scholarly journals Study on the Changes of Serum Vaspin Level and its Regulatory Mechanism in Patients with Thyroid Dysfunction

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Zhenzuo Li ◽  
Jian Zhang ◽  
Lin Li ◽  
Xiaoxia Pan ◽  
Li Zhang ◽  
...  
Keyword(s):  
Thyroid Dysfunction ◽  
Venous Blood ◽  
Ankle Brachial Index ◽  
Resistance Index ◽  
Blood Lipid ◽  
The Body ◽  
Control Group ◽  
Model Assessment ◽  
Significant Difference ◽  
And Control

Objective: To study the changes of serum vaspin levels in hyperthyroidism and hypothyroidism, and the correlation between serum vaspin and FT3, FT4, TSH and HOMA-IR. Methods: According to the diagnostic criteria of hyperthyroidism and hypothyroidism published in the 8th edition of internal medicine, the patients were divided into hyperthyroidism group (n = 47), male 14, female 33, average age (35 ± 9) years; hypothyroidism group: 23 hypothyroidism patients, 7 males and 16 females, with an average age of (38 ± 10) years. The blood pressure, height and weight of all the participants were measured by a specially assigned person, and the body mass index (BMI = weight (kg) / height (M2) and ankle brachial index (ABI) were calculated. Venous blood samples were drawn from all subjects after fasting for 8 hours in the morning to determine biochemical indexes. Fasting insulin (fins) was measured by chemiluminescence method, insulin resistance index (HOMA-IR, HOMA-IR = FPG × fins / 22.5) was calculated by homeostasis model assessment (HOMA-IR), and HbA1c was determined by high-pressure liquid chromatography. The levels of FT3, FT4 and TSH were detected by radioimmunoassay. Serum vaspin levels were measured by ELISA. Results: The level of BMI in hypothyroidism group was significantly higher than that in hyperthyroidism group and control group (P < 0.01), BMI level in hyperthyroidism group was significantly lower than that in control group (P < 0.05), FT3 and FT4 levels in hyperthyroidism group were significantly higher than those in hypothyroidism group and control group (P < 0.01), TSH level in hypothyroidism group was significantly higher than that in control group and hyperthyroidism group (P < 0.01). The level of FPG in hyperthyroidism group was significantly higher than that in control group (P < 0.01), but there was no significant difference between hyperthyroidism group and hypothyroidism group, and fins level in hypothyroidism group was significantly higher than that in control group and hyperthyroidism group (P < 0.01). The level of HOMA-IR in hyperthyroidism and hypothyroidism group was significantly higher than that in control group (P < 0.01). Compared with the control group and the control group, the blood lipid indexes (TC, LDL-C) in the hyperthyroidism group were lower than those in the control group and hypothyroidism group (P<0.01), and all the blood lipid indexes in the hypothyroidism group were significantly different from those in the control group (P<0.01). The vaspin level of hyperthyroidism group was significantly higher than that of control group and hypothyroidism group, and the latter two groups showed that the level of vaspin in hypothyroidism group was significantly lower than that of control group (P < 0.05). Correlation analysis showed that serum vaspin was positively correlated with FT3 and FT4 (r = 0.255, P = 0.005; r = 0.327, P = 0.001), and negatively correlated with BMI, TC and HDL (r = -0.250, P = 0.006; r = -0.244, P = 0.007; r = -0.258, P = 0.004). )   Conclusion: Serum vaspin level is related to thyroid function. The level of serum vaspin increases in hyperthyroidism and decreases in hypothyroidism. Abnormal changes of fat factor vaspin are associated with thyroid dysfunction.

scholarly journals The content of gas transmitters in umbilical cord blood and blood of newborns born to mothers with preeclampsia

