scholarly journals Serum vaspin levels in hypothyroid patients

2011 ◽  
Vol 165 (4) ◽  
pp. 563-569 ◽  
Author(s):  
Neşe Çinar ◽  
Neşe Ersöz Gülçelik ◽  
Kadriye Aydín ◽  
Şafak Akín ◽  
Aydan Usman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Animal Studies ◽  
Fasting Glucose ◽  
Resistance Index ◽  
The Body ◽  
Model Assessment ◽  
Free Triiodothyronine ◽  
Significant Difference ◽  
Before And After ◽  
Hypothyroid Patients

ObjectiveTo elucidate the link between TSH and obesity, the relationship between TSH and adipocytokines were previously studied. Animal studies demonstrated a possible relationship between vaspin levels and thyroid functions. In this study, we aimed to investigate vaspin levels in hypothyroid states and its relationship with insulin resistance parameters in humans.DesignProspective observational study.MethodsWe enrolled 27 overt hypothyroid, 33 subclinical hypothyroid and 41 euthyroid patients. We measured the body mass index (BMI), fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), lipid profile, TSH, free triiodothyronine, free thyroxine and vaspin levels. The change in vaspin levels in 12 overt hypothyroid patients after establishment of euthyroidism was analysed.ResultsAll groups were age-matched. Overt hypothyroid group had higher BMI values (P<0.05) than other groups. No significant difference was observed in insulin levels and HOMA-IR among the groups (P>0.05). Adjusted vaspin levels for BMI and age were similar among the groups. Mean vaspin levels in overt, subclinical and euthyroid patients were 1.20±1.17, 1.48±0.93 and 0.95±0.75 ng/ml respectively (P>0.05). There was no significant association between vaspin levels and BMI, fasting glucose, insulin and HOMA-IR (P>0.05). Establishing euthyroidism in hypothyroid patients did not result in a significant change in vaspin levels (before and after treatment, 1.35±1.06 and 1.25±0.68 ng/ml, respectively; P>0.05).ConclusionWe herein present novel data indicating vaspin levels are neither altered in overt and subclinical hypothyroidism nor have a relationship with features of insulin resistance in hypothyroid patients.

scholarly journals Endotrophin as a novel marker in PCOS and its relation with other adipokines and metabolic parameters: a pilot study

2021 ◽  
Vol 12 ◽  
pp. 204201882110496
Author(s):  
Gurhan Guney ◽  
Mine Islimye Taskin ◽  
Ozgur Baykan ◽  
Ertan Adali ◽  
Selin Gul Tezcan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Total Testosterone ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Ovary Syndrome ◽  
Significant Difference

Background: Polycystic ovary syndrome is known to be the most common hormonal disorder in women of reproductive age. Current evidence shows that regulatory proteins secreted from the adipose tissue called adipokines may have a role in polycystic ovary syndrome. We planned to investigate the role of endotrophin that has never been researched in polycystic ovary syndrome before and its correlation with other metabolic parameters and adipokines such as adiponectin and ghrelin in patients with polycystic ovary syndrome. Methods: Forty-three women ( n: 43) with polycystic ovary syndrome and 43 ( n: 43) women as a control group were enrolled in this cross-sectional study. Serum levels of endotrophin, adiponectin, and ghrelin levels were measured with the enzyme-linked immunosorbent assay method. High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol levels, luteinizing hormone/follicle-stimulating hormone ratio, total testosterone, and triglyceride levels were measured. Homeostasis model assessment for insulin resistance index, body mass index, Ferriman Gallwey Score, and waist-to-hip ratio were also evaluated. Results: Total testosterone, homeostasis model assessment for insulin resistance, C-reactive protein, luteinizing hormone/follicle-stimulating hormone ratio, and triglyceride levels were higher in patients with polycystic ovary syndrome ( p < 0.01). No difference was detected between the groups in terms of body mass index, Ferriman Gallwey Score, waist-to-hip ratio, total cholesterol, low-density lipoprotein, and high-density lipoprotein levels ( p > 0.05). We did not observe any significant difference in adiponectin and ghrelin levels between the groups ( p > 0.05). Patients with polycystic ovary syndrome had significantly higher endotrophin levels ( p < 0.01). According to our regression analyses [area under the curve: 0.973 (0.935–1.000), 95% confidence interval, 95.2% sensitivity, and 100% specificity], it was shown that endotrophin greater than 92 ng/ml and homeostasis model assessment for insulin resistance greater than 2.5 might be good predictors for polycystic ovary syndrome diagnosis. Conclusion: We demonstrated that endotrophin level is higher in patients with polycystic ovary syndrome and may have predicted polycystic ovary syndrome with increased homeostasis model assessment for insulin resistance index. There was no significant difference in adiponectin and ghrelin levels in the polycystic ovary syndrome group. Endotrophin may have a role in polycystic ovary syndrome etiology rather than other adipokines.

