What Do Very Low Plasma Concentrations of High-sensitivity C-reactive Protein (hs-CRP) Mean among Healthy Middle-aged Koreans?

This cross-sectional study aimed to investigate the associations between high-sensitivity C-reactive protein (hs-CRP) and renal impairment (RI) among middle-aged and elderly people. We collected and analyzed demographic, anthropometric, metabolic, and renal function data in a community-based population in Northern Taiwan. We excluded subjects with acute inflammation from this study and defined RI as the presence of urinary albumin–creatinine ratio 30–300 mg/g or an estimated glomerular filtration rate of <60 mL/min/1.73 m2. There were 131, 125, and 125 participants in the low (≤0.80 mg/L), middle (0.81–1.76 mg/L), and high (>1.77 mg/L) hs-CRP tertiles, respectively. hs-CRP exhibited significantly positive correlations with body mass index, waist circumference, systolic blood pressure, triglyceride, and fasting plasma glucose, and a negative correlation with high-density lipoprotein. The prevalence and odds ratio of RI significantly increased across hs-CRP tertiles from low to high, and this trend remained significant after adjusting for the conventional cardiometabolic risk factors. hs-CRP ≥ 1.61 mg/L in the total group and ≥2.03 mg/L in the elderly group accurately predicted RI (p = 0.01 and 0.03, respectively). These findings suggest that we should carefully evaluate the renal function for at-risk individuals with hs-CRP elevation.

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Levels of high‑sensitivity C‑reactive protein in young and middle‑aged individuals and their association with hypertension

Medical alphabet ◽

10.33667/2078-5631-2021-1-44-48 ◽

2021 ◽

pp. 44-48

Author(s):

O. A. Polyakova ◽

A. A. Kirichenko ◽

I. A. Borodin

Keyword(s):

Systemic Inflammation ◽

Hormone Replacement ◽

Statistical Processing ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Lower Detection ◽

Hs Crp ◽

Acute Inflammatory Disease

Background. Chronic systemic inflammation plays a key role in the development of cardiovascular disease. However, the causal relationship between inflammation and arterial hypertension (AH) is not fully determined.Objective. To assess the levels of high-sensitivity С-reactive protein (hs-CRP) in young and middle-aged individuals and their association with АН. Materials and methods. The study involved 427 patients aged 30 to 55 years (41 [35; 48] years) undergoing a periodic medical examination on the basis of Gazprom Transgaz Moscow’s Centre for Diagnostics and Rehabilitation from November 2018 to February 2020. 169 patients were evaluated in dynamics after a year. Patients with acute inflammatory disease or chronic exacerbation, taking hypolipidemic, anti-inflammatory, hormone replacement therapy were excluded from the study. The hs-CRP level was determined by an immunoturbodimetric method with latex gain, with a lower detection limit of 0.1 mg/l. Statistical processing of the results was carried out in Statistica 10 program. Differences were considered statistically significant at p < 0.05.Results. Among young and middle-aged individuals increase in the level of hs-CRP ≥ 2 mg/l was found in 26.9 % of participants of the research. Protein concentrations were most significantly associated with body mass index (r = 0.53; p < 0.05) and systolic blood pressure (r = 0.28; p < 0.05). Persons with hs-CRP ≥ 2 mg/l had a frequency of identification of AH above, then at persons with normal levels of a marker (65.2 against 40.1 %; р = 0.000004). There was a statistically significant association between an increase in the level of hs-CRP and hypertension (OR = 2.8; 95 % CI: 1.8–4.4; p = 0.000004).Conclusions. The findings indicate that elevated hs-CRP levels are associated with AH in young and middle-aged individuals, and also suggest that chronic systemic inflammation is an independent contributor to the development of AH.

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Levels of high-sensitivity c-reactive protein in young and middle-aged working men

Consilium Medicum ◽

10.26442/20751753.2021.1.200577 ◽

2021 ◽

Vol 23 (1) ◽

pp. 99-102

Author(s):

Andrey A. Kirichenko ◽

◽

Olga A. Polyakova ◽

Irina N. Dubovskaia ◽

◽

...

