Association of irisin and oxidative stress with biochemical parameters in patients with metabolic syndrome

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Israa Issa Hassan ◽  
Alan Bapeer Hassan ◽  
Heevi Ameen Rajab ◽  
Farsat Saeed Saadi ◽  
Deldar Morad Abdulah ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Biochemical Parameters ◽  
Energy Homeostasis ◽  
International Diabetes Federation ◽  
The Difference ◽  
And Gender ◽  
Analysis Models ◽  
Linear Regressions ◽  
Control Study

Abstract Background Irisin, a hormone-like myokine, is suspected to have a role in metabolic syndrome (MetS) through regulating energy homeostasis and mediating physical activity. In this regard, the role of irisin and malondialdehyde (MDA) along with some other biochemical parameters in the prediction of MetS was examined in the present investigation. Materials and methods In the present case-control study, 36 subjects diagnosed with MetS according to International Diabetes Federation were considered as cases and were matched in age and gender with 31 healthy participants. The difference of biochemical indicators between cases and controls were determined whether by independent t-test or the Mann-Whitney U-test. The predictors of MetS and insulin resistance (IR) were examined through logistic and linear regressions analysis models, respectively. Results Irisin and MDA were not found to be predictors for MetS in logistic regression; p = 0.258 and p = 0.694, respectively. The IR was found to be the only direct predictor of MetS (p = 0.010). Similarly, in linear regression, irisin and MDA were not identified to be predictors for IR; p = 0.801 and p = 0.781, respectively. Conclusions The study did not show that irisin and MDA, directly and indirectly, were predictors of MetS disorder. The IR was only predictor of MetS.

Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events

2015 ◽  
Vol 113 (01) ◽  
pp. 85-96 ◽  
Author(s):  
Claudia M. Radu ◽  
Luca Spiezia ◽  
Sabrina Gavasso ◽  
Mariangela Fadin ◽  
Barry Woodhams ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Annexin V ◽  
Normal Weight ◽  
Obese Patients ◽  
Inflammatory Parameters ◽  
Circulating Microparticles ◽  
Obese Subjects ◽  
And Gender ◽  
Control Study

SummaryThe role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in overweight and obese patients with and without metabolic syndrome is still a matter of debate. In a case-control study, the presence of hypercoagulability was evaluated in overweight and obese patients by measuring MP, thrombin generation (TG) and FVIIa-AT complexes. Twenty overweight patients (body mass index [BMI] range 25–29.9 kg/m2), 20 with I degree (30–34.9 kg/m2), 20 with II degree (35–39.9 kg/m2) and 20 with III degree obesity (≥ 40 kg/m2) were enrolled and compared to 40 age and gender-matched normal weight individuals. A significant increase in median levels of all MP subtypes was observed in the three degrees of obese patients compared to controls. Overweight patients had higher levels of annexin V-MP (AMP), endothelial-derived, leukocyte-derived and TF-bearing MP than controls. Obese patients had a significantly shorter median lag time (p< 0.05), higher median peak thrombin (p< 0.01) and increased median endogenous thrombin potential [ETP] (p< 0.001) compared to controls. Overweight subjects had significantly increased ETP compared to controls (p< 0.05). Both AMP levels and ETP were found to positively correlate with BMI, waist circumference, and inflammatory parameters. No significant increase in FVIIa-AT complex was seen in cases compared to controls. We conclude that obesity is associated with overproduction of procoagulant MP and increase TG. Interestingly, hypercoagulability is found in overweight patients free of metabolic syndrome and increases with the severity of obesity. Assessment of MP and TG may be helpful in the early characterisation of the prothrombotic state in obese patients.

scholarly journals Understanding the role of oxidative stress in the incidence of metabolic syndrome and obstructive sleep apnea

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Behnam Kargar ◽  
Zahra Zamanian ◽  
Majid Bagheri Hosseinabadi ◽  
Vahid Gharibi ◽  
Mohammad Sanyar Moradi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Obstructive Sleep Apnea ◽  
Logistic Regression ◽  
Sleep Apnea ◽  
International Diabetes Federation ◽  
Binary Logistic Regression ◽  
Stress Index ◽  
Obstructive Sleep

