Analysis of the current state and prospects for the development of sedatives in the modern Ukrainian pharmaceutical market

Modern research has shown that cognitive impairments are directly related to behavioral disorders and psychopathological syndromes. Nootropic drugs used for pharmacotherapy of cognitive impairments demonstrate low clinical efficiency for the treatment of psychoemotional disorders. In this case, it is advisable to correct such states by prescribing sedatives that have an integrated effect on etiological factors, pathogenetic links and symptomatic manifestations of the disease. The aim of the research was to carry out a comprehensive assortment analysis of sedative drugs within the pharmaceutical market of Ukraine. Materials and methods. Studies were carried out through generally accepted statistical and marketing studies (State Register of Medicines of Ukraine, September, 2020). Our research focused on the information on the structure of the market of sedatives registered in Ukraine. Graphical and logical methods were used in the course of the study. Results. The results of the study have shown that the products manufactured in the Ukrainian pharmaceutical enterprises take 71.50 % of this segment; whereas sedatives produced in Germany – 7.50 %; in Poland – 3.56 %; in Italy, Slovenia, France – 1.50 % for each respectively; in Austria, Malta, Great Britain – 1.02 % for each respectively. The preparations of this group are represented in solid (tablets, coated tablets, capsules, granules, herbs in packs and filter bags) and liquid (tinctures, drops, liquid extracts, elixirs, syrups, oral solutions) dosage forms. Among the studied medicines, solid dosage forms predominate; their share makes 62.7 % of the assortment, and the highest percentage rate is held by tablets (45.5 %). The largest market share of liquid medicinal forms is made by tinctures, in particular 18.9 %. The lowest percentage rates are observed in such medicinal forms as liquid extracts, drops, elixirs, syrups and oral solutions (15.5 % in general). Analysis of the state of the Ukrainian pharmaceutical market of sedatives shows that synthetic drugs account for 24.55 % of the market (tablets – 92.7 %), natural (plant) medicines – 75.45 % (solid dosage forms – 89.6 %). Conclusions. Marketing studies were carried out on the modern market of sedative medicines in Ukraine. It has been established that the quantitative and qualitative diversity of the current assortment is presented by the imported drugs and domestic producers. Analysis of the state of the Ukrainian pharmaceutical market of sedatives was performed. Sedative preparations of natural (plant) origin have been found to be predominant and occupy 2/3 of the total range of sedatives registered in Ukraine as of September, 2020. Synthetic sedative drugs are mainly combined. Monodrugs of plant origin make up the majority of assorted items. Development of drugs aimed at providing complex pharmacotherapeutical correction of cognitive and psychoemotional disorders and based on such peptides as vasopressin, is one of the most significant and relevant problems in modern neurology and is of great scientific and practical value.

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Application of clay as a means of support to biomaterial with anti-inflammatory agents

MRS Proceedings ◽

10.1557/proc-1277-s6-15 ◽

2010 ◽

Vol 1277 ◽

Author(s):

M.L. Domínguez-Patiño ◽

M Chávez-Castillo ◽

A. Rodríguez-Martínez ◽

R.M. Melgoza Alemán ◽

E Jiménez-Ferrer ◽

...

Keyword(s):

Human Body ◽

Current Trend ◽

Dosage Forms ◽

Native Plant ◽

Plant Origin ◽

Solid Dosage Forms ◽

Organic Extract ◽

Solid Dosage ◽

Inflammatory Agent ◽

Anti Inflammatory

In the last fifteen years, there have been significant changes in the production of medicines, mainly in the addition of new components to the formulation of solid dosage forms. The current trend of “back to nature” to lead to a healthier life has led those who are engaged in the pharmaceutical field to develop new formulations that allow the use of natural products of plant originFor example, excipient ingredients, used as carriers for a drug's active ingredients, are now being used. These are incorporated into a drug in order to facilitate the drug's preparation, maintenance, or administration. The excipient is beneficial to the patient because it allows the drug to be easily administered and absorbed by the human body [3]There is evidence that the clays have great potential for both absorption and adsorption due to its tiny particles. In addition, it has been reported that some clays have an effective antiseptic and healing ability [5–8]In the present work, a clay called bentonite was tested as a support vehicle of an inflammatory agent derived from a Mexican native plant called Distictis buccinatoria, commonly named “Tonacaxóchitl”. Studies carried out by Rojas et al. have shown that the organic extract of this plant has important antibacterial, antifungal, cytotoxic and anti-inflammatory properties [9]

