COVID 19 vaccine in patients of hypercoagulable disorders: a clinical perspective

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Nitin Ashok John ◽  
Jyoti John ◽  
Praful Kamble ◽  
Anish Singhal ◽  
Vandana Daulatabad ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Vascular Endothelial Cell ◽  
Blood Stasis ◽  
Vascular Endothelial ◽  
The Public ◽  
Care Workers ◽  
Review Management ◽  
Rare Side Effect ◽  
To Receive

Abstract COVID 19 is an infectious disease caused by severe acute respiratory syndrome corona virus 2. Thromboembolism has been a characteristic manifestation in most of the severely ill COVID-19 patients. Thromboembolism in COVID 19 infection is attributed to injury to the vascular endothelial cell, hypercoagulability and blood stasis. The hypercoagulable state of blood and thrombophilic diseases leads to hypercoagulability. COVID 19 infected patients with pre-existing hypercoagulable disorders have higher risk of developing thrombosis and thromboembolism and such thrombotic episodes may prove to be severely morbid in these patients. As immune-prophylaxis COVID 19 vaccines are being administered to the public. The known side effects of the COVID 19 vaccine are mild to moderate and include fever, chills, nausea, vomiting, headache, fatigue, myalgia, malaise, pain and swelling at injection site and diarrhea. Thrombosis with thrombocytopenia has been noted as a rare side effect of COVID 19 vaccine. Such side effect of COVID 19 vaccine in patients of hypercoagulable disorder may prove to be fatal. The health care workers should be cautious and judicious in managing such patients. A detailed lab profile for coagulable state of blood should be carried out in all patients COVID 19 infected patients with pre-existing hypercoagulability diseases. The patients should also be health educated regarding side effects of vaccine especially with those indicating thrombosis and they should be warranted to receive immediate medical care in case of any side effects or complications. Paucity of literature gave us an impetus to review management profile in patients of hypercoagulable disorders.

scholarly journals Side effects of the metacognitive training for depression compared to a cognitive remediation training in patients with depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mona Dietrichkeit ◽  
Marion Hagemann-Goebel ◽  
Yvonne Nestoriuc ◽  
Steffen Moritz ◽  
Lena Jelinek
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Statistical Power ◽  
Controlled Trial ◽  
Treatment Options ◽  
Cognitive Remediation ◽  
Negative Effects ◽  
Metacognitive Training ◽  
To Receive

AbstractAlthough awareness of side effects over the course of psychotherapy is growing, side effects are still not always reported. The purpose of the present study was to examine side effects in a randomized controlled trial comparing Metacognitive Training for Depression (D-MCT) and a cognitive remediation training in patients with depression. 84 patients were randomized to receive either D-MCT or cognitive remediation training (MyBrainTraining) for 8 weeks. Side effects were assessed after the completion of each intervention (post) using the Short Inventory of the Assessment of Negative Effects (SIAN) and again 6 months later (follow-up) using the Negative Effects Questionnaire (NEQ). D-MCT and MyBrainTraining did not differ significantly in the number of side effects. At post assessment, 50% of the D-MCT group and 59% of the MyBrainTraining group reported at least one side effect in the SIAN. The most frequently reported side effect was disappointment in subjective benefit of study treatment. At follow-up, 52% reported at least one side effect related to MyBrainTraining, while 34% reported at least one side effect related to the D-MCT in the NEQ. The most frequently reported side effects fell into the categories of “symptoms” and “quality”. Our NEQ version was missing one item due to a technical error. Also, allegiance effects should be considered. The sample size resulted in low statistical power. The relatively tolerable number of side effects suggests D-MCT and MyBrainTraining are safe and well-received treatment options for people with depression. Future studies should also measure negative effects to corroborate our results.

Dermal Discoloration Secondary to Triamcinolone Acetonide Injection Observed in Patients with Autoimmune Disorders

2021 ◽  
Vol 111 (4) ◽  
Author(s):  
James A. Wright ◽  
Jessica A. Wenz ◽  
Gabrielle Jackson Madrigal
Keyword(s):  
Psoriatic Arthritis ◽  
Side Effects ◽  
Autoimmune Disease ◽  
Triamcinolone Acetonide ◽  
Current Literature ◽  
Side Effect ◽  
Inflammatory Conditions ◽  
Rare Side Effect ◽  
History Of ◽  
Synthetic Glucocorticoid

Triamcinolone acetonide is a synthetic glucocorticoid used to treat numerous acute and chronic inflammatory conditions. The various side effects of this drug from parenteral administration are well documented in the literature. In this study, three patients present with a rare side effect of violaceous dermal pigmentation. To the best of the authors' knowledge, this finding is rarely presented in the current literature. The purpose of this study is to provide awareness of a less-documented, delayed side effect from triamcinolone acetonide administration. Although all patients presenting in this study had a known history of autoimmune disease (eg, lupus, psoriatic arthritis) further research is needed to suggest a possible association between dermal violaceous change and the use of triamcinolone.

