New horizon in the treatment of sepsis: a systematic review of alternative medicine

2016 ◽  
Vol 13 (4) ◽  
Author(s):  
Sarah Mousavi ◽  
Alireza Ghannadi ◽  
Mohsen Meidani
Keyword(s):  
Herbal Medicine ◽  
Active Component ◽  
Web Of Science ◽  
Immune Dysfunction ◽  
Mesh Term ◽  
Inclusion Criteria ◽  
Sepsis Mortality ◽  
Human Sepsis ◽  
Natural Remedies

AbstractBackgroundDespite great advancement in treatment of sepsis, mortality of sepsis remains unacceptably high, even with the modern antibiotic and intensive care technologies. Considering the key role of immune dysfunction in sepsis pathophysiology, different treatments were evaluated, but failed to improve survival of patients. Natural remedies have been tested in various studies to overcome sepsis. In this study, we aim to review some of the evidence from clinical,MethodsThe following databases were searched up to March 2014: PubMed, Scopus, Web of Science, Ovid and Google Scholar using combination of Mesh term. AllResultsOut of 95 relevant studies, the inclusion criteria were met for 79 cases. Among them, 18 studies were performed on humans. The most herbal medicine, includingConclusionsModulation of immune system, anti-inflammatory activities and improvement of survival were the action of herbal medicine. A monovalent approach is not enough for treatment of sepsis, we recommend further studies to identify active component of herbal and use them in combination. Also an animal model of sepsis does not exactly mimic human sepsis, so more clinical studies should be performed. With no new drug on the horizon, herbal medicine will be promising for treatment of sepsis.

scholarly journals THE BEST INTERESTS OF THE CHILD: AN INTEGRATIVE REVIEW OF ENGLISH AND PORTUGUESE LITERATURES

2019 ◽  
Vol 24 ◽  
Author(s):  
Josimar Antônio de Alcântara Mendes ◽  
Thomas Ormerod
Keyword(s):  
Web Of Science ◽  
Well Being ◽  
Best Interests ◽  
Google Scholar ◽  
Emotional Needs ◽  
Inclusion Criteria ◽  
Familial Bonds ◽  
English Articles ◽  
Relational Contexts

The best interests of the child (BIC) should be of primary consideration in any situation involving children. Thus, BIC is commonly adopted as a principle, doctrine or test to weight decision-making regarding children. This study consists of an integrative literature review of English and Portuguese publications aimed at investigating how various studies address BIC definitions, characteristics and applications. The inclusion criteria were: 1) articles published between 2012 and 2017, and 2) those clearly addressing a BIC definition, characteristic and/or application. The chosen English databases were ASSIA, PsychARTICLES, PsychInfo, Scopus, Web of Science and Google Scholar; the Portuguese databases were: LILACS, PePsic, Redalyc, Periódicos CAPES and Google Scholar. The main descriptor used was ‘best interests of the child’ which led to 1488 articles being found, and 14 selected. Brazilian articles have focused on the need to protect the child’s physical and psycho-socioemotional well-being, highlighting the child as a subject of rights, and maintaining child’s familial bonds. English articles have broadened the BIC perspective, highlighting the child’s idiosyncrasies, the role of the parent’s interests, and BIC as non-individualistic, flexible and complex. Other results show that BIC is largely related to the child’s development, which is divided into ‘material-physiological’ (basic needs and surviving) and ‘contextual’ (non-material and psychosocial and emotional needs) domains. Overall, BIC is a pluralistic, complex and multi-dimensional construct that depends on the child’s relational contexts.

scholarly journals The Role of Epigenetics in Periodontal and Systemic Diseases and Smoking: A Systematic Review

2021 ◽  
Vol 11 (11) ◽  
pp. 5269
Author(s):  
Ismael Khouly ◽  
Rosalie Salus Braun ◽  
Michelle Ordway ◽  
Iya Ghassib ◽  
Lena Larsson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Web Of Science ◽  
Periodontal Diseases ◽  
Smoking Habit ◽  
Patient Characteristics ◽  
Systemic Diseases ◽  
Inclusion Criteria ◽  
Search Terms

