scholarly journals Decreased plasma adiponectin concentrations in nondiabetic women with elevated homeostasis model assessment ratios

2003 ◽  
pp. 343-350 ◽  
Author(s):  
M Matsubara ◽  
S Katayose ◽  
S Maruoka
Keyword(s):  
Insulin Resistance ◽  
Multiple Regression ◽  
Serum Insulin ◽  
Sandwich Elisa ◽  
Serum Triglyceride ◽  
Model Assessment ◽  
Continuous Variables ◽  
Homeostasis Model Assessment ◽  
Cross Sectional ◽  
Plasma Adiponectin

OBJECTIVE: Whether the adipocyte-derived protein adiponectin is associated with insulin resistance independently of the effects of adiposity and the diabetic state is an important question. We explored, in a cross-sectional study of 486 Japanese nondiabetic women, the relationship between the calculated insulin resistance (homeostasis model assessment ratio (HOMA-R)) and adiponectin levels determined using a validated sandwich ELISA. DESIGN AND METHODS: All participants were stratified into tertiles for HOMA-R (approximately <1.5, 1.5< or = approximately <3.0, 3.0< or = approximately ) and the differences across tertiles of continuous variables were tested with ANOVA. Two-way ANOVA was used to determine possible relationships for plasma adiponectin between tertiles of HOMA-R and several stratified parameters. Multiple regression analyses were performed with HOMA-R or fasting serum insulin as dependent variable, and diastolic blood pressure (BP), body mass index (BMI), serum triglyceride (TG), leptin and adiponectin as independent determinants. RESULTS: Mean plasma adiponectin in the high HOMA-R group decreased compared with that in the low HOMA-R group both before (mean+/-s.e.m. 6.2+/-0.6 vs 9.2+/-0.3 microg/ml, P<0.001) and after adjustment for body fat mass (BFM) as kg or percent (0.31+/-0.04 vs 0.69+/-0.03, 0.18+/-0.02 vs 0.34+/-0.01, both P<0.001). HOMA-R was inversely associated with adiponectin levels both before (r=-0.37, P<0.001) and after adjustment for BFM (r=-0.49, -0.46, both P<0.001). After covariate adjustment for age, diastolic BP, BMI and serum TG, HOMA-R retained a significant correlation with adiponectin/BFM (kg). Both adiponectin and leptin were the significant determinants of HOMA-R or fasting insulin in multiple regression models. CONCLUSIONS: Adiponectin was inversely associated with insulin resistance in nondiabetic subjects, independently from age, BP, adiposity and serum lipids. Because adiponectin is thought to have an anti-atherogenic action, the presence of hypoadiponectinemia may predispose subjects to atherosclerosis, and may progress the atherogenesis in insulin resistance.

scholarly journals A Replication Study Identified Seven SNPs Associated with Quantitative Traits of Type 2 Diabetes Among Chinese Population (P18-079-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ailing Liu ◽  
Chao Song ◽  
Caicui Ding ◽  
Hui Li ◽  
Likui Wan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Insulin Release ◽  
Quantitative Traits ◽  
Serum Insulin ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Cross Sectional ◽  
Index Value

Abstract Objectives To explore genetic variants for quantitative traits of type 2 diabetes (T2D) such as insulin resistance and insulin release among Chinese adults. Methods A total of 2216 subjects were selected from cross-sectional 2010–2012 China National Nutrition and Health Surveillance. Fasting plasma glucose(FPG) and fasting serum insulin(FSIN) were tested and 81 T2D single nucleotide polymorphisms (SNPs) were genotyped. Insulin resistance was defined by exceeding top quartile of insulin resistance of homeostasis model assessment(HOMA-IR) index value and insulin release was defined under lower quartile of insulin release of homeostasis model assessment(HOMA-B) index value in nondiabetic individuals, respectively. Logisticregression model was utilized to explore association between each SNP and quantitative traits. Results The risk C allele of GRK5 rs10886471, the risk C allele of IGF2BP2 rs1470579 and the risk A allele of GCK rs4607517 was associated with increased HOMA-IR(P = 0.043, P = 0.014, P = 0.050), and the risk T allele of SEC16B rs574367 was associated with decreased HOMA-IR(P = 0.028). The risk A allele of SCAP rs4858889 associated with decreased HOMA-B(P = 0.004), while FTO rs1558902 and MAEA rs6815464 both had inverse effect on HOMA-B(P = 0.018, P = 0.048). Conclusions The rs10886471, rs1470579 and rs4607517 might be risk loci for T2D by mediating insulin receptors or insulin signal transduction to reduce insulin sensitivity. Individuals carrying the risk A allele of rs4858889 predisposed to T2D may by decreasing insulin secretion. Our findings will provide clue for casual relationship between SNPs and T2D-related traits. Funding Sources The Ministry of Healthand the Ministry of Science and Technology in China(2001-DEA30035, 2003-DIA6N008).

