scholarly journals Elevation of circulating serotonin improves calcium dynamics in the peripartum dairy cow

2016 ◽  
Vol 230 (1) ◽  
pp. 105-123 ◽  
Author(s):  
Samantha R Weaver ◽  
Austin P Prichard ◽  
Elizabeth L Endres ◽  
Stefanie A Newhouse ◽  
Tonia L Peters ◽  
...  
Keyword(s):  
Dairy Cow ◽  
Therapeutic Benefit ◽  
Holstein Cows ◽  
Calcium Dynamics ◽  
Total Calcium ◽  
Serotonin Synthesis ◽  
Peripartum Period ◽  
Jersey Cows ◽  
Potential Therapeutic Benefit ◽  
Infusion Period

Hypocalcemia is a metabolic disorder that affects dairy cows during the transition from pregnancy to lactation. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 days prepartum with either saline or 1.0mg/kg bodyweight of the immediate precursor to serotonin synthesis, 5hydroxy-l-tryptophan (5-HTP). On infusion days, blood was collected before, after, and at 2, 4, and 8h postinfusion. Blood and urine were collected daily before the infusion period, for 14 days postpartum and on day 30 postpartum. Milk was collected daily during the postpartum period. Feed intake and milk yield were unaffected by 5-HTP infusion postpartum. Cows infused with 5-HTP had elevated circulating serotonin concentrations prepartum. Infusion with 5-HTP induced a transient hypocalcemia in Jersey cows prepartum, but not in any other treatment. Holstein cows infused with saline had the highest milk calcium on the day of and day after parturition. Postpartum, circulating total calcium tended to be elevated, and urine deoxypyridinoline (DPD) concentrations were elevated in Holstein cows infused with 5-HTP. Overall, Jerseys had higher urine DPD concentrations postpartum when compared with Holsteins. Taken together, these data warrant further investigation of the potential therapeutic benefit of 5-HTP administration prepartum for prevention of hypocalcemia. Further research should focus on delineation of mechanisms associated with 5-HTP infusion that control calcium homeostasis during the peripartum period in Holstein and Jersey cows.

scholarly journals Serum proteinogram and biochemistry of Holstein cows in the peripartum period

2019 ◽  
Vol 39 (5) ◽  
pp. 342-347
Author(s):  
Thaís G. Rocha ◽  
Camila Bortoletto ◽  
Daniela G. Silva ◽  
Kalina M.M.G. Simplício ◽  
Luiz F. Zafalon ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Dairy Cows ◽  
Total Protein ◽  
Repeated Measures ◽  
Transition Period ◽  
Serum Levels ◽  
Inorganic Phosphorus ◽  
Holstein Cows ◽  
Total Calcium ◽  
Peripartum Period

ABSTRACT: In face of the few reports found in national literature analyzing the potential influence of parturition number in serum proteinogram and biochemical profile in the peripartum period of high yielding dairy cows, the aim of the present study was to comparatively evaluate the dynamics of these serum constituents’ concentrations in blood samples obtained from primiparous and multiparous Holstein cows, 60 and 30 days prepartum and in the day of parturition. Data were analyzed by repeated measures variance analysis (ANOVA) and differences between groups and moments were analyzed by Tukey’s test. Results were considered significant when P<0.05. Parity influenced levels of total protein, albumin, globulins, magnesium, cholesterol, which were higher in multiparous cows, as well as concentrations of ceruloplasmin, total calcium, chloride and alkaline phosphatase activity, which were higher in primiparous cows. Parturition influenced serum concentrations of ceruloplasmin (+58%), transferrin (-25%), haptoglobin (+33%), total protein (-17%), globulins (-25%), immunoglobulin A (-43%), immunoglobulin G (-24%), total calcium (-12%), inorganic phosphorus (-10%), chloride (+5%), sodium (+4%), cholesterol (-23%), triglycerides (-38.6%), as well as activities of aspartate aminotransferase (+14%) and alkaline phosphatase (+28%). A decrease in serum levels of total calcium, inorganic phosphorus, cholesterol and triglycerides was more pronounced in multiparous than in primiparous cows. These results demonstrate that the interpretation of proteinogram and serum constituents should take into consideration lactation number and the moment of parturition as relevant factors in high yielding dairy cows in the transition period.

