scholarly journals Progress in Research on the Mechanism and Treatment of Post-stroke Infection

2016 ◽  
Vol 5 (3) ◽  
pp. 69-74
Author(s):  
Hongtao Zhang
Keyword(s):  
Immune System ◽  
Inflammatory Responses ◽  
The Body ◽  
Main Mechanism ◽  
Inflammatory Factors ◽  
Stroke Patients ◽  
Lesion Area ◽  
Peripheral Immune System ◽  
Post Stroke ◽  
Stroke Center

AbstractPost-stroke infection hinders the recovery of stroke patients and can even cause death. The main mechanism of post-stroke infection is related with the post-stroke center, the activation of the peripheral immune system, and the release of inflammatory factors caused by the lesion area and pathophysiological changes in the body. Therefore, elucidating the body’s abnormal immune inflammatory responses after stroke is crucial for the prevention, treatment, and alleviation of post-stroke infection.

scholarly journals Topological map of the body in post-stroke patients: Lesional and hodological aspects.

2019 ◽  
Vol 33 (4) ◽  
pp. 499-507 ◽  
Author(s):  
Antonella Di Vita ◽  
Liana Palermo ◽  
Maddalena Boccia ◽  
Cecilia Guariglia
Keyword(s):  
The Body ◽  
Stroke Patients ◽  
Topological Map ◽  
Post Stroke

Abstract TP99: Human Lung Endothelial Cell Anti-Inflammatory and Regenerative Responses in Acute Ischemic Stroke

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Nikunj Satani ◽  
Kaavya Giridhar ◽  
Natalia Wewior ◽  
Dominique D Norris ◽  
Scott D Olson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Inflammatory Responses ◽  
Inflammatory Factors ◽  
Stroke Severity ◽  
Stroke Patients ◽  
Anti Inflammatory ◽  
Lung Endothelial Cells ◽  
Stroke Mimic

Background: Inflammatory responses after stroke consists of central and peripheral immune responses. The role of the spleen after stroke is well-known, however the role of the lungs has not been studied in detail. We explored the relation between stroke severity and immunomodulatory changes in lung endothelial cells. Methods: Human pulmonary endothelial cells (hPECs, Cell Biologics) were cultured at passage 3. Serum from stroke patients with NIH Stroke Scale (NIHSS) severity ranging from 0 to 20 was collected at 24 hours after stroke. hPECs were exposed to media with 1) 10% FBS alone (N=6), 2) 10% serum from stroke patients (N=72), or 3) 10% serum from stroke mimic patients (N=6). After 3 hour of exposure, fresh media was added and secretomes from hPECs were measured after 24 hours. We isolated RNA from hPECs after 3 hour of serum exposure and measured gene expression (N=6 for each group). Secretome and gene changes in hPECs were analyzed based on stroke severity, tPA treatment, and co-morbidities. Results: Serum from stroke patients reduced the secretion of IL-8, MCP-1 and Fractalkine (p<0.01), and increased the secretion of VEGF and BDNF (p<0.01) from hPECs. These effects were more pronounced depending on stroke severity (Fig). There was no effect of tPA or T2DM on hPECs secretomes. There was significantly reduced gene expression of IL-6, IL-8, MCP-1 and IL-1β and significantly higher expression of ICAM1, IGF-1 and TGF-β1 as compared to stroke mimics. Conclusion: Exposure of hPECs to serum from stroke patients alters their immunomodulatory properties. Higher severity of stroke leads to more protective response from hPECs by reducing the secretion of pro-inflammatory factors, while increasing the secretion of anti-inflammatory factors.