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Analysis of the range of antiprotozoal drugs for veterinary use

Veterinariya, Zootekhniya i Biotekhnologiya ◽

10.36871/vet.zoo.bio.202110007 ◽

2021 ◽

Vol 1 (10) ◽

pp. 47-54

Author(s):

Aleksandr A. Deltsov ◽

◽

Olga R. Rodkina ◽

Irina V. Kosova ◽

◽

...

Keyword(s):

Russian Federation ◽

Active Ingredient ◽

Dosage Forms ◽

The State ◽

Solid Dosage Forms ◽

Solid Dosage ◽

State Register ◽

Prevention And Treatment ◽

The Russian Federation ◽

Antiparasitic Drugs

This paper presents an analysis of the range of veterinary antiparasitic drugs registered in the territory of the Russian Federation and used for the prevention and treatment of protozoan diseases. At the time of 08/07/2021, 54 antiprotozoal drugs were entered into the State Register of Medicines for Veterinary Use. The most common active ingredient in their composition is Toltrazuril (contained in 12 TN – 22,2%). It was determined that the Russian Federation is a leader in the production and development of anti-protozoal drugs registered on its territory. It was found that most of the investigated drugs are produced in solid dosage forms (35 TN – 64,8%), effective for the treatment of coccidiosis (45 TN – 83,33%) and is used in birds (39 TN – 72,22%). The average annual registration of antiprotozoal drugs is 9% (5 drugs per year).

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PHARMACEUTICAL MARKET ASSORTMENT RESEARCH OF DRUGS FOR VAGINAL USE WITH PROBIOTIC MEDICINES DETAILING

Ukrainian Scientific Medical Youth Journal ◽

10.32345/usmyj.4(127).2021.55-67 ◽

2021 ◽

Vol 127 (4) ◽

pp. 55-67

Author(s):

Svitlana Aleinyk

Keyword(s):

Web Sites ◽

Marketing Research ◽

Storage Period ◽

Dosage Forms ◽

Pharmaceutical Market ◽

Brand Names ◽

Solid Dosage Forms ◽

Solid Dosage ◽

State Register ◽

Probiotic Activity

vaginal route delivery of drugs is an integral part of gynaecological diseases treatment including different genesis vulvovaginitis. The aim of this study it to analyze Ukrainian pharmaceutical market assortment of drugs for vaginal use with probiotic medicines determination. The marketing research was conducted with using of analysis, synthesis, comparison, generalization, content-analysis, statistical, graphical methods. The data of State register of medicines (as of June, 30, 2021), register of wholesale dispensing prices for medicines (as of June, 30, 2021), official web-sites LLC «Morion», «Pharmacy.online», «Compendium.online» were used as objects of the study. As a result, it is determined that as of June 30, 2021 142 medicines for vaginal use are registered on Ukrainian pharmaceutical market with dosage forms, active substances doses, condition for dispensing consideration, 100 brand names, 26 international nonproprietary names, 7 synonymous names. Structural ATC-classification analysis has shown that medicines for vaginal use are included in ATC-groups G «Genito urinary system and sex hormones» and D «Dermatologicals» The assortment macrocontour is formed, it demonstrates that 67,2% of drugs for vaginal use are involved in group G01A «Аntiinfectives and antiseptics, excluding combinations with corticosteroids». More than 80% of drugs for vaginal use are registered as solid dosage forms, and almost half of them as suppositories or pessaries. Almost 65% of medicines are foreign, and 3/4 of them contain only active substance, more than 50% are prescription only medicines. For 44,4% drugs for vaginal use the storage period of 3 years (36 months) is determined. Detailing analysis of medicines with probiotic activity has shown assortment deficiency (only 3 brand names are registered). The liquidity coefficients calculations for this brand manes don’t allow to characterize these drugs as economically affordable. The obtained results of this study inform about the domestic drugs for vaginal use with probiotic activity development relevance, especially in pessaries as dominant dosage form on the pharmaceutical market.