scholarly journals Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population

2004 ◽  
Vol 89 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Yukihiro Yamamoto ◽  
Hiroshi Hirose ◽  
Ikuo Saito ◽  
Kanako Nishikai ◽  
Takao Saruta
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Lipid Profile ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Resistance Index ◽  
Serum Adiponectin ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Insulin Resistance Index

It has been reported that the serum adiponectin level was negatively correlated with body mass index (BMI), insulin resistance index, and triglycerides and was positively correlated with high-density lipoprotein cholesterol in several cross-sectional studies. However, the causal relationship has not been elucidated. We investigated whether the baseline adiponectin level could predict subsequent changes in insulin resistance, lipid profile, or body weight in a 2-yr longitudinal study. This study included 590 male Japanese subjects, aged 30–65 yr, who received annual health checkups in both 2000 and 2002. Blood pressure, heart rate, and anthropometric and metabolic parameters, including serum insulin and adiponectin levels, were determined. The insulin resistance index was calculated based on homeostasis model assessment. Baseline adiponectin level was not correlated with the subsequent change in lipid profile or BMI in 2 yr after adjustment for each baseline value. However, the baseline adiponectin level was negatively correlated with subsequent changes in insulin and insulin resistance index based on homeostasis model assessment, even after adjustment for change in BMI (r = −0.162 and r = −0.140, respectively). These findings suggest that the serum adiponectin concentration predicts subsequent changes in insulin resistance, but not in lipid profile or body weight.

scholarly journals Distribution of the homeostasis model assessment of insulin resistance in Mexican children and adolescents

2012 ◽  
Vol 166 (2) ◽  
pp. 301-306 ◽  
Author(s):  
Celia Aradillas-García ◽  
Martha Rodríguez-Morán ◽  
María Eugenia Garay-Sevilla ◽  
Juan Manuel Malacara ◽  
Ramón Alberto Rascon-Pacheco ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Children And Adolescents ◽  
Fasting Glucose ◽  
Population Based ◽  
Healthy Children ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Mexican Children

ObjectiveSeveral cutoff points of the homeostasis model assessment of insulin resistance (HOMA-IR; varying from 2.5 to 4.0) have been suggested for diagnosing IR in youth. In this study, we determined the distribution of the HOMA-IR in Mexican children and adolescents.Design and methodsA total of 6132 children and adolescents from San Luis Potosi, León, Queretaro, and Durango, which are cities in central and northern Mexico, were enrolled in a population-based cross-sectional study. Eligible participants were apparently healthy children and adolescents aged 6–18 years. Pregnancy and the presence of chronic illnesses were exclusion criteria.ResultsA total of 3701 (60.3%) girls and 2431 (39.7%) boys were included in this study. In the overall population, the mean body mass index, insulin levels, and fasting glucose levels were 21.8±1.3 kg/m2, 7.1±3.2 μU/ml, and 86.2±10.0 mg/dl respectively. The concentrations of insulin and fasting glucose gradually increased from 6 to 12 years of age, whereas the concentrations tended to plateau in the 13- to 18-year-old population. The absolute mean of the HOMA-IR was 2.89±0.7. The HOMA-IR gradually increased with age and reached a plateau at 13 years of age.ConclusionsBecause the insulin concentrations, glucose levels, and HOMA-IR exhibited a gradual increase with age that was not related to obesity, our results suggested that the evaluation of IR in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point.

