Bryophyllum Pinnatum: A Review on Medicinal Benefits and Potent Bioactive Molecules

2020 ◽  
Vol 16 (7) ◽  
pp. 978-992
Author(s):  
Punit Kumar ◽  
Sujata Malik ◽  
Kashyap K. Dubey
Keyword(s):  
Web Of Science ◽  
Folk Medicine ◽  
Bioactive Molecules ◽  
Phytochemical Analysis ◽  
Traditional Herbal Medicine ◽  
Pharmacological Activities ◽  
Online Databases ◽  
Natural Remedies ◽  
Medicinal Properties ◽  
Bryophyllum Pinnatum

Background: Since its inception, people are using herbal extracts as natural remedies for the treatment of various diseases. Bryophyllum pinnatum, also known as the air plant, is a well-recognized herb used in folk medicine. It is native to Madagascar and further planted in tropical and subtropical areas around the world. It is known for the profusion of miniature plantlets which arise from the margins of phylloclade. Objective: The aim of this review is to provide the information regarding local and traditional uses, pharmacological activities and different phytochemicals reported from leaves extracts of Bryophyllum pinnatum. Methods: This review article contains a detailed survey of the literature about Bryophyllum pinnatum available in different online databases, such as; PubMed, Web of Science, Science Direct, Elsevier, and Google Scholar, etc. In this review, authors have focused on ethnopharmacological importance and phytochemicals present in Bryophyllum pinnatum and their structure. The structures of the phytochemical were prepared by the ChemDraw tool. Results: This plant is used as a traditional herbal medicine around the globe due to medicinal properties like; anthelmintic, immunosuppressive, hepatoprotective, antinociceptive, anti-inflammatory, antidiabetic, nephroprotective, antioxidant, antimicrobial, analgesic, anticonvulsant and antipyretic. Phytochemical analysis revealed the presence of many bioactive compounds like; alkaloids, flavonoids, triterpenes, steroids, glycosides, bufadienolides, lipids, and organic acids, etc. which are associated with different medicinal properties. Conclusion: Bryophyllum pinnatum possesses diverse pharmacological importance and remarkable medicinal properties. Investigators have reported a large number of phytochemicals exhibiting different medicinal properties and correlation of medicinal properties.

scholarly journals Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marjan Talebi ◽  
Mohsen Talebi ◽  
Tahereh Farkhondeh ◽  
Jesus Simal-Gandara ◽  
Dalia M. Kopustinskiene ◽  
...  
Keyword(s):  
Blood Cells ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Experimental Studies ◽  
Protective Effects ◽  
Pharmacological Activities ◽  
Current Review ◽  
Mesh Terms ◽  
Online Databases ◽  
Anti Cancer

AbstractChrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstract

scholarly journals Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olumide Samuel Fadahunsi ◽  
Peter Ifeoluwa Adegbola ◽  
Olubukola Sinbad Olorunnisola ◽  
Temitayo Idris Subair ◽  
David Oluwasegun Adepoju ◽  
...  
Keyword(s):  
Tropical Rainforest ◽  
Biological Activities ◽  
Folk Medicine ◽  
Sub Saharan Africa ◽  
Phytochemical Analysis ◽  
Menstrual Pain ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Intestinal Worms ◽  
Sub Saharan

Abstract Background Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae) is a tropical rainforest tree commonly found in sub-Saharan region of Africa. It is a useful and very popular plant among the locals due to the outstanding anti-diabetic activity of the seeds. Methods A comprehensive literature search on articles published on phytochemical analysis and various pharmacological activities of Hunteria umbellate was carried out using search engines such as Google Scholar, PubMed and Science Direct. Results In this review, it was deduced that H. umbellate is employed in folk medicine as an elixir for obesity, fever, leprosy sores, menstrual pain, infertility, yaws, intestinal worms, abdominal discomfort and stomach ache. Due to their durability and immunity against termites, the stems are coveted and desired as timbers in the construction of houses, while the bark has been reportedly exported to Europe for medicinal uses. Pharmacological activities such as fertility enhancing, aphrodisiac, hypoglycemic, anti-inflammatory, has been ascribed to the different morphological organs of H. umbellate. Moreover, compounds belonging to important classes of secondary metabolites with biological activities such as triterpenoids, flavonoids, tannins, alkaloids, quinic acids have been identified and characterized from the plant. Conclusion From this review, it can be inferred that, numerous and bioactive principles with known biological usefulness are present in the extracts of H. umbellate and might be responsible for the observed biological and pharmacological activities.

scholarly journals Mini-Review on Phytochemistry and Pharmacological Studies of Piper regnellii (Miq.) C.DC.

