METABOLIC EFFECTS OF THYROTROPHIC HORMONE IN MAN

1962 ◽  
Vol 41 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Bengt Skanse ◽  
Wilfried von Studnitz
Keyword(s):  
Serum Proteins ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Point Of View ◽  
Metabolic Effects ◽  
Total Serum ◽  
Thyrotrophic Hormone ◽  
Γ Globulins ◽  
Inflammatory Processes ◽  
Rebound Phenomenon

ABSTRACT The metabolic effects of prolonged administration of thyrotrophic hormone were studied in 5 euthyroid subjects and in 1 patient who had been subjected to total thyroidectomy. Thyrotrophic hormone (TSH) had no effect in the thyroidectomized patient, thus showing that the metabolic effects were mediated by stimulation of the thyroid. In the euthyroid subjects the TSH caused an increase in thyroid activity as judged by the rise in basal metabolic rate (BMR) and serum protein-bound iodine (PBI) and the clinical symptoms. The administration of TSH resulted in: elevation of the erythrocyte sedimentation rate (ESR), and in an increase of the fibrinogen, haptoglobin, coeruloplasmin and total hexose content of the serum; an increase of α1-, α2-, and β2-globulins and smaller and less consistent changes in the albumin and β1- and γ-globulins, i. e. changes of the type seen in acute infections or acute inflammatory diseases; a fall in the total serum lipids, cholesterol and phospholipids, and less consistent changes in the α- and β-lipoproteins. During continued administration of TSH all the above mentioned metabolic effects tended to level off and/or disappear, probably owing to formation of antibodies. Withdrawal of TSH was followed by a rebound phenomenon, presumably because of diminished production of thyroid hormone. From the clinical point of view the possibility of increased thyroid function being a cause of elevated ESR and of the serum proteins changes resembling those seen in acute inflammatory processes should perhaps be considered.

scholarly journals The electrophoretic pattern of serum proteins in dairy cows with inflammatory diseases

2017 ◽  
Vol 67 (2) ◽  
pp. 178-190 ◽  
Author(s):  
Csilla Tóthová ◽  
Pavol Mudroň ◽  
Oskar Nagy
Keyword(s):  
Dairy Cows ◽  
Serum Protein ◽  
Serum Proteins ◽  
Inflammatory Diseases ◽  
Post Partum ◽  
Electrophoretic Pattern ◽  
Protein Fractions ◽  
Total Serum ◽  
Control Group ◽  
Γ Globulins

Abstract The objective of the study was to evaluate the electrophoretic pattern of serum proteins in dairy cows suffering from various inflammatory diseases, and to study the influence of these diseases on the concentrations of protein fractions. Fourty dairy cows with clinical signs of various inflammatory diseases were used in the study, including cows with post-partum metritis (n=10), mastitis (n=7), and hoof diseases (n=23). The cows were of a black pied Holstein-Friesian breed, Slovak spotted breed and their crossbreeds at the age of 3.5 to 8 years. Fourteen clinically healthy dairy cows were taken as the control group. The cows were blood sampled for the determination of total serum proteins and serum protein fractions. The protein fractions were divided into albumin, α1-, α2-, β1-, β2-, and γ-globulins. In cows with post-partum metritis we found significantly lower concentrations of albumin (P<0.001) and significantly higher values of α1-globulins (P<0.01) compared with healthy animals. Significantly higher concentrations of β1-globulins were observed in cows with mastitis (P<0.001), while the γ-globulin fraction was non-significantly higher. In cows with hoof diseases we recorded significantly lower values of albumin (P<0.001), significantly higher concentrations of α1- and β1-globulins (P<0.001), and non-significantly higher β2- and γ-globulins. Moreover, in the electrophoretic pattern of serum proteins we found β-γ bridging in thirteen cows with hoof diseases. Presented data suggest marked influence of inflammatory diseases on the concentrations of serum protein fractions in dairy cows. However, further investigations are needed to establish the diagnostic utility of serum protein electrophoresis in bovine clinical practice in relation to inflammatory diseases.

scholarly journals The effect of chronic respiratory diseases in calves on the serum protein electrophoretic pattern

2012 ◽  
Vol 81 (4) ◽  
pp. 365-370 ◽  
Author(s):  
Csilla Tóthová ◽  
Oskar Nagy ◽  
Herbert Seidel ◽  
Gabriel Kováč
Keyword(s):  
Serum Protein ◽  
Respiratory Diseases ◽  
Clinical Symptoms ◽  
Electrophoretic Pattern ◽  
Protein Fractions ◽  
Total Serum Protein ◽  
Total Serum ◽  
Chronic Respiratory Diseases ◽  
Γ Globulins ◽  
Protein Electrophoretic Pattern