scholarly journals Hyperkinetic reaction to dihydrocodeine

2020 ◽  
Vol 13 (1) ◽  
pp. e233264 ◽  
Author(s):  
James David van Oppen ◽  
Neeta Patel ◽  
Aamir Tarique
Keyword(s):  
Emergency Department ◽  
Side Effects ◽  
Otitis Media ◽  
Side Effect ◽  
Theoretical Basis ◽  
Vital Signs ◽  
Suppurative Otitis Media ◽  
Rare Side Effect ◽  
Serotonin Toxicity

A young man was using dihydrocodeine analgesia for ear pain having had suppurative otitis media. He attended the emergency department with restlessness and twitching movements in his arms and legs. He had fever with otherwise normal vital signs. He had no signs of cerebellar pathology. Investigations were normal. The working diagnosis was of hyperkinetic reaction to dihydrocodeine. Symptoms resolved within 48 hours of withdrawing the drug. Serotonin toxicity is a rare side effect of dihydrocodeine. There is a theoretical basis for increased side effects when taken with cannabidiol-based substances.

A Multicentre Double Blind Trial of Fluoxetine versus Amitriptyline in the Treatment of Depressive Illness

1993 ◽  
Vol 27 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Fiona K. Judd ◽  
Kate Moore ◽  
Trevor R. Norman ◽  
Graham D. Burrows ◽  
Ramesh K. Gupta ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Serotonin Reuptake ◽  
Depressive Illness ◽  
Fixed Dose ◽  
Side Effect Profile ◽  
Double Blind Trial ◽  
Double Blind ◽  
Antidepressant Efficacy ◽  
To Receive

The antidepressant efficacy and side effect profile of a fixed dose of 20 mg/day of fluoxetine, a specific serotonin reuptake inhibitor, were compared to those of amitriptyline. Fifty-eight patients with DSM-III-R depression were randomly assigned to receive either fluoxetine or amitriptyline. Fifty-six patients (fluoxetine N = 23, amitriptyline N = 23) completed the 6 week study. Comparable antidepressant efficacy was demonstrated for the two drugs. Patients taking fluoxetine reported less side-effects than those taking amitriptyline.

scholarly journals RIFAXIMIN INDUCED HYPONATREMIA: A CASE REPORT

2016 ◽  
Vol 9 (9) ◽  
pp. 1 ◽  
Author(s):  
Shalini Upadhyay ◽  
Prabhat Agrawal ◽  
Manish Bansal ◽  
Anjalika Gupta
Keyword(s):  
Irritable Bowel Syndrome ◽  
Case Report ◽  
Clinical Practice ◽  
Side Effects ◽  
Side Effect ◽  
Aged Woman ◽  
Rare Side Effect ◽  
Middle Aged Woman ◽  
The Common ◽  
Irritable Bowel

ABSTRACTRifaximin is one of the common drugs used in clinical practice in the management of traveler’s diarrhea, irritable bowel syndrome (IBS), and hepaticencephalopathy. Hyponatremia is one of the rare side effects of this drug. We hereby present the case of a middle-aged woman who was a known caseof IBS: Diarrhea predominant who developed symptoms of hyponatremia after a short duration of rifaximin treatment, no other cause of hyponatremiawas found on evaluation, so we suspect this as a rare side effect of rifaximin therapy.Keywords: Rifaximin, Hyponatremia, Irritable bowel syndrome.

Can low-dose propranolol induce a manic syndrome? Case report of an unexpected side effect

2013 ◽  
Vol 25 (3) ◽  
pp. 184-186 ◽  
Author(s):  
Mahin Eslami Shahrbabaki ◽  
Fariborz Estilaee ◽  
Amir Eslami Shahrbabaki
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Side Effects ◽  
Panic Disorder ◽  
Side Effect ◽  
Adrenergic Receptor ◽  
Low Dose ◽  
Manic Symptoms ◽  
Rare Side Effect ◽  
Adrenergic Antagonists

ObjectivesPropranolol, the first discovered b-adrenergic receptor antagonist, has been prescribed by physicians in various fields for more than three decades. It has been applied for treating psychiatric disorders including schizophrenia, mania and anxiety disorders, as well as for controlling withdrawal symptoms or other side effects.MethodsWe describe the case of an 11-year-old boy with bipolar-I disorder comorbid with panic disorder who developed manic symptoms with a single dose of 10 mg of propranolol.Results and ConclusionAlthough depression is a better-known side effect of b-adrenergic antagonists, clinicians should take mania as a rare side effect into consideration as well.

scholarly journals Sodium Polystyrene Sulfonate-Induced Gastric Pneumatosis: A Rare Side Effect

2021 ◽  
pp. 878-883
Author(s):  
Neethi Dasu ◽  
Yaser Khalid ◽  
Kirti Dasu ◽  
Lucy Joo ◽  
Brian Blair
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Side Effect ◽  
Case Reports ◽  
Sodium Polystyrene Sulfonate ◽  
Polystyrene Sulfonate ◽  
Unique Case ◽  
Rare Side Effect ◽  
Colonic Necrosis ◽  
The Usa

