Electrospun acetaminophen-loaded cellulose acetate nanofibers fabricated using an epoxy-coated spinneret

e-Polymers ◽  
2015 ◽  
Vol 15 (5) ◽  
pp. 311-315 ◽  
Author(s):  
Xia Wang ◽  
Xiao-Yan Li ◽  
Ying Li ◽  
Hua Zou ◽  
Deng Guang Yu ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Cellulose Acetate ◽  
Amorphous State ◽  
Electrospun Nanofibers ◽  
Electrospinning Technique ◽  
Stainless Steel Capillary ◽  
Dissolution Tests ◽  
Model Drug ◽  
Functional Nanofibers

AbstractThis paper reports the investigation about the usage of an epoxy (EP)-coated spinneret for the preparation of medicated electrospun nanofibers. Cellulose acetate (CA) and acetaminophen (APAP) were used as the polymeric carrier and model drug, respectively. The electrospinning was undertaken using both EP-coated spinneret and traditional stainless steel capillary as spinnerets. According to the images from scanning electron microscopy, it is obvious that the nanofibers produced using the EP-coated spinneret had a finer diameter and a narrower size distribution (450±90 nm) than nanofibers fabricated using stainless steel equivalent (660±180 nm). In vitro dissolution tests revealed that the sustained-release profiles of nanofibers from the EP-coated spinneret were superior to those of their stainless steel equivalents, although APAP existed in a similar amorphous state in both nanofibers. Because the EP-coated material can exploit the electrical forces more effectively than its steel analogue, it can enhance the electrospinning technique for producing polymeric functional nanofibers.

scholarly journals Fabrication and Evaluation of Polycaprolactone/Gelatin-Based Electrospun Nanofibers with Antibacterial Properties

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Lor Huai Chong ◽  
Mim Mim Lim ◽  
Naznin Sultana
Keyword(s):  
Drug Loading ◽  
Antibacterial Properties ◽  
Electrospun Nanofibers ◽  
Contact Angle Measurement ◽  
Angle Measurement ◽  
Electrospinning Technique ◽  
Water Contact ◽  
Nanofibrous Scaffolds ◽  
Model Drug

Nanofibrous scaffolds were fabricated through blending of a synthetic polymer, polycaprolactone (PCL), and a natural polymer, gelatin (GE), using an electrospinning technique. Processing and solution parameters were optimized to determine the suitable properties of PCL/GE-based nanofibers. Several characterizations were conducted to determine surface morphology by scanning electron microscopy (SEM), wettability using water contact angle measurement, and chemical bonding analysis using attenuated total reflectance (ATR) of PCL/GE-based nanofibers. Experimental results showed that 14% (w/v) PCL/GE with a flow rate of 0.5 mL/h and 18 kV demonstrated suitable properties. This nanofiber was then further investigated for itsin vitrodegradation, drug loading (using a model drug, tetracycline hydrochloride), and antibacterial testing (using zone inhibition method).

scholarly journals Fabrication and Characterization of Electrospun Nanofibers for the Modified Release of the Chronobiotic Hormone Melatonin

2018 ◽  
Vol 16 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Marilena Vlachou ◽  
Stefanos Kikionis ◽  
Angeliki Siamidi ◽  
Konstantina Tragou ◽  
Stefania Kapoti ◽  
...  
Keyword(s):  
Cellulose Acetate ◽  
Electrospun Nanofibers ◽  
Release Profile ◽  
Modified Release ◽  
Gelatin Capsules ◽  
Fiber Matrices ◽  
Fabrication And Characterization ◽  
Hard Gelatin Capsules

Objective: Aiming at the modified release of melatonin (MLT), electrospun-MLT loaded nanofibers, filled into hard gelatin and DRcapsTM capsules, were used as formulants. Methods: Cellulose acetate, polyvinylpyrrolidinone and hydroxypropylmethylcellusose (HPMC 2910) were used for the preparation of the fiber matrices through electrospinning. The in vitro modified release profile of MLT from the fabricated matrices in gastrointestinal-like fluids was studied. At pH 1.2, the formulations CA1, CA2, PV1, HP1, HP2 and the composite formulations CAPV1-CAPV5 in hard gelatin capsules exhibited fast MLT release. Results: In general, the same trend was observed at pH 6.8, with the exception of CAPV1 and CAPV2. These two composite formulations delivered 52.08% and 75.25% MLT, respectively at a slower pace (6 h) when encapsulated in DRcapsTM capsules. In all other cases, the release of MLT from DRcapsTM capsules filled with the MLT-loaded nanofibers reached 100% at 6h. Conclusion: These findings suggest that the MLT-loaded nanofibrous mats developed in this study exhibit a promising profile for treating sleep dysfunctions.

