scholarly journals Oral Mucosa in Coronavirus Infection

2021 ◽  
Vol 13 ◽  
Author(s):  
U. Zhabborova ◽  
A. Sh. Inoyatov
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Antibacterial Agents ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Hygienic Measures ◽  
Inflammatory Processes ◽  
Coronavirus Infection ◽  
Recurrent Nature

Inflammatory diseases of the oral mucosa can manifest themselves by various nosological processes of the oral cavity, but sometimes even against the background of pronounced inflammatory processes, stomatitis, gingivitis and many other diseases do not form, often this is due to systemic viral processes, for example, coronavirus infection. At the same time, clinical symptoms can be very diverse, or even absent even against the background of changes in the immune and microbial landscape of the oral cavity. With the progression of the disease, the process may spread to the palate, gums, palatine tonsils, larynx, and digestive tract. It is important to distinguish weakened individuals, individuals with immunodeficiency conditions who were on long-term use of antibacterial agents, corticosteroids and antineoplastic drugs. The persistence and recurrent nature of such inflammatory lesions requires not only the usual hygienic measures for the care of the oral cavity and teeth, but also appropriate justified therapy aimed at stimulating the protective forces of the oral mucosa.

scholarly journals DIAGNOSIS OF ORAL MUCOSAL PATHOLOGY IN PATIENTS WITH VARIOUS MANIFESTATIONS OF GROUP B VITAMIN IMBALANCE

2021 ◽  
Vol 16 (4) ◽  
pp. 77-83
Author(s):  
Anna Yatsenko ◽  
Lidiya Trankovskaya ◽  
Olga Artyulova
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Human Body ◽  
Clinical Symptoms ◽  
Negative Impact ◽  
Vitamin B12 Deficiency ◽  
Vitamin Deficiency ◽  
The Body ◽  
B Vitamins ◽  
Group B

Subject. The scientific works of recent years show an increase in the degree of negative impact of vitamin deficiency and vitamin-like substances on the state of health of the population. With the deficiency of most vitamins, synthetic processes and regeneration of oral tissues are reduced, so often the initial signs of hypovitaminosis are stomatitis, gingivitis, glossitis, and therefore, it is dentists who are the first to diagnose deviations in the body associated with vitamin deficiency. This justifies the relevance and practical value of studying and describing clinical cases of manifestations of deficient vitamin conditions in the oral cavity. The object – is to study the effect of B vitamins on the oral mucosa in order to increase the effectiveness of diagnosis of vitamin-deficient conditions of the human body. Methodology. These clinical examples illustrate the management experience of patients with manifestations of deficient vitamin conditions on the oral mucosa. Clinical and laboratory methods of diagnosing the analysed conditions of the organism were applied. Statistical processing of materials was carried out using the STATISTICA 10 software (StatSoft, Inc., USA). Results. The deficient condition of the organism in relation to vitamins B2, B6, B12 in patients 18-75 years old has been studied. Characteristic clinical changes on the oral mucosa of the examined patients were established. So, in most patients with vitamin B2 deficiency, the classic Sebrel triad was found: dermatitis, glossitis, cheilitis. In those examined with a lack of vitamin B6, language desquamations (smoothed, polished language) were determined in the 83.6%, often combined with glossodinia. Patients with vitamin B12 deficiency were characterized by a lesion in the form of Meller-Gunter glossitis in 74.9% of cases, moreover, 67.6% of patients showed paresthesia in the area of tongue and oral mucosa. Conclusions. The study found that the first clinical symptoms of deficient conditions of the presented vitamins of group B were found from the oral cavity. Thus, it is the dentist who is the first to diagnose the pathological states of lack of group B vitamins in the human body, which emphasizes the importance and relevance of continuing to study these states of the body.