Distribution of HOMA-IR in a population-based cohort and proposal for reference intervals

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Bassel Matli ◽  
Andreas Schulz ◽  
Thomas Koeck ◽  
Tanja Falter ◽  
Johannes Lotz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fasting Glucose ◽  
Reference Group ◽  
Reference Interval ◽  
Population Based ◽  
Reference Intervals ◽  
Health Study ◽  
Specific Reference ◽  
Model Assessment ◽  
Significant Difference

Abstract Objectives Insulin resistance (IR) is a hallmark of type 2 diabetes mellitus (DM). The homeostatic model assessment of insulin resistance (HOMA-IR) provides an estimate for IR from fasting glucose and insulin serum concentrations. The aim of this study was to obtain a reference interval for HOMA-IR for a specific insulin immunoassay. Methods The Gutenberg Health Study (GHS) is a population-based, prospective, single-center cohort study in Germany with 15,030 participants aged 35–74 years. Fasting glucose, insulin, and C-peptide were available in 10,340 participants. HOMA-IR was calculated in this group and three reference subgroups with increasingly more stringent inclusion criteria. Age- and sex-dependent distributions of HOMA-IR and reference intervals were obtained. In a substudy three insulin assays were compared and HOMA-IR estimated for each assay. Results Among the 10,340 participants analyzed there were 6,590 non-diabetic, 2,901 prediabetic, and 849 diabetic individuals. Median (interquartile range [IQR]) HOMA-IR was 1.54 (1.13/2.19), 2.00 (1.39/2.99), and 4.00 (2.52/6.51), respectively. The most stringently selected reference group consisted of 1,065 persons. Median (IQR) HOMA-IR was 1.09 (0.85/1.42) with no significant difference between men and women. The 97.5th percentile was 2.35. There was a non-significant trend towards higher values with older age. Comparison of three immunoassays for insulin showed an unsatisfactory correlation among the assays and systematic differences in calculated HOMA-IR. Conclusions We present HOMA-IR reference intervals for adults derived by more or less stringent selection criteria for the reference cohort. In addition we show that assay specific reference intervals for HOMA-IR are required.

scholarly journals Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Chih-Hsun Chu ◽  
Hing-Chung Lam ◽  
Jenn-Kuen Lee ◽  
Chih-Chen Lu ◽  
Chun-Chin Sun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Plasma Concentrations ◽  
Serum Glucose ◽  
Antithyroid Drugs ◽  
Control Group ◽  
Model Assessment ◽  
Insulin Levels ◽  
Significant Difference ◽  
Before And After ◽  
Antithyroid Treatment

To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves' disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls. All hyperthyroid patients were treated with antithyroid drugs and were re-evaluated after thyroid function normalized. Before antithyroid treatment, the adiponectin plasma concentrations were not different comparing with those in control group. The adiponectin levels remained unchanged after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) in hyperthyroid group was higher before treatment than after treatment. There was no significant difference in serum glucose and insulin levels between hyperthyroid and control groups and in the hyperthyroid group before and after treatment. BMI-adjusted adiponectin levels were not different among three groups. On the other hand, BMI-adjusted insulin levels and HOMA-IR values were significantly decreased after management of hyperthyroidism. Pearson's correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels. However, adiponectin did not correlate with T3, FT4, insulin, HOMA-IR and thyrotropin receptor autoantibody (TRAb) levels. In conclusion, insulin resistance associated with hyperthyroidism is not mediated by the levels of plasma adiponectin.