Kayexalate has been used in the USA since 1975 for the treatment of hyperkalemia. Prior case reports have shown that sorbitol added to kayexalate has been known to cause rare side effects of colonic necrosis. We present a unique case report of gastric pneumatosis as a complication of kayexalate.

scholarly journals Levetiracetam Induced Hyperkalemia – A Rare Side Effect in Elderly with Pre-Existing Subclinical Renal Insufficiency Presenting with Bradyarrhythmia

2021 ◽  
pp. 185-190
Author(s):  
Abhishek Chande ◽  
Vidyashree Hulkoti ◽  
Shivam Khanna ◽  
Sunil Kumar
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Case Scenario ◽  
Rare Form ◽  
P Waves ◽  
Generalized Seizures ◽  
Rare Side Effect ◽  
Severe Hyperkalemia ◽  
Term Management

Levetiracetam is a commonly used drug in today’s world for long term management of partial as well as generalized seizures mainly due its major advantage that is has so few and non-threatening side effects[1].In the following case scenario, we show how a 70 years old male presented with severe hyperkalemia and after no other common culprits were seen, it was thought to be a side effect therapy with levetiracetam and after discontinuing it and managing hyperkalemia, the patient’s condition improved from a very critical state. We also show a rare form ECG presentation of severe hyperkalemia in the form of bradyarrhythmia with absent P waves. Our experience shows that unpredictable and rare side effects of new anti-epileptic drugs should be given attention and such cases often go undiagnosed.

scholarly journals Using Positive Attribute Framing to Attenuate Nocebo Side Effects: A Cybersickness Study

2021 ◽  
Author(s):  
Alanna Mao ◽  
Kirsten Barnes ◽  
Louise Sharpe ◽  
Andrew L Geers ◽  
Suzanne G Helfer ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Informed Consent ◽  
Side Effects ◽  
Healthy Volunteers ◽  
Empirical Data ◽  
Side Effect ◽  
Spatial Awareness ◽  
Nocebo Effect ◽  
Positive Attribute ◽  
To Receive

Abstract Background Side effect warnings can contribute directly to their occurrence via the nocebo effect. This creates a challenge for clinicians and researchers, because warnings are necessary for informed consent, but can cause harm. Positive framing has been proposed as a method for reducing nocebo side effects whilst maintaining the principles of informed consent, but the limited available empirical data are mixed. Purpose To test whether positive attribute framing reduces nocebo side effects relative to negative framing, general warning, and no warning. Methods Ninety-nine healthy volunteers were recruited under the guise of a study on virtual reality (VR) and spatial awareness. Participants were randomized to receive positively framed (“7 out of 10 people will not experience nausea”), negatively framed (“3 out of 10 people will experience nausea”), general (“a proportion of people will experience nausea”), or no side effect warnings prior to VR exposure. Results Receiving a side effect warning increased VR cybersickness relative to no warning overall, confirming that warnings can induce nocebo side effects. Importantly, however, positive framing reduced cybersickness relative to both negative framing and the general warning, with no difference between the latter two. Further, there was no difference in side effects between positive framing and no warning. Conclusions These findings suggest that positive framing not only reduces nocebo side effects relative to negative framing and general warnings, but actually prevents nocebo side effects from occurring at all. As such, positive attribute framing may be a cheap and ethical way to reduce nocebo side effects.

scholarly journals Abuse of The Law in Medical Cases

2015 ◽  
Vol 25 (2) ◽  
pp. 76-82
Author(s):  
Arvydas Šilys ◽  
Viktoras Justickis
Keyword(s):  
Health Care ◽  
Side Effects ◽  
Medicinal Product ◽  
Health Care Workers ◽  
Side Effect ◽  
Final Conclusion ◽  
Care Workers ◽  
Regulatory Institutions ◽  
The Law

Abuse of process-this is the “use of the law against the Law” [5]. “The letters of the law is used against its goals and spirit”[5]. Numerous legislation are adopted in order to better ensure the rights of a patient. A variety of authorities supervise it. However, the complexity of the legislative and the great number of regulatory institutions creates a lot of opportunities for abuse of the law. It is , first of all, the opportunity for a party to “play for time”, when the outcome of the case seems to be undesirable for this party it misu- ses the law to postpone the final conclusion of the court. Second, the law is abused to exhaust the opponent, to cause him to spend a great deal of money and time and this way to urge him to refuse persecuting his just aims. Third, the law can be misused to “punish” the opponent for his pursuit of the truth in the case. Most of agencies proceeding the case duplicate the same supervisory body to hear the case, neither one of which is able to take the final conclusion.The case presented in this article the typical traits of the abuse are outlined. They are, first, the obvious groundlessness of the patient‘s complaint. The patient complains of side effects of the drug. He was worned on this side effect, this drug was used only after more save ones probed to be ineffective. medicinal product in respect of which it was notified, and which has been used only where there are other inefficiency. Second, the complaint consistently pass a number of identical checks, all accessing the same conclusions. Third,a myriad of health-care workers were involved into this case distracting them from their main duties.

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