Addition of Vitamin B Complex to Prime Solution in Cobalamin-Deficient Patients to Prevent Postoperative Delirium

Objective: In this study, we investigated whether the addition of vitamin B complex to prime solution for cardiopulmonary bypass (CPB) in cobalamin-deficient patients undergoing on-pump coronary artery bypass grafting (CABG) helps prevent the development of postoperative delirium (POD). Materials and Methods: In the present study, 69 of 138 patients with serum vitamin B12 levels <200 pg/mL based on the blood sample taken within 1 week prior to on-pump CABG between January 2013 and December 2017 were enrolled. The control group included 69 patients. Vitamin B complex (25 mg vitamin B1, thiamine hydrochloride, 2.734 mg vitamin B2, riboflavin phosphate ester monosodium, 5 mg vitamin B6, pyridoxine hydrochloride, 15 mcg vitamin B12, 50 mg niacinamide, and 17.2 mg D-panthenol) was added to the prime solution for CPB in the study group. The Intensive Care Delirium Screening Checklist (ICDSC) was used for the diagnosis of POD, and the severity of delirium was assessed by using the Delirium Rating Scale-Revised-98 (DRS-R-98). Results: Twenty-nine patients in the control group (42%) and 18 patients (26%) in the study group developed POD (P = .017), delirium severity scores were higher in the control group (16.5 ± 2.9 versus 15.03 ± 2.48, P = .034). Logistic regression analyses showed vitamin B complex was an independent protective factor for preventing the development of POD in patients undergoing on-pump CABG (odds ratio [OR]: 0.23, 95% confidence interval [95% CI]: 0.06-0.83, P = .025). Conclusion: On the basis of the results of our study, the addition of vitamin B complex to the prime solution for CPB decreases the incidence of POD in cobalamin-deficient patients undergoing on-pump CABG.

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Maternal and neonatal micronutrient levels in newborns with CHD

Cardiology in the Young ◽

10.1017/s1047951117002372 ◽

2018 ◽

Vol 28 (4) ◽

pp. 523-529 ◽

Cited By ~ 3

Author(s):

Dilek Dilli ◽

Nazan Neslihan Doğan ◽

Utku Arman Örün ◽

Murat Koç ◽

Ayşegül Zenciroğlu ◽

...

Keyword(s):

Vitamin D ◽

Folic Acid ◽

Large Scale ◽

Control Group ◽

Vitamin B ◽

Study Group ◽

Transposition Of Great Arteries ◽

Vitamin D Levels ◽

High Zinc ◽

Zinc Levels

AbstractObjectiveIt is suggested that folic acid and/or multivitamins, taken periconceptionally, have a role in the prevention of many congenital anomalies. The aim of this study was to determine the serum micronutrient levels in mother–infant pairs with CHD compared with those with healthy newborns and their mothers.MethodsSerum levels of folic acid, homocysteine, zinc, vitamin A, vitamin D, and vitamin B12 were measured from 108 newborns with CHD (study group) and 103 healthy newborns (control group). The mothers’ micronutrient levels were also measured simultaneously.ResultsWhen compared with healthy newborns, for both maternal and neonatal data, homocysteine and zinc levels were higher and vitamin D levels were lower in the study group. In multivariate analysis, only maternal high zinc levels were associated with CHD in the newborns (p=0.02, OR: 0.9, 95% CI 0.8–0.9). The results did not change when analysed for truncal anomalies including truncus arteriosus, tetralogy of Fallot, and d-transposition of great arteries. There were positive correlations between maternal and neonatal levels of micronutrients, except vitamin B12.ConclusionWe thought that high homocysteine and zinc levels and low vitamin D levels in mother–infant pairs might have a role in the aetiopathogenesis of CHD. Large-scale, prospective studies are needed to clarify the role of micronutrients in CHDs.