2021 ◽  
Vol 12 (2) ◽  
pp. 1791-1802
Keyword(s):  
Web Of Science ◽  
Therapeutic Potential ◽  
Folk Medicine ◽  
Modern Medicine ◽  
Convincing Evidence ◽  
Herbaceous Plant ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Treatment Of Wounds ◽  
Phytochemical Studies

Piper regnellii (Miq.) C.DC. is an herbaceous plant that can be found in tropical and subtropical regions of the world and commonly employed in folk medicine for the treatment of wounds, swellings, and skin irritations. In particular, phytochemical studies on P. regnellii have yielded essential oils, benzofuran neolignans, and phenylpropanoids, while the extracts and compounds demonstrated a broad spectrum of pharmacological activities. The present study aims to provide a review of previously published studies conducted on both the phytochemistry and pharmacological activities of P. regnellii. Accordingly, the scientific journals used for this brief literature review were obtained from various electronic sources, including Science Direct, PubMed, Google Scholar, Scopus, and Web of Science. In particular, the outcome of this review is expected to support the therapeutic potential of P. regnellii further as well as provide convincing evidence to its future clinical applications in modern medicine. Overall, this is aimed to increase the amount of data that supports the application and exploitation of new drug development.

scholarly journals Pistacia atlantica Desf. A review of its traditional uses, phytochemicals and pharmacology

2018 ◽  
Vol 11 (3) ◽  
pp. 180-186 ◽  
Author(s):  
Fatemeh Mahjoub ◽  
◽  
Kambiz Akhavan Rezayat ◽  
Mahdi Yousefi ◽  
Masoud Mohebbi ◽  
...  
Keyword(s):  
Web Of Science ◽  
18Th Century ◽  
Middle Eastern ◽  
Gastrointestinal Diseases ◽  
Review Article ◽  
New Drugs ◽  
Pharmacological Activities ◽  
Pistacia Atlantica ◽  
Stomach Diseases ◽  
Medicinal Properties

Pistacia atlantica is the main herbal medicine that has been widely used in the Middle Eastern and Mediterranean areas since ancient time. Pistacia atlantica has been used for multiple purposes like stomach diseases, renal disorders, wounds and coughs. The aim of this study is to review its botanical characterization, traditional applications, photochemistry effects and pharmacological activities. Data in this review article was gathered from credible pharmacopeias, electronic databases such as Web of Science, Science Direct, PubMed, EMBASE, Scopus, EBSCO, Google Scholar, SID and Iran Medex and textbooks of Persian medicine such as Canon of medicine (Ibn-e Sina, 980-1037 AD) and Makhzan-al-Advia (Aghili, 18th century). The keywords were searched in Persian and English books on medicinal plants and traditional medicine. The results showed that P. atlantica has many medicinal properties such as antioxidant, antidiabetic, antihyperlipidemic, along with others. It can also be effective in gastrointestinal diseases. Thus, different new drugs can be formulated based on P. atlantica for the management of various diseases.

scholarly journals Pharmacological Properties of Crocetin and Crocin (Digentiobiosyl Ester of Crocetin) from Saffron

2006 ◽  
Vol 1 (1) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Liang Xi ◽  
Zhiyu Qian
Keyword(s):  
Blood Circulation ◽  
The Body ◽  
Water Soluble ◽  
Cerebral Injury ◽  
Traditional Herbal Medicine ◽  
Pharmacological Activities ◽  
Research Attention ◽  
Water Soluble Compound ◽  
Bioactive Ingredients ◽  
Medicinal Properties

Functional plant foods and medicinal herbs provide a wide variety of natural products for new drug research and development. Crocetin and crocin (digentiobiosyl ester of crocetin) are the major bioactive ingredients of saffron which is used as a costly spice, food colorant and traditional herbal medicine. These particular carotenoids have gained much research attention for their extensive pharmacological activities. Following oral administration, crocetin is rapidly absorbed into the blood circulation and widely distributed into the extra-vascular tissues of the body, whereas the water-soluble compound crocin is hardly absorbed through the gastrointestinal tract. Crocetin and crocin have been shown to be effective in the prevention and/or treatment of several diseases such as atherosclerosis, myocardial ischemia, hemorrhagic shock, cancer and cerebral injury. The compounds exert their biological and pharmacological effects largely through their strong antioxidant activity. However, there seems to be substantial variation in the effectiveness of both phytochemicals when used in different diseases. The aim of this review is to discuss the pharmacokinetic and medicinal properties of crocetin and crocin based on related literature and our research results.