Keyword(s):

Cardiovascular Diseases ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Screening Programs ◽

Reactive Protein ◽

Working Age ◽

Hs Crp

Cardiovascular diseases remain the leading cause of death in the working age population. In recent decades, more and more attention has been attracted to a subacute chronic inflammatory process as the cause of the progression of atherosclerosis and the development of atherothrombosis. A high-sensitivity C-reactive protein (hs-CRP) is recognized as an independent marker of cardiovascular disease risk, comparable in value to cholesterol or blood pressure. Aim. Measurement of hs-CRP levels in the group of initially healthy young and middle-aged working men. Materials and methods. The study included 349 men aged 28 to 56 years, who undergo periodic medical examination at the Diagnostic and Rehabilitation Center of “Gazprom transgaz Moscow” OOO from November 2018 to February 2020.The examination was carried out according to an employee occupation by order of the Ministry of Health and Social Development of Russia No. 302n. dated 12.04.2011. Additionally, a blood test for hs-CRP was performed. Results. An increase in hs-CRP ≥2 mg/L was found in 26.7% of the men examined. In the majority of cases (89.2%), the increase in CRP ranged between 2 and 5 mg/L, in 7.5% of cases – between 5 and 10 mg/L, and only in 3,2% it exceeded 10 mg/L. All patients with elevated hs-CRP levels showed no signs of an acute inflammatory reaction. A direct correlation of hs-CRP levels with overweight and abdominal obesity, which increases with age, was revealed. In 151 men, hs-CRP levels were assessed in dynamics, of which baseline increase of ≥2 mg / l was noted in 28.5%, and after a year – in 23.2%. When assessing the absolute value of biomarker concentration, an increase in this indicator after a year was registered in 45.3% of men. Conclusion. The high incidence of increased baseline hs-CRP levels in the group of relatively healthy young and middle-aged working men, and the tendency for this indicator to increase after a year in 45.3% of men makes it appropriate to include routine measurement of the basal hs-CRP concentration in men over 40 years of age in screening programs and standards of medical examinations. Keywords: high-sensitivity C-reactive protein, atherosclerosis, cardiovascular diseases For citation: Kirichenko AA, Poliakova OA, Dubovskaia IN. Levels of high-sensitivity C-reactive protein in young and middle-aged working men. Consilium Medicum. 2021; 23 (1): 99–102. DOI: 10.26442/20751753.2021.1.200577

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Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women

American Journal of Clinical Nutrition ◽

10.1093/ajcn/75.3.492 ◽

2002 ◽

Vol 75 (3) ◽

pp. 492-498 ◽

Cited By ~ 371

Author(s):

Simin Liu ◽

JoAnn E Manson ◽

Julie E Buring ◽

Meir J Stampfer ◽

Walter C Willett ◽

...

Keyword(s):

Glycemic Load ◽

Plasma Concentrations ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein

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High-sensitivity C reactive protein and risk of cardiovascular disease in China-CVD study

Journal of Epidemiology & Community Health ◽

10.1136/jech-2018-211433 ◽

2018 ◽

Vol 73 (2) ◽

pp. 188-192 ◽

Cited By ~ 3

Author(s):

Ying Dong ◽

Xin Wang ◽

Linfeng Zhang ◽

Zuo Chen ◽

Congyi Zheng ◽

...

Keyword(s):

Cardiovascular Disease ◽

Chinese Population ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Net Reclassification Improvement ◽

Increased Risk ◽

Hs Crp

BackgroundThis study aimed to assess the association of high sensitivity C-reactive protein (hs-CRP) with cardiovascular disease (CVD) in middle-aged Chinese population.MethodsThe baseline was collected 2009–2010, and follow-up was conducted in 2016–2017. Data of hs-CRP were from baseline examination and re-examination in 2016–2017 using transmission turbidimetry with a measurement range of 0–42 000. The primary outcome was CVD including coronary heart disease events and stroke events.ResultsAmong 8688 participants free from CVD (at baseline, mean age, 50.1 years, 3897 were males), there were 189 CVD events, occurred during a median follow-up of 6.34 years (54 685 person-years at risk). From the Kaplan-Meier curve, we found that there was a progressive increase in CVD event rates by hs-CRP tertiles (log-rank test, p<0.001). Baseline hs-CRP was linearly associated with CVD (p for trend=0.015) even after adjusting for known CVD risk factors. Furthermore, the net reclassification improvement when hs-CRP was added to a model based on traditional factors was 7.85% for CVD (p=0.003). In addition, the correlation between change of hs-CRP and CVD was conducted in a subgroup (n=4778). However, we did not find the correlation between hs-CRP change and CVD (correlation coefficient: −0.003, p=0.846).ConclusionsIn the middle-aged Chinese population, hs-CRP was associated with increased risk of developing CVD. Although there was no correlation between hs-CRP change and CVD, the level of hs-CRP was higher at follow-up than baseline even among those with CVD. More attention should be given to those with higher level of hs-CRP for CVD prevention.

