scholarly journals The relationship between vitamin D deficiency and thyroid autoimmunity in Graves' disease

2015 ◽  
Author(s):  
Tugba Arkan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Thyroid Autoimmunity ◽  
Graves Disease ◽  
The Relationship

scholarly journals The Concept of Vitamin D Sufficiency and Insufficiency in Graves’ Disease

2017 ◽  
Vol 7 (2) ◽  
pp. 160-163
Author(s):  
Zafar Ahmed Latif
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Thyroid Hormone Receptor ◽  
Receptor Gene ◽  
Thyroid Autoimmunity ◽  
Graves Disease ◽  
Endocrine Gland ◽  
Early Improvement ◽  
Increased Risk ◽  
Auto Antibody

Graves’ disease (GD) is an autoimmune disorder of the thyroid gland resulting from dysregulation of the immune system against this important endocrine gland. The disease is characterized by hyperthyroidism and presence of circulation auto antibody which stimulates the Thyroid Hormone Receptor(TSHR). The auto antibody is also responsible for goiter and other extra-thyroidal manifestation like ophthalmic, dermatological and others. Vitamin D (Vit.-D) deficiency is reported to link with variety of autoimmune diseases. However the relation between thyroid autoimmunity of Graves’ disease and Vitamin D deficiency is still not very clear. But in some studies10-12, it was found that there is strong correlation between thyroid autoimmunity and vitamin D – 1,25-(OH) deficiency in newly diagnosed GD. It was found < 15 pmol/L. In one study it was found <12.5pmol/ L. According to definition of insufficiency or deficiency most of the Author agreed to describe insufficiency when Vit D level is less than 30pmol/L and deficient when less than 20 pmol/L. Vitamin D Receptor gene polymorphism is also associated with increased risk of Graves’ (4D) disease and higher volume of goiter. In other studies it was found that, the increased thyroid antibody titer was associated with Vitamin D deficiency. Some other studies showed that, treatment with Vitamin D in GD there is significant early improvement of the diseases. Meta-analysis showed low Vitamin D was also associated with higher risk of development of GD. Moreover, hyperthyroidism leading to osteoporosis in GD is also associated with low Vitamin D level and improves by treatment with Vitamin D. However, whether Vitamin D deficiency or insufficiency favor’s the onset of GD or supplementation of Vitamin D has any beneficial effect, needs further research.Birdem Med J 2017; 7(2): 160-163

scholarly journals The Relationship between Vitamin D Deficiency and Pulmonary Artery Atherosclerosis in Chronic Thromboembolic Patients

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Tarik Kivrak ◽  
Hasan Ata Bolayir ◽  
Batur Gonenc Kanar ◽  
Dursun Akaslan ◽  
Hakan Gunes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Artery ◽  
Vitamin D Deficiency ◽  
The Relationship

scholarly journals Vitamin D deficiency and depression in adults: systematic review and meta-analysis

2013 ◽  
Vol 202 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Rebecca E. S. Anglin ◽  
Zainab Samaan ◽  
Stephen D. Walter ◽  
Sarah D. McDonald
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
Randomised Controlled ◽  
The Relationship

BackgroundThere is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available.AimsTo determine the relationship, if any, between vitamin D deficiency and depression.MethodA systematic review and meta-analysis of observational studies and randomised controlled trials was conducted.ResultsOne case-control study, ten cross-sectional studies and three cohort studies with a total of 31 424 participants were analysed. Lower vitamin D levels were found in people with depression compared with controls (SMD = 0.60,95% Cl 0.23–0.97) and there was an increased odds ratio of depression for the lowest v. highest vitamin D categories in the cross-sectional studies (OR = 1.31, 95% CI 1.0–1.71). The cohort studies showed a significantly increased hazard ratio of depression for the lowest v. highest vitamin D categories (HR=2.21, 95% CI 1.40–3.49).ConclusionsOur analyses are consistent with the hypothesis that low vitamin D concentration is associated with depression, and highlight the need for randomised controlled trials of vitamin D for the prevention and treatment of depression to determine whether this association is causal.

scholarly journals THE RELATIONSHIP BETWEEN THE COTININE LEVEL IN URINE AND VITAMIN D IN THE UNIVERSITY STUDENTS

2020 ◽  
Vol 6 (6) ◽  
pp. 214-219
Author(s):  
Ayse Berivan Bakan ◽  
Naim Uzun ◽  
Senay Karadag Arli ◽  
Metin Yıldız
Keyword(s):  
Vitamin D ◽  
University Students ◽  
Vitamin D Deficiency ◽  
Age Groups ◽  
Cotinine Level ◽  
Screening Design ◽  
Significant Relationships ◽  
Blood And Urine Samples ◽  
The University ◽  
The Relationship

