scholarly journals Glycated Hemoglobin and Lipid Profile Association Among Pregnant Women in Saudi Arabian Population

2018 ◽  
Vol 7 (2) ◽  
pp. 216-222
Author(s):  
Farah Anjum ◽  
Rana Zaini ◽  
Ashjan Shami ◽  
Amani Rehaili ◽  
Rahma Kufia
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Glycated Hemoglobin ◽  
Previous History ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Significant Difference

Objectives: Glycated hemoglobin (HbA1c) is the most commonly used glycemic index among diabetic patients. The present study sought to investigate the relationship between HbA1c and lipid parameters among healthy pregnancies and gestational diabetic cases. Materials and Methods: Seventy-five Saudi pregnant women within the age group of 19 to 43 years were selected for this crosssectional study. The participants were categorized into with and without gestational diabetes (GDM), all of whom were non-smokers; in addition, they neither had a previous history of chronic illnesses nor were they on any medications which could alter lipid profile and HbA1c concentrations. Totally, 75 g of oral glucose tolerance test (OGTT) was utilized to identify 25 women with GDM. All biochemical tests including HbA1c, fasting blood sugar (FBG), total cholesterol (TC), low-density lipoprotein (LDL-cholesterol), triglycerides (TG), and high-density lipoprotein (HDL-cholesterol) were performed by a biochemical auto-analyzer. The collected data were statistically analyzed using a paired student’s t test. The P values of <0.05 were considered statistically significant on all the analyses related to healthy pregnancies and those associated with GDM. Results: The HbA1c and FBG values demonstrated significant correlation with GDM (P<0.001 each). However, TC, LDL-cholesterol, and TG failed to indicate any significant difference between the 2 groups. Conversely, HDL-cholesterol and the ratio of TG and HDLcholesterol revealed remarkable differences between GDM and healthy participants (P<0.05 each). Conclusions: In general, the blood levels of glucose, HbA1c, TG, and HDL-cholesterol are of paramount significance in GDM. Predictably, HbA1c can be employed as one of the markers in evaluating the risk factors in developing dyslipidemia among pregnant women.

scholarly journals A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup

2017 ◽  
Vol 21 (2) ◽  
pp. 73-75
Author(s):  
S Vinod Babu ◽  
Anusha R Jagadeesan ◽  
Jothimalar Ramalingam
Keyword(s):  
Comparative Study ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Health Checkup ◽  
Group I ◽  
Significant Difference

ABSTRACT Introduction Obesity is emerging as an epidemic worldwide. Obesity is associated with a number of comorbid conditions, such as diabetes mellitus, hypertension, cancer, dyslipidemia, cardiovascular abnormalities, anemia, obstructive sleep apnea, and psychosocial abnormalities. Aim This study aims at comparing the lipid profile levels of obese and nonobese men. Materials and methods This was a case—control study conducted at a tertiary care center. Totally, 80 men in the age group of 20 to 47 years attending the master health checkup were included in the study, out of which 40 men with normal body mass index (BMI) of 18 to 25 belonged to group I and 40 men with increased BMI of 30 and above belonged to group II. Lipid profile parameters, such as triglycerides (TGLs), total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were estimated in them. The data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software version 15.0. Results Statistically significant difference was found in the total cholesterol levels with a p-value of 0.040 while the difference in LDL cholesterol was statistically highly significant with a p-value of 0.040. Conclusion Among lipid profile parameters, only total cholesterol and LDL cholesterol showed significant difference between the obese and nonobese individuals. However, the other parameters like HDL cholesterol and TGLs did not show any significant difference. How to cite this article Babu SV, Jagadeesan AR, Ramalingam J. A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup. Indian J Med Biochem 2017;21(2):73-75.

scholarly journals A study of lipid profile Levels of Type II Diabetes Mellitus

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Murwan Khalid Sabahelkhier ◽  
Mohammed Ali Awadllah ◽  
Atif Saeed Mohammed Idrees ◽  
Ali Abdel-Ghaffar Abel Rahheem Mohammed ◽  
Mohammed Abdel Rahman Idris
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Diabetic Patients ◽  
Low Density ◽  
Type Ii