scholarly journals Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Hang Sun ◽  
Xingchun Wang ◽  
Jiaqi Chen ◽  
Aaron M. Gusdon ◽  
Kexiu Song ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Acanthosis Nigricans ◽  
Resistance Index ◽  
Inflammatory Factors ◽  
Model Assessment ◽  
Obese Patients ◽  
Inflammatory Status ◽  
Before And After ◽  
Matsuda Index

Objective. This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN). Methods. A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial. Insulin sensitivity, glucose metabolism, inflammatory factors, and other biochemical parameters before and after the administration of melatonin were measured. Results. After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 ± 5.10 versus 7.77 ± 5.21, p<0.05) and fasting insulin (37.09 5 ± 20.26 μU/ml versus 32.10 ± 20.29 μU/ml, p<0.05) were significantly decreased. Matsuda index (2.82 ± 1.54 versus 3.74 ± 2.02, p<0.05) was significantly increased. There were also statistically significant declines in the AN scores of the neck and axilla, body weight, body mass index, body fat, visceral index, neck circumference, waist circumference, and inflammatory markers. Conclusions. It was concluded that melatonin could improve cutaneous symptoms in obese patients with acanthosis nigricans by improving insulin sensitivity and inflammatory status. This trial is registered with ClinicalTrials.gov NCT02604095.

scholarly journals Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey

2020 ◽  
Vol 17 (13) ◽  
pp. 4833 ◽  
Author(s):  
Róza Ádány ◽  
Péter Pikó ◽  
Szilvia Fiatal ◽  
Zsigmond Kósa ◽  
János Sándor ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Association Studies ◽  
Characteristic Curve ◽  
Resistance Index ◽  
Premature Mortality ◽  
Special Focus ◽  
Model Assessment ◽  
Full Spectrum ◽  
Significant Difference ◽  
Surrogate Measures

Data mainly from one-off surveys clearly show that the health of Roma, the largest ethnic minority of Europe, is much worse than that of the general population. However, results from comprehensive exploratory studies are missing. The aim of our study was to create a complex database for comparative and association studies to better understand the background of the very unfavourable health of Roma, especially the high burden of cardiometabolic diseases. A three-pillar (questionnaire-based, physical and laboratory examinations) health survey was carried out on randomly selected samples of the Hungarian general (HG, n = 417) and Roma (HR, n = 415) populations, and a database consisting of more than half a million datapoints was created. Using selected data, the prevalence rates of metabolic syndrome (MetS) and of its components were determined, and to estimate the risk of insulin resistance (IR), surrogate measures (the homeostasis model assessment of insulin resistance index, quantitative insulin sensitivity check index, McAuley and TyG indices and the TG/HDL-C ratio) were calculated. Receiver operating characteristic curve analysis and Youden’s method were used to define the optimal cut-off values of each IR index. The prevalence of MetS was very high in both study populations (HG: 39.8%, HR: 44.0%) with no statistically significant difference between the two groups in females or males. The prevalence of MetS showed a very marked increase in the HR 35–49 years age group. Among surrogate measures, the TyG index showed the greatest power for predicting IR/MetS at a cut-off value of 4.69 (77% sensitivity, 84% specificity) and indicated a 42.3% (HG) and 40.5% (HR) prevalence of IR. The prevalence of MetS and IR is almost equally very unfavourable in both groups; thus, the factors underlying the high premature mortality burden of Roma should be further clarified by investigating the full spectrum of risk factors available in the database, with a special focus on the access of Roma people to preventive and curative health services.

scholarly journals The state of carbohydrate metabolism in children with gallstone disease