2021 ◽  
Vol 66 (4) ◽  
pp. 53-57
Author(s):  
I. G. Popova ◽  
O. G. Sitnikova ◽  
S. B. Nazarov ◽  
G. N. Kuzmenko ◽  
M. M. Klychevа ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Life Support ◽  
Venous Blood ◽  
The Body ◽  
Control Group ◽  
Control Groups ◽  
And Control

To assess endothelial function in the newborns born to mothers with preeclampsia and without preeclampsia the scientists assessed the content of nitricoxide and hydrogen sulfide in the umbilical and venous blood of these children. The main group consisted of 80 women with moderate preeclampsia and their80 newborns; the control group included 50 children born to women without preeclampsia. The authors studied the content of nitric oxide by determining the totalnitrates and nitrites (NOx), hydrogen sulfide in mixed cord blood collected within 30 minutes after delivery, and venous blood taken from newborns on the 1-3rd day of life. Umbilical cord blood demonstrated no significant differences in the content of NO xand hydrogen sulfide in newborns of the main and control groups. However, in general, the study of umbilical cord blood revealed a relationship between the concentration of hydrogen sulfide and the possibility of developing intraventricular hemorrhagein a newborn of the main and control groups. In the venous blood there was a significant increase in the content of NOx and hydrogen sulfide in newborns born to mothers with preeclampsia. It may cause vasodilation asa compensatory reaction of the body during the period of postnatal adaptation of the child’s body, aimed at life support.

scholarly journals The Effect of Balloon Inflating Distraction on Pain Intensity During Venous Blood Sampling in Children: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Somaeh. Salehi Sarbijan ◽  
Roghiah Mehdipoor Rabori ◽  
Esmat Nouhi
Keyword(s):  
Venous Blood ◽  
Blood Sampling ◽  
Control Group ◽  
Negative Consequences ◽  
Randomized Controlled ◽  
Pain Scores ◽  
Significant Difference ◽  
Average Pain ◽  
And Control ◽  
Venous Blood Sampling

Abstract Background: A large number of children are subject to prevention, diagnosis, and treatment procedures that mostly require venous blood sampling. Painful procedures such as blood sampling in children have annoying physical and emotional effects and can lead to wider negative consequences such as physical, behavioral, and social disorders in children. This study aimed to determine the effect of distraction by balloon inflating on the amount of pain during taking blood samples from children aged 4 to 7. Method: This study had a randomized controlled clinical trial that was conducted on 80 children admitted to the pediatric department of Imam Khomeini Hospital in Jiroft-Kerman province who met the inclusion criteria after obtaining their parent’s consent. The children were randomly grouped into the intervention (n = 40) and control (n = 40) groups. The pain level in children in the intervention group was measured during the venous blood sampling while the children were watching inflating a balloon. However, the pain in children in the control group was measured without any intervention during blood sampling. Wong–Baker Faces Pain Rating Scale questionnaire was used for pain assessment. Results: The average pain scores for the children in the two groups showed no significant difference before the intervention but the average pain scores after the intervention in the intervention and control groups were 1.38±2.56 and 4.2±1.58; showing a significant difference between the two groups after the intervention (p-value < 0.05). Conclusion: Using balloon inflation distraction during venous blood sampling reduces pain in children.

scholarly journals THE EFFECTS OF ANALOGY INSTRUCTIONS ON SPRINT PERFORMANCE AND KINEMATICS

2021 ◽  
Vol 17 (1) ◽  
pp. 35
Author(s):  
Hanisah Abdullah ◽  
Jeffrey Low Fook Lee
Keyword(s):  
Sprint Performance ◽  
The Body ◽  
Control Group ◽  
Kinematic Data ◽  
Significant Difference ◽  
Post Test ◽  
Timing Gate ◽  
Post Hoc ◽  
And Control ◽  
Running Mechanics