Abstract TP224: Interleukin-37 Level is Elevated in Acute Ischemic Stroke

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Saif Bushnaq ◽  
Atif Zafar ◽  
Kempuraj Duraisamy ◽  
Nudrat Tasneem ◽  
Mohammad M Khan ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Inflammatory Responses ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Delayed Presentation ◽  
Stroke Patients ◽  
Post Stroke ◽  
Urine And Serum ◽  
Serum And Urine

Background: Interleukin-37 (IL-37) is a new member of IL-1 cytokine family with a defined role as a negative feedback inhibitor of pro-inflammatory responses. IL-37 has yet to be evaluated in non-immune neurological diseases like ischemic or hemorrhagic stroke. This study aimed to measure the urine and serum IL-37 levels in patients with acute ischemic stroke. Method: Twelve patients consented for the study. Two sets of serum and urine samples were obtained and analyzed; one upon admission to the hospital, and the second the next morning after overnight fasting. The trends in serum level of IL-37 in 5 stroke patients, while trends in urine level of 6 patients were available, measured by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). Prior studies with healthy volunteers as control group have consistently showed IL-37 plasma level around or less than 65 pg/ml with maximum normal levels on ELISA approximated at 130 pg/ml. Results: IL-37 level in urine in stroke patients ranged from 297 - 4467. IL-37 levels were in the range of 300s to 1000s in patients with ischemic stroke compared with reported healthy controls in literature where the level was always less than 90. Three of these 10 patients presented within 3 hours of stroke onset with IL-37 serum levels being 2655 pg/ml, 3517 pg/ml and 5235 pg/ml. In all others, it ranged much less than that, with the trend of delayed presentation giving less IL-37 levels, both in urine and serum. There were no clear differences found in patients with or without tPA, diabetes, hyperlipidemia and high blood pressure in our small study. Conclusion: The study shows a rather stable elevation of IL-37 levels post-ischemic stroke, which if compared to available data from other studies, is 3-10 times elevated after acute ischemic stroke with an uptrend in the first few days. IL-37 plays some role in mediating post-stroke inflammation with significant rise in serum and urine IL-37 levels suggesting a key role of this novel cytokine in post-stroke pathology. This is the first ever reported study measuring and trending IL-37 levels in human plasma after an acute ischemic stroke.

scholarly journals Effect of BLV Infection on the Immune Function of Polymorphonuclear Neutrophil in Dairy Cows

2021 ◽  
Vol 8 ◽  
Author(s):  
Guanxin Lv ◽  
Hai Wang ◽  
Jianfa Wang ◽  
Shuai Lian ◽  
Rui Wu
Keyword(s):  
Immune System ◽  
Immune Function ◽  
Dairy Cows ◽  
Respiratory Burst ◽  
Inflammatory Responses ◽  
Late Onset ◽  
Leukemia Virus ◽  
Polymorphonuclear Neutrophil ◽  
Inflammatory Factors ◽  
Provirus Load

Enzootic bovine leukemia is a late-onset, neoplastic infection caused by the bovine leukemia virus (BLV). BLV infection hinders the function of the immune system and induces other diseases, which negatively affects the performance and health of the infected cows. As the first line of defense against invading foreign pathogenic microorganisms, polymorphonuclear neutrophil (PMN) plays a vital role in the immune system of dairy cows. However, research on the effect of BLV infection on the immune function of PMN in dairy cows is scarce. Therefore, this experiment aimed to elucidate the effects and effect mechanisms of BLV infection on the immune function of PMN in dairy cows with different BLV provirus loads by detecting the chemotaxis, migration, adhesion, phagocytosis, respiratory burst function, and the formation of NETs. The experimental results showed that BLV infection had no significant effect on the phagocytosis of PMN but inhibited their migration and respiratory burst function, and the effects were closely related to the BLV provirus load. Under high BLV provirus load, PMN produced large amounts of NETs, chemokine CXCL7, adhesion molecule CD18, and pro-inflammatory factors IL-8 and TNF-α, triggering inflammatory responses, and tissue damage. The results of this study will help reveal the reason why BLV infection causes the high incidence of mammary gland inflammation in dairy cows.

scholarly journals Oxidative Stress, Antioxidant Defenses, COVID-19 and Pollution