Hemocompatibility of Layer-by-Layer Hyaluronic Acid/Heparin Nanostructure Coating on Stainless Steel for Cardiovascular Stents and its Use for Drug Delivery

2006 ◽  
Vol 6 (9) ◽  
pp. 3163-3170 ◽  
Author(s):  
Li-Ying Huang ◽  
Ming-Chien Yang
Keyword(s):  
Drug Delivery ◽  
Stainless Steel ◽  
Hyaluronic Acid ◽  
Anticoagulant Activity ◽  
Layer By Layer ◽  
Cardiovascular Stents ◽  
Drug Eluting ◽  
Model Drug ◽  
Ss Substrates

In order to develop drug-eluting cardiovascular stents, stainless steel (SUS316L) sheets were coated with hyaluronic acid (HA) and heparin (HEP), and their in vitro characteristics and drug release pattern were investigated. The surface of stainless steel (SS) was treated with nitric acid and followed by anchoring aminotrimethoxysilane (ATMS), then a nanolayer of HA was covalently immobilized onto the surface. Heparin was then covalently bonded to the HA-immobilized SS substrate. After repeating 1 to 5 cycles, 1 to 5 layers polyelectrolyte complex (PEC) nanobrush of HA/HEP were resulted with the thickness ranging from 280 to 630 nm (measured with ellipsometry). A model drug (sirolimus) was loaded in the HA/HEP layers at a density ranging from 1.02 to 3.12 μg/cm2. The SS-ATMS-HA-HEP substrates were evidenced by X-ray photoelectron spectroscope (XPS), contact angle, and AFM measurement. The effect of this surface modification on the coagulation time of the resulting SS substrates was investigated. The results show that the multilayer HA/HEP stainless steel would exhibit higher anticoagulant activity than pure SS substrates. In addition, the results of the in vitro drug delivery study showed that release of sirolimus from the 5-layer-HA-HEP stainless steel was able to maintain more than 30 days. Thus layer-by-layer HA/HEP PEC can improve the hemocompatibility of SS surface and control the drug released rate by multiple layers of HA/HEP PEC. These results indicate that the multi-layer HA/HEP PEC coated stainless steel would be suitable for drug eluting stents.

scholarly journals Customizing the Protoscolicidal Activity by a Drug Delivery System: Application of Guar Gum in Electrospun Nanofibers

2021 ◽  
Author(s):  
Fatemeh TAVAKOLI ◽  
Reza GHASEMIKHAH ◽  
Hadi SHAFIEE
Keyword(s):  
Drug Release ◽  
Ethyl Cellulose ◽  
Reliable Method ◽  
Guar Gum ◽  
Cellulose Nanofibers ◽  
Electrospun Nanofibers ◽  
Hydatid Cysts ◽  
Electrospinning Technique ◽  
Electrospinning Method

Background: The present study aimed to control mebendazole drug release from ethyl cellulose nanofibers containing guar gum produced by Electrospinning Method (ESM) on mortality of hydatid cyst protoscoleces under laboratory conditions. Methods: The study was conducted in Arak Islamic Azad University, 2019. After preparation of ethyl cellulose nanofibers containing guar gum with concentrations 10, 250, 50 and 500 ppm with ESM, the uniformity and fineness of nanofibers were investigated by electron microscope. By determining the absorption of nanofibers during 312 h via spectrophotometry method, the amount of drug release was obtained. Then, the mortality of live protoscoleces in-vitro with nanofibers made with different concentrations was studied during 13 days. Results: Guar gum nanofiber with four concentrations of 10, 50, 250 and 500 ppm had 0.78512, 0.83729, 1.0098 and 1.0633 absorption respectively and showed drug release 42.09%, 39.95%, 33.05% and 30.96% after 312 hours. Therefore, the survival of protoscoleces in the presence of guar gum with four concentrations was zero after 3, 6, 11 and 13 days (P<0.05). Conclusion: To produce nanofibers carrying the drug for research related to the treatment of hydatid cysts, the electrospinning technique can be considered as a reliable method.