The purpose of this study was to examine the effects of analogy and explicit instructions on 50-m sprint performance and their running kinematics. Forty-five male Physical Education undergraduates participated in this study and were randomly divided into three groups, (i.e. analogy, explicit and control). Their sprint performances were assessed using wireless timing gate while the kinematic data was assessed by Kinovea software. The analogy group received three analogies which were “run tall”, “chin to pocket” and “claw the track” throughout the intervention sessions whereas the explicit group received “keep the body posture in an upright position and aligned, head and butt not tilting outward”, “arms should maintain a 90-degree angle at the elbow throughout the upswing as well as backswing” and “the foot landing should always be on the balls of the feet”. The control group did not receive any instruction throughout the intervention period. All participants were tested again after three weeks for the post test and retention test a week after. A 3 group x 3 tests mixed design ANOVA was used to analyze the sprinting performance whereas the kinematic data was analyzed by using one way MANOVA test. Results displayed that there was no significant difference in sprint performance among the groups. However, the post hoc test showed that the analogy group improved significantly in the post test. The kinematic data showed that both intervention groups were significantly better than the control group. This study concluded that both analogy and explicit instructions resulted in better running mechanics but only the analogy group elicited better in performance. Thus, analogy instructions are suggested to be an effective method to coach sprinters.

scholarly journals Pengaruh Latihan Renang Teratur dan Latihan Renang Tidak Teratur Terhadap Kadar Trigliserida Plasma pada Rattus norvegicus

2018 ◽  
Vol 2 (1) ◽  
pp. 24-40
Author(s):  
Adi Wijayanto
Keyword(s):  
Rattus Norvegicus ◽  
Exercise Program ◽  
The Body ◽  
Control Group ◽  
Regular Exercise ◽  
Control Group Design ◽  
Group Design ◽  
Significant Difference ◽  
Post Test ◽  
And Control

Triglycerides are source of energy in the body, but triglyceride deposits that exceed the threshold will cause health problems, so triglycerides should be lowered to normal. The reduction of triglycerides can be done through physical activity, therefore this study aims to reveal the effect of regular swimming exercises and irregular exercises against triglyceride levels. This research is an experimental research using The Post Test Only Control Group Design design. Subjects of the study were male of Rattus Norvegicus Wistar, 39 subjects was divided into 3 groups with Matched Subject Design technique, which consisted of 2 groups of treatment that is regular and irregular group, and control group. The exercise program was given a swimming with a 3% weight of body weight and was tied 5 cm from the tip of the tail which was performed 3 times per week consistently for regular exercise and 0 to 5 times per week inconsistently for irregular exercise for 12 weeks, While the control group was not given training. In the last week before the blood was taken, the first three groups were given swimming treatment exercises. Based on the results of the anava test, there was a significant difference in the reduction of triglyceride levels among white mice who were given regular exercise with irregular exercise. These results suggest that regular exercise has a better impact on triglyceride reduction than irregular exercise, due to the higher adaptation process of regular exercise.

scholarly journals Investigation of Body Composition of Footballers by Bioelectrical Impedance Method

2019 ◽  
Vol 5 (2) ◽  
pp. 118
Author(s):  
Yakup Aktas ◽  
Ismail Gokhan
Keyword(s):  
Skeletal Muscle ◽  
Body Mass ◽  
Bioelectrical Impedance ◽  
The Body ◽  
Control Group ◽  
Football Players ◽  
Fat Percentage ◽  
Muscle Weight ◽  
Significant Difference ◽  
And Control

