). When performing the ROC curve analysis, the area under the curve was 0.976, indicating an excellent accuracy of the diagnostic method. For a value of 204 μg/L (4338 mU/L), sensitivity and specificity were calculated at 0.932 and 0.891, respectively. When a cut off value of 204 μg/L (4338 mU/L) was used, specificity was 93.2%, and sensitivity 89.1%, acceptable to reliably differentiate between micro- and macro- adenomas.

Risikoabschätzung einer akuten Exazerbation bei COPD-Patienten im Rahmen einer pneumologischen Anschluss-Rehabilitation anhand der Prävalenz und Schwergradausprägung von Komorbiditäten

Pneumologie ◽  
2021 ◽  
Author(s):  
P. Luu ◽  
S. Tulka ◽  
S. Knippschild ◽  
W. Windisch ◽  
M. Spielmanns
Keyword(s):  
Receiver Operating Characteristic ◽  
Charlson Comorbidity Index ◽  
Operating Characteristic ◽  
Rating Scale ◽  
Area Under The Curve ◽  
Sensitivität Und Spezifität ◽  
Comorbidity Index ◽  
Receiver Operating

Zusammenfassung Einleitung Akute COPD-Exazerbationen (AECOPD) im Rahmen einer pneumologischen Rehabilitation (PR) sind häufige und gefährliche Komplikationen. Neben Einschränkungen der Lebensqualität führen sie zu einem Unterbrechung der PR und gefährden den PR-Erfolg. Eine Abhängigkeit zwischen dem Krankheitsstatus und einem erhöhten Risiko für eine AECOPD ist beschrieben. Dabei stellt sich die Frage, ob der Charlson Comorbidity Index (CCI) oder die Cumulative Illness Rating Scale (CIRS) dafür geeignet sind, besonders exazerbationsgefährdete COPD-Patienten in der PR im Vorfeld zu detektieren. Patienten und Methoden In einer retrospektiven Untersuchung wurden die Daten von COPD-Patienten, welche im Jahr 2018 eine PR erhielten, analysiert. Primärer Endpunkt der Untersuchung war die Punktzahl im CCI. Alle Daten wurden dem Klinikinformationssystem Phönix entnommen und COPD-Exazerbationen erfasst. Die laut Fallzahlplanung benötigten 44 Patienten wurden zufällig (mittels Zufallsliste für jede Gruppe) aus diesem Datenpool rekrutiert: 22 Patienten mit und 22 ohne Exazerbation während der PR. CCI und CIRS wurden für die eingeschlossenen Fälle für beide Gruppen bestimmt. Die Auswertung des primären Endpunktes (CCI) erfolgte durch den Gruppenvergleich der arithmetischen Mittel und der Signifikanzprüfung (Welch-Tests). Weitere statistische Lage- und Streuungsmaße wurden ergänzt (Median, Quartile, Standardabweichung).Zusätzlich wurde mittels Receiver Operating Characteristic (ROC)-Analyse sowohl für den CCI als auch für den CIRS ein optimaler Cutpoint zur Diskriminierung in AECOPD- und Nicht-AECOPD-Patienten gesucht. Ergebnisse 244 COPD-Patienten erhielten eine stationäre PR von durchschnittlich 21 Tagen, wovon 59 (24 %) während der PR eine behandlungspflichtige AECOPD erlitten. Die ausgewählten 22 Patienten mit einer AECOPD hatten einen mittleren CCI von 6,77 (SD: 1,97) und die 22 Patienten ohne AECOPD von 4,32 (SD: 1,17). Die Differenz von –2,45 war zu einem Signifikanzniveau von 5 % statistisch signifikant (p < 0,001; 95 %-KI: [–3,45 ; –1,46]). Die ROC-Analyse zeigte einen optimalen Cutpoint für den CCI bei 6 mit einer Sensitivität zur Feststellung einer AECOPD von 81,8 % und einer Spezifität von 86.,4 % mit einem Wert der AUC (area under the curve) von 0,87. Der optimale Cutpoint für den CIRS war 19 mit einer Sensitivität von 50 %, einer Spezifität von 77,2 % und einer AUC von 0,65. Schlussfolgerung COPD-Patienten mit einer akuten Exazerbation während der pneumologischen Rehabilitation haben einen höheren CCI. Mithilfe des CCI lässt sich mit einer hohen Sensitivität und Spezifität das Risiko einer AECOPD von COPD-Patienten im Rahmen eines stationären PR-Programms einschätzen.

scholarly journals Comparison between near miss criteria in a maternal intensive care unit