2020 ◽  
Vol 8 (10) ◽  
Author(s):  
Selva Rivas-Arancibia ◽  
Jennifer Balderas-Miranda ◽  
Lizbeth Belmont-Zúñiga ◽  
Martín Martínez-Jáquez ◽  
Eduardo Hernández-Orozco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Immune System ◽  
Inflammatory Response ◽  
Inflammatory Responses ◽  
The Body ◽  
Antioxidant Defenses ◽  
Cochrane Library ◽  
Antioxidant Systems ◽  
Low Levels

Patients with degenerative diseases present a chronic oxidative stress state, which puts them at a disadvantage when facing viral infections such as COVID-19. This is because there is a close relationship between redox signaling and this inflammatory response. Therefore, chronic changes in the redox balance cause alterations in the regulation of the immune system. An inflammatory response that must be reparative and self-limited loses its function and remains over time. In a chronic state of oxidative stress, there is a deficiency of antioxidants. This results in low levels of hormones, vitamins and trace elements, which are essential for the regulation of these systems. Furthermore, low levels of antioxidants imply a diminished capacity for a regulated inflammatory responses are much more vulnerable to a cytokine storm that mainly attacks the lungs, since they present a vicious circle between the null or diminished response of the antioxidant systems and the loss of regulation of the inflammatory process. Therefore, these patients are at a disadvantage in counteracting the response of defense systems to infection from SAR-COV19. A plausible option may be to restore the levels of Vitamins A, B, C, D, E and of essential trace elements such as manganese, selenium, zinc, in the body, which are key to either preventing or reducing the severity of the response of the immune system to the disease caused by SAR-CoV2. For the present review, we searched the specific sites of the Cochrane library database, PubMed and Medscape. The inclusion criteria were documents written in English or Spanish, published during the last 10 years.

scholarly journals Sarcopenic Obesity and Activities of Daily Living in Stroke Rehabilitation Patients: A Cross-Sectional Study

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 255
Author(s):  
Tatsuya Matsushita ◽  
Shinta Nishioka ◽  
Shiori Taguchi ◽  
Anna Yamanouchi ◽  
Ryusei Nakashima ◽  
...  
Keyword(s):  
Activities Of Daily Living ◽  
Daily Living ◽  
Older Patients ◽  
Functional Independence ◽  
The Body ◽  
Sarcopenic Obesity ◽  
Fat Percentage ◽  
Stroke Patients ◽  
Post Stroke ◽  
Simple Obesity

Reports investigating the relationship between sarcopenic obesity and activities of daily living in older patients with stroke were limited. This study aimed to examine the prevalence of sarcopenic obesity and its association with activities of daily living in older post-stroke patients in convalescent rehabilitation wards. This study was performed in older post-stroke patients admitted to convalescent rehabilitation wards between January 2017 and March 2019. Sarcopenia was diagnosed based on the skeletal muscle mass index and hand grip strength according to the criteria of the 2019 Asian Working Group for Sarcopenia. Obesity was diagnosed according to the body fat percentage; ≥27% in men, ≥38% in women. The primary outcome was the Functional Independence Measure (FIM) score upon admission, which was analyzed using multiple linear regression. In total, 376 participants (women 44%; mean age 77.5 years) were analyzed and classified as normal (22%), simple obesity (17%), sarcopenia without obesity (32%), and sarcopenic obesity (28%). The presence of sarcopenic obesity was independently associated with the FIM score (95% CI, −16.157 to −5.353), whereas simple obesity and sarcopenia without obesity were not. In conclusion, sarcopenic obesity was independently associated with lower activities of daily living capability in older patients with stroke.

scholarly journals Rancang bangun alat monitoring fisioterapi pasien pasca stroke menggunakan sensor MPU6050 melalui media transmisi bluetooth

JURNAL ELTEK ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 39
Author(s):  
Lis Diana Mustafa ◽  
Azam Muzakhim Imamuddin ◽  
Yoyok Heru Prasetio
Keyword(s):  
Transient Ischemic Attack ◽  
Knee Flexion ◽  
The Body ◽  
Stroke Patients ◽  
Post Stroke ◽  
Elbow Movement ◽  
Mild Stroke ◽  
Ischemic Attack ◽  
The Brain ◽  
Average Angle