Objective: This study aims at examining the body composition of male football players who perform regular football training by Bioelectrical Impedance (BIA) method and comparing it with a healthy control group and investigating the effect of regular exercise on body composition.Materials and Methods: A total of 60 people participated in the study, including 30 volunteer male football players performing football trainings regularly from 11 Nisan Football Club playing in Turkey Football Federation Regional Amateur League (BAL) and 30 healthy volunteer control group consisting of male students from Harran University Medical Faculty. Both groups’ ages and body mass indexes are similar to each other.  Bioelectrical Impedance (BIA) method was used for Osseosis, skeletal muscle weight (SMM), body mass index (BMI), body fat percentage (BFP), waist hip ratio (WHR), and basal metabolism parameters of the participants. The data obtained were evaluated with SPSS 23.0 statistical package program, and the significance level was evaluated as p < 0.01 and p < 0.05.Findings: There was no statistically significant difference between the values of age, height, weight, intracellular fluid, extracellular fluid, protein, mineral, skeletal muscle weight (SMM), body mass index (BMI) and muscle ratios of the experimental and control groups (p > 0.05). When the parameters of basal metabolism, Osseosis and skeletal muscle weight of the experimental group were discussed, no significant relationship was detected, although they were high numerically (p > 0.05). It was determined that the body fat percentage (BFP) of the experimental and control groups was correlated at p < 0.01 level and waist-hip ratio was correlated (WHR) at p < 0.05 level, which was statistically significant. As a result, although there was no significant difference between BMI values between the football players and the control group, the fact that the players' lower BMI values and lower waist-hip ratios showed that regular training reduces the risk of developing chronic diseases.

The Comparison on Changes of the Body Heats in Electroacupuncture Analgesia and Anesthesia by Ketamine Hydrochloride in Dogs

2006 ◽  
Vol 34 (01) ◽  
pp. 69-76 ◽  
Author(s):  
Sang-Eun Lee ◽  
Ji-Min Seo ◽  
Jianzhu Liu ◽  
Min-Sung Hong ◽  
Young-Won Lee ◽  
...  
Keyword(s):  
The Body ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Ketamine Hydrochloride ◽  
Ketamine Anesthesia ◽  
Healthy Dogs ◽  
And Control ◽  
Experimental Group ◽  
Body Heat

This study was performed to clarify the differences of the body heats between electroacupuncture analgesia (EA) and anesthesia by ketamine hydrochloride (ketamine anesthesia) in dogs. Nine clinically healthy dogs were divided into ketamine anesthesia (control: 5 heads) and EA (experimental: 4 heads) groups, respectively. The acupoints GV-5 and Bai-Hui were used. The infrared thermographic system was used to determine the body heats. The body heats was determined at areas such as the dorsocranial (DCr), dorsocaudal (DCd), ventrocranial (VCr) and ventrocaudal (VCd) regions, on pretreatment, 10, 20, 30, 50 and 90 minutes after treatments, respectively in control and experimental groups. The body heats showed decreasing tendency until 30 minutes after ketamine injection, and then showed increasing pattern until 90 minutes after at all areas investigated in the control group. However, no significant differences of the body heats in the DCr, DCd, VCr and VCd regions were found in the control group. On the other hand, the body heats showed increasing tendency until 30 minutes, and then showed decreasing pattern until 90 minutes after EA, in the experimental group. The significant difference was observed at 30 minutes in the DCr region, and also at 10, 20 and 30 minutes in the DCd regions in the experimental group ( p < 0.05). The significant differences of the body heats were detected at 20 minutes in the DCr region, at 30 minutes in the DCd region and at 30 minutes in the VCd region between the experimental and control groups ( p < 0.05). In conclusion, EA increases of the body heat in the contrary to that of ketamine anesthesia.

scholarly journals Serum vaspin levels in hypothyroid patients

2011 ◽  
Vol 165 (4) ◽  
pp. 563-569 ◽  
Author(s):  
Neşe Çinar ◽  
Neşe Ersöz Gülçelik ◽  
Kadriye Aydín ◽  
Şafak Akín ◽  
Aydan Usman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Animal Studies ◽  
Fasting Glucose ◽  
Resistance Index ◽  
The Body ◽  
Model Assessment ◽  
Free Triiodothyronine ◽  
Significant Difference ◽  
Before And After ◽  
Hypothyroid Patients