The aim of this study was to evaluate the effect of chronic respiratory diseases in calves on the serum protein electrophoretic pattern. Twenty five calves of the Slovak Spotted breed, Low-land Black Spotted breed, and their crossbreeds with clinical symptoms of chronic respiratory diseases were included into this study. Blood serum was analyzed for the total serum protein concentrations, and the relative and absolute values of serum protein fractions. The results obtained in sick animals were compared with those in 29 clinically healthy calves of the same age and breed. In the calves suffering from chronic respiratory diseases, we found significantly (P < 0.001) higher total serum protein concentrations than in healthy calves. In sick calves a marked shift in the concentrations of the most of protein fractions was observed, with significantly higher values of α1-, β1-, β2- and γ-globulins (P < 0.001, P < 0.05, P < 0.001, and P < 0.01, respectively). On the other hand, the concentrations of albumin in the calves with respiratory diseases were significantly (P < 0.001) lower than those measured in healthy ones. The presented results indicate a marked effect of chronic respiratory diseases in calves on the serum protein electrophoretic pattern, with a shift in the albumin and globulin concentrations, which could be useful for clinicians for better evaluation of the pathological changes in affected animals.

scholarly journals Comparison of serum protein electrophoretic pattern in cows and small ruminants

2015 ◽  
Vol 84 (2) ◽  
pp. 187-195 ◽  
Author(s):  
Oskar Nagy ◽  
Csilla Tóthová ◽  
Veronika Nagyová ◽  
Gabriel Kováč
Keyword(s):  
Serum Protein ◽  
Adult Female ◽  
Serum Proteins ◽  
Electrophoretic Pattern ◽  
Small Ruminants ◽  
Protein Fractions ◽  
Total Serum Protein ◽  
Total Serum ◽  
Γ Globulins ◽  
Protein Electrophoretic Pattern

Determination of the physiological electrophoretic patterns in animals is very useful for clinicians in diagnosing healthy and sick animals. The objective of this study was to investigate the serum protein electrophoretic pattern in cows, sheep, and goats in order to evaluate the differences in the size and number of protein fractions between the evaluated ruminant species. Ten adult multiparous high-yielding dairy cows, 10 adult female sheep and 10 adult female goats were included in this study. All the evaluated animals were clinically healthy. Serum was analyzed for total serum protein concentrations, and for the relative and absolute values of protein fractions with calculation of albumin/globulin ratios. Serum protein fractions were separated by zone electrophoresis on buffered agarose gel. Serum protein electrophoresis identified 6 distinct bands, comprising albumin, alpha1- (α1), alpha2- (α2), beta1- (β1), beta2- (β2), and gamma- (γ) globulins in cows. In sheep, serum proteins exhibited 6 fractions: albumin, α1-, α2-, β-, γ1- and γ2-globulins. In goats, serum proteins were separated into 5 fractions: albumin, α1-, α2-, β- and γ-globulins. Significant differences in the relative as well as absolute means were found for the albumin/globulin ratio and most of the protein fractions, except γ-globulins. No significant differences were found in the concentration of total proteins. These results describe the marked species differences in most of serum protein fractions between the evaluated groups of animals, and contribute to the current knowledge about the physiological electrophoretic pattern of serum proteins in ruminants, which can be used for diagnostic purposes.

scholarly journals Changes in the Serum Protein Fractions in Goats after Treatment of Natural Gastrointestinal Parasite Infections

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Frederika Chovanová ◽  
Csilla Tóthová ◽  
Róbert Klein ◽  
Oskar Nagy
Keyword(s):  
Serum Protein ◽  
Serum Proteins ◽  
Gastrointestinal Parasites ◽  
Protein Fractions ◽  
Dairy Goat ◽  
Total Serum ◽  
Parasitic Infections ◽  
Gastrointestinal Infections ◽  
Γ Globulins ◽  
Antiparasitic Treatment

Gastrointestinal parasitic infections in small ruminants belong to major health problems. The regulation of gastrointestinal infections in goats and the responses developed against them appear to be different from those observed in sheep. In the literature, there is a lack of data on the effect of gastrointestinal parasitic infections on the serum protein profile in goats. Therefore, the aim of the study was to determine the electrophoretic pattern of serum proteins in goats naturally infected with gastrointestinal parasites and to compare the changes in the total serum proteins and serum protein fractions (albumin and α1-, α2-, β-, and γ-globulins) obtained after antihelminthic treatment. Eight adult female goats of the white shorthaired breed from a small dairy goat farm at the age ranging between 3 and 5 years with average body weight 35.4 ± 3.2 kg and body condition score (BCS) from 1.5 to 2.5 were used in the study. The serum proteins in goats were separated into five fractions: albumin, α1- and α2-globulins, and β- and γ-globulins. Significant changes after treatment were found in the relative concentrations of albumin ( P < 0.01 ) and α2- ( P < 0.05 ), β- ( P < 0.001 ), and γ-globulins ( P < 0.01 ), as well as albumin/globulin ratio ( P < 0.01 ). The mean concentration of total serum proteins was, after the antiparasitic treatment, significantly higher. Among the globulin fractions, the γ-globulin fraction contributed most significantly to these changes ( P < 0.001 ). The results presented in the study suggest a significant effect of antiparasitic treatment in goats on the synthesis of blood serum proteins and on the changes of the proportion of serum protein fractions.