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Use of superphosphate as a phosphorus supplement for lambs – effect of calcination or supplementation with oral cobalt or parenteral vitamin B12

The Journal of Agricultural Science ◽

10.1017/s0021859600064546 ◽

1971 ◽

Vol 77 (3) ◽

pp. 467-471 ◽

Cited By ~ 1

Author(s):

O. N. Agarwala ◽

K. Nath ◽

V. Mahadevan

Keyword(s):

Adverse Effects ◽

Vitamin B12 ◽

Fluorine Content ◽

Control Group ◽

Common Salt ◽

Vitamin B ◽

Mineral Supplement ◽

Group I ◽

Group Ii ◽

Basal Ration

SUMMARYA feeding and balance trial was conducted for 15 weeks on 25 lambs (aged 3–5 months) divided into five groups of 5 animals each on a basal ration consisting of oats, groundnut cake, barley, common salt, green grass and wheat straw. The five groups were fed a mineral supplement as follows:Group I. Basal ration plus ‘Supermindiff’ mineral mixture (control group).Group II. Basal ration plus calcined superphosphate.Group III. Basal ration plus superphosphate.Group IV. Basal ration plus superphosphate plus oral cobalt chloride (3 mg Co/10 kg body weight).Group V. Basal ration plus superphosphate plus parenteral vitamin B12 (50 μg/week/ animal).Calcination of fertilizer-grade superphosphate at 600°C for 2 h reduced the fluorine content from 23350ppm to 1600 ppm. The results show that high fluorine or superphosphate significantly reduced growth rate and retention of calcium and phosphorus and significantly increased blood inorganic phosphorus. Calcination of superphosphate in Group II gave comparable results to the control group (Group I). The oral Co or parenteral vitamin B12 supplementation (Groups IV and V) did not ameliorate the adverse effects of high fluorine in superphosphate.It is concluded that calcination of superphosphate at 600°C for 2 h yields a suitable defluorinated product which can be used as a phosphorus supplement in the feeding of animals. Fertilizer-grade superphosphate is unsuitable due to its high fluorine content, the adverse effects of which are not mitigated by oral Co or parenteral vitamin B12 supplementation.

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Low vitamin B12 level in relation to trace element, total sialic acid and antioxidant enzymes in children with vitamin B12 deficiency anemia

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000716 ◽

2021 ◽

pp. 1-10

Author(s):

Isa Kiran ◽

Suat Ekin ◽

Özge Vural

Keyword(s):

Sialic Acid ◽

Vitamin B12 ◽

Vitamin B12 Deficiency ◽

Deficiency Anemia ◽

Control Group ◽

Vitamin B ◽

Cobalt Chromium ◽

Control Subjects ◽

Total Sialic Acid ◽

The Mean

Abstract. In this study, children with vitamin B12 deficiency anemia (V-B12DA) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, glutathione, malondialdehyde, serum total sialic acid, total antioxidant status, cobalt, chromium, copper, selenium, vanadium, zinc, iron, lead, magnesium, calcium, sodium, potassium, chloride, phosphorus levels, and the associations of these variables were assessed. The study included 50 children with V-B12DA and 50 control subjects. It was found that the V-B12DA group was significantly lower than the control group, with regard to the mean±the standard error of the mean levels of cobalt (0.089±0.009; 0.058±0.0063 μmol/L, p<0.01), selenium (2.19±0.087; 1.88±0.057 μmol/L, p<0.01), vanadium (1.31±0.053; 1.18±0.035 μmol/L, p<0.05), magnesium (3.02±0.15; 2.73±0.068 μmol/L, p<0.05), zinc (50.76±1.96; 42.23± 1.53 μmol/L, p<0.001), and vitamin B12 (427.20±21.45; 157.08±3.96 pg/mL, p<0.001). Moreover, a significant elevation in total sialic acid (1.44±0.050; 1.61±0.043 mmol/L, p<0.01), and mean corpuscular volume (MCV) (75.37±0.95; 79.91±1.14 fL, p<0.01). It was observed that in the V-B12DA, significantly linear correlations were observed between cobalt – vitamin B12 (r=0.334; p=0.025), vanadium – MCV (r=0.315; p=0.017), vitamin B12 – MCV (r=−0.297; p=0.026). The findings of the study indicated that the levels of cobalt, vanadium significantly associated with traditional vitamin B12-deficiency parameters. Vitamin B12 and MCV should be measured together with cobalt, vanadium for monitoring the vitamin B12 deficiency anemia.