2021 ◽  
Vol 1 (1) ◽  
pp. 118-126
Author(s):  
E. A. Potapova ◽  
L. A. Kharitonova ◽  
Yu. E. Milova
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Carbohydrate Metabolism ◽  
Gallstone Disease ◽  
Resistance Index ◽  
The State ◽  
The Body ◽  
Main Role ◽  
Model Assessment ◽  
C Peptide

Cholelithiasis (cholelithiasis) has become increasingly common in childhood. Currently, the features of the clinical course have been studied, the criteria for the diagnosis and prevention of cholelithiasis in children have been worked out. However, the features of metabolic disorders are still not studied, among which not the least role in the genesis of the formation of gallstones is played not only by the exchange of lipids, but also carbohydrates.The main role in the regulation of carbohydrate metabolism is played by insulin. The process of production of insulin in the body in the blood serum fully reflects the concentration of C-peptide. The ratio between insulin and C-peptide is not always constant. It may shift in one direction or another against the background of diseases of the internal organs, including the GI tract.The analysis for C-peptide and insulin allows you to identify not only hypo — or hyperglycemia, but also to determine insulin resistance, calculate the HOMA index and, accordingly, make a forecast for the development of dyslipidemia. In this regard, it was of interest to study the state of carbohydrate metabolism (glucose, insulin, C-peptide) in children with cholelithiasis.The purpose of the study. To improve the early diagnosis of the complicated course of cholelithiasis by studying the features of carbohydrate metabolism for practicing therapeutic tactics and preventive measures.Materials and methods. Under our supervision at the Department of Pediatrics infectious diseases, faculty of postgraduate education of physicians of the Russian national research medical University of Minzdrav of Russia (head.DEP. — M. D., Professor L. A. Kharitonov), city children’s polyclinic № 122 (chief doctor — PhD Bragin A. I.) were 140 children aged from birth to 15 years. Carbohydrate metabolism was studied in 140 children of the study group. Boys were 62, average age 10.0±4.9, girls were 78, average age 8.8±4.5. The parameters of serum glucose, insulin, and C-peptide were evaluated. The Homeostatic Model Assessment (NOMA) Insulin resistance Index will be calculated using the formula: NOMA-IR = (fasting plasma glucose (mmol/l) x fasting serum insulin (mkED / ml))/22.5 (Cuartero B., 2007). The physical development of children was evaluated according to WHO standards (2006) using the WHO Anthro Plus program (2009). We evaluated the values of the average values of body weight(MT), height (body length, DT) and body mass index (BMI) in five groups of newborns. The nutritional status was determined by the values of the Z-score value. Mathematical calculation of the results was carried out on a personal IBM — compatible computer using the statistical program Statistica 6.0.Results. In children with GI, there was a tendency to increase the NOME index, both in frequency and in absolute terms, from the age of 8 and persisted until the age of 15(0,65±0,14;0,42±0,04; 4,89±1,12; 4,86±0,44; according to the age periods, p< 0.005).Conclusion. Thus, disorders of carbohydrate metabolism in children with GI depend on the child’s age and body weight. In overweight children, an increase in C-peptide, insulin, and the resistance index was observed, which suggests that children with GI occurring against the background of overweight at the age of 8–11 and 12–15 years are threatened by the formation of metabolic syndrome, diabetes mellitus, and arterial hypertension.

scholarly journals A comparative study of insulin resistance in acne vulgaris

2017 ◽  
Vol 3 (3) ◽  
pp. 403
Author(s):  
Prathima Munichandrappa ◽  
Manjunath K. G. ◽  
Kiran C. ◽  
Anirudh Variyar
Keyword(s):  
Insulin Resistance ◽  
Fasting Glucose ◽  
Acne Vulgaris ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Homeostasis Model Assessment ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Significant Difference