Background: Vitamin D deficiency is today acknowledged as a pandemic. Vitamin D deficiency and insufficiency are associated with many chronic diseases, including common cancers, cardiovascular diseases, metabolic syndrome, and infectious and autoimmune diseases.Objective: This study aims to investigate the relationship between the cotinine level in urine and Vitamin D.Methods: This study employed a descriptive and relational screening design.  It was conducted with 74 smoking university students between January 2019 and March 2020. Data were collected through socio-demographic form and Fagerstrom test for nicotine dependence. Besides, the participating students’ blood and urine samples were taken in a suitable environment.Results: The average age of the participating students was 21.50±2.09. Of all the students, 71.6% were males, 62.2% were exposed to the sun between 12 p.m. and 2 p.m., and the average number of cigarettes smoked daily was 13.52±8.22. The average Vitamin D level in blood was 32.4±15.3 (ng/mL), and the average cotinine level in urine was 1.60 ± .32 (ng/L). No statistically significant relationships were found between the Vitamin D level and the cotinine level (p<0.05).Conclusion: Smoking causes diseases and death in many people, and it is a changeable risk factor.  Nursing practices on the struggle against smoking are effective. No significant relationships were found between the Vitamin D level in blood and cotinine level in urine. Similar studies are recommended to be conducted with larger groups and participants from different age groups.

scholarly journals Assessment of vitamin D among Sudanese Patients with Hypothyroidism

2021 ◽  
Vol 1 (2) ◽  
pp. 057-061
Author(s):  
Hasna Osman Fadalla Mohamed ◽  
Omer Fadol Edris ◽  
Gad Allah Modawe ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Vitamin D ◽  
Autoimmune Diseases ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Control Hospital ◽  
Study Population ◽  
Thyroid Profile ◽  
Methods Analytical ◽  
The Relationship

Background: Vitamin D deficiency is a worldwide health issue and its role as an immune modulator has recently been emphasized. Evidence increasingly indicates the important role of vitamin D in reducing the incidence of autoimmune diseases. However, at this time the search for its role in autoimmune diseases and thyroid is not critical. Objectives: The study aimed to assess the relationship between vitamin D deficiency in Sudanese patients with hypothyroidism. Methods: Analytical case control hospital based study, conducted in Fadil Hospital and Police Hospital, Khartoum city, Khartoum state. The study carried out from March 2018 to September 2018. A total of 100 subjects were enrolled in the study. Vitamin D deficiency was set at levels below 20 ng / ml. Thyroid hormones (TSH, T3 and T4) were assessed in all participants using auto analyzer TOSOH AIA 313,while vitamin D was estimated using ELIZA. The data were analyzed using SPSS version (21). Results: The study included 76(76%) females and 24(24%) males, no significance differences between thyroid profile among study population.75 (75%) deficiency of vitamin D and 25(25%) normal vitamin D. vitamin D deficiency was significantly lower in female than male with( p =0.001). Conclusion: The results indicated that patients with hypothyroidism suffer from vitamin D deficiency significantly associated with the degree and severity of hypothyroidism. This encourages the desirability of vitamin D supplementation and recommends the detection of vitamin D deficiency for all hypothyroidism patients.

The role of vitamin D dificiency in the development of pathology in women of perimenopausal age

2018 ◽  
pp. 76-79
Author(s):  
Kh.V. Kozak ◽  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Neurological Diseases ◽  
Research Direction ◽  
Literary Sources ◽  
Autoimmune Conditions ◽  
Calcium Phosphorus ◽  
The Relationship

The article presents an analysis of literary sources about contemporary views on the role of vitamin D deficiency in the health problems of women of the perimenopausal period. According to research data of recent years, vitamin D plays a role not only in the control of calcium-phosphorus metabolism, but also plays a role in the pathogenesis of cardiovascular and neurological diseases, insulin resistance and diabetes, in the development of cancer and autoimmune conditions, especially in women of perimenopausal age. It is important to continue the study of the relationship between vitamin D deficiency and menopausal and menopausal disorders. Currently, the existing principles and effectiveness of the correction of lack of vitamin D in improving the quality of life of women of perimenopausal age are ambiguously assessed, which determines the relevance of this research direction. Key words: perimenopausal period, insufficiency/deficiency of vitamin D.