scholarly journals Phytochemical Analysis of Caesalpinia pulcherrima (L.) Sw. Leaf Extract Using GC-MS Analysis

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Saravanan P.
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Bioactive Compounds ◽  
Leaf Extract ◽  
Folk Medicine ◽  
Phytochemical Analysis ◽  
Pharmacological Activities ◽  
Malarial Infection ◽  
Ms Analysis ◽  
Soxhlet Apparatus

Most of the worlds populations residing in developing countries depend on alternative medicine and use of plant ingredients. Caesalpinia pulcherrima (Fabaceae) is used in folk medicine for the treatment of various diseases including asthma, bronchitis, cholera, diarrhea, dysentery and malarial infection. The aim of the study to identified bioactive compounds presence in the chloroform leaf extract of Caesalpinia pulcherrima (L.) Sw. using Gas Chromatography and Mass Spectrometry (GC-MS) analysis. The leaf extraction was done by Soxhlet apparatus method. The GC-MS analysis has shown the presence of thirteen compounds in the chloroform leaf extract of Caesalpinia pulcherrima (L.) Sw. The identified bioactive compounds from this plant have been known to possess pharmacological activities.

Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis

2019 ◽  
Vol 25 (6) ◽  
pp. 715-728 ◽  
Author(s):  
Hai-Yue Lan ◽  
Bin Zhao ◽  
Yu-Li Shen ◽  
Xiao-Qin Li ◽  
Su-Juan Wang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Southeast Asia ◽  
Clinical Application ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Momordica Cochinchinensis

Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. It is known as gac in Vietnam and as Red Melon in English. Gac is reputed to be extremely benificial for health and has been widely used as food and folk medicine in Southeast Asia. In China, the seed of M. cochinchinensis (Chinese name: Mu biezi) is used as traditional Chinese medicine (TCM) for the treatment of various diseases. More than 60 chemical constituents have been isolated from M. cochinchinensis. Modern pharmacological studies and clinical practice demonstrate that some chemical constituents of M. cochinchinensis possess wide pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammatory, etc. This paper reviews the phytochemistry, pharmacological activities, toxicity, and clinical application of M. cochinchinensis, aiming to bring new insights into further research and application of this ancient herb.

scholarly journals Physical activity in patients with rheumatoid arthritis - an agile lifelong behaviour: a qualitative meta-synthesis

RMD Open ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e001635
Author(s):  
Emma Swärdh ◽  
Christina Opava ◽  
Nina Brodin
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Web Of Science ◽  
Body Awareness ◽  
Main Theme ◽  
Inclusion Criteria ◽  
Online Databases ◽  
Taking Action ◽  
The Impact

BackgroundPhysical activity (PA) in rheumatoid arthritis (RA) is considered a cornerstone in the treatment. To highlight aspects involved in supporting a positive PA behaviour, it is important to understand the patients’ perceptions of the phenomenon.ObjectiveThe aim of this qualitative meta-synthesis was to explore and synthesise patient perceptions of PA in RA.MethodsA purposeful search was conducted across three online databases (PubMed, CINAHL and Web of Science). The methodological quality of the included studies was appraised, and data were extracted and analysed using an interpretive inductive thematic synthesis.ResultsFifteen studies met the inclusion criteria and were included. PA was identified as an agile lifelong behaviour, with one main theme: The disease as a persistent catalyst for or against PA illustrating how the constant presence of the disease itself underlies the entire process of a life with or without regular PA. Seven subthemes: ‘considering aggravated symptoms’, ‘acknowledging the impact on health’, ‘becoming empowered and taking action’, ‘keeping informed to increase awareness’, ‘creating body awareness’, ‘dealing with social support’ and ‘feeling satisfied with circumstances and achievements’ were interpreted as facilitators and/or challenges.ConclusionThis synthesis has identified PA as an agile lifelong behaviour in which the disease pervades all aspects of an individuals’ perception of PA. Placed in a theoretical context, our findings outline a model for tailoring PA support to the drivers and determinants of a certain individual, which will improve clinical practice for the benefit of both health professionals and patients with RA.