The aims of this systematic review were to identify and synthesize the evidence for an association in DNA methylation/histone modifications between periodontal diseases and systemic diseases/smoking. Electronic database searches using relevant search terms in PubMed, Embase, MEDLINE, CINAHL, Web of Science, Scopus, and SciELO, and manual searches, were independently conducted to identify articles meeting the inclusion criteria. Nine studies of 1482 participants were included. Periodontitis was compared to metabolic disorders, rheumatoid arthritis (RA), cancer, and smokers, as well as healthy controls. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology was found. IL6 and TNF were modified similarly in RA and periodontitis. While TIMP-3 and GSTP-1 were significantly lower in periodontitis patients and controls than in cancer, SOCS-1, RMI2, CDH1, and COX2 were modified similarly in both cancer and periodontitis. While TLR4 in and CXCL8 were affected in periodontitis independent of smoking habit, smoking might change the transcription and methylation states of ECM organization-related genes, which exacerbated the periodontal condition. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal diseases and systemic diseases or smokers compared to healthy patients or non-smokers.

scholarly journals The Role of Telecardiology in Dealing with Patients with Cardiac Rhythm Disorders in Family Medicine – Systematic Review

2020 ◽  
Vol 59 (2) ◽  
pp. 108-116
Author(s):  
Staša Vodička ◽  
Husam Franjo Naji ◽  
Erika Zelko
Keyword(s):  
Web Of Science ◽  
Heart Rhythm ◽  
Cost Effective ◽  
Quality And Safety ◽  
Review Of Literature ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Heart Rhythm Disorders ◽  
Life Threatening

AbstractPurposeHeart rhythm disorders (HRD) are often present in patients visiting their family physician (FP). Dealing with their problems is not always simple, efficient and cost effective. The aim of this paper is to review the existing literature about the use and experience of telecardiology in patients experiencing HRD.MethodsWe conducted a review of literature in PubMed biographical databases (MeSH thesaurus), Web of Science and Cochrane, between 1995 and 2019. We included original articles in English that describe the use of telecardiology at primary and secondary healthcare levels. Exclusion criteria are those publications that discuss heart failure or observation of the activity of pacemakers or defibrillators and the age of patients under 18 years. A total of 19 papers met the inclusion criteria, thirteen of them were original scientific articles and we included them in the analysis.ResultsUse of telemedicine can shorten the time from diagnosis to the necessary treatment (2/13), telemedicine can reduce mortality in patients with acute myocardial infarction (4/13), it can shorten the time to diagnose atrial fibrillations (4/13), it can help determine the diagnosis for patients complaining about heart rhythm disorders which were not detected on the standard ECG recording (2/13) and can also help identify cardiac causes for syncope or collapse (2/13). All studies have confirmed that the use of telecardiology significantly reduces the number of unnecessary referrals to a cardiologist or hospitalization, and shortens the time needed to treat patients with life-threatening conditions.ConclusionThe use of telecardiological techniques increases the quality and safety of work in managing patients with cardiovascular disease in FP practice. Usage of telecardiologic devices can also save money and bridge the gap between the primary and secondary healthcare levels.

scholarly journals The role of eHealth, telehealth, and telemedicine for chronic disease patients during COVID-19 pandemic: A rapid systematic review

2021 ◽  
Vol 7 ◽  
pp. 205520762110093
Author(s):  
Hind Bitar ◽  
Sarah Alismail
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
English Language ◽  
Web Of Science ◽  
Healthcare Services ◽  
Current Status ◽  
Inclusion Criteria ◽  
Expert Opinions ◽  
Chronic Disease Patients

Objective To summarize the current status of, and the current expert opinions, recommendation and evidence associated with the use and implementation of electronic health (eHealth), telemedicine, and/or telehealth to provide healthcare services for chronic disease patients during the COVID-19 pandemic. Materials and methods We searched four electronic databases (PubMed, Google Scholar, Science Direct, and Web of Science Core Collection) to identify relevant articles published between 2019 and 2020. Searches were restricted to English language articles only. Two independent reviewers screened the titles, abstracts, and keywords for relevance. The potential eligible articles, papers with no abstract, and those that fall into the uncertain category were read in full text independently. The reviewers met and discussed which articles to include in the final review and reached a consensus. Results We identified 51 articles of which 25 articles met the inclusion criteria. All included articles indicated the promising potential of eHealth, telehealth, and/or telemedicine solutions in delivering healthcare services to patients living with chronic diseases/conditions during the COVID-19 pandemic. We synthesized the main findings into ten usages and eight recommendations concerning the different activities for delivering healthcare services remotely for those living with chronic diseases/conditions in the era of COVID-19. Discussion and conclusions There is limited evidence available about the effectiveness of such solutions. Further research is required during this pandemic to improve the credibility of evidence on telemedicine, telehealth, and/or eHealth-related outcomes for those living with chronic diseases.

Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis

2020 ◽  
Author(s):  
Shamim Mushtaq
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Web Of Science ◽  
The Body ◽  
Main Role ◽  
Hallmarks Of Cancer ◽  
Cyclin Dependent Kinases ◽  
Tumor Studies ◽  
Cycle Regulation

Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are frequently down regulated or up regulated in various cancers. Two CDK family members, CDK 11 and 12, have contradicting views about their roles in different cancers. For example, one study suggests that the CDK 11 isoforms, p58, inhibits growth of breast cancer whereas, the CDK 11 isoform, p110, is highly expressed in breast tumor. Studies regarding CDK 12 show variation of opinion towards different parts of the body, however there is a consensus that upregulation of cdk12 increases the risk of breast cancer. Hence, CDK 11 and CDK 12 need to be analyzed to confirm their mechanism and their role regarding therapeutics, prognostic value, and ethnicity in cancer. This article gives an outline on both CDKs of information known up to date from Medline, PubMed, Google Scholar and Web of Science search engines, which were explored and thirty relevant researches were finalized.

The Effects of Herbal Medicines on Women Sexual Dysfunction: A Systematic Review

2020 ◽  
Vol 17 ◽  
Author(s):  
Tahereh Molkara ◽  
Maliheh Motavasselian ◽  
Farideh Akhlaghi ◽  
Mohammad Arash Ramezani ◽  
Hamideh Naghedi Baghdar ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Herbal Medicine ◽  
Sexual Health ◽  
Sexual Function ◽  
Psychological Health ◽  
Health Management ◽  
Herbal Medicines ◽  
Physical And Psychological Health ◽  
Female Sexual Response

: Sexual health plays an important role in the women’s health and quality of life. Sexual health management is a prerequisite for physical and psychological health of women. Sexual desire, arousal, and orgasm are three factors of female sexual response. So far many different methods has been known for the treatment of female sexual dysfunction, however none of them are not an efficacious therapy. Generally, use of herbal medicine is a safe and effective therapeutic method in the treatment of women with sexual dysfunction. The role of herbal and nutritional supplementation in female sexual function has attracted researchers’ interest in recent years. This study aimed to the evaluation of the studies focusing on the herbal medicine on women sexual function and the assessment of its effectiveness.

Bryophyllum Pinnatum: A Review on Medicinal Benefits and Potent Bioactive Molecules

2020 ◽  
Vol 16 (7) ◽  
pp. 978-992
Author(s):  
Punit Kumar ◽  
Sujata Malik ◽  
Kashyap K. Dubey
Keyword(s):  
Web Of Science ◽  
Folk Medicine ◽  
Bioactive Molecules ◽  
Phytochemical Analysis ◽  
Traditional Herbal Medicine ◽  
Pharmacological Activities ◽  
Online Databases ◽  
Natural Remedies ◽  
Medicinal Properties ◽  
Bryophyllum Pinnatum

Background: Since its inception, people are using herbal extracts as natural remedies for the treatment of various diseases. Bryophyllum pinnatum, also known as the air plant, is a well-recognized herb used in folk medicine. It is native to Madagascar and further planted in tropical and subtropical areas around the world. It is known for the profusion of miniature plantlets which arise from the margins of phylloclade. Objective: The aim of this review is to provide the information regarding local and traditional uses, pharmacological activities and different phytochemicals reported from leaves extracts of Bryophyllum pinnatum. Methods: This review article contains a detailed survey of the literature about Bryophyllum pinnatum available in different online databases, such as; PubMed, Web of Science, Science Direct, Elsevier, and Google Scholar, etc. In this review, authors have focused on ethnopharmacological importance and phytochemicals present in Bryophyllum pinnatum and their structure. The structures of the phytochemical were prepared by the ChemDraw tool. Results: This plant is used as a traditional herbal medicine around the globe due to medicinal properties like; anthelmintic, immunosuppressive, hepatoprotective, antinociceptive, anti-inflammatory, antidiabetic, nephroprotective, antioxidant, antimicrobial, analgesic, anticonvulsant and antipyretic. Phytochemical analysis revealed the presence of many bioactive compounds like; alkaloids, flavonoids, triterpenes, steroids, glycosides, bufadienolides, lipids, and organic acids, etc. which are associated with different medicinal properties. Conclusion: Bryophyllum pinnatum possesses diverse pharmacological importance and remarkable medicinal properties. Investigators have reported a large number of phytochemicals exhibiting different medicinal properties and correlation of medicinal properties.