Stroke Transient Ischemic Attack (TIA ) adalah kondisi stroke ringan. Stroke ringan diakibatkan oleh berkurangnya suplai darah menuju otak. Kelumpuhan disebabkan oleh kurangnya aliran darah ke otak, sehingga sisi tubuh akan mengalami kelumpuhan terutama pada siku dan lutut. Fisioterapi pada pasien pasca stroke ringan dilakukan dengan metode terapi gerakan antara lain seperti penggunaan alat bantu fisioterapi pasien pasca stroke menggunakan sensor MPU6050 melalui media transmisi Bluetooth. Sistem rancangan ini membantu latihan pada pasien berbentuk sensor MPU6050 yang digunakan untuk  mendeteksi sudut serta banyaknya gerakan rehabilitasi pasien pasca stroke. Sensor gyroscope menghasilkan deteksi sudut pada siku sebesar 150  dan sudut pada  lutut sebesar 135 . Data yang didapatkan diproses oleh arduino nano menggunakan metode I2C. Penelitian ini bertujuan untuk merancang alat bantu fisioterapi pasien pasca stroke berbasis mikrokontroler guna memperoleh hasil yang maksimal karena bentuk alat ini yang portable. Stroke Transient Ischemic Attack (TIA) is a mild stroke condition that can be caused by reduced blood supply to the brain due to blocked blood vessels. Lack of blood flow to the brain can cause paralysis, usually only on one side of the body such as the elbows and knees. Physiotherapy in post-stroke patients is carried out using movement therapy methods, including elbow and knee flexion. Currently, patients come to the therapist or vice versa to perform therapeutic movements, so a telemonitoring system for post-stroke patient physiotherapy tools is made using the MPU6050 sensor which is connected to ESP 232 and the internet network and can be monitored by therapists and clinic admins where the therapy is done. This system helps monitor elbow and knew flexion exercises using the MPU6050 sensor which is used to detect the angle and number of rehabilitation movements of post-stroke patients. . From the results of testing the accuracy of this sensor is able to detect the angle of elbow movement from 00-1500 and knee flexion angle of 00-1350 by 99%.The telemonitoring application for physiotherapy tools for post-stroke patients based on Android is equipped with a therapist menu so that the number of movements and the average angle of movement of the knees and elbows can be monitored by the therapist, this tool can also be used anywhere and anytime due to the portable form of this tool.

scholarly journals Evaluation of spatio-temporal parameters of the non-paretic limb in the gait performance of post stroke patients

2021 ◽  
Author(s):  
Rodrigo Andreola Serraglio ◽  
Ana Carolina Pauleto ◽  
Guilherme Augusto de Oliveira
Keyword(s):  
Functional Dependence ◽  
Step Length ◽  
The Body ◽  
Stroke Patients ◽  
Post Stroke ◽  
Swing Time ◽  
Paretic Limb ◽  
Spatio Temporal ◽  
High Level ◽  
Support Phase

The objective of this study is to evaluate the compensation of the non-paretic side in the gait of post-stroke hemiparetic patients submitted to computerized gait analysis in the Centro Hospitalar de Reabilitação Ana Carolina Moura Xavier, Curitiba - PR, in a study carried out in 2015. Spatio-temporal data were evaluated: speed, stride and step length, swing time and support of both members. The sample consisted of twenty individuals with a mean time after stroke of 6.9 months. The results showed that the median speed was equivalent to 16.17% of the normal standard value, stride length to 31.22%, step length of the non-paretic limb to 31.69%. The swing time on the nonparetic side corresponded to 35% of the total cycle and the support time corresponded to 86%. There is a favoring of the paretic limb over the non-paretic one, as a compensation mechanism for weakness and impaired balance. Thus, the non-paretic limb spends more time in the support phase to allow a longer step length of the paretic limb while in swing. In contrast, the paretic limb is unable to support the body in the support phase for a long time, reducing the step length of the non-paretic limb. The significant reduction in gait speed indicates the high level of functional dependence in these patients. If there is an opportunity to act early in the rehabilitation of post-stroke patients, still in the acute phase, it is possible to quantify the improvement in the ability to walk.