scholarly journals A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

2021 ◽  
Vol 22 (14) ◽  
pp. 7463
Author(s):  
Ismat Majeed ◽  
Komal Rizwan ◽  
Ambreen Ashar ◽  
Tahir Rasheed ◽  
Ryszard Amarowicz ◽  
...  
Keyword(s):  
Web Of Science ◽  
Scientific Literature ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Folk Medicine ◽  
Nutritional Values ◽  
Biological Potential ◽  
The World ◽  
The Future ◽  
Pharmacological Potential

The Mimosa genus belongs to the Fabaceae family of legumes and consists of about 400 species distributed all over the world. The growth forms of plants belonging to the Mimosa genus range from herbs to trees. Several species of this genus play important roles in folk medicine. In this review, we aimed to present the current knowledge of the ethnogeographical distribution, ethnotraditional uses, nutritional values, pharmaceutical potential, and toxicity of the genus Mimosa to facilitate the exploitation of its therapeutic potential for the treatment of human ailments. The present paper consists of a systematic overview of the scientific literature relating to the genus Mimosa published between 1931 and 2020, which was achieved by consulting various databases (Science Direct, Francis and Taylor, Scopus, Google Scholar, PubMed, SciELO, Web of Science, SciFinder, Wiley, Springer, Google, The Plant Database). More than 160 research articles were included in this review regarding the Mimosa genus. Mimosa species are nutritionally very important and several species are used as feed for different varieties of chickens. Studies regarding their biological potential have shown that species of the Mimosa genus have promising pharmacological properties, including antimicrobial, antioxidant, anticancer, antidiabetic, wound-healing, hypolipidemic, anti-inflammatory, hepatoprotective, antinociceptive, antiepileptic, neuropharmacological, toxicological, antiallergic, antihyperurisemic, larvicidal, antiparasitic, molluscicidal, antimutagenic, genotoxic, teratogenic, antispasmolytic, antiviral, and antivenom activities. The findings regarding the genus Mimosa suggest that this genus could be the future of the medicinal industry for the treatment of various diseases, although in the future more research should be carried out to explore its ethnopharmacological, toxicological, and nutritional attributes.

Diterpenes from Euphorbia myrsinites and Their Anti-inflammatory Property

Planta Medica ◽  
2021 ◽  
Author(s):  
Laura Grauso ◽  
Bruna de Falco ◽  
Giuseppe Lucariello ◽  
Raffaele Capasso ◽  
Virginia Lanzotti
Keyword(s):  
Folk Medicine ◽  
Phytochemical Analysis ◽  
Spectroscopic Techniques ◽  
Significant Activity ◽  
Relative Configuration ◽  
Drug Candidates ◽  
The Usa ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Diterpene Alcohol

Abstract Euphorbia myrsinites is one of the oldest spurges described and used in folk medicine. It is characterized by blue-grey stems similar to myrtle, and it is spread in the Mediterranean region, Asia, and the USA. Chemical analysis of E. myrsinites collected in Turkey afforded the isolation of 4 diterpenes based on the so-called myrsinane skeleton being tetraesters of the tetracyclic diterpene alcohol myrsinol. In this study, the phytochemical analysis of this species collected in Italy has been undertaken to afford the isolation of a new atisane diterpene, named myrsatisane, 3 ingenol derivatives, along with the 4 tetraester derivatives previously found. A triterpene compound based on the euphane skeleton has also been isolated. Structural elucidation of the new myrsatisane was based on spectroscopic techniques, including HR-MS and 1- and 2-dimensional NMR experiments. Its relative configuration was determined by NOE correlations, while absolute stereochemistry was obtained by quantum-mechanical DFT studies. While diterpenes with the atisane skeleton are relatively common in Euphorbia species, this is the first report of an atisane diterpene from E. myrsinites. All the isolated terpenes were tested for anti-inflammatory activity on J774A.1 macrophages stimulated with lipopolysaccharide by evaluation of nitrite and pro-inflammatory cytokine Il-1β levels. Among tested compounds, the 3 ingenol diterpenes exhibited a dose-dependent (0.001 – 3 µM) significant activity, thus showing their potential as anti-inflammatory drug candidates.

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