Clinical Significance of Salivary Lactoferrin for Individual Prognosis Complications at Sanation of Oral Cavity in Patients with Locally Common Cancer of Oral Mucosa

10.12737/5905 ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 82-85
Author(s):  
Иванов ◽  
V. Ivanov ◽  
Иванова ◽  
O. Ivanova ◽  
Шейкин ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Therapy Assessment ◽  
Non Invasive ◽  
Common Cancer ◽  
Dental Procedures ◽  
Mucus Membrane ◽  
Inflammatory Processes ◽  
Invasive Method ◽  
Therapeutic Measures

Purpose of the investigation is to develop and introduce the methods of prognosis complications of oral sanitation at the treatment of the patients with locally common cancer of oral mucosa. Sanitation of oral cavity in patients with locally common cancer of oral mucus membrane is connected with development of various complications among which infections and hemorrhages play a leading part. It determines problem of development of methods of forecasting of these complications as relevant. Material and methods: Based on a comparative analysis of 340 patients with above pathology the authors have traced dependence between the development of complications in oral cavity after chemical and radial therapy and levels of lactoferrin (LF) in saliva. This simple and non-invasive method can be as a marker of pathological states in oral cavity. Among the complex of the parameters the authors have studied risk factors of complications after the use of the cytostatics and radial therapy with resulting index of prognosis (IP) for development of complications. Based on the index of prognosis individual tactics of treatment was determined. Results: Depending on the saliva levels of lactoferrin in patients receiving chemo- and radial therapy a complex of prophylactic and curable measures was developed, which allowed to decreasing the number of inflammatory processes in a zone of dental procedures from 14,1 to 2,8% and the number of bleedings from 8,0 to 5,0%. Conclusions. Level of LF in saliva can be considered as valid prognostic marker of the development of destructive complications while oral sanitation in patients received chemo- and radial therapy. Assessment of the probability of these complications with correction of preventive and therapeutic measures should be implemented depending on the prognostic value of the index. Prevention activities for development of complications in sanitation of oral cavity in cancer patients after combined and complex treatment can reduce the number of hemorrhagic complications to 5.0%, and the local inflammatory processes to 2.8%.

METABOLIC EFFECTS OF THYROTROPHIC HORMONE IN MAN

1962 ◽  
Vol 41 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Bengt Skanse ◽  
Wilfried von Studnitz
Keyword(s):  
Serum Proteins ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Point Of View ◽  
Metabolic Effects ◽  
Total Serum ◽  
Thyrotrophic Hormone ◽  
Γ Globulins ◽  
Inflammatory Processes ◽  
Rebound Phenomenon

ABSTRACT The metabolic effects of prolonged administration of thyrotrophic hormone were studied in 5 euthyroid subjects and in 1 patient who had been subjected to total thyroidectomy. Thyrotrophic hormone (TSH) had no effect in the thyroidectomized patient, thus showing that the metabolic effects were mediated by stimulation of the thyroid. In the euthyroid subjects the TSH caused an increase in thyroid activity as judged by the rise in basal metabolic rate (BMR) and serum protein-bound iodine (PBI) and the clinical symptoms. The administration of TSH resulted in: elevation of the erythrocyte sedimentation rate (ESR), and in an increase of the fibrinogen, haptoglobin, coeruloplasmin and total hexose content of the serum; an increase of α1-, α2-, and β2-globulins and smaller and less consistent changes in the albumin and β1- and γ-globulins, i. e. changes of the type seen in acute infections or acute inflammatory diseases; a fall in the total serum lipids, cholesterol and phospholipids, and less consistent changes in the α- and β-lipoproteins. During continued administration of TSH all the above mentioned metabolic effects tended to level off and/or disappear, probably owing to formation of antibodies. Withdrawal of TSH was followed by a rebound phenomenon, presumably because of diminished production of thyroid hormone. From the clinical point of view the possibility of increased thyroid function being a cause of elevated ESR and of the serum proteins changes resembling those seen in acute inflammatory processes should perhaps be considered.

scholarly journals CONCEPTUAL FRAMEWORK FOR ORAL CANCER PREVENTION

2021 ◽  
Vol 21 (2) ◽  
pp. 123-126
Author(s):  
P.V. Sheleshko ◽  
V.P. Bashtan ◽  
L.M. Vasko ◽  
O.V. Korneev ◽  
O.O. Kаlishenko
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Conceptual Framework ◽  
Oral Mucosa ◽  
Inflammatory Diseases ◽  
Visual Assessment ◽  
Chewing Tobacco ◽  
Underlying Causes ◽  
Over 40 Years ◽  
Early Detection And Prevention