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Screening tool for malignant bowel obstruction in relapsed, metastatic ovarian cancer

ESMO Open ◽

10.1136/esmoopen-2018-000463 ◽

2019 ◽

Vol 4 (2) ◽

pp. e000463 ◽

Cited By ~ 3

Author(s):

Robert D Morgan ◽

Sofia Stamatopoulou ◽

Nerissa Mescallado ◽

Geoff Saunders ◽

Richard Welch ◽

...

Keyword(s):

Ovarian Cancer ◽

Bowel Obstruction ◽

Clinical Symptoms ◽

Screening Tools ◽

Control Group ◽

Study Group ◽

Malignant Bowel Obstruction ◽

Screening Questionnaire ◽

Improve Risk Stratification ◽

Severity Scores

BackgroundMalignant bowel obstruction (MBO) is a common cause of morbidity and mortality in women diagnosed with ovarian cancer. Earlier detection of MBO may improve patient outcomes. There are currently no screening tools to assist detection.AimWe report a screening questionnaire that can be used to detect MBO, and how the severity score for key clinical symptoms correlate with radiological evidence of MBO from ovarian cancer.DesignA case–control study in which patients with relapsed, metastatic ovarian cancer were asked to answer 10 questions related to key clinical symptoms associated with intestinal obstruction. The study group included women with CT-confirmed MBO, whereas the control group had no evidence of MBO. Patients scored each question according to severity from 1 (least severe) to 5 (most severe).Setting/participantsBetween 1 June and 31 December 2016, 37 women completed the screening questionnaire.ResultsPatients in the study group (n=17) reported significantly higher (ie, more severe) scores for abdominal pain, nausea, vomiting and constipation. In contrast, differences in severity scores between groups did not differ significantly in response to questions regarding abdominal swelling, borborygmi, diarrhoea or loss of appetite. All patients in the study group more frequently stated that their symptoms had deteriorated within the 2 months prior to completing the questionnaire.ConclusionHere we report the key clinical symptoms associated with radiologically-confirmed MBO in relapsed, metastatic ovarian cancer. We recommend healthcare practitioners focus on these specific symptoms during patient consultations in order to improve risk stratification of MBO.

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The relationship of Vitamin B 12 with Two Symptoms of Shingles: Who has Pain and Who has Itch?

10.22541/au.161787803.35019047/v1 ◽

2021 ◽

Author(s):

İlkay Özer ◽

Günseli Kekeç ◽

Duygu İlke Yıldırım ◽

ARZU ATASEVEN ◽

Recep Dursun

Keyword(s):

Vitamin B12 ◽

Negative Impact ◽

Vitamin B12 Deficiency ◽

Nerve Damage ◽

Control Group ◽

Vitamin B ◽

Significant Difference ◽

Patient Will ◽

Vitamin B 12 ◽

Pain Symptoms

Background; Both herpetic pain and itching in shingles are two symptoms whose pathogenesis has not been elucidated, although they are thought to be due to nerve damage. These two symptoms are difficult to treat and negative impact quality of life. In addition, It is unclear which patient will have the symptoms of itching or pain. Vitamin B 12 is a neurotropic agent which is contributes to the treatment of nerve damage, and effective in treating neuropathic pain and itch. In this study we investigated that is relationship between vitamin B12 both herpetic pain and herpetic itch. Methods; In this study, we investigated the effect of vitamin B12 values on itching and pain symptoms that patients with shingles have in the acute period. Vitamin B 12 values of 53 adults with patients with shingles with herpetic pain or herpetic itching were recorded and compared with the control group. Results; We found that patients with herpetic pain had lower vitamin B12 values than the control group (p=0.046) and patients with herpetic itch (p=0.021). Vitamin B12 values of herpetic itch patients did not show significant difference from the control group (p=0.816). Conclusions; Although vitamin B12 deficiency plays a role in the etiology of herpetic pain, it has no effect on herpetic itching. Our study supports that the etiopathogenesis of HI is different from herpetic pain, and will help studies focusing on herpetic itching etiopathogenesis.

