scholarly journals Anesthetic Preconditioning of the Small Intestine in Hemorrhagic Hypotension

2021 ◽  
Vol 17 (2) ◽  
pp. 45-54
Author(s):  
A. V. Efremov ◽  
T. P. Khramikh ◽  
N. V. Govorova ◽  
O. V. Korpacheva
Keyword(s):  
Small Intestine ◽  
Brush Border ◽  
Male Rats ◽  
Control Group ◽  
Small Intestinal Mucosa ◽  
Ether Anesthesia ◽  
Excretory Function ◽  
Hemorrhagic Hypotension ◽  
Group 2 ◽  
Group 1

Aim of the study. To investigate the preconditioning effect of sevoflurane on small intestinal mucosa in experimental hemorrhagic hypotension.Material and methods. The study was performed on a cohort of 106 male rats that included two experimental groups: one exposed to ether (Group 1, n=40) and another one exposed to sevoflurane (Group 2, n=40); two control groups included 20 intact animals, of which 10 were anesthetized with ether and 10 with sevoflurane. Six animals were excluded from the study because they died by the 2nd hour of hemorrhagic hypotension under ether anesthesia. The study parameters were measured at 15 min, 30 min, 1 h, and 2 h of hemorrhagic hypotension. Amylolytic activity of the small intestine mucosa was determined by E. A. Zabelinsky, B. W. Smith and I. M. Roe technique modified by A. M. Ugolev. The data were statistically analyzed using the nonparametric Mann-Whitney method.Results. By 15 min of hemorrhagic hypotension, the activity of amylase fractions in all small intestine regions in Group 2 animals was significantly lower vs the Group 1 rats. By 30 min of hemorrhagic hypotension, the activity of the enzyme fractions in all small intestine regions in Group 2 animals remained significantly lower than in Group 1, by an average of 2 to 9 times (P=0.01; P<0.001), and after 1 h of hemorrhagic hypotension, it was 2 and 4 times lower (P=0.02; P<0.001). By the 2nd hour of hemorrhagic hypotension, the activity of nearly all duodenal amylase fractions in the Group 2 animals remained 3-4 times lower compared to Group 1. Meanwhile, a significantly higher activity of slowly desorbing and intracellular amylase fractions vs the control group was observed in jejunum and ileum.Conclusion. In hemorrhagic hypotension under sevoflurane anesthesia, a decrease of the pancreas excretory function, stabilization of the brush border of the mucosa of all small intestine regions, including enterocyte membranes, was found during the first hour of experiment. Two hours after the hemorrhage, the biochemical evidence of brush border damage in the jejunum and ileum was revealed.

scholarly journals The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes

2002 ◽  
Vol 1 (2) ◽  
pp. 47-52
Author(s):  
S. V. Logvinov ◽  
E. Yu. Varakuta ◽  
A. V. Potapov
Keyword(s):  
Diabetes Mellitus ◽  
Alloxan Diabetes ◽  
Light Exposure ◽  
Early Stage ◽  
Male Rats ◽  
Control Group ◽  
Group 3 ◽  
Group 2 ◽  
Alloxan Injection ◽  
Group 1

The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect.

scholarly journals HISTOLOGICAL STRUCTURE OF PROXIMAL METAPHYSEAL CARTILAGE OF HUMERUS IN RATS AFTER 60-DAY TARTRAZINE ADMINISTRATION

