Synergistic Effects of Acoustics-based Therapy and Immunotherapy in Cancer Treatment

Cancer is an intractable disease and has ability to escape immunological recognition. Cancer immunotherapy to enhance the autogenous immune response to cancer tissue is reported to be the most promising method for cancer treatment. After the release of damage-associated molecular patterns, dendritic cells come mature and then recruit activated T cells to induce immune response. To trigger the release of cancer associated antigens, cancer acoustics-based therapy has various prominent advantages and has been reported in various research. In this review, we classified the acoustics-based therapy into sonopyrolysis-, sonoporation-, and sonoluminescence-based therapy. Then, detailed mechanisms of these therapies are discussed to show the status of cancer immunotherapy induced by acoustics-based therapy in quo. Finally, we express some future prospects in this research field and make some predictions of its development direction

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Overcoming the problem of the lack of an immune response to cancer: A possible haptogenic approach to cancer immunotherapy

Cancer Research and Cellular Therapeutics ◽

10.31579/2640-1053/072 ◽

2021 ◽

Vol 5 (1) ◽

pp. 01-04

Author(s):

Patrick Riley

Keyword(s):

Immune Response ◽

Cancer Cells ◽

Cancer Immunotherapy ◽

Immunological Response ◽

Gene Products ◽

Malignant Cells ◽

Deviant Behaviour ◽

Anti Cancer ◽

Immune Response To Cancer ◽

Normal Gene

Cancer cells possess a number of unusual features, most of which are explicable in the light of the theory of epigenetic carcinogenesis. This includes the remarkable failure of malignant cells to evoke an immunological response from the host which is ascribed to their deviant behaviour resulting from anomalous expression of normal gene products. Given this background a possible approach to eliciting a specific anti-cancer immune response is proposed which involves selective haptenation of an identifiable target protein.

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The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective

Nanoscale ◽

10.1039/c9nr05371a ◽

2019 ◽

Vol 11 (37) ◽

pp. 17157-17178 ◽

Cited By ~ 12

Author(s):

Yongjiang Li ◽

Ciceron Ayala-Orozco ◽

Pradipta Ranjan Rauta ◽

Sunil Krishnan

Keyword(s):

Immune Response ◽

Cancer Treatment ◽

Cancer Immunotherapy ◽

Treatment Modality ◽

Promising Treatment

Cancer immunotherapy is emerging as a promising treatment modality that suppresses and eliminates tumors by re-activating and maintaining the tumor-immune cycle, and further enhancing the body's anti-tumor immune response.

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Cancer Immunotherapy and the Nectin Family

Annual Review of Cancer Biology ◽

10.1146/annurev-cancerbio-060920-084910 ◽

2020 ◽

Vol 5 (1) ◽

Author(s):

Robert J. Johnston ◽

Peter S. Lee ◽

Pavel Strop ◽

Mark J. Smyth

Keyword(s):

Immune Response ◽

Cancer Immunotherapy ◽

Online Publication ◽

Cancer Biology ◽

Recent Progress ◽

Clinical Development ◽

Annual Review ◽

Publication Date ◽

Immune Response To Cancer

It is increasingly clear that the nectin family and its immunoreceptors shape the immune response to cancer through several pathways. Yet, even as antibodies against TIGIT, CD96, and CD112R advance into clinical development, biological and therapeutic questions remain unanswered. Here, we review recent progress, prospects, and challenges to understanding and tapping this family in cancer immunotherapy. Expected final online publication date for the Annual Review of Cancer Biology, Volume 5 is March 4, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Modelling the Immune Response to Cancer: An Individual-Based Approach Accounting for the Difference in Movement Between Inactive and Activated T Cells

Bulletin of Mathematical Biology ◽

10.1007/s11538-018-0412-8 ◽

2018 ◽

Vol 80 (6) ◽

pp. 1539-1562 ◽

Cited By ~ 9

Author(s):

Fiona R. Macfarlane ◽

Tommaso Lorenzi ◽

Mark A. J. Chaplain

Keyword(s):

Immune Response ◽

T Cells ◽

Activated T Cells ◽

Immune Response To Cancer ◽

The Difference

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Nanoparticles in enhancing microwave imaging and microwave Hyperthermia effect for liver cancer treatment

REVIEWS ON ADVANCED MATERIALS SCIENCE ◽

10.1515/rams-2021-0014 ◽

2021 ◽

Vol 60 (1) ◽

pp. 223-236

Author(s):

Walaa Maamoun ◽

Mohamed I. Badawi ◽

Ayman A Aly ◽

Y. Khedr

Keyword(s):