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Acne is common skin problem among adolescents and young adults. Recently the role of insulin resistance in acne is being widely researched.</span>The o<span lang="EN-IN">bjectives of the study were to evaluate insulin resistance in acne, to compare the insulin resistance among cases and controls using homeostasis model assessment of insulin resistance</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">45 cases and 45 controls were recruited. Acne severity was graded using the global acne grading system(GAGS). Fasting glucose, fasting insulin levels were done and insulin resistance was assessed using homeostasis model assessment of insulin resistance (HOMA-IR)</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">We did not find any statistically significant difference in fasting insulin levels between cases and controls. However, a weak positive correlation between acne severity and fasting insulin levels (r =0.3, p=0.04) were observed. Fasting glucose levels and HOMA-IR values observed between cases and controls were not statistically significant (p=0.05, p=0.59 respectively). </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Our study did not suggest a major role of insulin resistance in acne.</span></p>

scholarly journals Study on the Changes of Serum Vaspin Level and its Regulatory Mechanism in Patients with Thyroid Dysfunction

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Zhenzuo Li ◽  
Jian Zhang ◽  
Lin Li ◽  
Xiaoxia Pan ◽  
Li Zhang ◽  
...  
Keyword(s):  
Thyroid Dysfunction ◽  
Venous Blood ◽  
Ankle Brachial Index ◽  
Resistance Index ◽  
Blood Lipid ◽  
The Body ◽  
Control Group ◽  
Model Assessment ◽  
Significant Difference ◽  
And Control

Objective: To study the changes of serum vaspin levels in hyperthyroidism and hypothyroidism, and the correlation between serum vaspin and FT3, FT4, TSH and HOMA-IR. Methods: According to the diagnostic criteria of hyperthyroidism and hypothyroidism published in the 8th edition of internal medicine, the patients were divided into hyperthyroidism group (n = 47), male 14, female 33, average age (35 ± 9) years; hypothyroidism group: 23 hypothyroidism patients, 7 males and 16 females, with an average age of (38 ± 10) years. The blood pressure, height and weight of all the participants were measured by a specially assigned person, and the body mass index (BMI = weight (kg) / height (M2) and ankle brachial index (ABI) were calculated. Venous blood samples were drawn from all subjects after fasting for 8 hours in the morning to determine biochemical indexes. Fasting insulin (fins) was measured by chemiluminescence method, insulin resistance index (HOMA-IR, HOMA-IR = FPG × fins / 22.5) was calculated by homeostasis model assessment (HOMA-IR), and HbA1c was determined by high-pressure liquid chromatography. The levels of FT3, FT4 and TSH were detected by radioimmunoassay. Serum vaspin levels were measured by ELISA. Results: The level of BMI in hypothyroidism group was significantly higher than that in hyperthyroidism group and control group (P < 0.01), BMI level in hyperthyroidism group was significantly lower than that in control group (P < 0.05), FT3 and FT4 levels in hyperthyroidism group were significantly higher than those in hypothyroidism group and control group (P < 0.01), TSH level in hypothyroidism group was significantly higher than that in control group and hyperthyroidism group (P < 0.01). The level of FPG in hyperthyroidism group was significantly higher than that in control group (P < 0.01), but there was no significant difference between hyperthyroidism group and hypothyroidism group, and fins level in hypothyroidism group was significantly higher than that in control group and hyperthyroidism group (P < 0.01). The level of HOMA-IR in hyperthyroidism and hypothyroidism group was significantly higher than that in control group (P < 0.01). Compared with the control group and the control group, the blood lipid indexes (TC, LDL-C) in the hyperthyroidism group were lower than those in the control group and hypothyroidism group (P<0.01), and all the blood lipid indexes in the hypothyroidism group were significantly different from those in the control group (P<0.01). The vaspin level of hyperthyroidism group was significantly higher than that of control group and hypothyroidism group, and the latter two groups showed that the level of vaspin in hypothyroidism group was significantly lower than that of control group (P < 0.05). Correlation analysis showed that serum vaspin was positively correlated with FT3 and FT4 (r = 0.255, P = 0.005; r = 0.327, P = 0.001), and negatively correlated with BMI, TC and HDL (r = -0.250, P = 0.006; r = -0.244, P = 0.007; r = -0.258, P = 0.004). )   Conclusion: Serum vaspin level is related to thyroid function. The level of serum vaspin increases in hyperthyroidism and decreases in hypothyroidism. Abnormal changes of fat factor vaspin are associated with thyroid dysfunction.