This study consists of two parts; the Part one is to evaluate the level of Blood glucose and lipid profile  among diabetic patients(121 patients) which are compared with non-diabetic subjects (60 persons)  and  part two is to correlate lipid profile with cardiovascular abnormalities among type II diabetic patients. The diabetic patients were collected from Jabir Aboeleiz Center for Diabetes (51.9±11.22 years). Sixty healthy non-diabetic subjects were chosen as controls (52.44±10.76years). Blood glucose, total cholesterol (TC), triglycerides (TG) and high density lipoprotein (HDL) were measured by enzymatic colorimetric methods in both groups, and low density lipoprotein cholesterol (LDL) was calculated for each sample. Among diabetic patients, there is high glucose level, serum total cholesterol, triglycerides and LDL cholesterol (p<0.5), while low level of HDL cholesterol was observed when compared to non-diabetic subjects. No statistically variation was found in the level of glucose and lipid profile between male and female diabetic patients. In our study, we have found that serum lipid - cholesterol, triglycerides and low-density lipoprotein - levels were significantly (p < 0.05) correlated to cardiovascular abnormalities, while HDL had shown a statistically non-significant correlation (p>0.05). The study concluded that higher level of cholesterol, triglyceride and LDL-cholesterol in diabetic patients compared to non-diabetic subjects with lower level of serum HDL-cholesterol in diabetic patient compared to non- diabetic subjects.Keywords: Diabetic, Insulin, Mellitus and lipid.

scholarly journals Role of Helicobacter Pylori Infection on Diabetic and Lipid Profile in Pre-diabetic Patients

2021 ◽  
Author(s):  
Akash Chaudhary ◽  
Abdullah Ansari
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Diabetic Patients ◽  
Peptic Ulcers ◽  
Cholesterol Levels ◽  
Group A ◽  
Group B

Introduction:Helicobacter Pylori (H.pylori) infection is related to gastritis, peptic ulcers, gastric cancers and Mucosa Associated Lymphoid Tissue lymphomas (MALT). It is also associated with several extra-gastrointestinal pathologies owing to its association with increased production of proinflammatory cytokines, bacterial virulence factors and environmental factors. It may have an effect on onset of diabetes mellitus and alter lipid profile. Aim: To find the effect of H.pylori infection on diabetic and lipid profile in pre-diabetic patients. Materials and Methods: A single centre, cross-sectional study was conducted over a period from January 2019 to June 2020, on pre-diabetic patients (HbA1c 5.7-6.4%.). A total of 118 patients were recruited in the study and divided into two groups based on the H.pylori positive (group A) and negative (group B) results. HbA1c, Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) were investigated at baseline, six months and 12 months and the results of the two groups were compared using student’s t-test. Supply Support Planning and Execution (SSPE) Software version 20.0 were used for analysis of the collected data. A p-value<0.05 to be considered significant. Results: Of the 118 patients, 96 (mean age 48.3 years) completed the study. There 59 (61.5%) were males and 37 (38.5%) were females. A total of 54 (56%) of the study population tested positive for the H.pylori colonisation. The study showed that patients infected with H.pylori (group A) had comparative rapid increase in the HbA1c levels (p-value=0.048) when compared with the non-infective group (group B). The group A also had statistically significant increase in the LDL cholesterol levels (p-value=0.032) and decrease in HDL cholesterol levels (p-value=0.02) than group B. Conclusion: Infection with H.pylori is associated with increase in the level of HbA1c in pre-diabetics. It is also associated with increase in the LDL cholesterol levels and decrease in the HDL cholesterol levels. Eradication of the pathogen may help in preventing or delaying the progression of pre-diabetes and dyslipidemia. However, larger studies without any confounding factors are needed to establish the association between H.pyloriinfection and its effect on diabetic and lipid profile.