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Analysis of the Range of Medicines used in the Treatment of Skin Diseases

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i1231250 ◽

2021 ◽

pp. 29-36

Author(s):

Ibragim Khalidovich Akhtaev ◽

Elizaveta Vitalievna Romantseva ◽

Danila Vasiliev ◽

Anastasia Kulish ◽

Mata Musaevna Altemirova ◽

...

Keyword(s):

Czech Republic ◽

Skin Diseases ◽

Dosage Forms ◽

Solid Dosage Forms ◽

Customer Demand ◽

Third Place ◽

Synthetic Drugs ◽

Solid Dosage ◽

Financial Condition ◽

Pharmacy Organization

The purpose of this article is to analyze the range of medicines that are used in the treatment of skin diseases. This topic is currently relevant, since the analysis of retail sales allows you to assess the financial condition of a pharmacy organization, identify unclaimed drugs, develop measures to stimulate sales, as well as study customer demand and develop a strategy for product movement. Accordingly, conducting a study of the main indicators of the assortment of this group of drugs will make it possible to expand their representation on the shelves of pharmacies, as well as to study the demand for them from potential consumers. During the analysis, the following data were obtained. The range under study was represented in the pharmacy by 22 items. The analysis of dosage forms of medicines intended for the treatment of skin diseases showed that liquid dosage forms accounted for 22.73%; solid dosage forms - 4.55%; soft dosage forms – 59.08%; gaseous dosage forms -13.64%. When analyzing the drugs, it was revealed that the largest number in the assortment is synthetic drugs - 68.18%; the share of phytopreparations was 31.82%. Analysis of the producing countries showed that most of the drugs presented to the pharmacy by domestic producers (54,53%), in the second place drugs manufactured in India -18,17%; third place was shared by countries: Poland, Croatia, Belgium, Germany, Czech Republic, USA -4,55%. The analysis of price categories of pharmaceuticals for the treatment of skin diseases revealed that in the price category from 100 to 200 RUB presents 22,73% of drugs; in the category from 200 to 300 rubles-49,89%; from 300 to 400 rubles from 33.73%; from 400 to 700 rubles - on 4,55%.

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ANALYSIS OF PHARMACEUTICAL WORKERS RECOMMENDATIONS FOR WOUND-HEALING DRUGS IN UKRAINE

Ukrainian Scientific Medical Youth Journal ◽

10.32345/usmyj.3(125).2021.13-22 ◽

2021 ◽

Vol 125 (3) ◽

pp. 13-22

Author(s):

Arsenii Kondratskyi ◽

Olena Glushchenko ◽

Tetiana Butkevych

Keyword(s):