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Association of high sensitivity C-reactive protein and metabolic syndrome components in middle-aged subjects without overt cardiovascular disease in LitHiR primary prevention programme

Seminars in Cardiovascular Medicine ◽

10.2478/semcard-2020-0003 ◽

2020 ◽

Vol 26 (1) ◽

pp. 14-19

Author(s):

Ieva Marija Saulė ◽

Jurgita Mikolaitytė ◽

Jolita Badarienė ◽

Jūratė Zupkauskienė ◽

Roma Puronaitė ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Fasting Blood Glucose ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Hs Crp ◽

Aged Subjects

Summary Objectives: Circulating levels of inflammatory markers such as high sensitivity C-reactive protein (hs-CRP) have been reported to be associated with increased risk of cardiovascular disease (CVD), as well as with metabolic syndrome (MetS). Therefore, our objectives were to investigate the associations between hs-CRP levels and individual MetS components as well as to analyse if hs-CRP levels are linked with the number of MetS components present in middle-aged subjects. Design and methods: A cross-sectional study included 4628 middle-aged MetS subjects from the Lithuanian High Cardiovascular Risk primary prevention programme (LitHiR) from 2011 to 2020. MetS was diagnosed according to the National Cholesterol Education Program ATP III modified criteria. CRP was measured by a validated high-sensitivity assay. A hs-CRP cutpoint of 5 mg/l was used to differentiate high and low hs-CRP groups. Results: The mean value of hs-CRP was 3.23 ± 4.04 mg/l, and significantly increased as the number of components of MetS increased (p < 0.001). The concentration of serum hs-CRP was significantly associated with waist circumference, systolic and diastolic blood pressure, and fasting blood glucose (all p < 0.001). However, no statistically significant associations were found between hs-CRP and serum triglycerides (p = 0.340) or serum high-density lipoprotein cholesterol (p = 0.148). Conclusions: Serum hs-CRP increased progressively with increased waist circumference, blood pressure, fasting blood glucose in middle-aged subjects with MetS. The higher values of hs-CRP were more often present in obese subjects and women. The incremental rise in mean serum hs-CRP level was found with an increasing number of MetS components.

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Plasma Retinol Levels and High-Sensitivity C-Reactive Protein in Prepubertal Children

Nutrients ◽

10.3390/nu10091257 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1257 ◽

Cited By ~ 2

Author(s):

Olaya de Dios ◽

Pilar Navarro ◽

Henar Ortega-Senovilla ◽

Leticia Herrero ◽

Teresa Gavela-Pérez ◽

...

Keyword(s):

Pearson Correlation ◽

Plasma Concentrations ◽

High Sensitivity ◽

Healthy Children ◽

Lipid Levels ◽

C Reactive Protein ◽

Prepubertal Children ◽

Reactive Protein ◽

Hs Crp ◽

Plasma Retinol

The relationship between C-reactive protein (CRP) levels and plasma antioxidants has been established in adults. However, the association has been rarely investigated in healthy children. Thus, we examined the cross-sectional association of high-sensitivity CRP (hs-CRP) levels with fat-soluble plasma antioxidant concentrations in a cohort of healthy prepubertal children. We determined hs-CRP levels in 543 healthy six–eight-year-old children using a high-sensitivity CRP enzyme-linked immuno sorbent assay (ELISA) kit. The plasma concentrations of lipids, apolipoproteins and lipid-soluble antioxidants (α-tocopherol, γ-tocopherol, lycopene, α-carotene, β-carotene and retinol) were determined using standardized methods. Pearson correlation analysis showed significant correlations between plasma hs-CRP and α-carotene and retinol concentrations. After adjusting by sex, body mass index (BMI) and lipid levels, only the association with retinol remains significant, with children in the highest hs-CRP tertile group (hs-CRP ≥ 0.60 mg/dL) showing significantly lower levels of retinol than those from the tertiles 1 and 2. A stepwise linear regression selected retinol, BMI, apo A-I and sex as predictors of hs-CRP levels, in a model explaining 19.2% of the variability of hs-CRP. In conclusion, in healthy prepubertal children, after adjusting by sex, BMI and lipid levels, hs-CRP concentrations were highly associated with plasma retinol, which is transported in blood bound to retinol-binding protein but were not associated with the lipoprotein-bound antioxidants.

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Associations between Pre-Bariatric High-Sensitivity C-Reactive Protein and Post-Surgery Outcomes

Diagnostics ◽

10.3390/diagnostics11040721 ◽

2021 ◽

Vol 11 (4) ◽

pp. 721

Author(s):

Tannaz Jamialahmadi ◽

Mohsen Nematy ◽

Simona Bo ◽

Valentina Ponzo ◽

Ali Jangjoo ◽

...