Silver Nanoparticles ◽

Liver Cancer ◽

Cancer Treatment ◽

Electromagnetic Waves ◽

Microwave Imaging ◽

Healthy Tissue ◽

Cancer Tissue ◽

Hyperthermia Treatment ◽

Hyperthermia Therapy ◽

Surrounding Healthy Tissue

Abstract Hyperthermia therapy is a promising therapy for liver cancer treatment that utilizes external electromagnetic waves to heat the tumor zone to preferentially kill or minimize cancer cells. Nevertheless, it’s a challenge to realize localized heating of the cancer tissue without harming the surrounding healthy tissue. This research proposes to utilize nanoparticles as microwave absorbers to enhance microwave imaging and achieve localized hyperthermia therapy. A realistic 3D abdomen model has been segmented using 3D Slicer segmentation software, and then the obtained segmented CAD model exported to Computer Simulation Technology (CST STUDIO) for applying the Finite Element Modeling (FEM). Next investigating both imaging and treatment capability. Finally, the specific absorption rate (SAR) and temperature distribution were computed without nanoparticles and with different types of nanoparticles such as gold (GNPs) and silver nanoparticles at frequency 915 MHz. By comparing the achived results, it was seen that Silver nanoparticles can make a great enhancement in raising the temperature. However, this result was unsatisfactory but, after adding gold nanoparticles the temperature exceed 42°C, at frequency 915 MHz which is achieving the hyperthermia treatment without harming the nearby healthy tissue, GNPs also can achieve a great enhancement in SAR result

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Immunotherapy: New insights in breast cancer treatment

Human Antibodies ◽

10.3233/hab-210443 ◽

2021 ◽

pp. 1-10

Author(s):

Bader Alshehri

Keyword(s):

Breast Cancer ◽

Immune Response ◽

Immune System ◽

Cancer Treatment ◽

Immune Evasion ◽

Breast Tumor ◽

Parp Inhibitor ◽

Breast Cancer Treatment ◽

New Treatment

Breast cancer being the most malignant and lethal disease persistent among women globally. Immunotherapy as a new treatment modality has emerged in understanding the loopholes in the treatment of breast cancer which is mainly attributed to the potential of tumor cells to evade and survive the immune response by developing various strategies. Therefore, improved understanding of the immune evasion by cancer cells and the monoclonal antibodies against PD- and PD-L1 can help us in the diagnosis of this malignancy. Here in this article, I have highlighted that in addition to focusing on other strategies for breast cancer treatment, the involvement of immune system in breast cancer is vital for the understanding of this malignancy. Further, the complete involvement of immune system in the relapse or recurrence of the breast tumor and have also highlighted the role of vaccines, PD-1 and CTLA-4 with the recent advances in the field. Moreover, in addition to the application of immunotherapy as a sole therapy, combinations of immunotherapy with various strategies like targeting it with MEK inhibitors, Vaccines, chemotherapy and PARP inhibitor has shown to have significant benefits is also discussed in this article.

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Combinations of two synthetic adjuvants: Synergistic effects of a surfactant and a polyanion on the humoral immune response

Cellular Immunology ◽

10.1016/0008-8749(85)90001-2 ◽

1985 ◽

Vol 92 (2) ◽

pp. 203-209 ◽

Cited By ~ 23

Author(s):

Luuk A.Th. Hilgers ◽

Harm Snippe ◽

Margriet Jansze ◽

Jan M.N. Willers

Keyword(s):

Immune Response ◽

Humoral Immune Response ◽

Synergistic Effects ◽

Humoral Immune

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Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver

Journal of Virology ◽

10.1128/jvi.76.11.5692-5700.2002 ◽

2002 ◽

Vol 76 (11) ◽

pp. 5692-5700 ◽

Cited By ~ 28

Author(s):

Huang-Ge Zhang ◽

Jinfu Xie ◽

Liang Xu ◽

Pingar Yang ◽

Xin Xu ◽

...

Keyword(s):

Gene Therapy ◽

Immune Response ◽

Transgene Expression ◽

Cell Activation ◽

Nk Cell ◽

Death Domain ◽

Activated T Cells ◽

Tnf Α ◽

Product Expression ◽

Ifn Γ

ABSTRACT A major limitation of adenovirus (Ad) gene therapy product expression in the liver is subsequent elimination of the hepatocytes expressing the gene therapy product. This elimination is caused by both necrosis and apoptosis related to the innate and cell-mediated immune response to the Ad. Apoptosis of hepatocytes can be induced by the innate immune response by signaling through death domain receptors on hepatocytes including the tumor necrosis factor alpha (TNF-α) receptor (TNFR), Fas, and death domain receptors DR4 and DR5. We have previously shown that blocking signaling through TNFR enhances and prolongs gene therapy product expression in the liver. In the present study, we constructed an Ad that produces a soluble DR5-Fc (AdsDR5), which is capable of neutralizing TNF-related apoptosis-inducing ligand (TRAIL). AdsDR5 prevents TRAIL-mediated apoptosis of CD3-activated T cells and decreases hepatocyte apoptosis after AdCMVLacZ administration and enhances the level and duration of lacZ transgene expression in the liver. In addition to blocking TRAIL and directly inhibiting apoptosis, AdsDR5 decreases production of gamma interferon (IFN-γ) and TNF-α and decreases NK cell activation, all of which limit Ad-mediated transgene expression in the liver. These results indicate that (i) AdsDR5 produces a DR5-Fc capable of neutralizing TRAIL, (ii) AdsDR5 can reduce activation of NK cells and reduce induction of IFN-γ and TNF-α after Ad administration, and (iii) administration of AdsDR5 can enhance Ad gene therapy in the liver.

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