2018 ◽  
Vol 52 (0) ◽  
Author(s):  
Alana Santos Monte ◽  
Liana Mara Rocha Teles ◽  
Mônica Oliveira Batista Oriá ◽  
Francisco Herlânio Costa Carvalho ◽  
Helen Brown ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Maternal Death ◽  
High Sensitivity ◽  
High Specificity ◽  
Near Miss ◽  
World Health ◽  
Maternal Near Miss ◽  
Chi Square ◽  
Cross Sectional

ABSTRACT Objective: The aim of this study was to compare the incidence of different criteria of maternal near miss in women admitted to an obstetric intensive care unit and their sensitivity and specificity in identifying cases that have evolved to morbidity. Method: A cross-sectional analytical epidemiological study was conducted with women admitted to the intensive care unit of the Maternity School Assis Chateaubriand in Ceará, Brazil. The Chi-square test and odds ratio were used. Results: 560 records were analyzed. The incidence of maternal near miss ranged from 20.7 in the Waterstone criteria to 12.4 in the Geller criteria. The maternal near-miss mortality ratio varied from 4.6:1 to 7.1:1, showing better index in the Waterstone criteria, which encompasses a greater spectrum of severity. The Geller and Mantel criteria, however, presented high sensitivity and low specificity. Except for the Waterstone criteria, there was an association between the three other criteria and maternal death. Conclusion: The high specificity of Geller and Mantel criteria in identifying maternal near miss considering the World Health Organization criteria as a gold standard and a lack of association between the criteria of Waterstone with maternal death.

Considerations on the region of interest in the ROC space

2021 ◽  
pp. 096228022110605
Author(s):  
Luigi Lavazza ◽  
Sandro Morasca
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
False Positive Rate ◽  
Area Under The Curve ◽  
Region Of Interest ◽  
True Positive Rate ◽  
True Positive ◽  
Receiver Operating Characteristic Curves ◽  
Positive Rate ◽  
Receiver Operating

Receiver Operating Characteristic curves have been widely used to represent the performance of diagnostic tests. The corresponding area under the curve, widely used to evaluate their performance quantitatively, has been criticized in several respects. Several proposals have been introduced to improve area under the curve by taking into account only specific regions of the Receiver Operating Characteristic space, that is, the plane to which Receiver Operating Characteristic curves belong. For instance, a region of interest can be delimited by setting specific thresholds for the true positive rate or the false positive rate. Different ways of setting the borders of the region of interest may result in completely different, even opposing, evaluations. In this paper, we present a method to define a region of interest in a rigorous and objective way, and compute a partial area under the curve that can be used to evaluate the performance of diagnostic tests. The method was originally conceived in the Software Engineering domain to evaluate the performance of methods that estimate the defectiveness of software modules. We compare this method with previous proposals. Our method allows the definition of regions of interest by setting acceptability thresholds on any kind of performance metric, and not just false positive rate and true positive rate: for instance, the region of interest can be determined by imposing that [Formula: see text] (also known as the Matthews Correlation Coefficient) is above a given threshold. We also show how to delimit the region of interest corresponding to acceptable costs, whenever the individual cost of false positives and false negatives is known. Finally, we demonstrate the effectiveness of the method by applying it to the Wisconsin Breast Cancer Data. We provide Python and R packages supporting the presented method.

scholarly journals miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery

2019 ◽  
Vol 34 (3) ◽  
pp. 302-308 ◽  
Author(s):  
Xiqi Peng ◽  
Xiang Pan ◽  
Kaihao Liu ◽  
Chunduo Zhang ◽  
Liwen Zhao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Receiver Operating Characteristic ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
The Cancer Genome Atlas ◽  
Receiver Operating

Background: miR-142-3p has proved to be involved in tumorigenesis and the development of renal cell carcinoma. The present study aimed to explore the prognostic value of miR-142-3p. Methods: Total RNA was extracted from renal cell carcinoma specimens and the expression level of miR-142-3p was measured. Pearson Chi-square test, Kaplan–Meier analysis, as well as univariate and multivariate regression analysis were performed to determine the correlation between miR-142-3p and the prognosis of renal cell carcinoma patients. Receiver operating characteristic curves were constructed to evaluate the predictive efficiency of miR-142-3p for the prognosis of renal cell carcinoma patients. Data from The Cancer Genome Atlas (TCGA) were utilized to validate our findings. Results: Our results demonstrated that upregulation of miR-142-3p was correlated with shorter overall survival (P=0.002) and was, in the meantime, an independent prognostic factor for renal cell carcinoma patients (P=0.002). The receiver operating characteristic curve combining miR-142-3p expression with tumor stage showed an area under the curve of 0.633 (95% confidence interval 0.563, 0.702). The result of TCGA data was consistent with our findings. Conclusions: Our results suggest miR-142-3p expression is correlated with poor prognosis of renal cell carcinoma patients and may serve as a prognostic biomarker in the future.