Inflammatory diseases of the teeth, mucous membranes with its precancerous alterations in the form of leuko- and erythroplakia, hyperkeratosis, papillomas occur in the oral cavity under the influence of its microflora. Among the causal factors there is chronic pressure onto oral mucosa areas caused by laminar dentures, tooth fragments, as well as chewing tobacco, and alcohol abuse. Occupational hazards can also contribute to the occurrence of precancerous conditions. The objective of this study is to provide the conceptual framework for prevention of oral cancer with the consideration of its underlying causes and their early detection and prevention in accordance with medical and diagnostic tactics and visual assessment of their effectiveness. The study included 54 patients treated for precancerous diseases of the oral cavity at the Department of Head and Neck Tumours, Poltava Regional Clinical Oncology Dispensary. There were 34 men and 20 women aged from 42 to 76 years. According to the anamnesis of the patients, local changes in the oral mucosa were painless, small in size, their duration varied from 3 to more than 2 years. Local papillomatous mucosal newgrowths 1 cm in diameter were found in 17 patients, the same size changes with pronounced hyperkeratosis were diagnosed in 8 patients, leukoplakia was found in 9 patients, and warty leukoplakia slightly raised over the mucosa was seen in 8 patients. 18 patients had those changes in the area of ​​the root of the tongue,13 patients – on the lateral surface of the tongue; 11 patients – in the area of ​​the buccal mucosa. Histological findings of removed warty leukoplakia in 4 patients and papillomatous masses in 2 patients revealed atypism of the basal cell epithelium with its proliferation that indicates the beginning of malignancy. Precancerous alterations in the oral mucosa because of their silent cause can result in the progression of the disease and its late detections. Timely diagnosis of precancerous alterations in the oral mucosa due to their foci character and painlessness is impossible without a thorough intraoral examination. This examination should become a component of mandatory annual preventive checkups for persons over 40 years.

scholarly journals Compositions of essential oils with antimicrobial properties against isolates from oral cavities of patients with inflammatory diseases of the periodontium

2018 ◽  
Vol 9 (4) ◽  
pp. 491-494 ◽  
Author(s):  
M. V. Kryvtsova ◽  
Y. Y. Kostenko ◽  
I. Salamon
Keyword(s):  
Oral Cavity ◽  
Essential Oils ◽  
Inflammatory Diseases ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Antimicrobial Effect ◽  
Diffusion Method ◽  
Antibiotic Resistant ◽  
Inflammatory Processes ◽  
Opportunistic Pathogenic

The significant spread of antibiotic-resistant microorganisms which are part of microbial associations of the oral cavity is considered one of the main causes for the complications and relapses of inflammatory diseases of the periodontium. This problem underlines the importance of constant monitoring of the circulation of polyantibiotic-resistant isolates, and development of new approaches and means of correction for the microbiocoenosis of the oral cavity affected by inflammatory processes. The paper is dedicated to research of antimicrobial properties of essential oil compositions against opportunistic pathogenic microorganisms, agents of inflammatory diseases of the periodontium. Out of the microorganisms isolated from the nidus of inflammation, the extra antibiotic-resistant ones were chosen. For the purpose of antibiotic susceptibility and antimicrobial activity testing, the disc diffusion method was used. The following compositions were manufactured from essential oils: Hyssopus officinalis L. + Rossmarinus officinalis L.; Menta piperita L. + H. officinalis; R. officinalis + Coriandrum sativum L.; R. officinalis + M. piperita + H. officinalis. The compositions H. officinalis + R. officinalis; M. piperita + H. officinalis were shown to have the highest level of antibacterial activity against clinical and typical isolates. Combinations of essential oils demonstrated a broader spectrum of activity against microorganisms than their components taken separately. Certain essential oils and the compositions H. officinalis + R. officinalis; M. piperita + H. officinalis were ascertained to have a high anti-mycotic activity against Candida genus microscopic fungi. This fact proves the advantage of application of combinations of essential oils compared to the use of their separate components. However, not all variants reviewed showed additive antimicrobial effect of the use of combinations of essential oils. The compositions that showed high antibacterial properties against the reviewed isolates may be used for oral hygiene products.

scholarly journals Neurological diseases caused by coronavirus infection of the respiratory airways