Role of Vajraka Taila in the management of Vrana

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Ranjit Singh ◽  
Upasana Priya ◽  
Mahesh Chand Purvya
Keyword(s):  
The Other ◽  
Inclusion Criteria ◽  
Extrinsic Factors ◽  
External Application ◽  
Major Aspect

In today’s busy and fast life more people are living with conditions that increase their susceptibility to traumatic wounds, due to one or the other cause; thereby taking a heavy toll of life. As per Ayurveda, these type of wounds, which are caused by extrinsic factors are known as Sadyovrana. The major aspect of the management of the traumatic wounds is prevention of the infection, speedy healing, reducing pain, discharge and less discoloration after healing. In Ayurveda, various formulations for debridement are mentioned such as Kwaatha, Kalka, Churna, Rasakriya, Varti, Taila and Ghrita depending on the Avastha of Vrana. In the present study use of Vajraka Taila for external application, has been chosen. Total 30 patients fulfilling the inclusion criteria were selected and the treatment was given for 15 days. The study showed that Vajraka Taila is very effective in Vrana.

scholarly journals Systematic Review of Alexithymia in the Population of Hemodialysis Patients

2021 ◽  
Vol 10 (13) ◽  
pp. 2862
Author(s):  
Đorđe Pojatić ◽  
Ivana Tolj ◽  
Davorin Pezerović ◽  
Dunja Degmečić
Keyword(s):  
Mental Health ◽  
Literature Review ◽  
Web Of Science ◽  
Major Effect ◽  
Hemodialysis Patients ◽  
Bibliographic Databases ◽  
Inclusion Criteria ◽  
The Matrix ◽  
Negative Effect ◽  
Bodily Sensations

Alexithymia is a construct defined as the inability to differentiate between emotional experiences and bodily sensations. According to existing knowledge, alexithymia may have a major effect on the process of treatment and the outcome of the hemodialysis disease. The objective of this literature review was to determine the significance that alexithymia has for compliance and variables of clinical and mental health in the population of hemodialysis patients. For the above purpose, bibliographic databases “MEDLINE” and “Web of Science” were searched. The matrix method was used in analysis of articles. Searching both databases resulted in 248 articles. After applying exclusion and inclusion criteria, we included results of 13 articles in the literature review. The results of the search are findings regarding the prevalence and correlation of alexithymia with variables of clinical and mental health in hemodialysis patients. Alexithymia is significantly more common in the population of hemodialysis patients, and it has a negative effect on their mental and somatic health. Alexithymia levels in hemodialysis patients are more pronounced in cases where there is a greater number of comorbidities. Alexithymia is the predictor of high mortality rate in the population of hemodialysis patients, independent of other comorbidities.

scholarly journals Impact of Vibration on the Levels of Biomarkers: A Systematic Review

2021 ◽  
pp. 030157422110195
Author(s):  
Ashish Agrawal ◽  
TM Chou
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Cochrane Collaboration ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Inclusion Criteria ◽  
Electronic Search ◽  
Proquest Dissertation

Introduction: The objective of this systematic review is to assess the effect of vibrational force on biomarkers for orthodontic tooth movement. Methods: An electronic search was conducted for relevant studies (up to December 31, 2020) on the following databases: Pubmed, Google scholar, Web of Science, Cochrane Library, Wiley Library, and ProQuest Dissertation Abstracts and Thesis database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. The 2 authors extracted the data and analyzed it. Results: Six studies fulfilled the inclusion criteria. The risks of biases were high for 4, low and some concern for other 2 studies. The biomarkers, medium, device, frequency and duration of device, as well as other data were extracted. The outcomes of the studies were found to be heterogenous. Conclusion: One study showed highly statistically significant levels of IL-1 beta with <.001. Rate of tooth movement was correlated with levels of released biomarkers under the influence of vibrational force in 3 studies, but it was found to be significant only in 1 study. It was further observed that vibration does not have any significant reduction in pain and discomfort.

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