P3-328: Alzheimer's disease psychosis: Potential therapeutic benefit of pimavanserin, a 5-HT2A inverse agonist

2010 ◽  
Vol 6 ◽  
pp. S548-S548
Author(s):  
Krista McFarland ◽  
Diana L. Price ◽  
Sean A. Gorman ◽  
Robert W. Johnson ◽  
Douglas W. Bonhaus
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Benefit ◽  
Inverse Agonist ◽  
Potential Therapeutic Benefit

PARENTAL REPORTS OF SEASONAL MOOD AND BEHAVIOR CHANGES IN CHILDREN

PEDIATRICS ◽  
1994 ◽  
Vol 94 (5) ◽  
pp. A70-A70
Author(s):  
Mary A. Carskadon ◽  
Christine Acebo
Keyword(s):  
Response Rate ◽  
Light Therapy ◽  
The United States ◽  
Therapeutic Benefit ◽  
Behavior Changes ◽  
Regional Effects ◽  
Parental Reports ◽  
And Behavior ◽  
Potential Therapeutic Benefit ◽  
Careful Assessment

Objective: The chief purpose of this study was to investigate the nature and prevalence of children's seasonal symptoms. Method: Parental reports of seasonal changes in six mood or behavioral symptoms (sleeping, eating, irritability, energy, withdrawal, and sadness) were surveyed for children living across the United States. The sample included 892 girls (mean age = 10.5 ± 1.0 years) and 788 boys (mean age = 10.6 ± 0.9 years), with a response rate of 46% for girls' parents and 39% for boys' parents. Results: At least one winter recurring symptom was reported in 48.5% of children, as compared with 91% in fall and 10.8% in spring. Winter symptoms were reported equally in girls and boys with one exception ("is tired"); age effects were found for three symptoms only in girls ("sleeps more," "is tired," and "withdraws"). Regional effects showed more winter symptoms reports in northern zones than in southern zones. Conclusions: Given the potential therapeutic benefit of light therapy in children with seasonal patterns, careful assessment of seasonality is merited for children with winter mood and behavior problems.

scholarly journals A new lead to NLRP3 inhibition

2017 ◽  
Vol 214 (11) ◽  
pp. 3147-3149 ◽  
Author(s):  
Mohamed Lamkanfi ◽  
Vishva M. Dixit
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Therapeutic Benefit ◽  
Human Diseases ◽  
Molecule Inhibitor ◽  
Wide Range ◽  
Potential Therapeutic Benefit

The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).

Preparation Of Antithrombin, High Activity Heparin And A Heparin-Antithrombin Complex By A Rapid Two-Step Affinity Method

1981 ◽  
Author(s):  
R Jordan ◽  
T Zuffi ◽  
M Fournel ◽  
D Schroeder
Keyword(s):  
Ionic Strength ◽  
High Activity ◽  
Tight Binding ◽  
Therapeutic Benefit ◽  
Purification Scheme ◽  
The Matrix ◽  
Low Ionic Strength ◽  
Potential Therapeutic Benefit