Abstract Background Understanding the causes and risk factors of metabolic syndrome is important for promoting population health. Oxidative stress has been associated with metabolic syndrome, and also obstructive sleep apnea. These are two diseases which have common prognostic characteristics for heart disease. The aim of this study was to examine the role of oxidative stress in the concurrent presence of metabolic syndrome and obstructive sleep apnea in a working population. Methods Participants were 163 artisan bakers in Shahroud, Iran, routinely exposed to significant heat stress and other oxidative stress indicators on a daily basis as part of their work. Using a cross-sectional design, data relevant to determining metabolic syndrome status according to International Diabetes Federation criteria, and the presence of obstructive sleep apnea according to the STOP-Bang score, was collected. Analyses included hierarchical binary logistic regression to yield predictors of the two diseases. Results Hierarchical binary logistic regression showed that oxidative stress – alongside obesity, no regular exercise, and smoking – was an independent predictor of metabolic syndrome, but not obstructive sleep apnea. Participants who were obese were 28 times more likely to have metabolic syndrome (OR 28.59, 95% CI 4.91–63.02) and 44 times more likely to have obstructive sleep apnea (OR 44.48, 95% CI 4.91–403.28). Participants meeting metabolic syndrome criteria had significantly higher levels of malondialdehyde (p <  0.05) than those who did not. No difference in oxidative stress index levels were found according to obstructive sleep apnea status. Conclusions Our findings suggest that oxidative stress contributes to the onset of metabolic syndrome, and that obstructive sleep apnea is involved in oxidative stress. Whilst obesity, exercise, and smoking remain important targets for reducing the incidence of metabolic syndrome and obstructive sleep apnea, policies to control risks of prolonged exposure to oxidative stress are also relevant in occupations where such environmental conditions exist.

scholarly journals Understanding The Role Of Oxidative Stress In The Incidence Of Metabolic Syndrome And Obstructive Sleep Apnea

2021 ◽  
Author(s):  
Behnam KARGAR ◽  
Zahra ZAMANIAN ◽  
Majid Bagheri HOSSEINABADI ◽  
Vahid Gharibi ◽  
Mohammad Sanyar MORADI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Obstructive Sleep Apnea ◽  
Logistic Regression ◽  
Sleep Apnea ◽  
Prolonged Exposure ◽  
International Diabetes Federation ◽  
Stress Index ◽  
Obstructive Sleep

Abstract Background: Understanding the causes and risk factors of metabolic syndrome is important for promoting population health. Oxidative stress has been associated with metabolic syndrome, and also obstructive sleep apnea. These are two diseases which have common prognostic characteristics for heart disease. The aim of this study was to examine the role of oxidative stress in the concurrent presence of metabolic syndrome and obstructive sleep apnea in a working population. Methods: Participants were 163 artisan bakers in Shahroud, Iran, routinely exposed to oxidative stress indicators on a daily basis as part of their work. Using a cross-sectional design, data relevant to determining metabolic syndrome status according to International Diabetes Federation criteria, and the presence of obstructive sleep apnea according to the STOP-Bang score, was collected. Analyses included hierarchical binary logistic regression to yield predictors of the two diseases. Results: Logistic regression showed that oxidative stress – alongside obesity, no regular exercise, and smoking – was an independent predictor of metabolic syndrome, but not obstructive sleep apnea. Participants who were obese were 28 times more likely to have metabolic syndrome (OR 28.59, 95% CI 4.91-63.02) and 44 times more likely to have obstructive sleep apnea (OR 44.48, 95% CI 4.91-403.28). Participants meeting metabolic syndrome criteria had significantly higher levels of malondialdehyde (p < 0.05) than those who did not. No difference in oxidative stress index levels were found according to obstructive sleep apnea status. Conclusions: Our findings suggest that oxidative stress contributes to the onset of metabolic syndrome, and that obstructive sleep apnea is involved in oxidative stress. Whilst obesity, exercise, and smoking remain important targets for reducing the incidence of metabolic syndrome and obstructive sleep apnea, policies to control risks of prolonged exposure to oxidative stress are also relevant in occupations where such environmental conditions exist.

scholarly journals Fascin-1 and its role as a serological marker in prostate cancer: a prospective case–control study