scholarly journals Post-Genomics and Skin Inflammation

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Daniela Braconi ◽  
Giulia Bernardini ◽  
Annalisa Santucci
Keyword(s):  
Scientific Community ◽  
Inflammatory Diseases ◽  
Skin Inflammation ◽  
Point Of View ◽  
Future Research ◽  
Genomic Technologies ◽  
Research Challenges ◽  
Common Skin ◽  
Inflammatory Processes ◽  
Chronic Skin

Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the most common skin disorders involving inflammatory processes, seems to be still quite neglected under the post-genomic point of view. In this paper, we will review how post-genomic technologies have provided new fundamental tools for the analysis of these three conditions and we will cast light on their potential in addressing future research challenges.

scholarly journals Electrophoretic and Immunological Studies on Sera from Calves from Birth to Weaning I. Electrophoretic Studies

1955 ◽  
Vol 53 (3) ◽  
pp. 247-260 ◽  
Author(s):  
A. E. Pierce
Keyword(s):  
Serum Proteins ◽  
Calf Serum ◽  
In Utero ◽  
Total Serum ◽  
Electrophoretic Mobilities ◽  
Significant Difference ◽  
Γ Globulins ◽  
The Relationship

Summary1. The serum proteins of calves from birth to weaning, and the maternal colostral whey have been examined with the ‘classical’ Tiselius electrophoresis apparatus. Differences were shown between calves fed colostrum and those partially deprived of colostrum.2. A study of the pre-colostral calf serum showed the presence of albumin and of two major components with mobilities similar to the α and β globulins of adult serum. A component forming approximately 1·4 % of the total serum proteins and with a mobility similar to that of γ1 or fibrinogen represented the γ1 globulin. This globulin component was not unconverted fibrinogen and may be autogenous γ globulin or γ globulin passively acquired in utero.3. Autogenous γ globulin was evident in colostrum-fed and colostrum-deprived calves shortly after birth. The γ1 and γ2 components could be distinguished by the 10th day after birth, at which time the γ1 globulin was the greater. By the 30th day the γ2 globulin exceeded the γ1 globulin and a smaller component termed the γ3 globulin could usually be detected between the γ2 and the salt boundary.4. Albumin concentrations generally fluctuated inversely to changes in the total serum globulins.5. The α globulins associated with fetuin declined shortly after birth in the colostrum-fed group. In the deprived group α globulin first rose and then fell. In both groups minimum α globulin values were reached at about the 30th day, when the α1 globulin, although initially the major component in pre-colostral calf serum, was more depleted than the α2.6. The β globulin frequently showed a transient though marked increase when the α globulins were at their lowest values.7. No changes in the electrophoretic mobilities of the major serum proteins were detected as the calves matured, and no significant difference was found between the mobilities of the electrophoretic components of calf and adult sera.8. The electrophoretic examination of colostral whey, colostral lacto-globulin fractions and calf serum immediately after suckling usually showed one lacto-globulin component. The relationship between the serum γ globulins and the lacto-globulin. is discussed.The author wishes to thank Dr M. Robertson, F.R.S., and Sir Alan Drury, F.R.S. for their interest and encouragement during the course of this work, Dr W. R. Kerr for his co-operation in supplying most of the serum and colostrum samples, and Dr A. W. Stableforth and Dr J. S. Paterson for making certain cattle available for these experiments.

scholarly journals Oral Mucosa in Coronavirus Infection

2021 ◽  
Vol 13 ◽  
Author(s):  
U. Zhabborova ◽  
A. Sh. Inoyatov
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Antibacterial Agents ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Hygienic Measures ◽  
Inflammatory Processes ◽  
Coronavirus Infection ◽  
Recurrent Nature

Inflammatory diseases of the oral mucosa can manifest themselves by various nosological processes of the oral cavity, but sometimes even against the background of pronounced inflammatory processes, stomatitis, gingivitis and many other diseases do not form, often this is due to systemic viral processes, for example, coronavirus infection. At the same time, clinical symptoms can be very diverse, or even absent even against the background of changes in the immune and microbial landscape of the oral cavity. With the progression of the disease, the process may spread to the palate, gums, palatine tonsils, larynx, and digestive tract. It is important to distinguish weakened individuals, individuals with immunodeficiency conditions who were on long-term use of antibacterial agents, corticosteroids and antineoplastic drugs. The persistence and recurrent nature of such inflammatory lesions requires not only the usual hygienic measures for the care of the oral cavity and teeth, but also appropriate justified therapy aimed at stimulating the protective forces of the oral mucosa.