The tight binding affinity of antithrombin for heparin makes possible a relatively selective purification scheme based on salt elution from heparin-Sepharose. We have found, however, that purity can often be greatly increased if the elution is carried out with soluble heparin instead. This heparin can be removed from the antithrombin, either in whole or part, by a second affinity step on Concanavalin A Sepharose. The antithrombin, which binds to the matrix through its glycosidic moieties, retains its ability to bind heparin at physiological ionic strengths. Thus, the complex of antithrombin and heparin is readily isolated free of unbound heparin species. The complex can be eluted intact with low ionic strength buffers containing sugars which compete for binding to the lectin. Alternatively, the high activity heparin (400–500 units/mg) can be obtained separately by a 1 M NaCl wash which is then followed by a carbohydrate wash to obtain the purified antithrombin.We have made certain preliminary biochemical and anticoagulant characterizations of these materials. Not unexpectedly, both the high activity heparin and its complex with antithrombin show significantly greater in vitro potency in comparison to unfractionated heparin. In vivo anticoagulant efficacy, as evaluated in a rabbit infusion model, confirmed the in vitro findings and further suggests some potential therapeutic benefit may be derived from infusion of a preformed heparin-antithrombin complex.

scholarly journals Effects of dry period length on follicular dynamics in early lactating Holstein cows

2009 ◽  
Vol 2009 ◽  
pp. 134-134
Author(s):  
A Soleimani ◽  
A Heravi Moussavi ◽  
M Danesh Mesgaran ◽  
S Safa
Keyword(s):  
Dairy Cow ◽  
Detrimental Effect ◽  
Good Reason ◽  
Period Length ◽  
Holstein Cows ◽  
Dry Period ◽  
Management Change ◽  
Lactating Cows ◽  
Current Advice ◽  
Follicular Dynamics

For profitable production of milk, a nonlactating or dry period is established between lactations of dairy cow. There has been substantial recent interest in shortening dry periods. Physiological studies show that the changes the udder goes through to prepare for the next lactation take about three weeks, and yet current advice is that the most appropriate dry period for a modern dairy cow is 45 to 60 days. More recent studies show good reason to question that advice, and suggest dry periods of 30 to 35 days have no detrimental effect on production, but information relating the effects of dry period to subsequent reproductive performance of lactating cows is sparse (Grummer, 2007). Also, the effect of this management change on follicular dynamic has not been adequately evaluated. Therefore, the objective of the present study was to determine the effects of dry period length on follicular dynamics in early lactating Holstein cows.

scholarly journals Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831769979 ◽  
Author(s):  
Richard E Kast ◽  
Quentin A Hill ◽  
Didier Wion ◽  
Håkan Mellstedt ◽  
Daniele Focosi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Antiviral Drug ◽  
Therapeutic Benefit ◽  
Lipid Lowering ◽  
Common Finding ◽  
European Medicines Agency ◽  
Gm Csf ◽  
Growth Promoting ◽  
The Brain ◽  
Potential Therapeutic Benefit

Increased ratio of circulating neutrophils to lymphocytes is a common finding in glioblastoma and other cancers. Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF and/or GM-CSF (G(M)-CSF) synthesized by the brain. Glioblastoma cells themselves also synthesize G(M)-CSF. G(M)-CSF synthesized by brain due to damage by a growing tumor and by the tumor itself stimulates bone marrow to shift hematopoiesis toward granulocytic lineages away from lymphocytic lineages. This shift is immunosuppressive and generates the relative lymphopenia characteristic of glioblastoma. Any trauma to brain—be it blunt, sharp, ischemic, infectious, cytotoxic, tumor encroachment, or radiation—increases brain synthesis of G(M)-CSF. G(M)-CSF are growth and motility enhancing factors for glioblastomas. High levels of G(M)-CSF contribute to the characteristic neutrophilia and lymphopenia of glioblastoma. Hematopoietic bone marrow becomes entrained with, directed by, and contributes to glioblastoma pathology. The antibiotic dapsone, the lipid-lowering agent fenofibrate, and the antiviral drug ribavirin are Food and Drug Administration– and European Medicines Agency–approved medicines that have potential to lower synthesis or effects of G(M)-CSF and thus deprive a glioblastoma of some of the growth promoting contributions of bone marrow and G(M)-CSF.

Sign in / Sign up

Export Citation Format

Share Document