2021 ◽  
pp. FSO745
Author(s):  
Octavian Sabin Tătaru ◽  
Orsolya Martha ◽  
Felice Crocetto ◽  
Biagio Barone ◽  
Septimiu Voidazan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Control Study ◽  
Sandwich Elisa ◽  
Case Control ◽  
Elisa Method ◽  
Diagnostic Role ◽  
The Difference ◽  
Blood Specimens ◽  
Control Study

Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer patients compared with patients without neoplasia. Material & methods: Clinical data and blood specimens from patients with and without prostate cancer were obtained. A quantitative sandwich ELISA method was used to determine serological values of FSCN1. Results: Although serum values of FSCN1 were dissimilar in the two cohorts of patients (6.90 vs 7.33 ng/ml), the difference was not statistically significant (p = 0.20). Serum values of FSCN1 stratified for Gleason score groups were not significantly distinguishable (p = 0.65). A negative correlation (rho = -0.331; p = 0.009) was reported between FSCN1 and age. Conclusion: Further studies are required to evaluate a possible diagnostic role of FSCN1 in prostate cancer.

scholarly journals Association between Two Resistin Gene Polymorphisms and Metabolic Syndrome in Jilin, Northeast China: A Case-Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Yingli Fu ◽  
Yaqin Yu ◽  
Yanhua Wu ◽  
Yueyue You ◽  
Yangyu Zhang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
International Diabetes Federation ◽  
Case Control ◽  
Han Chinese ◽  
Jilin Province ◽  
Han Chinese Population ◽  
Control Study

Metabolic syndrome (MetS) is a significant health care problem worldwide and is characterized by increased fasting glucose and obesity. Resistin is a protein hormone produced both by adipocytes and immunocompetent cells, including those residing in adipose tissue, and is believed to modulate glucose tolerance and insulin action. This study examined the association of resistin gene polymorphisms, rs1862513 and rs3745368, and related haplotypes with the development of metabolic syndrome in a Han Chinese population. This case-control study was performed on 3792 subjects, including 1771 MetS cases and 2021 healthy controls from the Jilin province of China. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Logistic regression analysis was used to estimate the relationship between gene polymorphism and MetS. Our results showed that there were no significant associations between MetS and the genotype distributions in four kinds of inheritance models, allele frequencies, and related haplotypes of resistin gene polymorphisms rs1862513 and rs3745368 (allpvalues > 0.05). Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China.

ASSESSMENT OF KNOWLEDGE AND AWARENESS REGARDING METABOLIC SYNDROME AND ITS COMPONENTS AMONG UNDERGRADUATE PHYSIOTHERAPY STUDENTS

2019 ◽  
pp. 17-25
Author(s):  
CHIGULAPALLI NEHA ◽  
KRISHNA VENI DV ◽  
SOUNDARYA VEMURI ◽  
SRAVYA REDDY
Keyword(s):  
Metabolic Syndrome ◽  
Healthy Lifestyle ◽  
Poor Knowledge ◽  
The Public ◽  
Hereditary Factors ◽  
Level Of Knowledge ◽  
The Difference ◽  
Physiotherapy Students ◽  
Structured Questionnaire

Objective: The objective of the study was to assess the level of knowledge and awareness about metabolic syndrome (Met S) and its components among the 1st year physiotherapy students and also the difference in the level of knowledge and awareness among male and female students. Methods: A self-administered structured questionnaire consisting of 90 questions about components of Met S was distributed among 38 students studying 1st year physiotherapy at Apollo College of Physiotherapy, Hyderabad, after obtaining a written consent from them. The data extracted were tabulated, statistically analyzed and results were obtained. Results: Physiotherapy students have good knowledge about types and causes of diabetes and poor knowledge about symptoms, biochemical process, and complications of Met S. They expressed poor knowledge to understand the link between hypertension and pregnancy. They could understand the role of hereditary factors only in diabetes but not in other components. Conclusion: Met S is a common disorder in the society; therefore, the awareness should be raised among the student population and as paramedics, it is their responsibility to communicate with the public about the risk factors and complications associated with it and counsel them to adopt a healthy lifestyle to protect themselves from the complications.