Wound Healing ◽

Dosage Form ◽

Dosage Forms ◽

The State ◽

Second Phase ◽

Skin Defect ◽

Solid Dosage Forms ◽

Solid Dosage ◽

Semi Solid ◽

Trade Names

The occurrence of superficial wounds remains one of the most significant problems all the time among different types of household injuries. Up to 40 % persons annually have such damages of the skin like abrasions, scratches, cracks, suppurations, cuts, bedsores, and others. The problem of choosing a suitable drug arises acutely, since most pharmacists consider the issue of treatment by themselves. Patient’s referral to hospital departments for doctors advise remains minimal. Pharmacy specialists carry out pharmaceutical care and perform a personal analysis due to the given initial information about the mechanism, place of occur, size of wound and stage of the process of wound healing. Considering previous experience in fulfilling customer needs, they select optimal remedy, determine the majority of choice and thus, may be identified as the sales leaders. As for January 2021, the range of topical drugs used for the treatment of wounds numbered 270 trade names according to the State registry of medicines of Ukraine. They included 62 types of active pharmaceutical ingredients. Antimicrobial (antiseptic), anti-inflammatory, decongestant, protective and emollient action properties are underlined in their pharmaceutical inserts. It is similar for most of the medicines that are available on the Ukrainian pharmaceutical market. After all, their effectiveness to satisfy a patient need is as different as the price point. The choice of the optimal in composition and rational in the dosage form causes certain difficulties among the available wide range of medicines. Registrated semi-solid wound-healing drugs are represented by three groups of ATC classification: D03 – drugs for wounds and ulcers, D06 – antibiotics and chemotherapeutic drugs for use in dermatology, D08 – antiseptic and disinfectant drugs (table 1). Ointments predominate among semi-solid dosage forms with range 67.3 %, creams –26.5 %, gels – 10.2 %, liniments – 6.1 %, and jellies only 2.0 % of the market. 59.2 % of semi-solid wound-healing drugs are produced by domestic enterprises, and 40.8 % – by foreign manufacturers. The recommendations for the use of semi-solid drugs were distributed as follows: for the first phase of wound process – 48.9 %, for the first and second phases – 12.2 %, for the second phase – 10.2 %, for the second and third phases – 26.4 %, for the third phase – 2.0 %. The article summarizes the results of a questionnaire of pharmaceutical specialists on the available and free sale wound-healing medicines among registered on the Ukrainian market, that are most promoted and recommended. The purpose of our work was to single out available and free sale wound-healing medicines among registered on the Ukrainian market, that are most promoted and recommended by pharmaceutical specialists. This would help to highlight the real picture of sales, to analyze the components of leading products and, as a result of additional research, to propose a model for the complex pharmaceutical development of a new wound-healing medicine in a rational dosage form with safe and effective active ingredients of plant origin, and, consequently, competitive for pharmaceutical manufacturers. The list of registered medicines was composed in accordance with the data from the State Register of Medicines of Ukraine (registrated trade names). The total number of respondents was 176. Questionnaire survey was the main method of information’s collecting: 46 respondents were interviewed individually, 130 persons of the target audience – by electronic form. Questionnaire contained the same questions for the individual survey and online one. Questionnaire contained particular situational tasks and questions related to the practical experience of the pharmaceutical specialists: 12 questions, among which 5 questions provided an answer in detail. Whole data was analyzed systematically and statistically. 342 reviews on 36 medicines trade names were received while answering the question about the drug’s recommendation for quick healing of abrasions and scratches. Various drugs promoting rapid injury healing («Bepanten®» ointment, «Levomekol» ointment, «Pantestin-Darnitsa®» gel and «Riativnyk®» cream) determined in the most mentioned requests. We found out that most pharmaceutical specialists chose semi-solid dosage forms containing dexpanthenol for light burn wounds healing («Bepanten®» cream and ointment, «D-panthenol», «Pantecream», «Pantexol-Jadran», «HepiDerm-Zdorovye»). Pharmaceutical specialists recommend «Contractubex®» and «Solcoseryl» mostly to improve wound healing and minimizing the development of a cosmetic scar. Only 1/3 of respondents would recommend to a pharmacy visitor to exam skin defect by doctor or cosmetician and get reliable advice. The recommendations of pharmaceutical specialists for shallow cuts were predominantly determined by antiseptic drugs – most of them chose iodine solutions. 264 reviews were received for 32 trade names of medicines as effective treatment for bedsores. Respondents preferred zinc oxide preparations usage. According to the investigation, the opinions of the interviewed pharmaceutical specialists were focused on the semi-solid dosage forms (ointments, creams etc) for various wound care (abrasions and scratches, burns, scars, bedsores). Dosage forms of medicines for the treatment of cut wounds were an exception. Solutions and new kind of plasters – Skin glue, were the drugs of choice in this group. Phytomedicines practically did not appear among the respondents answers.

