scholarly journals Post-Genomics and Skin Inflammation

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Daniela Braconi ◽  
Giulia Bernardini ◽  
Annalisa Santucci
Keyword(s):  
Scientific Community ◽  
Inflammatory Diseases ◽  
Skin Inflammation ◽  
Point Of View ◽  
Future Research ◽  
Genomic Technologies ◽  
Research Challenges ◽  
Common Skin ◽  
Inflammatory Processes ◽  
Chronic Skin

Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the most common skin disorders involving inflammatory processes, seems to be still quite neglected under the post-genomic point of view. In this paper, we will review how post-genomic technologies have provided new fundamental tools for the analysis of these three conditions and we will cast light on their potential in addressing future research challenges.

scholarly journals Comparison of the Inhibitory Activities of 5,6-Dihydroergosterol Glycoside α- and β-Anomers on Skin Inflammation

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 371 ◽  
Author(s):  
Tae Kim ◽  
Young Cho ◽  
HoonGyu Park ◽  
Tae Lee ◽  
Hakwon Kim
Keyword(s):  
Protein Expression ◽  
Inflammatory Diseases ◽  
Skin Barrier ◽  
Skin Inflammation ◽  
New Drugs ◽  
Inflammatory Biomarker ◽  
Cytokines And Chemokines ◽  
Inflammatory Stimuli ◽  
Mrna And Protein Expression ◽  
Chronic Skin

Chronic skin inflammatory diseases, such as atopic dermatitis, are associated with a dysfunctional skin barrier due to an increase in various inflammatory stimuli, for instance inflammatory cytokines and chemokines. In particular, CCL17 and CCL22 expression is increased in patients with chronic skin inflammation. In this study, we synthesized several α- and β-anomers of dihydroergosterol (DHE)-glycosides and assessed their effects on CCL17 and CCL22 expression. We confirmed that the β-anomers of DHE-glycosides were superior to α-anomers of DHE-glycosides in inhibiting CCL17 and CCL22 mRNA and protein expression. In addition, we determined that DHE-glycoside β-anomers showed strong inhibitory activity towards pro-inflammatory cytokine mRNA and protein expression, including that of TNF-α, IL-6, and IL-1β- in stimulated HaCaT cells. These results imply that DHE-glycoside α- and β-anomers should be separated during synthesis of drugs for chronic skin inflammation. Our results also suggest that β-anomers of DHE-glycosides may play an important role as new drugs for chronic skin inflammation because of their ability to inhibit the skin inflammatory biomarker proteins CCL17 and CCL22.

scholarly journals An Important Role of Blood and Lymphatic Vessels in Inflammation and Allergy

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Silvana Zgraggen ◽  
Alexandra M. Ochsenbein ◽  
Michael Detmar
Keyword(s):  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Experimental Studies ◽  
Lymphatic Vessels ◽  
Allergic Inflammation ◽  
Skin Inflammation ◽  
Chronic Inflammatory Diseases ◽  
Chronic Skin ◽  
Targeted Inhibition ◽  
Endothelial Growth Factor

Angiogenesis and lymphangiogenesis, the growth of new vessels from preexisting ones, have received increasing interest due to their role in tumor growth and metastatic spread. However, vascular remodeling, associated with vascular hyperpermeability, is also a key feature of many chronic inflammatory diseases including asthma, atopic dermatitis, psoriasis, and rheumatoid arthritis. The major drivers of angiogenesis and lymphangiogenesis are vascular endothelial growth factor- (VEGF-)A and VEGF-C, activating specific VEGF receptors on the lymphatic and blood vascular endothelium. Recent experimental studies found potent anti-inflammatory responses after targeted inhibition of activated blood vessels in models of chronic inflammatory diseases. Importantly, our recent results indicate that specific activation of lymphatic vessels reduces both acute and chronic skin inflammation. Thus, antiangiogenic and prolymphangiogenic therapies might represent a new approach to treat chronic inflammatory disorders, including those due to chronic allergic inflammation.