Helicid-Loaded Zein Microparticles Prepared Using Electrohydrodynamic Atomization

2012 ◽  
Vol 164 ◽  
pp. 487-491
Author(s):  
Deng Guang Yu ◽  
Xia Wang ◽  
Yao Zu Liao ◽  
Ying Li ◽  
Wei Qian ◽  
...  
Keyword(s):  
Drug Release ◽  
Amorphous State ◽  
In Vitro Dissolution ◽  
Infrared Analysis ◽  
X Ray Diffraction ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Dissolution Tests ◽  
Electrohydrodynamic Atomization

An electrohydrodynamic atomization (EHDA) process was exploited to prepare helicid-loaded zein microparticles. SEM observations showed that all the particles prepared under varied voltages were round and solid with their sizes gradually decreased from 3.4 ± 1.7 to 1.1 ± 0.5 μm as the applied voltages rose from 6 to 18 kV. Wide-angle X-ray diffraction analyses demonstrated that helicid had been totally converted into an amorphous state in the zein matrix microparticles. Attenuated total reflectance Fourier transform infrared analysis disclosed that the hydrogen bonding presented between helicid and zein molecules. In vitro dissolution tests verified that the microparticles were able to provide a fine sustained drug release profile. The present study provides an easy way to develop novel biomaterials for drug delivery and for providing sustained drug release profiles.

scholarly journals Synthesis of Biocompatible and Environmentally Nanofibrous Mats Loaded with Moxifloxacin as a Model Drug for Biomedical Applications

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1029
Author(s):  
Mahmoud H. Teaima ◽  
Fatma A. Abdelnaby ◽  
Maha Fadel ◽  
Mohamed A. El-Nabarawi ◽  
Kamel R. Shoueir
Keyword(s):  
Pathogenic Bacteria ◽  
Guest Molecule ◽  
Pure Water ◽  
Electrospun Nanofibers ◽  
In Vitro Cytotoxicity ◽  
Total Antioxidant ◽  
Synthetic Routes ◽  
Model Drug ◽  
Mcf 7

Biopolymeric chitosan structure (Cs) is rationally investigated owing to its potentiality in pharmaceutical applications. The synthetic routes of biomimetic Cs-based blend electrospun nanofibers were studied. Herein, biocompatible crosslinked electrospun polyvinyl alcohol (PVA)/Cs-reduced gold nanoparticles (Cs(Rg))/β-CD (beta-cyclodextrin) in pure water were fabricated. To this end, supportive PVA as a carrier, Cs bio modifier, and gold reductant and β-CD as smoother, inclusion guest molecule, and capping agent exhibit efficient entrapment of moxifloxacin (Mox) and consequently accelerate release. Besides, PVA/Cs(Rg)/β-CD paves towards controlled drug encapsulation-release affinity, antimicrobial, and for wound dressing. Without losing the nanofiber structure, the webs prolonged stability for particle size and release content up to 96.4%. The synergistic effect of the nanoformulation PVA/Cs(Rg)/β-CD against pathogenic bacteria, fungus, and yeast, including Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger, posed clear zones up to 53 φmm. Furthermore, a certain combination of PVA/Cs (Rg)/β-CD showed a total antioxidant capacity of 311.10 ± 2.86 mg AAE/g sample. In vitro cytotoxicity assay of HePG2 and MCF-7 NF6 can eradicate 34.8 and 29.3 µg/mL against selected cells.

scholarly journals Development of a Highly Proliferated Bilayer Coating on 316L Stainless Steel Implants

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1022 ◽  
Author(s):  
Fatemeh Khosravi ◽  
Saied Nouri Khorasani ◽  
Shahla Khalili ◽  
Rasoul Esmaeely Neisiany ◽  
Erfan Rezvani Ghomi ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Cell Attachment ◽  
Electrospun Nanofibers ◽  
Water Contact ◽  
Bilayer Coating ◽  
316 L Stainless Steel ◽  
Sbf Solution ◽  
Vitro Analysis ◽  
Cell Growth And Proliferation

In this research, a bilayer coating has been applied on the surface of 316 L stainless steel (316LSS) to provide highly proliferated metallic implants for bone regeneration. The first layer was prepared using electrophoretic deposition of graphene oxide (GO), while the top layer was coated utilizing electrospinning of poly (ε-caprolactone) (PCL)/gelatin (Ge)/forsterite solutions. The morphology, porosity, wettability, biodegradability, bioactivity, cell attachment and cell viability of the prepared coatings were evaluated. The Field Emission Scanning Electron Microscopy (FESEM) results revealed the formation of uniform, continuous, and bead-free nanofibers. The Energy Dispersive X-ray (EDS) results confirmed well-distributed forsterite nanoparticles in the structure of the top coating. The porosity of the electrospun nanofibers was found to be above 70%. The water contact angle measurements indicated an improvement in the wettability of the coating by increasing the amount of nanoparticles. Furthermore, the electrospun nanofibers containing 1 and 3 wt.% of forsterite nanoparticles showed significant bioactivity after soaking in the simulated body fluid (SBF) solution for 21 days. In addition, to investigate the in vitro analysis, the MG-63 cells were cultured on the PCL/Ge/forsterite and GO-PCL/Ge/forsterite coatings. The results confirmed an excellent cell adhesion along with considerable cell growth and proliferation. It should be also noted that the existence of the forsterite nanoparticles and the GO layer substantially enhanced the cell proliferation of the coatings.