scholarly journals High HOMA-IR Index in Healthcare Shift Workers

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 186 ◽  
Author(s):  
Caterina Ledda ◽  
Diana Cinà ◽  
Serena Matera ◽  
Nicola Mucci ◽  
Massimo Bracci ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Shift Work ◽  
Healthcare Workers ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Shift Workers

Background and objectives: Evidence shows that shift work may be correlated with insulin resistance (IR). Therefore its estimation in clinical and prevention practice is of great significance. A cross-sectional study was performed to examine the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) Index among healthcare shift workers (HCSW). Materials and Methods: A total of 272 healthcare workers (HCWs) were invited to participate in the study within an occupational surveillance framework, 137 were HCSW while 135 were healthcare non-shift workers (HCNSW). Fasting glucose, insulin, and HOMA-IR Index were evaluated in each participant and correlated with shift workers. Results: Indicators of glucose metabolism were significantly higher in HCSW p < 0.001, and logistic regression analysis confirmed a significant positive association between increased values of HOMA-IR Index and shift workers (p < 0.05). Conclusions: Shift work could be a risk factor in developing insulin resistance and metabolic syndrome.

scholarly journals Optimal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Cut-Offs: A Cross-Sectional Study in the Czech Population

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 158 ◽  
Author(s):  
Dagmar Horáková ◽  
Ladislav Štěpánek ◽  
Vladimír Janout ◽  
Jana Janoutová ◽  
Dalibor Pastucha ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Logistic Regression ◽  
Clinical Practice ◽  
Predictive Accuracy ◽  
Predictive Ability ◽  
Glucose Metabolism Disorders ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Cross Sectional ◽  
Czech Population

Background and Objectives: The key pathogenetic mechanism of glucose metabolism disorders, insulin resistance (IR), can be assessed using the Homeostasis Model Assessment of IR (HOMA-IR). However, its application in clinical practice is limited due to the absence of cut-offs. In this study, we aimed to define the cut-offs for the Czech population. Methods: After undergoing anthropometric and biochemical studies, the sample of 3539 individuals was divided into either nondiabetics, including both subjects with normal glucose tolerance (NGT, n = 1947) and prediabetics (n = 1459), or diabetics (n = 133). The optimal HOMA-IR cut-offs between subgroups were determined to maximize the sum of the sensitivity and specificity for diagnosing type 2 diabetes mellitus (T2DM) or prediabetes. The predictive accuracy was illustrated using receiver operating characteristic (ROC) curves. Logistic regression was performed to assess the association between a target variable (presence/absence of T2DM) depending on the HOMA-IR score as well as on the age and sex. Results: The HOMA-IR cut-off between nondiabetics and diabetics for both sexes together was 3.63, with a sensitivity of 0.56 and a specificity of 0.86. The area under the ROC curve was 0.73 for T2DM diagnosing in both sexes. The HOMA-IR cut-off between the NGT subjects and prediabetics was 1.82, with a sensitivity of 0.60 and a specificity of 0.66. Logistic regression showed that increased HOMA-IR is a risk factor for the presence of T2DM (odds ratio (OR) 1.2, 95% confidence interval (CI) 1.14–1.28, p < 0.0001). The predictive ability of HOMA-IR in diagnosing T2DM is statistically significantly lower in females (OR 0.66, 95% CI 0.44–0.98). The results are valid for middle-aged European adults. Conclusions: The results suggest the existence of HOMA-IR cut-offs signaling established IR. Introduction of the instrument into common clinical practice, together with the known cut-offs, may contribute to preventing T2DM.

scholarly journals Independent predictors of insulin resistance in Brazilian adolescents: Results of the study of cardiovascular risk in adolescents–Brazil

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246445
Author(s):  
Maria Izabel Siqueira de Andrade ◽  
Juliana Souza Oliveira ◽  
Vanessa Sá Leal ◽  
Poliana Coelho Cabral ◽  
Pedro Israel Cabral de Lira
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Age Groups ◽  
Serum Triglyceride ◽  
Public Health Problem ◽  
High Serum ◽  
Model Assessment ◽  
Important Public Health Problem ◽  
Cross Sectional ◽  
Sample Distribution

