scholarly journals Rice bran as source of nutraceuticals for management of cardiovascular diseases, cardio-renal syndrome and hepatic cancer

2020 ◽  
Vol 9 (1) ◽  
pp. 68-74
Author(s):  
Sahar Y. Al-Okbi ◽  
Doha A. Mohamed ◽  
Thanaa E. Hamed ◽  
Enas S.K. Al-Siedy
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cardiovascular Diseases ◽  
Renal Dysfunction ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Cardiorenal Syndrome ◽  
Protective Effects ◽  
Anticancer Effects ◽  
Tnf Α ◽  
Group 5

Introduction: The interrelation between cardiovascular diseases (CVDs) and renal dysfunction and the beneficial role of nutraceuticals are worthy to be studied. Nutraceuticals with anticancer effects are gaining great importance. The aim of this research was studying the anti-cancer, CVDs prevention and renal dysfunction properties of γ-oryzanol (γ-O) and rice bran oil/γ-O mixture (RBO/γ-O) as nutraceuticals. Methods: Rats were divided into 7 groups. Group 1 was fed on balanced diet and served as normal control (NC). Group 2 consumed high-fat-sucrose diet (HFSD) as CVD control. Groups 3 and 4 were fed on HFSD and treated by γ-O and RBO/γ-O, respectively. Group 5 was maintained on HFSD with cisplatin injection (cardiorenal syndrome control) (CRSC). Groups 6 and 7 were treated like group 5 and given either γ-O or RBO/γ-O. Plasma lipid profile, malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), catalase activity, creatinine and urea were determined besides urinary creatinine clearance. Nutraceuticals’ anticancer effect was assessed in hepatocellular carcinoma cell (HepG2) line. Results: Significant increases (P < 0.05) in lipid parameters with reduction of high-density lipoprotein cholesterol (HDL-C) were noticed in CVD control compared to NC group; the same changes were demonstrated in CRSC with lesser extent. In CVD control and CRSC groups; a significant increase (P < 0.05) in MDA and TNF-α with a reduction in catalase were noticed. Kidney dysfunction was demonstrated in the CRSC group. Administration of both RBO/γ-O and γ-O produced variable improvements in all parameters in both models and had anticancer effects. Conclusion: RBO/γ-O and γ-O had protective effects on CVDs and cardiorenal syndrome as well as anti-hepatocellular carcinoma activities with superiority of RBO/γ-O.

The ulcerogenic and protective action of rice and rice fractions in experimental peptic ulceration

1987 ◽  
Vol 72 (4) ◽  
pp. 463-466 ◽  
Author(s):  
A. P. Jayaraj ◽  
F. I. Tovey ◽  
C. G. Clark ◽  
K. R. Rees ◽  
J. S. White ◽  
...  
Keyword(s):  
Geographical Distribution ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Protective Action ◽  
Protective Effects ◽  
P Values ◽  
The World ◽  
Plausible Hypothesis ◽  
Ulcerogenic Effect ◽  
Ulcer Model

1. The ulcerogenic and protective effects of various rice fractions in the diet were studied in the pylorus ligated ulcer model in the rat. 2. Oil present in rice and particularly rice bran becomes ulcerogenic on storage and in this model results in a significant increase in the median (range) numbers of ulcers from six (one to ten) to nine (six to 15) (P > 0.05). The ulcerogenic effect of stored rice bran oil was reversed by cysteine which significantly reduced the ulcer incidence from 100% to 60% (P > 0.005) and the numbers of ulcers from 26 (six to 70) to one (zero to four) (P > 0.001). 3. Fresh rice bran significantly reduced the numbers of ulcers from six (one to ten) to one (one to four) (P > 0.05). Similarly, unmilled rice and freshly milled newly harvested rice was also shown to be protective in this model by significantly reducing the ulcer incidence from 87.5% to 50% and 0% respectively (P values > 0.025) and the numbers of ulcers from three (zero to 17) to one (zero to one) and zero (zero to zero) respectively (P values > 0.001). 4. These results could in part explain the geographical distribution of duodenal ulceration, where the incidence is high in all the rice eating areas of the world, and provide a plausible hypothesis to explain the mechanism of dietary ulcerogenesis.