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Is There a Relation Between Vitamin B₁₂ Levels and Headaches in Children and Adolescents?

Journal of Dr Behcet Uz Children s Hospital ◽

10.5222/buchd.2021.32767 ◽

2021 ◽

Author(s):

Müge Ayanoğlu ◽

Hale Tuhan ◽

Ayça Kömüroğlu ◽

Ayşe Tosun

Keyword(s):

Vitamin B12 ◽

Children And Adolescents ◽

Tension Type Headache ◽

Control Group ◽

Vitamin B ◽

Primary Headaches ◽

Healthy Children ◽

Significant Difference ◽

Type Headache ◽

Lower Vitamin

Objective: Primary headaches are common and benign discomforts both in children and adolescents. However, they have a negative influence on the quality of life. This retrospective study aimed to determine the relationship between vitamin B12 results and primary headaches in Turkish children. Methods: Demographical features, headache types, laboratory results, including vitamin B12, were assessed retrospectively. Headache types were categorized as tension-type headache, migraine, and unclassified headache according to the International Classification of Headache Disorders-beta version (ICD-3 beta). Patients with seconder headaches, anemia, and macrocytosis were excluded. Results: The study group consisted of 133 (86 female, 47 male) patients with headache and a control group of 103 (57 female, 46 male) healthy children. There was no significant difference in terms of age and gender between groups (p>0.05). Vitamin B₁₂ levels in tension-type headache, migraine, and unclassified headache groups were significantly lower (p<0.0001) than in the control group. Logistic regression has identified lower vitamin B12 levels than 400 pg/ml as an independent risk factor for headache (OR: 3.212, 95% CI: 1.850-5.576). Conclusion: We conclude that lower vitamin B12 levels than 400 pg/mL may be associated with tension-type headache, migraine, and unclassified headache.

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Role of Nutritional Supplementation with Vitamin B12 and Folic Acid on Serum Homocysteine Levels of Deep Vein Thrombosis

Journal of Nutritional Biology ◽

10.18314/jnb.v4i2.1183 ◽

2018 ◽

Vol 4 (2) ◽

pp. 232-235

Author(s):

Simmi Kharb ◽

Khandelwal A ◽

Singh K ◽

Vashist MG

Keyword(s):

Deep Vein Thrombosis ◽

Folic Acid ◽

Vitamin B12 ◽

Clinical Features ◽

Control Group ◽

Study Group ◽

Vein Thrombosis ◽

Serum Homocysteine ◽

Deep Vein

Deep vein thrombosis is a common vascular disorder and association of Homocysteine with DVT is known. Evidence of decrease B12 and folic acid levels in DVT with Hyperhomocysteinemia has also been reported. Scanty data is available regarding role of folate and vitamin B12 on Homocysteine levels in DVT patients. The present study was undertaken in 100 patients. Study group comprised of 50 patients who had clinical features suggestive of DVT and 50 patients, who did not have clinical features suggestive of any venous or arterial disorder, were labelled as control group. All the patients of study group were given vitamin B12 and folic acid treatment along with standard treatment of DVT. Serum Homocysteine, folate, vitamin B12 were measured in all the patients in both the groups and estimated by chemiluminescence technology. After 12 weeks of vitamin B12 and folic acid therapy, serum Homocysteine levels, folic acid levels and vitamin B12 levels of study group were again estimated. The collected records and data was analysed statistically by Student t-test and Chi-square test. Mean Homocysteine level in study group was significantly higher as compared to control group (19.63 ± 19.14 µmol/mL vs. 7.0 ± 4.94 µmol/mL). Mean Homocysteine levels before treatment were 19.63 ± 19.14 µmol/mL and after treatment they were significantly reduced. Hyperhomocysteinemia is a risk factor for deep vein thrombosis. Folic acid and B12 therapy reduced the level of Homocysteine suggesting that this may decrease the chances of recurrence of DVT.