ObjectiveTo elucidate the link between TSH and obesity, the relationship between TSH and adipocytokines were previously studied. Animal studies demonstrated a possible relationship between vaspin levels and thyroid functions. In this study, we aimed to investigate vaspin levels in hypothyroid states and its relationship with insulin resistance parameters in humans.DesignProspective observational study.MethodsWe enrolled 27 overt hypothyroid, 33 subclinical hypothyroid and 41 euthyroid patients. We measured the body mass index (BMI), fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), lipid profile, TSH, free triiodothyronine, free thyroxine and vaspin levels. The change in vaspin levels in 12 overt hypothyroid patients after establishment of euthyroidism was analysed.ResultsAll groups were age-matched. Overt hypothyroid group had higher BMI values (P<0.05) than other groups. No significant difference was observed in insulin levels and HOMA-IR among the groups (P>0.05). Adjusted vaspin levels for BMI and age were similar among the groups. Mean vaspin levels in overt, subclinical and euthyroid patients were 1.20±1.17, 1.48±0.93 and 0.95±0.75 ng/ml respectively (P>0.05). There was no significant association between vaspin levels and BMI, fasting glucose, insulin and HOMA-IR (P>0.05). Establishing euthyroidism in hypothyroid patients did not result in a significant change in vaspin levels (before and after treatment, 1.35±1.06 and 1.25±0.68 ng/ml, respectively; P>0.05).ConclusionWe herein present novel data indicating vaspin levels are neither altered in overt and subclinical hypothyroidism nor have a relationship with features of insulin resistance in hypothyroid patients.

scholarly journals Evaluation of Thyroid Dysfunction in Adult Patients of Celiac Disease

2021 ◽  
Vol 8 (4) ◽  
pp. 3-8
Author(s):  
Nauman Wazir ◽  
Shafqat Ur Rehman
Keyword(s):  
Celiac Disease ◽  
Thyroid Dysfunction ◽  
Adult Patients ◽  
Control Group ◽  
Overt Hypothyroidism ◽  
Thyroid Peroxidase ◽  
Serological Evidence ◽  
Adult Celiac Disease ◽  
Significant Difference ◽  
And Control

OBJECTIVES: To assess free thyroxine (fT4), thyroid stimulating hormone (TSH), and anti thyroid peroxidase antibodies (anti TPO abs) in adult Celiac disease patients and non-celiac controls and to find out any statistically significant difference in their corresponding means between the two groups. METHODOLOGY: The study design was analytical cross sectional. Sixty adult patients of celiac disease (CD) and 30 apparently healthy non-celiac adults were included in the study. CD patients had earlier been diagnosed by elevated levels of serological evidence of elevated (greater than 15X ULN) anti tissue transglutaminase (TTG) (IgA class) antibodies. CD was ruled out in the control group by normal levels of the antibodies. TSH, fT4 and anti TPO abs were obtained from all individuals of CD patient and control groups. RESULTS: Mean age of Celiac disease in patients was 23.85±5.43 years. Mean age of individuals in the control group was 24.26±5.55 years. Statistically significant difference in mean TSH and anti-TPO abs levels between the CD patient group and control group (p values of 0.03 and 0.038, respectively) was present. No statistically significant difference was seen between mean fT4 of patients and control group (p=0.74). Subclinical and overt hypothyroidism was present in 10% and 5% of CD patients, while anti TPO abs was positive in 16.6% of CD patients. CONCLUSION: There is a considerably high prevalence of subclinical and overt hypothyroidism as well as serological evidence of thyroid dysfunction in adult patients of CD.

scholarly journals Keefektifan ekstra putih telur terhadap peningkatan albumin dan penurunan IL-1β pada pasien tuberkulosis dengan hipoalbuminemia

2014 ◽  
Vol 10 (3) ◽  
pp. 111
Author(s):  
Agus Prastowo ◽  
Wiryatun Lestariana ◽  
Siti Nurdjanah ◽  
Retno Sutomo
Keyword(s):  
High Energy ◽  
Egg White ◽  
The Body ◽  
World Health ◽  
Bivariate Analysis ◽  
Control Group ◽  
Study Group ◽  
Research Results ◽  
Significant Difference ◽  
And Control