Influence of hypoproteinemia on bile proteins

1959 ◽  
Vol 197 (3) ◽  
pp. 558-560 ◽  
Author(s):  
Taketo Katsuki ◽  
Charles G. Johnston ◽  
Charles Koucky
Keyword(s):  
Serum Protein ◽  
Protein Concentration ◽  
Serum Proteins ◽  
Protein A ◽  
Total Serum Protein ◽  
Total Serum ◽  
Blood Proteins ◽  
Additional Function ◽  
Γ Globulins ◽  
Bile Protein

Plasmapheresis was performed in dogs to change the serum protein and bile protein. A low caloric diet and plasmapheresis resulted in a diminished plasma albumin, slightly increased α-globulin, and definitely increased ß- and γ-globulins. Simultaneously, B-fraction (albumin-containing-fraction of bile) decreased while the C-fraction (α-globulin-containing-fraction of bile) and D-fraction (ß- and γ-globulin-containing-fraction of bile) increased. When the plasmapheresis was discontinued and a normal caloric diet supplied, there was a gradual reversal of these changes toward the original levels. This is further indication that B-, C- and D-fraction of bile proteins arise from blood proteins. It is apparent that this is not by simple transudation of proteins from capillaries to bile canaliculi because the smallest protein molecular B-fraction comprises a smaller proportion of bile proteins than of serum proteins, whereas the larger molecular D-fraction comprises a larger proportion of bile proteins than of serum proteins, and yet the total bile protein concentration is always much less than the total serum protein concentration. There must be some mechanism regulating the occurrence of the bile proteins, and this may be an additional function of the hepatic cells.

scholarly journals Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines

2019 ◽  
Vol 20 (3) ◽  
pp. 459 ◽  
Author(s):  
Leila Kheirandish-Gozal ◽  
David Gozal
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Inflammatory Diseases ◽  
Sleep Apnea Syndrome ◽  
Special Focus ◽  
Normal Body Mass Index ◽  
Low Grade ◽  
Obstructive Sleep ◽  
Inflammatory Processes ◽  
Factor Α

Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the lifespan, particularly in overweight and obese individuals, which has been associated with an independent risk for neurocognitive, behavioral, and mood problems as well as cardiovascular and metabolic morbidities, ultimately fostering increases in overall mortality rates. In adult patients, excessive daytime sleepiness (EDS) is the most frequent symptom leading to clinical referral for evaluation and treatment, but classic EDS features are less likely to be reported in children, particularly among those with normal body-mass index. The cumulative evidence collected over the last two decades supports a conceptual framework, whereby sleep-disordered breathing in general and more particularly OSAS should be viewed as low-grade chronic inflammatory diseases. Accordingly, it is assumed that a proportion of the morbid phenotypic signature in OSAS is causally explained by underlying inflammatory processes inducing end-organ dysfunction. Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients.

scholarly journals The Effect of Dietary Intake and Nutritional Status on Anthropometric Development and Systemic Inflammation: An Observational Study

2021 ◽  
Vol 18 (11) ◽  
pp. 5635
Author(s):  
Roxana Maria Martin-Hadmaș ◽  
Ștefan Adrian Martin ◽  
Adela Romonți ◽  
Cristina Oana Mărginean
Keyword(s):  
Serum Proteins ◽  
Caloric Intake ◽  
Saturated Fat ◽  
The Body ◽  
Total Serum ◽  
Fat Intake ◽  
Trans Fats ◽  
Study Objective ◽  
Inflammatory Status ◽  
Total Fat

(1) Background: Daily caloric intake should aim to reduce the risk of obesity or poor anthropometric development. Our study objective was to analyze the association between food consumption, inflammatory status and anthropometric development; (2) Methods: We performed a prospective observational analytical research during September 2020 and April 2021 on a group of 160 healthy subjects, aged between 6 and 12 years old, by analyzing food ingestion, the basal metabolic rate, anthropometric development and the inflammatory status; (3) Results: IL-6 was significantly correlated to the sum of skinfolds, along with both serum proteins and triglycerides. The skin folds were significantly correlated with the caloric intake and with total fat intake, next to saturated and trans fats. Unlike the skin folds, the body weight was significantly correlated with the caloric intake along with some vitamins, such as Vitamin A and Vitamin B12. Inactive mass increased with excessive folic acid, Vitamin E, Vitamin K and saturated fat intake; (4) Conclusions: The inflammatory status was influenced by the ingestion of micronutrients, total serum lipids and proteins. The anthropometric development was associated with the ingestion of carbohydrates, energy balance and energy intake. We can conclude that daily menu and nutrition imbalances can influence both the risk of obesity and the inflammatory status.

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