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The Effects of Magnesium – Melatonin - Vit B Complex Supplementation in Treatment of Insomnia

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.771 ◽

2019 ◽

Vol 7 (18) ◽

pp. 3101-3105 ◽

Cited By ~ 1

Author(s):

Gorica Djokic ◽

Petar Vojvodic ◽

Davor Korcok ◽

Anita Agic ◽

Anica Rankovic ◽

...

Keyword(s):

Control Group ◽

Vitamin B ◽

Study Group ◽

Allosteric Modulators ◽

Athens Insomnia Scale ◽

Falling Asleep ◽

General Feeling ◽

And Control ◽

Insomnia Symptoms ◽

Zero Points

Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). Mean AIS score at zero points was 14,93 ± 3,778 in the study group and 14,37 ± 4,081 in the control group (p = 0,476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10,50 ± 4,21 corresponding to mild insomnia, while median AIS score in the control group was 15,13 ± 3,76 which is referred to moderate insomnia, and difference among groups was significant (p = 0,000). Our founding’s indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.

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Changes in CD4+CD8–/CD4–CD8+ Ratio and Humoral Immune Functions in Vitamin B12-Deficient Rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.70.4.167 ◽

2000 ◽

Vol 70 (4) ◽

pp. 167-171 ◽

Cited By ~ 8

Author(s):

Ulala Funada ◽

Masahiro Wada ◽

Tetsunori Kawata ◽

Kazumi Mori ◽

Hiroko Tamai ◽

...

Keyword(s):

Vitamin B12 ◽

Immune Function ◽

Control Group ◽

Vitamin B ◽

Immune Functions ◽

Normal Range ◽

Humoral Immune ◽

Deficient Group

To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8–/CD4–CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4+CD8–/CD4–CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.

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Pretreatment with Methylprednisolone Improves Myocardial Protection during On-Pump Coronary Artery Bypass Surgery

The Heart Surgery Forum ◽

10.1532/hsf.1367 ◽

2015 ◽

Vol 18 (4) ◽

pp. 171 ◽

Cited By ~ 1

Author(s):

Tolga Demir ◽

Mehmet Umit Ergenoglu ◽

Hale Bolgi Demir ◽

Nursen Tanrikulu ◽

Mazlum Sahin ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass ◽

Myocardial Protection ◽

Troponin T ◽

Artery Bypass ◽

Control Group ◽

Study Group ◽

Cabg Surgery ◽

Anti Inflammatory ◽

Pump Coronary Artery Bypass

Background: This study was undertaken to determine whether methylprednisolone could improve myocardial protection by altering the cytokine profile toward an anti-inflammatory course in patients undergoing elective coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). Methods: Forty patients who were scheduled for elective CABG surgery were randomized into two groups: the study group (n = 20), who received 1 g of methylprednisolone intravenously before CPB, and the control group (n = 20), who underwent a standard CABG surgery without any additional medication. Blood samples were withdrawn prior to surgery (T1) and then 4 hours (T2), 24 hours (T3), and 36 hours (T4) after CPB. Plasma levels of interleukin (IL)-6, IL-10, creatine kinase isoenzyme MB (CK-MB), cardiac troponin-t (cTnT), and blood glucose as well as neutrophil counts were measured at each sampling time. Results: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P < .001; T3: P < .001; T4: P < .001). IL-10 levels were significantly higher in the study group at T2 compared with the control group (P = .007). CK-MB levels were significantly lower in the study group than in the control group at T4 (P = .001). The increase of cTnT was higher in the control group at T3 and T4 compared with the study group (T3: P = .002; T4: P = .001). Conclusions: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10.

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