METABOLIC EFFECTS OF THYROTROPHIC HORMONE IN MAN

1962 ◽  
Vol 41 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Bengt Skanse ◽  
Wilfried von Studnitz
Keyword(s):  
Serum Proteins ◽  
Clinical Symptoms ◽  
Inflammatory Diseases ◽  
Point Of View ◽  
Metabolic Effects ◽  
Total Serum ◽  
Thyrotrophic Hormone ◽  
Γ Globulins ◽  
Inflammatory Processes ◽  
Rebound Phenomenon

ABSTRACT The metabolic effects of prolonged administration of thyrotrophic hormone were studied in 5 euthyroid subjects and in 1 patient who had been subjected to total thyroidectomy. Thyrotrophic hormone (TSH) had no effect in the thyroidectomized patient, thus showing that the metabolic effects were mediated by stimulation of the thyroid. In the euthyroid subjects the TSH caused an increase in thyroid activity as judged by the rise in basal metabolic rate (BMR) and serum protein-bound iodine (PBI) and the clinical symptoms. The administration of TSH resulted in: elevation of the erythrocyte sedimentation rate (ESR), and in an increase of the fibrinogen, haptoglobin, coeruloplasmin and total hexose content of the serum; an increase of α1-, α2-, and β2-globulins and smaller and less consistent changes in the albumin and β1- and γ-globulins, i. e. changes of the type seen in acute infections or acute inflammatory diseases; a fall in the total serum lipids, cholesterol and phospholipids, and less consistent changes in the α- and β-lipoproteins. During continued administration of TSH all the above mentioned metabolic effects tended to level off and/or disappear, probably owing to formation of antibodies. Withdrawal of TSH was followed by a rebound phenomenon, presumably because of diminished production of thyroid hormone. From the clinical point of view the possibility of increased thyroid function being a cause of elevated ESR and of the serum proteins changes resembling those seen in acute inflammatory processes should perhaps be considered.

scholarly journals How COVID changed surgical acute inflammatory diseases and surgeons clinical practice during the first wave of COVID-19

2020 ◽  
Author(s):  
Hector Guadalajara ◽  
Jose Luis Muñoz de Nova ◽  
Saul Fernandez Gonzalez ◽  
Marina Yiasemidou ◽  
Maria Recarte Rico ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Recovery Phase ◽  
Control Measures ◽  
Future Research ◽  
Surgical Services ◽  
Infection Control Measures ◽  
Number Of Patients ◽  
Inflammatory Processes ◽  
History Of ◽  
The Impact

Abstract BackgroundAnecdotal evidence suggests that community infection control measures during the COVID-19 outbreak have modified the number and natural history of acute surgical inflammatory processes (ASIP - appendicitis, cholecystitis, diverticulitis and perianal abscesses) admissions. This study aims to evaluate the impact of the COVID-19 pandemic on the presentation and treatment ASIP and quantify the effect of COVID-19 infection on the outcomes of ASIP patients. MethodsThis was a multicentre, comparative study, whereby ASIP cases from March 14th to May 2nd 2019 acted as historical controls for the cohort of patients with the same pathology during the COVID-19 pandemic. Data regarding patient and disease characteristics as well as outcomes, were collected from sixteen centres in Madrid, and one in Seville (Spain).ResultsThe number of patients treated for ASIP in 2019 was 822 compared to 521 in 2020. This reduction occurs mainly in patients with mild cases, while the number of severe cases was similar. ConclusionsThe number of ASIP cases treated during the pandemic was reduced by more than one third mainly due to a dramatic reduction in mild cases. This also has represented a selection of severe cases. We also found a more conservative approach to the patients this year, non-justified by clinical circumstances.The positive COVID-19 status itself did not have a direct impact on either morbidity or mortality. This is an interesting finding which if confirmed through future research with a larger sample size of COVID-19 positive patients, can expedite the recovery phase of acute surgical services.

Determinants of Co-creative Behaviour of Patients: A Case Study in Jammu

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Jyoti Sharma ◽  
Lata Raj ◽  
Anil Gupta
Keyword(s):  
Customer Value ◽  
Research Area ◽  
Point Of View ◽  
Customer Participation ◽  
Citizenship Behavior ◽  
Future Research ◽  
Creative Behavior ◽  
Customer Profiling ◽  
Customer Citizenship Behavior ◽  
Lifestyle Diseases

The purpose of this study is to measure the existence of co-creation behavior between doctors and patients. The research also studies customer participation and customer citizenship behavior as the dimensions of co-creative behavior and tries to establish the relationship between co-creative behavior and satisfaction. This study uses Yi and Gong (2013) scale for collecting data regarding co-creation behavior and its dimensions which are customer participation (CP) and customer citizenship behavior (CCB). The data was collected from 204 patients who were suffering from various chronic/lifestyle diseases and getting their treatment from private clinics in Jammu city. The study uses 7-point Likert scale in the questionnaire ranging from 1 completely disagree through 7 completely agree, with a midpoint labeled 4 neither agree nor disagree. The analysis of paper reflects that co-creation behavior is prevalent among the patients and not only participation but the citizenship behavior also affects the co-creation behavior of patients. The study is conducted from patients point of view whereas doctors perspective should also be used in future research. The research area is restricted to Jammu city only. The research provides several implications-doctors can also use this scale for market segmentation and customer profiling for maximizing customer value co-creation behavior by gaining the useful information.