Keyword(s):

Bariatric Surgery ◽

Morbid Obesity ◽

Weight Loss ◽

Success Rate ◽

Liver Stiffness ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Post Surgery ◽

Hs Crp

Background: Obesity is a chronic inflammatory condition associated with increased circulating levels of C-reactive protein (CRP). Bariatric surgery has been reported to be effective in improving both inflammatory and liver status. Our aims were to elucidate the relationships between pre-surgery high sensitivity-CRP (hs-CRP) values and post-surgery weight loss and liver steatosis and fibrosis in patients with severe obesity undergoing Roux-en-Y gastric bypass. Methods: We conducted an observational prospective study on 90 individuals with morbid obesity, who underwent gastric bypass. Anthropometric indices, laboratory assessment (lipid panel, glycemic status, liver enzymes, and hs-CRP), liver stiffness and steatosis were evaluated at baseline and 6-months after surgery. Results: There was a significant post-surgery reduction in all the anthropometric variables, with an average weight loss of 33.93 ± 11.79 kg; the mean percentage of total weight loss (TWL) was 27.96 ± 6.43%. Liver elasticity was significantly reduced (from 6.1 ± 1.25 to 5.42 ± 1.52 kPa; p = 0.002), as well as liver aminotransferases, nonalcoholic fatty liver disease fibrosis score (NFS) and the grade of steatosis. Serum hs-CRP levels significantly reduced (from 9.26 ± 8.45 to 3.29 ± 4.41 mg/L; p < 0.001). The correlations between hs-CRP levels and liver fibrosis (elastography), steatosis (ultrasonography), fibrosis-4 index, NFS, and surgery success rate were not significant. Regression analyses showed that serum hs-CRP levels were not predictive of liver status and success rate after surgery in both unadjusted and adjusted models. Conclusions: In patients with morbid obesity, bariatric surgery caused a significant decrease in hs-CRP levels, liver stiffness and steatosis. Baseline hs-CRP values did not predict the weight-loss success rate and post-surgery liver status.

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Colchicine effectively attenuates inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) in patients with non-ST-segment elevation myocardial infarction: a randomised, double-blind, placebo-controlled clinical trial

Inflammopharmacology ◽

10.1007/s10787-021-00865-0 ◽

2021 ◽

Vol 29 (5) ◽

pp. 1379-1387

Author(s):

Arash Gholoobi ◽

Vahid Reza Askari ◽

Hossein Naghedinia ◽

Mostafa Ahmadi ◽

Vida Vakili ◽

...

Keyword(s):

High Sensitivity ◽

Controlled Clinical Trial ◽

C Reactive Protein ◽

Double Blind ◽

Inflammatory Biomarker ◽

St Segment Elevation ◽

Reactive Protein ◽

Segment Elevation Myocardial Infarction ◽

St Segment ◽

Hs Crp

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Relationship Between High Sensitivity C-reactive Protein and CagA Positive Helicobacter pylori in Cardiac Syndrome X

Journal of Scientific Research ◽

10.3329/jsr.v5i3.14171 ◽

2013 ◽

Vol 5 (3) ◽

pp. 527-533

Author(s):

Y. Rasmi ◽

M. H. Seyed-Mohammadzad ◽

S. Raeisi

Keyword(s):

High Sensitivity ◽

Syndrome X ◽

C Reactive Protein ◽

Cardiac Syndrome X ◽

Elisa Method ◽

Reactive Protein ◽

Cardiac Syndrome ◽

Cytotoxin Associated Gene A ◽

Hs Crp ◽

Caga Status

Cytotoxin-associated gene A (CagA) may induce a persistent systemic inflammatory response in cardiac syndrome X (CSX). We aimed to evaluate relationship of CagA status and high sensitivity C-reactive protein (hs-CRP) in CSX patients. Sixty CSX patients and 60 gender matched controls were enrolled. Plasma samples were tested in terms of the presence of IgG antibody to Helicobacterpylori (anti-H. pylori) and CagA (anti-CagA) using ELISA method. Also, plasma level of hs-CRP was measured by ELISA method. CSX patients were detected to have significantly higher plasma hs-CRP level in comparison with the control ones (3.64 ± 3.07 vs. 0.54 ± 0.49, µg/ml, P = 0.0001). Plasma levels of hs-CRP in CSX patients with anti-CagA+ were significantly higher than those in anti-CagA(-) (CSX: 4.66±3.63 vs. 2.58±1.95 µg/ml, P = 0.011). Also, plasma levels of hs-CRP in the controls with anti-CagA+ were significantly higher than those in anti-CagA- (1.05±0.68 vs. 0.32±0.31 µg/ml, respectively, P = 0.004). The present data suggested that CagA status was probably associated with susceptibility to severe CSX by causing inflammation. The evidence for this hypothesis indicated that levels of hs-CRP increased in anti-CagA+ patients compared to the anti-CagA- ones. Keywords: Cardiac syndrome X; Helicobacter pylori; Inflammation ; hs-CRP, Cytotoxin-associated gene A. © 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v5i3.14171 J. Sci. Res. 5 (3), 527-533 (2013)

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