2020 ◽  
Vol 6 (4) ◽  
pp. 324-343
Author(s):  
Waqas Ahmed ◽  
Adeel Khan ◽  
Wish Hal Sundar ◽  
Humaira Naseem ◽  
Wanghao Chen ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Clinical Symptoms ◽  
Neurological Diseases ◽  
Neurological Complications ◽  
Upper Respiratory Tract ◽  
Invasion Routes ◽  
Critical Problems ◽  
The Central Nervous System ◽  
Coronavirus Infection

Infections of the central nervous system (CNS) infections are critical problems for public health. They are caused by several different organisms, including the respiratory coronaviruses (CoVs). CoVs usually infect the upper respiratory tract causing the common cold. However, in infants, and in elderly and immunocompromised persons, they can also affect the lower respiratory tract causing pneumonia and various syndromes of respiratory distress. CoVs also have neuroinvasive capabilities because they can spread from the respiratory tract to the CNS. Once infection begins in the CNS cells, it can cause various CNS problems such as status epilepticus, encephalitis, and long‐term neurological disease. This neuroinvasive properties of CoVs may damage the CNS as a result of misdirected host immune response, which could be associated with autoimmunity in susceptible individuals (virus‐induced neuro‐immunopathology) or associated with viral replication directly causing damage to the CNS cells (virus‐induced neuropathology). In December 2019, a new disease named COVID‐19 emerged which is caused by CoVs. The significant clinical symptoms of COVID‐19 are related to the respiratory system, but they can also affect the CNS, causing acute cerebrovascular and intracranial infections. We describe the possible invasion routes of coronavirus in this review article, and look for the most recent findings associated with the neurological complications in the recently published literature.

scholarly journals Pathogenic treatment of the inflammatory diseases of the urogenital tract in women of reproductive age

2021 ◽  
Vol 4 (1) ◽  
pp. 59-64
Author(s):  
O.I. Letyaeva ◽  
◽  
O.R. Ziganshin ◽  
Keyword(s):  
Bacterial Vaginosis ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Genital Warts ◽  
Urogenital Tract ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Local Immunity ◽  
Papillomavirus Infection

This paper discusses one of the important gynecological issues, inflammatory diseases of the urogenital tract caused by opportunistic microbes. The treatment and long-term control over these conditions are challenging and depend on their occurrence and high risk of complications. Impaired local anti-infectious protection is one of the risk factors of chronic inflammation. Since the disease may recur even after successful treatment, domestic and foreign authors increasingly focus on immunotherapy as a part of complex strategy and isolated entity. Local immunotherapy may prevent recurrences and activate host defense. This paper describes the management of two women with mixed infections. The first woman with chronic recurrent inflammation (cervicitis caused by U. urealyticum, vulvovaginal candidiasis, and aerobic vaginitis) in whom prior etiological therapy was ineffective received immunotherapy which resulted in long-term remission. The second woman with coexistent papillomavirus infection (genital warts) and bacterial vaginosis received immunotherapy and topical etiological treatment. As a result, clinical symptoms, the size and number of genital warts reduced which greatly facilitated their chemical destruction. KEYWORDS: genital tract, urogenital infections, papillomavirus infection, bacterial vaginosis, local immunity, biofilms. FOR CITATION: Letyaeva O.I., Ziganshin O.R. Pathogenic treatment of the inflammatory diseases of the urogenital tract in women of reproductive age. Russian Journal of Woman and Child Health. 2021;4(1):59–64. DOI: 10.32364/2618-8430-2021-4-1-59-64.

scholarly journals Sulfasalazine Microparticles Targeting Macrophages for the Treatment of Inflammatory Diseases Affecting the Synovial Cavity

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 951
Author(s):  
Monica-Carolina Villa-Hermosilla ◽  
Ana Fernández-Carballido ◽  
Carolina Hurtado ◽  
Emilia Barcia ◽  
Consuelo Montejo ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Disease ◽  
Term Treatment ◽  
Particle Sizes ◽  
Duration Of Action ◽  
Tnf Α ◽  
Long Term Treatment ◽  
Inflammatory Processes