Background: Tuberculosis (TB) is world health problem which still needs attention. Recently, Indonesia ranks the third in TB prevalence after India and China. Research revealed that albumin decreases significantly in TB patients, due to lack of nutritious intakes such as low-calorie intake, anorexia, increased catabolism, enteropathy and acute protein reaction. Low albumin was associated with increased IL-1β and cytokines inflammation in TB patient. Albumin had a very important role in the body and white egg known as a good quality source of protein.Objective: To assess the effect of white egg supplementation in TB patient towards the level of albumin and the level of IL-1β.Method: A single-blind randomized controlled trial was conducted with 75 patient selected for the study and divided to 37 patient as the study group and 38 as a control group. Both groups received high energy high protein diet, while the study group received, additionally, an oral egg white-based on formula calculation Baxter for 14 days. Control group received, additionally, an extra soybean curd and mungbean powder. Albumin and IL-1β were checked before and after the intervention. Data is analyzed by using Mann-Whitney.Results: Research results show that average albumin pre-intervention in the study group was 2.82 g/dL and control group was 2.85 g/dL. Average albumin difference in the study group was 3.47 g/dL and control group was 2.81 g/dL. Bivariate analysis results show significant of increasing albumin between study group and control group (p<0.05). Research results show average IL-1β pre-intervention difference in study group (0.9 pg/mL) and control group (0.67 pg/mL). The average IL-1β difference in the study group was -0.39 pg/mL and control group was 0.76 pg/mL. Bivariate analysis results show a significant difference of IL-1β depletion between study group and control group (p<0.05).Conclusion: Egg white increase albumin level and IL-1β depletion in tuberculosis patients effectively.

scholarly journals Doxorubicin Deteriorates the Histomorphology of the Kidneys of Albino Rats

2017 ◽  
Vol 15 (1) ◽  
pp. 40-43
Author(s):  
Anup Pandeya ◽  
Chandra Bhushan Jha ◽  
Smriti Karki ◽  
Gajendra Prashad Rauniar
Keyword(s):  
Body Weight ◽  
The Body ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Final Body Weight ◽  
Histological Features ◽  
Male And Female Rats ◽  
Significant Difference ◽  
And Control

Background and Objectives: Nephrotoxicity is one of the limiting factors for using doxorubicin as an anticancer chemotherapeutic. Reactive oxygen species and cytokines have been implicated in the nephrotoxicity induced by doxorubicin. The main objective of the present study is to identify and compare the histomorphological features in kidneys of albino rats and gross morphological features such as weight of rats and weight of the kidneys due to administration of doxorubicin. Materials and Methods: In the study, albino rats were taken as the animal model. Sixty animals were taken as the sample size. They were divided into two equal groups: experimental (n=30) and control (n=30). Rats of experimental group were treated with anticancer drug doxorubicin at a single intraperitoneal dose of 10 mg/kg body weight while the Control group of rats received a similar volume of 0.9% normal saline. The ethical clearance was taken prior to the research from IERB committee BPKIHS Dharan.  Results: Our results showed that there was high effect of drug in experimental groups of rats. It was seen that there was significant decrease in the body weight and weight of kidneys. The final body weight and kidney weight between experimental and control group showed the significant difference. Similarly there were no significant differences in the normal architecture between the male and female rats. The normal renal histological features were seen on the kidneys in the control group whereas the rats intervened with the drug had some disrupted histological features which reveal the toxicity of the drugs in the kidneys. Conclusion: The study showed toxicity of the drug in the kidneys of experimental groups of rats irrespective of gender and suggest that doxorubicin causes significant loss of the body weight and weight of kidneys and causes the disruption in the normal histological features.

Sign in / Sign up

Export Citation Format

Share Document