scholarly journals Association between Endothelial Nitric Oxide Synthase Polymorphisms and Risk of Metabolic Syndrome

2013 ◽  
Vol 34 (3) ◽  
pp. 187-197 ◽  
Author(s):  
Chiu-Shong Liu ◽  
Ru-Jiun Huang ◽  
Fung-Chang Sung ◽  
Cheng-Chieh Lin ◽  
Chih-Ching Yeh
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Haplotype Analysis ◽  
Variant Genotype ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Self Administered Questionnaire ◽  
Control Study

BACKGROUND: Previous studies inferring that theNOS3gene was associated with the pathogenesis of metabolic syndrome (MetS) had inconsistent findings. We investigated the role of threeNOS3polymorphisms (T-786C, intron 4b/a, and G894T) in the risk of MetS using a hospital-based case-control study.METHODS: We recruited 339 MetS cases and 783 non-MetS controls at a central Taiwanese hospital. Information on sociodemographic and lifestyle factors was obtained using a self-administered questionnaire. Genotypes ofNOS3polymorphisms were compared between cases and controls. Effects of interactions between gene polymorphisms and smoking and between gene polymorphisms and drinking on the risk of MetS were also determined.RESULTS: The T-786C TC+CC genotype was significantly associated with a decreased risk of MetS (odds ratio (OR), 0.63; 95% confidence interval (CI), 0.43–0.91), compared to the T-786C TT genotype, according to a logistic regression analysis. This beneficial effect was much greater for those who had ever smoked cigarettes (OR, 0.47; 95% CI, 0.26–0.87) or those who had not consumed alcohol (OR, 0.45; 95% CI, 0.26–0.77). In addition, the intron 4b/a variant genotype was marginally associated with a reduced risk of MetS (OR, 0.68; 95% CI, 0.47–1.00), compared to the intron 4b/a bb genotype, particularly for never alcohol consumers (OR, 0.56; 95% CI, 0.33–0.95). In the haplotype analysis, there was a 53% decrease in the MetS risk among C4bG haplotype carriers (OR, 0.47; 95% CI, 0.25–0.90), compared to those with the most common T4bG haplotype.CONCLUSIONS: Our results suggest that theNOS3T-786C and intron 4b/a polymorphisms may contribute to the risk of MetS. Further studies are needed to confirm the findings.

scholarly journals Immunohistochemical Study of VEGF in Placenta of Hypertensive Mothers

2020 ◽  
Vol 7 (9) ◽  
pp. A474-477
Author(s):  
Sharath Kumar H K ◽  
Chaitra N ◽  
Nataraju G ◽  
Bharathi M
Keyword(s):  
Case Control Study ◽  
Immunohistochemical Study ◽  
Gestational Hypertension ◽  
Immunohistochemical Expression ◽  
Vegf Mrna ◽  
Negative Results ◽  
Notable Increase ◽  
The Difference ◽  
Control Study

Background: Pregnancy is most commonly complicated by Hypertensive disorders. In India, the incidence of gestational hypertension varies from 0.5-1.8%. VEGF is a prime regulator of angiogenesis and overall maintenance of endothelial cell health. This study aims to determine the role of VEGF in placentae of Hypertensive and Normotensive pregnancies by assessing its immunohistochemical expression in Syncytiotrophoblasts.   Methods: The study was conducted in the Department of Pathology in our institute. This is a case-control study which included 50 placentae. Out of which,25 were from Normal mothers and 25 placentae from Hypertensive mothers. Immunohistochemistry for VEGF was performed on tissue section using commercially available monoclonal antibodies. The results were interpreted by evaluating Positivity and Intensity of Immunostaining.   Result: Out of 25 Hypertensive placentae, 22 showed Positivity for VEGF immunostaining. Out of 25 Normotensive placentae, 23 showed Negative results for syncytiotrophoblastic staining of VEGF. The difference in VEGF expression in syncytiotrophoblast of hypertensive and normotensive placentae was statistically significant.   Conclusion: Hypoxia acts as a potent stimulus for induction of VEGF mRNA in an attempt to normalize fetal blood flow and thus VEGF is increased. This results in the notable increase in immunohistochemical expression of VEGF in the syncytiotrophoblasts of hypertensive placenta.

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