2020 ◽  
pp. 150-157
Author(s):  
V.I. Luzin ◽  
O.N. Fastova ◽  
V.N. Morozov ◽  
E.N. Morozova ◽  
S.V. Zabolotnaya
Keyword(s):  
Body Weight ◽  
Male Rats ◽  
Control Group ◽  
Histological Structure ◽  
Total Width ◽  
Adult Rats ◽  
Study Results ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The aim of the research is to study the histological structure of proximal metaphysial cartilage of the humerus in adult rats after 60 days of tartrazine administration (750 mg/kg and 1500 mg/kg body weight). Materials and Methods. The study was carried out on 90 white male rats, divided into 3 groups. In Group 1 (control), animals daily intragastrically received 1ml of 0.9 % isotonic sodium chloride solution for 60 days. Rats of Groups 2 and Group 3 received intragastrically 1ml of tartrazine solution (750 mg/kg and 1500 mg/kg body weight respectively) for 60 days. The readaptation period after the last tartrazine administration was 3, 10, 15, 24, or 45 days. The area of the proximal humerus metaphysis underwent treatment according to the standard histological protocol. The obtained sections were stained with hematoxylin-eosin and subjected to a subsequent histomorphometric study. Results. On the 3rd day of the readaptation period, the total width of the proximal metaphysial cartilage of the humerus in animals of Group 2, was by 8.59 % less than the values of the control group; the width of the indifferent, proliferating and definitive cartilage was by 6.11 %, 8.85 % and 7.15 % less; the width of the destruction zone was by 11.55 % less; and the width of the osteogenesis zone was by 9.92 % less. The content of primary spongiosis in the osteogenesis zone and the number of cells on the trabeculae surface were lower than the values of Group 1 by 8.45 % and 8.42 % respectively. During the readaptation period, the authors observed similar dynamics of changes in the histomorphometric parameters of the metaphysical cartilage of the humerus with levelling by the 45th day of the experiment. In rats of Group 3, during the entire readaptation period, the histomorphometric parameters changed more significantly and their recovery to control values was slower than in animals of Group 2. Conclusion. 60-day tartrazine administration to adult rats is accompanied by inhibition of the bone formation function of the proximal metaphysial cartilage of the humerus. It is confirmed by a decrease in the width of all its zones and components of the osteogenesis zone. More pronounced in amplitude and duration changes in the parameters studied were recorded in animals treated with tartrazine, 1500 mg/kg body weight. Keywords: humerus, metaphysial cartilage, tartrazine, histomorphometry. Цель исследования. Установить, оказывает ли влияние 60-дневное введение тартразина в дозах 750 и 1500 мг/кг массы тела на гистологическое строение проксимального метафизарного хряща плечевой кости у половозрелых крыс. Материалы и методы. Исследование проведено на 90 белых крысах-самцах, распределенных на 3 группы: 1-я – контрольная, в которой животные ежедневно в течение 60 дней получали физиологический раствор через желудочный зонд; 2-ю и 3-ю группы составили крысы, которые на протяжении 60 дней получали внутрижелудочно 1 мл раствора тартразина в дозах 750 и 1500 мг/кг массы тела соответственно. Сроки периода реадаптации после окончания введения тартразина составляли 3, 10, 15, 24, 45 сут. Проксимальный метафиз плечевой кости подвергался обработке по стандартному гистологическому протоколу. Полученные срезы окрашивались гематоксилин-эозином и подвергались последующему гистоморфометрическому исследованию. Результаты. У животных 2-й группы на 3-й день периода реадаптации общая ширина проксимального метафизарного хряща плечевой кости была меньше значений контрольной группы на 8,59 %, ширина зон индифферентного, пролиферирующего и дефинитивного хряща – на 6,11, 8,85 и 7,15 % меньше, ширина зоны деструкции – на 11,55 %, а ширина зоны остеогенеза – на 9,92 %. Содержание первичной спонгиозы в зоне остеогенеза и количество клеток на поверхности трабекул были меньше значений контрольной группы на 8,45 и 8,42 %. В ходе периода реадаптации сходная динамика изменений гистоморфометрических параметров метафизарного хряща плечевой кости сохранялась с тенденцией к сглаживанию к 45-м сут эксперимента. У крыс 3-й группы в ходе всего периода реадаптации изучаемые параметры изменялись более значимо и их восстановление до контрольных величин происходило медленнее, чем во 2-й группе. Выводы. 60-дневное введение тартразина половозрелым крысам сопровождается угнетением костеобразовательной функции проксимального метафизарного хряща плечевой кости, что подтверждается снижением ширины всех его зон и объемных компонентов зоны остеогенеза. Более выраженные по амплитуде и длительности изменения изучаемых параметров зафиксированы у животных, получавших тартразин в дозе 1500 мг/кг массы тела. Ключевые слова: плечевая кость, метафизарный хрящ, тартразин, гистоморфометрия.

scholarly journals The Effect of Anti Masquito Electric Gas that Consist Allethrin That Influence The Weight and Colour of Rats Liver

2017 ◽  
Vol 6 (2) ◽  
pp. 6
Author(s):  
Nurmawanti Nurmawanti ◽  
Ayly Soekanto
Keyword(s):  
Male Rats ◽  
Control Group ◽  
Control Groups ◽  
Control Group Design ◽  
Significant Difference ◽  
Post Test ◽  
Group 3 ◽  
The Subject ◽  
Group 2 ◽  
Group 1

The aim of this research is to know the influence of anti mosquito electric gas that consisted Allethrin to the weight and colour of the rats liver. This research used an experimental method with the post test only  control group design.  The subject of this research is male rats weight of 150 grams each and total there was 24 rats that were divided to 4 groups. The first one, the  control groups (PO) was not given any of the gas, the second one, group 1 (P1) was given the gas for 4 hours everday, the third one, group  2 (P2), was given for 6 hours and last, group 3  (P3) was given 8 hours everyday. After later, on  30 Th day, the rats were terminated and being put in a surgery to remove their liver. This data was analyzed using SPPS for windows version 16. To see the differences in weight between the groups, it was analyzed using anova, and  to obtain the discoloration of the rats liver was analyzed using Kruskal Wallis Test. From the statistic tests, it show that there is significant difference in weight and color of liver in the group that α ≤ 0,05. According Anova Test, it shows that there is a significant difference α = 0,034 and from Kruskal Wallis test α = 0,013. In the conclusion anti mosquito electric gas that consist Allethrin affects the weight and the color of rats liver.