Prevalence of Elevated Non-HDL Cholesterol among Patients with Diabetes in An Iranian Population

2020 ◽  
Author(s):  
Asma Kheirollahi ◽  
Azam Karkhaneh
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Data Set ◽  
Patients With Diabetes ◽  
Routine Assessment

Background and Aims: Non-high density lipoprotein cholesterol (non- HDL-C), which reflects all cholesterol present in potentially atherogenic lipoprotein particles, might be a useful marker of atherosclerosis in diabetic subjects. In the present study, we evaluated the prevalence of high non-HDL-C in patients with dyslipidemia in diabetic and non-diabetic subjects following LDL-C assessment as the first goal of therapy. Materials and Methods: A data set of 2142 individuals was included in the study. All values of lipid profile were compared between non-diabetic and diabetic groups and the prevalence of dyslipidemia was evaluated in two groups. Results and Conclusions: According to the results, 48% of patients with diabetes achieved combined LDL-C ≤2.5 mmol/L and non-HDL ≤3.3 mmol/L targets, and 58.2% of diabetic patients achieved LDL-C goal while only 50.2% attained non-HDL-C goal. Also, the results indicated that non-HDL-C significantly heightened in patients with diabetes. Therefore, non-HDL-C needs to be calculated as a routine assessment in patients with diabetes.

scholarly journals A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

2008 ◽  
Vol 93 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Olivier Valkenburg ◽  
Regine P. M. Steegers-Theunissen ◽  
Huberdina P. M. Smedts ◽  
Geesje M. Dallinga-Thie ◽  
Bart C. J. M. Fauser ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Atherogenic Lipid Profile ◽  
Control Study ◽  
Atherogenic Lipid

Abstract Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. Design: This was a case-control study. Setting: The study was performed at a single referral center. Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values ≤ 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

scholarly journals Association of PRDM16 rs12409277 and CtBP2 rs1561589 gene polymorphisms with lipid profile of adolescents

2021 ◽  
Author(s):  
Nela Maksimovic ◽  
Vanja Vidovic ◽  
Tatjana Damnjanovic ◽  
Biljana Jekic ◽  
Nada Majkic Singh ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Fasting Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Brown Adipose

IntroductionPositive regulatory domain containing 16 (PRDM16) protein represents the key regulator of brown adipose tissue (BAT) development. It induces brown fat phenotype and represses white adipose tissue specific genes through the association with C-terminal binding co-repressor proteins (CtBP1 and CtBP2). In healthy adults presence of BAT has been associated with lower glucose, total cholesterol and LDL (low-density lipoprotein) cholesterol levels. Our aim was to analyze the association of PRDM16 gene (rs12409277) and CtBP2 gene (rs1561589) polymorphisms with body mass index (BMI), fasting glucose level and lipid profile of adolescents.Material and methodsOur study included 295 healthy school children, 145 boys (49.2%) and 150 girls (50.8%), 15 years of age. Genotypes for the selected polymorphisms were detected by the real-time PCR method. Age, gender, height, weight, lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) and fasting glucose levels were recorded.ResultsWe did not find a statistically significant association of rs12409277 and rs1561589 polymorphisms with BMI, fasting glucose and lipid profile of adolescents. We further analyzed the combined effect of the two SNPs and the statistical analysis showed that carriers of CT genotype of rs12409277 polymorphism and GG genotype of rs1561589 polymorphism had significantly lower total cholesterol (p = 0.001) and LDL cholesterol (p = 0.008) levels compared to all other groups of genotypes.ConclusionsOur study suggests that rs12409277 and rs1561589 polymorphism might have an influence on total and LDL cholesterol levels in adolescents. Larger studies should be performed in order to confirm our results.

scholarly journals Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes

2005 ◽  
Vol 62 (7-8) ◽  
pp. 529-536 ◽  
Author(s):  
Miroslava Zamaklar ◽  
Katarina Lalic ◽  
Natasa Rajkovic ◽  
Danijela Trifunovic ◽  
Mirjana Dragasevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Oxidized Ldl ◽  
Hdl Cholesterol ◽  
Apo B ◽  
Significant Difference