scholarly journals Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance

2007 ◽  
Vol 99 (1) ◽  
pp. 44-48 ◽  
Author(s):  
F. J. Tinahones ◽  
F. Cardona ◽  
G. Rojo-Martínez ◽  
M. C. Almaraz ◽  
I. Cardona ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Uric Acid ◽  
Close Association ◽  
Plasma Concentrations ◽  
Resistance Index ◽  
Hdl Cholesterol ◽  
Oral Glucose ◽  
Model Assessment ◽  
Significant Difference ◽  
Glucose Challenge

Hyperuricaemia is one of the components of metabolic syndrome. Both oxidative stress and hyperinsulinism are important variables in the genesis of this syndrome and have a close association with uric acid (UA). We evaluated the effect of an oral glucose challenge on UA concentrations. The study included 656 persons aged 18 to 65 years. Glycaemia, insulin, UA and plasma proteins were measured at baseline and 120 min after an oral glucose tolerance test (OGTT). The baseline sample also included measurements of total cholesterol, triacylglycerol (TAG) and HDL-cholesterol. Insulin resistance was calculated with the homeostasis model assessment. UA levels were significantly lower after the OGTT (281·93 (sd92·19)v. 267·48 (sd90·40) μmol/l;P < 0·0001). Subjects with a drop in UA concentrations >40·86 μmol/l (>75th percentile) had higher plasma TAG levels (P = 0·0001), baseline insulin (P = 0·02) and greater insulin resistance (P = 0·034). Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0·019), concentration of plasma TAG (P = 0·0001) and a greater insulin resistance index (P = 0·029), whereas the only significant difference in men was the level of TAG. Multiple regression analysis showed that the basal TAG levels, insulin at 120 min, glycaemia at 120 min and waist:hip ratio significantly predicted the variance in the UA difference (r20·077). Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels.

scholarly journals Unique Metabolic Features of Adults Discordant for Indices of Insulin Resistance

2020 ◽  
Vol 105 (8) ◽  
pp. e2753-e2763
Author(s):  
Yilin Song ◽  
Esben Søndergaard ◽  
Michael D Jensen
Keyword(s):  
Insulin Resistance ◽  
Visceral Fat ◽  
Plasma Lipids ◽  
Resistance Index ◽  
Defined Medium ◽  
The Body ◽  
Model Assessment ◽  
Insulin Resistance Index ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model

Abstract Purpose Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and Adipose Insulin Resistance index (ADIPO-IR) values are often concordant. In this study we evaluated whether there are groups discordant for HOMA-IR and ADIPOpalmitate-IR and, if so, what are their defining characteristics. Methods The body composition, basal metabolic rate (BMR), fasting plasma lipids, insulin, glucose, and free fatty acid (FFA) palmitate concentrations data of 466 volunteers from previous research studies were abstracted and analyzed. The middle 2 population quartiles for HOMA-IR and Adipose Insulin Resistance index palmitate concentration (ADIPOpalmitate-IR) defined medium HOMA-IR and ADIPOpalmitate-IR (MH and MA), the top and bottom quartiles were defined as high/low HOMA (HH/LH), and high/low ADIPOpalmitate as HA/LA. Because ADIPOpalmitate-IR was significantly greater in women than in men, we established sex-specific quartiles for each index. We identified groups discordant for HOMA-IR and ADIPO-IR (HHMA, LHMA, MHHA, and MHLA). Results Body fat and fasting triglycerides (TGs) were significantly greater with higher indices in the concordant groups (HHHA &gt; MHMA &gt; LHLA). MHHA differed from MHLA by visceral fat (P &lt; .01) and fasting TGs (P &lt; .05), whereas HHMA differed (P &lt; .01) from LHMA by BMR. By multivariate regression, the group factor contributed to BMR (P &lt; .01) and visceral fat (P &lt; .05). Conclusions Adults discordant for HOMA-IR and ADIPO-IR have unique features including differences in visceral fat, TGs, and BMR. This suggests different forms of insulin resistance are present, which should be considered when studying insulin resistance in the future.

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