Rheumatoid arthritis (RA) is a chronic inflammatory disease with sulfasalazine (SSZ) extensively used for long-term treatment of both juvenile and adult RA. Its use is associated with adverse effects and toxicity due to its non-selective biodistribution. Macrophages play an important role in inflammatory processes. In order to target SSZ to macrophages in this work two microparticulate systems (MPs) are developed: SSZ-loaded PLGA MPs without and with α-tocopherol, with particle sizes lower than 5 μm and encapsulation efficiencies of 81.07 ± 11% and 63.50 ± 6.62%, respectively. Release of SSZ from MPs prepared with α-tocopherol was prolonged for 20 days. In RAW 264.7 cell macrophages MPs prepared with α-tocopherol were captured faster. Cell viability studies confirmed that SSZ-loaded MPs prepared without and with α-tocopherol did not produce cytotoxicity at the concentrations assayed. The anti-inflammatory activity of SSZ-loaded MPs was studied by quantifying interleukins IL-1, IL-6 and TNF-α in macrophages. All formulations produced a significant reduction of cytokine concentrations after 24 and 72 h, indicating that release of SSZ from the MPs was able to inhibit the inflammatory response induced by lipopolysaccharide (LPS). Gene expression of IL-1, IL-6 and TNF-α was decreased by SSZ-loaded MPs. SSZ-loaded MPs prepared with α-tocopherol will potentially allow increasing the residence time of SSZ in the synovial cavity, prolonging its duration of action, and reducing the adverse effects associated with its non-selective biodistribution.

Intra-arterial administration of drugs in the complex treatment of severe inflammatory diseases of the maxillofacial region

1980 ◽  
Vol 61 (4) ◽  
pp. 48-49
Author(s):  
V. A. Bulkin
Keyword(s):  
Inflammatory Diseases ◽  
Intensive Therapy ◽  
External Carotid Artery ◽  
External Carotid ◽  
Clinical Use ◽  
Complex Treatment ◽  
Maxillofacial Region ◽  
The Face ◽  
Inflammatory Processes

In the treatment of 54 patients with severe inflammatory processes of the maxillofacial region, the method of long-term catheterization of the external carotid artery through one of its branches was used to administer antibiotics and anticoagulants. The results obtained make it possible to recommend this technique for wide clinical use in the complex of intensive therapy for purulent processes of the face.

Features of treatment and rehabilitation of patients suffering from stable coronary heart disease with comorbid background at the outpatient stage

2021 ◽  
Vol 3 ◽  
Author(s):  
D.Yu. Gamayunov ◽  
◽  
V.A. Khaptanova ◽  
A.N. Kalyagin ◽  
N.M. Balabina ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Oral Cavity ◽  
Inflammatory Diseases ◽  
Beta Blockers ◽  
Cardiovascular Complications ◽  
Angle Closure ◽  
Deficiency Anemia ◽  
Stable Coronary Heart Disease ◽  
Coronavirus Infection

This literature review highlights the relevance of both cardiovascular diseases in general and coronary heart disease in particular. The features of the therapy of coronary heart disease and some comorbid conditions are considered: atrial fibrillation, arterial hypertension, diabetes mellitus, chronic kidney disease, gastrointestinal tract diseases, bronchial patency disorders, iron deficiency anemia, inflammatory diseases of the oral cavity, angle-closure glaucoma, new coronavirus infection COVID-19. Attention is drawn to the paradoxical relationship between cholesterol levels and the risk of cardiovascular complications and death in patients with end – stage CKD. The effect of omeprazole on reflux-induced myocardial ischemia is described. The possibility of using cardioselective beta -blockers in patients with COPD is emphasized. The choice of the form of nitrate release in inflammatory diseases of the oral cavity requires special attention. An urgent problem is the interaction of antiviral drugs and drugs of basic therapy of coronary heart disease in patients with a new coronavirus infection COVID – 19. Thus, patients taking CYP3A4 inhibitors are recommended to use prasugrel. The article examines the effect of comorbidity on the severity of persistent loss of body functions. Attention is drawn to the existing problems of rehabilitation of patients with coronary heart disease at the outpatient stage: patients ignoring non – drug rehabilitation methods, insufficiently attentive attitude to the issue of full – fledged secondary prevention. It is necessary to further improve the algorithms for the tactics of management of comorbid patients with coronary heart disease at the outpatient stage and a more detailed solution to the issue of medical and labor expertise and rehabilitation of this category of patients.

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