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The analysis of the drug assortment of immunostimulants presented at the Ukrainian market

Vìsnik farmacìï ◽

10.24959/nphj.21.46 ◽

2021 ◽

pp. 66-70

Author(s):

V. Rybachuk ◽

Yu. Lyakhovchenko ◽

A. Yanko

Keyword(s):

Dosage Forms ◽

Pharmaceutical Market ◽

New Drugs ◽

Sources Of Information ◽

Solid Dosage Forms ◽

Production Characteristic ◽

Solid Dosage ◽

Natural Clays ◽

Form Type ◽

Official Sources

Aim. To analyze the registered medicines of the group of immunostimulants in order to determine the feasibility of creating and organizing the production of new drugs based on natural clays, in particular green and yellow clays.Materials and methods. The list of medicinal products compiled from official sources of information was used in the work; it was processed by the methods of generalization, systematization, graphical method, as well as the methods of comparative and structural analysis.Results and its discussion. The analysis of the Ukrainian pharmaceutical market concerning the range of the registered immunostimulants has been performed. Structuring of the selected list of medicines by the ATC-classification, origin, composition, production characteristic and dosage form type has been carried out. By production basis the majority of medicines are of domestic production (63.58 %). It has been determined that drugs of the segment studied are produced in solid and liquid dosage forms. Solutions for injection are prevalent at the domestic pharmaceutical market, and the range of solid dosage forms is under developed. At the pharmaceutical market, there are no drugs of this group with natural clays, in particular yellow and green clays.Conclusions. The absence of immunostimulants based on natural clays at the Ukrainian market has been proven; it indicates the feasibility of introducing new domestic drugs with the immunostimulating action on the basis of natural clays, in particular yellow and green clays, to the market.

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Retrospective analysis of the pharmaceutical market of cardiological drugs in Ukraine for 2016–2020

Farmatsevtychnyi zhurnal ◽

10.32352/0367-3057.3.21.02 ◽

2021 ◽

pp. 14-24

Author(s):

Н. А. Симоненко ◽

М. В. Подгайна ◽

А. С. Немченко ◽

О. С. Шпичак

Keyword(s):

Cause Of Death ◽

Anatomical Therapeutic Chemical ◽

Dosage Forms ◽

The State ◽

Pharmaceutical Market ◽

Positive Trend ◽

Wholesale Market ◽

Ministry Of Health ◽

Solid Dosage ◽

Expert Center

In Ukraine, cardiovascular disease is the leading cause of death and is the highest cause of death among all countries. Nationwide, cardiovascular disease’s mortality has increased by almost 8% over the past 29 years. The aim of the work was to analyze the domestic pharmaceutical market of cardiac drugs (code of anatomical-therapeutic chemical classification (hereinafter – ATС) – C01, and C01 E separately) for the 2016–2020 in terms of pharmacotherapeutic groups, manufacturers, dosage forms and others. The object of the study was the data of the State Expert Center of the Ministry of Health of Ukraine, the proposals of distributors received from the «Morion» platform for 2016–2020. The research was carried out using modern methods of analysis, systematization and generalization, mathematical and statistical calculations. According to the database of the State Expert Center of the Ministry of Health in Ukraine, 256 cardiac drugs by dosage forms have been registered. Analysis of the group of cardiac drugs by ATС classification, allowed to establish a significant dominance of group C01 E – Other cardiac drugs – from 66% to 68% over the years of the study. According to the results of the analysis, a positive trend has been established – the dominance of domestically produced drugs in the group of cardiac drugs in the pharmaceutical market of Ukraine during 2016–2020. The general list of manufacturers presenting cardiac drugs in Ukraine consists of 66–68 companies, where the share of domestic companies was 53–55% during the study period. There is a steady trend towards a slight predominance of solid dosage forms (54–56% during the study period). In summary, it should be noted that the analysis of the domestic wholesale market of cardiac drugs showed a significant wide of the group’s assortment, the significant dominance of the group «Other cardiac drugs» in the overall structure, showed a positive trend of domestic cardiac drugs; among dosage forms, solid and liquid dosage forms have been presented evenly.

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