Background. Abnormal lipid profile is an important risk factor in the development of macrovascular atherosclerotic complications in patients with type 2 diabetes mellitus (T2D). Factors that contribute to endothelial cell dysfunction associated with the initiation of atherosclerosis include oxidative stress. The aim of this study was to investigate the relationship between lipid profile and oxidative stress in type 2 diabetics with and without ischemic heart disease (IHD). Methods. We studied 80 patients with T2D, 40 with IHD (group A1) and 40 without IHD (group A2). We also studied 51 non-diabetics, 31 with IHD (group B1), and 20 without IHD (group B2 - control group). Lipid profile was estimated by the total cholesterol, HDL cholesterol, LDL cholesterol, the level of triglyceride (Tg), lipoproteina a (Lp a), Apo A I, A II, B 100 and E. To evaluate the oxidative status we measured circulating oxidized LDL (ox LDL), erythrocyte antioxidative enzyme activity: superoxide dismutase (E-SOD), glutathione peroxidase (E-GPX), as well as the total antioxidative serum activity (TAS). Inflammatory reaction was estimated by C-reactive protein (CRP) and fibrinogen. Results. No significant difference was found in the lipid profile in groups A1, A2 and B1, but the group B2 had the lowest one. Lp a level was significantly higher in group B1 comparing to other groups (p < 0.05). There was no significant difference in the level of ox LDL between the groups. In diabetics, ox LDL positively correlated with the total cholesterol, LDL cholesterol, non HDL cholesterol, Apo B 100 and the relations between LDL/HDL and Tg/HDL (p < 0.001), as well as with Tg and fibrinogen (p < 0.05). In group B1, ox LDL positively correlated with total cholesterol, Tg (p < 0.01), LDL, and non HDL cholesterol (p < 0.05) and significantly with Apo B 100 (p < 0.001). There was no significant difference in the antioxidant enzyme activities between the groups of diabetics (A1 and A2), but fibrinogen was higher in the group with IHD (group A1, p < 0.05). Group B1 had lower ESOD activity than the groups A1 and A2 (p < 0.05), but CRP was higher (p < 0.05). There were no significant correlations between oxLDL and CRP in groups A1 and A2, but it was statistically significant in the group B1 (p < 0.05). Conclusion. In this study we demonstrated the increased oxidative stress in diabetics compared to non-diabetics regardless of the presence of IHD. Fibrinogen, but not CRP, was higher in diabetics with IHD, compared to diabetics without IHD. The increased oxidative stress, the reduced antioxidative activity E-SOD, and the higher level of CRP were found in non-diabetics with IHD compared to non-diabetics without IHD.

Chromium Yeast Supplementation Improves Fasting Plasma Glucose and LDL-Cholesterol in Streptozotocin-Induced Diabetic Rats

2006 ◽  
Vol 76 (6) ◽  
pp. 391-397 ◽  
Author(s):  
Lai ◽  
Chen ◽  
Cheng
Keyword(s):  
Lipid Metabolism ◽  
Blood Glucose ◽  
Body Mass ◽  
Ldl Cholesterol ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Significant Difference ◽  
Chromium Yeast

Chromium yeast supplementation has been studied for its ability to improve carbohydrate and lipid abnormalities. There have been some earlier literature-reported studies involving chromium supplementation amongst patients suffering diabetes, but the results would appear to be somewhat varied. Forty male Wistar rats (ten weeks old, 300 g in average body mass) were divided into one of four groups, namely (i) controls; (ii) controls treated with chromium yeast; (iii) diabetic controls; and (iv) diabetic rats treated with chromium yeast. In the present investigation, the effect of a four-week oral administration of chromium yeast (600 μg of Cr/kg body mass/day, by gavage) upon the glucose and lipid metabolism in streptozotocin (STZ)-induced diabetic rats was assessed. Supplemental Cr yeast decreased the fasting blood glucose amongst the STZ-diabetic rats. No significant difference was observed in plasma fructosamine levels of rats treated with chromium yeast compared to control rats. Supplemental Cr yeast did decrease the plasma low-density lipoprotein (LDL)-cholesterol level for the STZ-diabetic rats as compared to controls. We noted no significant effect of chromium supplementation upon plasma high-density lipoprotein (HDL)-cholesterol or triglycerides compared to controls. Treatment with chromium yeast significantly increased the blood and urine chromium levels for both the diabetic and normal rats compared to respective control groups. The results of these studies suggest that Cr yeast decreased the fasting blood glucose and LDL-cholesterol levels in STZ-induced diabetic rats. This raises the possibility that Cr yeast supplementation can be considered to improve carbohydrate and lipid metabolism amongst human patients featuring type 2 diabetes mellitus.