scholarly journals Involvement of lipids in immune system regulation: A mini-review

2021 ◽  
Vol 12 (1) ◽  
pp. 68-78
Author(s):  
Kurnia Putri Utami ◽  
Widya Wasityastuti ◽  
Marsetyawan HNE Soesatyo
Keyword(s):  
Fatty Acids ◽  
Immune System ◽  
Immune Cells ◽  
Inflammatory Responses ◽  
Nk Cell ◽  
The Body ◽  
Literature Study ◽  
Immune System Regulation ◽  
Complex Lipids ◽  
Published Research

An immune system recognizes and responds to antigens entering the body. Maintaining these roles, components of the immune system need energy obtained from nutrients such as carbohydrates, proteins, and lipids. This study reviews and discusses roles of lipids, particularly fatty acids, in regulations of the immune system. This study was conducted by conducting a literature study on published research articles written in English. The articles were obtained from PubMed and Google Scholar by using search keywords: lipid, fatty acids, immune, regulation, inflammation, and response. Lipids are a group of biomolecule compounds composed of carbon, oxygen, and hydrogen, and they are classified into simple, compound and complex lipids. Fatty acids are compound lipids that act as a main fuel for metabolism, an essential component for all membranes, and a gene regulator. Fatty acids have a modulating effect on immune cells, such as: acting as a host defence, activating the immune system, interacting with nuclear transcription factors, playing roles in inflammatory responses, promoting apoptosis, as well as influencing lymphocyte proliferation, cytokine production, and Natural Killer (NK) cell activities. However, the modulation of the immune system by lipids is influenced by various factors such as concentration and types of fatty acids, types of immune cells, and species. This study is suggested to provide an overview of beneficial roles of lipids in maintaining immunity.

scholarly journals Application Of Mirror Therapy On Upper Extremity Motor Recovery In Post-Stroke Patients

2021 ◽  
pp. 136-144
Author(s):  
Roh Hastuti Prasetyaningsih ◽  
Hendri Kurniawan
Keyword(s):  
Upper Extremity ◽  
Motor Recovery ◽  
The Body ◽  
P Value ◽  
Mirror Therapy ◽  
Research Subjects ◽  
Hand Rehabilitation ◽  
Stroke Patients ◽  
Post Stroke ◽  
Significant Difference

Background: Stroke is a health problem for both developed and developing countries, including Indonesia. Paralysis in stroke is mainly due to damage to the internal capsule. This damage requires neuroplasticity involving a number of parts of the brain to restore. One therapy that is beneficial for neuroplasticity is Mirror Therapy (MT). MT is a rehabilitation tool that aims to restore some of the pathological conditions in which the body representation is affected, including post-stroke motor impairment. Methods: This research is a quantitative pre-experimental design with the type one group pretest-postest. The research subjects were 15 post-stroke patients in residency of Semarang. Research data were collected in August-September 2020. Sample selection with  purposive sampling technique who conform inclusion criteria. The Fulg-Meyer Upper Extremity Assessment (FMA-UE) as an aoutcame measure that be avowed valid and reliabel. Data analysis using Paired Sample T-Test because of normally distributed. Results: Statistically the results represent a significant difference in the UE  motor ability of post-stroke patients between baseline and after mirror therapy intervention, with a mean difference (5,14) and p value =  0.000  (ρ < 0,05). Application  of MT effect on upper extremity motor recovery in post-stroke patients. Conclusions: MT program is an effective intervention for UE motor recovery and motor function improvement in post- stroke patients. MT program can be used as a standardized of hand rehabilitation intervention in hospital, clinics and homes.

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