Nanoencapsulation of rice bran oil increases its protective effects against UVB radiation-induced skin injury in mice

2015 ◽  
Vol 93 ◽  
pp. 11-17 ◽  
Author(s):  
Lucas Almeida Rigo ◽  
Cássia Regina da Silva ◽  
Sara Marchesan de Oliveira ◽  
Thaíssa Nunes Cabreira ◽  
Cristiane de Bona da Silva ◽  
...  
Keyword(s):  
Rice Bran ◽  
Rice Bran Oil ◽  
Protective Effects ◽  
Uvb Radiation ◽  
Skin Injury ◽  
Radiation Induced

scholarly journals Antioxidant and Anti-inflammatory Activity of γ-Oryzanol Compared to Rice Bran Oil to Repair Ovarian Histological Structure from One Push Transfluthrin Exposure Effect

2022 ◽  
Vol 10 (B) ◽  
pp. 1-12
Author(s):  
Lilis Lisnawati ◽  
Sri Poeranto ◽  
Agustina Tri Endharti ◽  
Moch. Istiadjid Edi Santoso
Keyword(s):  
Antioxidant Activity ◽  
Rice Bran ◽  
Reproductive System ◽  
Rice Bran Oil ◽  
Female Rats ◽  
Inflammatory Activity ◽  
Histological Structure ◽  
Exposure Effect ◽  
Tnf Α ◽  
Anti Inflammatory

BACKGROUND: Fertility is affected by both the reproductive organs and external factors (genetics, hormones, radiation exposure, use of insecticides, and nutrition). The histological structure of the ovaries is an indicator of reproductive function. Insect repellent use with pyrethroid active ingredients and its impact on health has become a discussion in the medical sector for years. Disruption of the reproductive system homeostasis may cause several issues, from disruption of ovarian function to infertility. γ-Oryzanol has higher antioxidants than vitamin E. It is found mostly in rice bran oil (RBO). Researchers have investigated the effectiveness of RBO and γ-Oryzanol, but the number of studies focusing on the reproductive system is very limited. Results of in silico showed anti-inflammatory potential, and nitric oxide γ-Oryzanol is stronger than the antioxidant activity. It also showed γ-Oryzanol bond with Foxo3a and Growth Differentiating Factor 9 (GDF9), indicating the γ-Oryzanol potential for reproductive health (women). Studies also reported that γ-Oryzanol administration caused anti-inflammatory and antioxidant activity compared to RBO in improving ovarian physiological function using tumor necrosis factor α (TNF-α) levels, Foxo3a expression, and GDF9 expression exposed to one push transfluthrin as the parameter. AIM: We aimed to investigate antioxidant and anti-inflammatory activity of γ-Oryzanol compared to rice bran oil to repair ovarian histological structure from one push transfluthrin exposure effect. METHODS: Experimental research, post-test only control group design approach, with a completely randomized design, consisted of 6 (six) groups of Wistar strain female rats. They were exposed to one push with the active ingredient of transfluthrin 21.3%, by inhalation for 6 hours, RBO 0.3 mg/g/ body weight (BW)/day, γ-Oryzanol 3.75 ml/g/BW/day. Statistical analysis was done with the Mann Whitney’s posthoc Kruskal Wallis test with IBM SPSS version 25 software. RESULTS: γ-Oryzanol had more potent anti-inflammatory and antioxidant activity than RBO in improving the ovarian histology structure (including maintaining ovarian weight, increasing follicular growth, and suppressing follicular abnormalities) through decreased TNF-α levels and decreased Foxo3a expression, and increased GDF9 expression. CONCLUSION: The administration of γ-Oryzanol improves the ovarian histological structure from free radicals effects, namely exposure to one push of transfluthrin.

Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
G Wiltberger ◽  
U Lange ◽  
H Hau ◽  
D Seehofer ◽  
F Krenzien ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Coffee Consumption ◽  
Protective Effects

RESEARCH ON PREPARATION OF&NBSP; GAMMA ORYZANOL ANTI-AGING CREAM

2017 ◽  
pp. 15-21
Author(s):  
Thi Minh Nguyet Le ◽  
Thi Kim Lien Phan
Keyword(s):  
Product Quality ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Aging Effect ◽  
Triterpene Alcohols ◽  
Beneficial Effects ◽  
Long Time ◽  
Formulation Parameters ◽  
Rice Water ◽  
Gamma Oryzanol

Background and Objectives: For a long time, Asian women have known to use rice water, rice bran for skin care, lightening dark spots and slowing down the aging process. Gamma Oryzanol, an ester mixture of trans-ferulic acid with phytosterols and triterpene alcohols extracted from rice bran oil, has been shown to have beneficial effects on the skin, especially its antioxidant and anti-aging effect. The aims of this research were to formulate Gamma Oryzanol-loaded anti-aging cream and to evaluate the product quality. Materials and Methods: Gamma Oryzanol was imported from Japan. Some formulation parameters such as emulsifi-ers, performance modifiers were investigated and the product quality was evaluated according to the criteria of drugs and cosmetics. Results: The excipients were chosen including 1% (w/w) of Lunamer with 3% (w/w) of Prolipid as emulsifiers and 8% (w/w) of mango seed butter as a state modifier in the formulation of Gamma Oryzanol anti-aging cream. The cream is ivory-white, thick, smooth, fragrant-smelling and satisfied all criteria of developed specification. Conclusion: The study was successful in the preparation of Gamma Oryzanol anti-aging cream. Key words: Gamma Oryzanol, anti-aging cream, Franz cells.

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