scholarly journals Study Of Serum Lipid Profile In Pre-Eclampsia And Eclampsia

1970 ◽  
Vol 5 (2) ◽  
pp. 56-59 ◽  
Author(s):  
NAF Islam ◽  
MAR Chowdhury ◽  
GM Kibria ◽  
S Akhter
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Significant Rise ◽  
Serum Lipid Profile ◽  
Cholesterol Concentration ◽  
High Density Lipoproteins

The present study was designed to evaluate the association of lipid profile in pre- eclampsia and eclampsia. This case-control study was carried out in the department of biochemistry, M.A.G. Osmani Medical College, Sylhet, during July 2005 to June 2006. Total 100 study subjects were evaluated, 40 normotensive pregnant women (mean age 24.90 ± 4.04) as normal and 60 already diagnosed preeclamptic & eclamptic women (mean age 24.17 ± 4.90) as study group. Age range was 15-45 years, gestational age 24 weeks to term were included. Patients with pre-existing hypertension were excluded. Serum lipid profile (total lipids, cholesterol, triglycerides, HDL-cholesterol and LDLcholesterol) of hundred women with Pre-eclampsia and Eclampsia (n=60), normotensive women (n=40) were monitored. The preeclampsia was associated with a significant rise in triglyceride (225.6 ± 28.93 vs 165.6 ± 17.22) and fall in HDL cholesterol concentration (42.4 ± 9.29 vs 55.7 ± 7.11), while eclamptic women showed significant fall in HDL cholesterol (41.8 ± 8.79 vs 55.7 ± 7.11) and rise in LDL cholesterol (133.4 ± 11.75 vs 115.2 ± 10.72) as compared to normal pregnant women. Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia and Eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia and eclampsia. This association may be significant in understanding the pathologic processes of preeclampsia and may help in developing strategies for prevention or early diagnosis of the disorder. Key Words: Preeclampsia; High Density Lipoproteins; Triglycerides; Low Density Lipoprotein. DOI: 10.3329/fmcj.v5i2.6823Faridpur Med. Coll. J. 2010;5(2):56-59

scholarly journals Serum Lipid Profile of Hypertensive Patients in the Northern Region of Bangladesh

1970 ◽  
Vol 14 ◽  
pp. 93-98 ◽  
Author(s):  
MS Saha ◽  
NK Sana ◽  
Ranajit Kumar Shaha
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Northern Region ◽  
Serum Lipid Profile ◽  
Hypertensive Patients ◽  
Control Subjects

A prospective study was conducted in the Northern region of Bangladesh, to investigate the serum lipid profile viz the level of total cholesterol (TC), Triglyceride (TG), HDL-cholesterol and LDL-cholesterol of hypertensive patients and compares them with levels of control subjects. The results revealed that serum total cholesterol, triglyceride and LDL-cholesterol were significantly markedly raised (p>0.001) whereas the level of HDL-cholesterol was significantly lower (p>0.001) in hypertensive patients as compared to control subjects. No significant changes of serum lipid profile were found between male and female hypertensive patients, but in control subjects, markedly higher levels of serum lipid profile was observed in male compared to that of female. It was concluded that hypercholesterolaemia, hypertrigyceridaemia and low density lipoprotein are the main lipid abnormalities on the incidence of hypertension in the study area. Key words: Hypertension, Total cholesterol (TC), triglyceride (TG), HDL- cholesterol and LDL-cholesterol. J. bio-sci. 14: 93-98, 2006

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