scholarly journals Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines

2019 ◽  
Vol 20 (3) ◽  
pp. 459 ◽  
Author(s):  
Leila Kheirandish-Gozal ◽  
David Gozal
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Inflammatory Diseases ◽  
Sleep Apnea Syndrome ◽  
Special Focus ◽  
Normal Body Mass Index ◽  
Low Grade ◽  
Obstructive Sleep ◽  
Inflammatory Processes ◽  
Factor Α

Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the lifespan, particularly in overweight and obese individuals, which has been associated with an independent risk for neurocognitive, behavioral, and mood problems as well as cardiovascular and metabolic morbidities, ultimately fostering increases in overall mortality rates. In adult patients, excessive daytime sleepiness (EDS) is the most frequent symptom leading to clinical referral for evaluation and treatment, but classic EDS features are less likely to be reported in children, particularly among those with normal body-mass index. The cumulative evidence collected over the last two decades supports a conceptual framework, whereby sleep-disordered breathing in general and more particularly OSAS should be viewed as low-grade chronic inflammatory diseases. Accordingly, it is assumed that a proportion of the morbid phenotypic signature in OSAS is causally explained by underlying inflammatory processes inducing end-organ dysfunction. Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients.

scholarly journals The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease

2021 ◽  
Vol 22 (9) ◽  
pp. 4676
Author(s):  
Katja Badanjak ◽  
Sonja Fixemer ◽  
Semra Smajić ◽  
Alexander Skupin ◽  
Anne Grünewald
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Inflammatory Cytokine ◽  
Population Ageing ◽  
Future Research ◽  
Cytokine Release ◽  
Vicious Cycle ◽  
Inflammatory Processes ◽  
Great Evidence

With the world’s population ageing, the incidence of Parkinson’s disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of PD patients. Thereby, PD progression is potentially driven by a vicious cycle between dying neurons and microglia through the instigation of oxidative stress, mitophagy and autophagy dysfunctions, a-synuclein accumulation, and pro-inflammatory cytokine release. Hence, investigating the involvement of microglia is of great importance for future research and treatment of PD. The purpose of this review is to highlight recent findings concerning the microglia-neuronal interplay in PD with a focus on human postmortem immunohistochemistry and single-cell studies, their relation to animal and iPSC-derived models, newly emerging technologies, and the resulting potential of new anti-inflammatory therapies for PD.

scholarly journals Sequestosome 1/p62 enhances chronic skin inflammation

2021 ◽  
Author(s):  
Supawadee Sukseree ◽  
Latifa Bakiri ◽  
Marta Palomo Irigoyen ◽  
Özge Uluçkan ◽  
Peter Petzelbauer ◽  
...  
Keyword(s):  
Skin Inflammation ◽  
Sequestosome 1 ◽  
Chronic Skin

scholarly journals Large-Scale Object Monitoring in Internet-of-Things: Energy-Efficient Perspectives

Electronics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 461
Author(s):  
Yongbin Yim ◽  
Euisin Lee ◽  
Seungmin Oh
Keyword(s):  
Energy Efficient ◽  
Large Scale ◽  
Future Research ◽  
Technological Evolution ◽  
Node Density ◽  
Mobile Objects ◽  
Research Challenges ◽  
Energy Efficient Communication ◽  
Efficient Communication ◽  
Architectural Principles

Recently, the demand for monitoring a certain object covering large and dynamic scopes such as wildfires, glaciers, and radioactive contaminations, called large-scale fluid objects (LFOs), is coming to the fore due to disasters and catastrophes that lately happened. This article provides an analytic comparison of such LFOs and typical individual mobile objects (IMOs), namely animals, humans, vehicles, etc., to figure out inherent characteristics of LFOs. Since energy-efficient monitoring of IMOs has been intensively researched so far, but such inherent properties of LFOs hinder the direct adaptation of legacy technologies for IMOs, this article surveys technological evolution and advances of LFOs along with ones of IMOs. Based on the communication cost perspective correlated to energy efficiency, three technological phases, namely concentration, integration, and abbreviation, are defined in this article. By reviewing various methods and strategies employed by existing works with the three phases, this article concludes that LFO monitoring should achieve not only decoupling from node density and network structure but also trading off quantitative reduction against qualitative loss as architectural principles of energy-efficient communication to break through inherent properties of LFOs. Future research challenges related to this topic are also discussed.

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