scholarly journals Acute Physiology and Chronic Health Evaluation (APACHE) II Pada Angka Kematian Pasien Gagal Nafas

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Bambang Suryadi ◽  
Nurul Ainul Shifa
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Chronic Health Evaluation ◽  
Apache Ii ◽  
Health Evaluation ◽  
Chi Square ◽  
Cross Sectional ◽  
Chronic Health

Pendahuluan: dalam penentuan kebutuhan dan prognosis kematian pasien diperlukan skoring kematian di Intensive care unit (ICU). Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan skoring Acute Physiology And Chronic Health Evaluation (APACHE II) terhadap angka kematian pada pasien gagal nafas di Ruang ICU Rumah Sakit PMI Bogor Tahun 2019. Metode: rancangan dalam penelitian ini adalah cross sectional. Jumlah sampel yaitu 56 pasien gagal nafas. Intrumen menggunakan lembar cheklist apache dan uji statistik menggunakan uji Chi Square. Hasil:Ada hubungan skoring APACHE II terhadap angka kematian pasien gagal nafas di Ruang ICU Rumah Sakit PMI Bogor dengan Pvalue 0,02 dan OR 4,63. Kesimpulan:Ada hubungan skoring APACHE II terhadap angka kematian pasien gagal nafas. Diharapkan perawat membuat integrasi ICU dengan perhitungan APACHE II di ruang ICU.

scholarly journals Factors Associated with the Nurse Implementation towards Eye Care among Comatose Patient in Intensive Care Unit

2019 ◽  
Author(s):  
Susy Puspasari
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Standard Procedure ◽  
Control Beliefs ◽  
Comatose Patient ◽  
Eye Care ◽  
Chi Square ◽  
Cross Sectional ◽  
Collection Data ◽  
Cross Sectional Design

Background: Comatosepatient’sexperiencesdeclineineyereflex.However,this issue receive less attention from the healthcare professional,particularly in the intensive care unit. Few studies exploring the associated factors of nurse implementation of eye care in intensive care unit. Theory of Planned Behavior (TPB) has been well-known as a framework to explore the behavior relation factors including nurse’s background, the certainty of behavior, normative, and control beliefs factors. Objectives: The purpose of this study was to analyze the factors that influence nurses in the implementation of eye care towards coma patients in intensive care rooms. Methods: This study used cross-sectional design to the nurses who working in intensive care units. The number ofsamplesusedinthisstudywastotalsampling.Atotalof104nursesworkinintensive care units participate as a sample of this study. A set questionnaire designed by the researcher was used for data collection. Data analysis was use distribution frequency, mean, SD and Chi square. Results:Half of nurse (50.96%) had a favorable background, unfavorable on normative assurance and belief factors. In the background factors resulted that nurse have favorable with a value of 50.96%. Conclusions: It is suggested that nurses who work in the hospital to use the information from this study to enhance their knowledge about eye care for comatose patient routinely and continuously. As for the intensive care unit, it is recommended to enforce algorithm, standard procedure, and particular supervision on the conduction of eye care for comatose patients.

Diagnostic value of the wideband acoustic absorbance test in middle-ear effusion

2015 ◽  
Vol 129 (11) ◽  
pp. 1078-1084 ◽  
Author(s):  
S Terzi ◽  
A Özgür ◽  
Ö Ç Erdivanli ◽  
Z Ö Coşkun ◽  
M Ogurlu ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Otitis Media ◽  
Middle Ear ◽  
Operating Characteristic ◽  
Otitis Media With Effusion ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Middle Ear Effusion ◽  
Ear Effusion ◽  
Receiver Operating

AbstractObjectives:This study aimed to investigate the diagnostic value of wideband acoustic absorbance testing in otitis media with effusion.Methods:This prospective study compared middle-ear wideband acoustic absorbance rates in three paediatric patient groups: a healthy group of 34 volunteers; 48 patients diagnosed with otitis media with effusion; and 28 patients with chronic effusion but no sign of effusion during myringotomy. The diagnostic value of absorbance testing was analysed with the receiver operating characteristic test.Results:The wideband acoustic absorbance rate was significantly lower in the otitis media with effusion group than in both the otitis media and healthy groups at the 0.375–2 kHz averaged mean absorbance (p < 0.017 and p < 0.001, respectively). Receiver operating characteristic analysis showed the highest diagnostic value for the 0.375–2 kHz averaged mean (area under the curve 0.984), followed by those at 1 and 1.5 kHz (area under the curve: 0.973 and 0.967, respectively).Conclusion:The wideband acoustic absorbance test is more accurate for detecting middle-ear effusion compared with conventional 226-Hz tympanometry. Its practicality and objectivity suggest that the wideband acoustic absorbance test may be a better alternative for diagnosing otitis media with effusion.

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