Alteration of the Intestinal Microbial Flora and the Serum IL-17 Level in Patients with Graves’ Disease Complicated with Vitamin D Deficiency

2021 ◽  
pp. 1-10
Author(s):  
Mengxue Yang ◽  
Fei Li ◽  
Rui Zhang ◽  
Yueyue Wu ◽  
Qian Yang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Intestinal Flora ◽  
Graves Disease ◽  
Newly Diagnosed ◽  
Tsh Receptor Antibody ◽  
Differential Species ◽  
Intestinal Microbial Flora ◽  
Deficiency Group ◽  
Case Number

<b><i>Background:</i></b> Intestinal flora is associated with Graves’ disease (GD). This study explored the association of serum 25(OH)D with the diversity of the intestinal flora and serum IL-17 in GD patients. <b><i>Methods:</i></b> Patients newly diagnosed with GD at 2 centers between 2018 and 2021 were consecutively included. According to their 25(OH)D levels, they were divided into the deficiency group, the insufficiency group, and the sufficiency group. Some patients with vitamin D deficiency or insufficiency were randomly selected and were matched with healthy volunteers (normal control [NC]) in terms of sex, age, and case number. The diversity and differential species of the intestinal flora and serum IL-17 levels were compared. <b><i>Results:</i></b> Serum 25(OH)D negatively correlated with serum IL-17, the platelet/lymphocyte ratio, and TSH receptor antibody. The diversity of the intestinal flora decreased in the GD group, with noticeable differences in the composition of the intestinal flora when compared with the NC group. At the phylum level, the GD group exhibited a significantly lower abundance of Firmicutes but a higher abundance of Actinobacteria. At the genus level, the GD group exhibited higher relative abundances of Bifidobacterium, Collinsella, and Pediococcus but lower abundances of Roseburia and Dialister. <b><i>Conclusions:</i></b> The changes in the vitamin D level and the composition of the intestinal flora may partially contribute to the development of GD.

scholarly journals Vitamin D Deficiency May Not Be an Independent Risk Factor for Peripheral Arterial Disease in Middle-Aged and Elderly Patients with Type 2 Diabetes in China

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yan Wang ◽  
Tongbao Feng ◽  
Hongxing Zhou ◽  
Kefeng Lu ◽  
Yang Bai ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Disease Duration ◽  
Arterial Disease ◽  
Regression Analyses ◽  
Middle Aged ◽  
Hba1c Control ◽  
Peripheral Arterial ◽  
The Relationship

Background. Vitamin D deficiency can lead to the increased severity and prevalence of metabolic disorders. However, the relationship between levels of 25-hydroxyvitamin D (25(OH)D) and peripheral arterial disease (PAD) is controversial. Therefore, the purpose of our study was to explore the relationship between 25(OH)D levels and PAD in middle-aged and elderly type 2 diabetes mellitus (T2DM) patients in China. Methods. In this study, a total of 183 patients with T2DM were enrolled and categorized into groups with or without PAD. Clinical and biochemical parameters were assessed, and a Pearson analysis was used to identify a possible association between levels of 25(OH)D and glycated hemoglobin (HbA1c). Some biochemical parameters were also assessed in the T2DM patients with PAD according to vitamin D status. Interactions were also explored among HbA1c control, 25(OH)D levels, and PAD. The possible risk factors for PAD were measured by multivariable logistic regression analyses. Results. Firstly, the parameters including age, HbA1c, and disease duration between T2DM and T2DM+PAD groups showed significantly different. In addition, the frequency of smoking in the group of T2DM patients was significantly less than that in the T2DM patients with the PAD group, while the frequency of well-controlled HbA1c in the patients with T2DM was significantly higher. There is a trend that the levels of 25(OH)D and HbA1c are correlated, but no interactions among vitamin D deficiency, HbA1c control, and PAD were found. However, HbA1c significantly differed between groups with vitamin D deficiency and insufficiency in the T2DM patients with PAD. According to the multivariate logistic regression analyses, the PAD risk factors of T2DM patients were family history of diabetes, smoking, age, disease duration, HbA1c, and LDL. Conclusions. The findings demonstrate that the deficiency of vitamin D level is not related to PAD, but HbA1c may be linked to the presence of PAD in middle-aged and elderly patients with T2DM in China.

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