Considering the current changes in dietary patterns and the increasing prevalence of excess weight throughout the world, several studies have reported insulin resistance, which is a key driver of many chronic diseases, to be an important public health problem in all age groups. Therefore, the aim of the present study was to identify the prevalence and independent predictors of insulin resistance in Brazilian adolescents. A cross-sectional study was conducted with a probabilistic, representative sample of Brazilian adolescents (n = 37,023) who participated in the Study of Cardiovascular Risk in Adolescents. Data were collected on demographic, socioeconomic, lifestyle, anthropometric, and biochemical characteristics as well as antioxidant micronutrient intake (vitamins A, C, E, zinc, and selenium). Insulin resistance was determined using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and classified based on the 75th percentile of the sample distribution. Insulin resistance was detected in 27% of the adolescents and was more prevalent among those aged 12 to 14 years (PR: 1.26 [95%CI: 1.13;1.41]), those residing in the southern and south-eastern regions of the country (PR: 1.47 [95%CI: 1.27;1.70]), those who were physically inactive (PR: 1.12 [95%CI: 1.02;1.23]), and those did not consume alcohol (PR: 1.50 [95%CI: 1.13;1.99]). The prevalence of insulin resistance was 2.5-fold higher among individuals with severe obesity (PR: 2.49 [95%CI: 2.07;3.00]). Waist circumference indicative of cardiovascular risk and high serum triglyceride levels increased the likelihood of insulin resistance (PR: 1.37 [95%CI: 1.19;1.59] and 1.60 [95%CI: 1.45;1.78], respectively). The prevalence of the outcome was higher among adolescents in the lower quartiles of vitamin E intake (p<0.05). In the present study, the prevalence of insulin resistance was high among Brazilian adolescents and we identified sociodemographic, lifestyle, anthropometric, biochemical, and dietary predictors of this outcome.

scholarly journals Hubungan Kadar Plasma Chemerin dengan Homeostasis Model Assessment Insulin Resistance pada Remaja Obesitas

Sari Pediatri ◽  
2020 ◽  
Vol 22 (1) ◽  
pp. 24
Author(s):  
Silvy Dioni ◽  
Eka Agustia Rini ◽  
Eti Yerizel
Keyword(s):  
Insulin Resistance ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Cross Sectional ◽  
Elisa Data

Latar belakang. Obesitas pada anak berhubungan dengan meningkatnya risiko sindrom metabolik, seperti resistensi insulin. HOMA-IR merupakan marker yang sering digunakan untuk menilai resistensi insulin. Chemerin merupakan protein 18 kDa yang dihasilkan jaringan adiposa, berfungsi sebagai chemoatractant memegang peran penting berkontribusi terhadap perkembangan inflamasi dan resistensi insulin. Tujuan. Untuk mengetahui hubungan kadar chemerin dengan HOMA-IR pada remaja obesitas.Metode. Penelitian ini merupakan penelitian cross sectional yang dilakukan pada 3 sekolah menengah umum (SMU) di kota Padang. Jumlah sampel berjumlah 28 remaja obesitas dan 28 remaja dengan IMT normal. Obesitas ditentukan berdasarkan nilai IMT, HOMA-IR dihitung berdasarkan rumus yang menggunakan nilai glukosa dan insulin puasa. Glukosa diukur dengan metode glucose hexokinase fotometrik, insulin diperiksa dengan metode chemiluminessence immunoassay dan kadar plasma chemerin dengan metode ELISA. Data dianalisis dengan sistem komputerisasi dengan uji korelasi.Hasil. Kadar plasma chemerin lebih tinggi pada kelompok obesitas dibandingkan kontrol 121,52 (SD 2,09) ng/ml vs 97,23(SD 2,41) ng/ml, p: 0,001 dan pada kelompok obesitas dengan resistensi insulin dibandingkan non resistensi insulin 133,1(SD 19,24) vs 115,09 (SD 19,52), p=0,001. Terdapat hubungan lemah kadar chemerin dengan nilai HOMA-IR pada obesitas(r=0,382;p=0,045) dan hubungan lemah kadar chemerin dengan nilai HOMA-IR pada obesitas resistensi insulin (r=0,297;p=0,405).Kesimpulan. Terdapat hubungan lemah kadar chemerin dengan nilai HOMA-IR pada remaja obesitas, dan hubungan lemah kadar chemerin dengan nilai HOMA-IR pada obesitas resistensi insulin.

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