scholarly journals Formulation and Evaluation of Biphasic Gastro Floating Tablets of Nateglinide and Atenolol

2020 ◽  
Vol 11 (3) ◽  
pp. 10906-10922
Keyword(s):  
Sustained Release ◽  
Low Cost ◽  
Diffusion Mechanism ◽  
Amorphous State ◽  
Immediate Release ◽  
In Vitro Dissolution ◽  
Fixed Dose ◽  
Floating Tablets ◽  
Model Drug

The aim was to design, formulate, and evaluate bilayer gastro floating tablets of an antidiabetic agent, nateglinide (immediate-release layer), and antihypertensive agent, atenolol (sustained-release layer). The solubility of model drug nateglinide was enhanced by using cremophor RH 40 and characterized by FTIR, DSC, XRD, SEM, and in vitro dissolution. It was found that selected ingredients were compatible, and crystalline nateglinide transits to an amorphous state. The gastro-bilayer tablets were directly compressed using the optimized nateglinide (solid dispersion equivalent to 60 mg of nateglinide) immediate-release layer (IRL2) containing different percentage of F-Melt type C and crospovidone and atenolol (50 mg) sustained-release layer (SRL6) using different percentage of HPMC K15, sodium bicarbonate, and MCC. Developed tablets were evaluated and found within the acceptance range as per the guidelines. The release of nateglinide and atenolol from an optimized bilayer tablet (BLT3) was 100 % within 60 min and 12 h, respectively. The floating lag time and total floating time were 2 min and 12 h, respectively. The atenolol sustained-release followed the diffusion mechanism. The combination of nateglinide and atenolol was successfully showed a biphasic release pattern. This formulation may strengthen the fixed-dose combination therapy for diabetes and hypertension at a low cost.

scholarly journals Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

Membranes ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 802
Author(s):  
Tingbao Ning ◽  
Yangjian Zhou ◽  
Haixia Xu ◽  
Shiri Guo ◽  
Ke Wang ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Amorphous State ◽  
Electrospun Nanofibers ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Working Fluid ◽  
Coaxial Electrospinning ◽  
Poorly Water Soluble ◽  
Fast Dissolution

The dissolution of poorly water-soluble drugs has been a longstanding and important issue in pharmaceutics during the past several decades. Nanotechnologies and their products have been broadly investigated for providing novel strategies for resolving this problem. In the present study, a new orodispersible membrane (OM) comprising electrospun nanofibers is developed for the fast dissolution of diclofenac sodium (DS). A modified coaxial electrospinning was implemented for the preparation of membranes, during which an unspinnable solution of sucralose was explored as the sheath working fluid for smoothing the working processes and also adjusting the taste of membranes. SEM and TEM images demonstrated that the OMs were composed of linear nanofibers with core-sheath inner structures. XRD and ATR-FTIR results suggested that DS presented in the OMs in an amorphous state due to the fine compatibility between DS and PVP. In vitro dissolution measurements and simulated artificial tongue experiments verified that the OMs were able to release the loaded DS in a pulsatile manner. The present protocols pave the way for the fast dissolution and fast action of a series of poorly water-soluble active ingredients that are suitable for oral administration.

Preparation of Poly(vinyl alcohol)/Polyoxalate Composite Nanofibers by Electrospinning and Drug Release Profiles

2014 ◽  
Vol 894 ◽  
pp. 369-373
Author(s):  
Nutthakritta Phromviyo ◽  
Ekaphan Swatsitang ◽  
Apiwat Chompoosor
Keyword(s):  
Drug Release ◽  
Rhodamine B ◽  
Vinyl Alcohol ◽  
In Vitro Release ◽  
Control Release ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Poly Vinyl Alcohol ◽  
Electrospinning Technique

This study investigated the use of a biodegradable polyoxalate blended with poly (vinyl alcohol) nanofibers to tailor properties of nanofibers and to control release of Rhodamine B from nanofibers. Nanofibers were prepared using an electrospinning technique. The morphology and average diameter of electrospun nanofibers were investigated using scanning electron microscopy. It was found that poly (vinyl alcohol) to polyoxalate ratio had a significant effect on the size of nanofibers (~175-403 nm). An in vitro release study showed that rate of Rhodamine B release increased with increasing poly (vinyl alcohol)/polyoxalate ratios yielding rate of release in the range of 0.1980.469 mg%/min. The mechanism of rhodamine B release can be explained by a two-stage process of diffusion and degradation. The results suggested that a water-insoluble polyoxalate could govern the rate of drug release. The ability to tune the release of chemicals from nanofibers has significant implications for controlled release of drugs.

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