INFLUENCE OF THE DURABLE APPLICATION OF PROTONIC PUMP INHIBITORS ON CYTOKINE CONCENTRATION IN RAT BLOOD SERUM

2021 ◽  
Vol 74 (7) ◽  
pp. 1575-1580
Author(s):  
Serhii V. Pylypenko ◽  
Andrii A. Koval ◽  
Makarchuk V. Viktoria ◽  
Kostiantyn F. Chub
Keyword(s):  
Blood Serum ◽  
Inflammatory Cytokines ◽  
Male Rats ◽  
Control Group ◽  
Hcl Secretion ◽  
Group 3 ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Student’S T ◽  
Group 1

The aim: Of the work was to determine the content of pro- and anti-inflammatory cytokines in the blood serum of the control group rats and after 28 days of inhibiting HCl secretion in the stomach by proton pump blockers “Omeprazole” and “Pantoprazole”. Materials and methods: The studies were performed on 30 white non-linear male rats weighing 160-180 g, divided into three groups with 10 animals in each. The control (group 1) were injected intraperitoneally with water for injections within 28 days once a day. Group 2 was administered omeprazole. Group 3 was administered pantoprazole. The concentration of cytokines in the blood serum of rats was determined by the enzyme immunoassay method. For statistic data processing, Student’s t-criterion for independent samples was applied. Results: After prolonged administration of omeprazole and pantoprazole, the blood serum concentrations of IFNγ, TNFα, IL-1 in rats increased by 58.5% and 3.41%, 73.3% and 48.4%, 80.2% and 40.8%, respectively, and IL-12B 40p decreased by 36.6% when using omeprazole and was almost indistinguishable from the control values when pantoprazole was administered. With administration of omeprazole, IL-4 concentration decreased by 39.8% and that of pantoprazole increased by 3.86% compared to the control. Administration of omeprazole and pantoprazole did not affect IL-6 concentration. Conclusion: Inhibition of hydrochloric acid secretion in the stomach of rats for 28 days using omeprazole and pantoprazole led to an imbalance between pro- and anti-inflammatory cytokines. The adverse effect of pantoprazole was less pronounced than that of omeprazole.

Toxicity of iron oxide nanoparticles, silver nanoparticles and their mixture on antioxidant enzymes and free radicals in male rats

2021 ◽  
Vol 1 (2) ◽  
pp. 009-020
Author(s):  
Ahmed Ibrahim Younus ◽  
Mokhtar Ibrahim Yousef ◽  
Maher Abdel-NabiKamel ◽  
Rakhad Alrawi ◽  
Jubran Mohammed Abdulrahman
Keyword(s):  
Antioxidant Enzymes ◽  
Thiobarbituric Acid ◽  
Male Rats ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Group 4 ◽  
Total Antioxidant ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

In the present study Wistar male rats were used. Rats were divided into 4 equal groups, 10 rats each. Group 1 served as control, group 2 was administered orally with Fe2O3NPs (5 mg/kg BW; >50 nm), group 3 was treated intraperitoneally with AgNPs (50 mg/kg BW; >100 nm) and group 4 was administered with the mixture of Fe2O3NPs with AgNPs. Animals were treated with the doses every day for 79 days. Results showed significant (P < 0.05) decrease in the antioxidant enzymes (GPX, GST, CAT and SOD) and reduced glutathione (GSH) and total antioxidant capacity (TAC), while significant (P < 0.05) increase in thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) in plasma and testes of rats treated with Fe2O3NPs, AgNPs and their combination compared to control group.

scholarly journals Uji Potensi Metabolit Sekunder Ekstrak Kulit Buah Petai (Parkia speciosa Hassk) terhadap Kadar Kreatinin dan Ureum Tikus Secara Spektrofotometri UV-Vis

KOVALEN ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 143-151
Author(s):  
Joni Tandi ◽  
Heru Khairul Muttaqin ◽  
Kiki Rizki Handayani ◽  
Sri Mulyani ◽  
Recky Patala
Keyword(s):  
Laboratory Experiment ◽  
Effective Dose ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Normal Control Group ◽  
Male Rats ◽  
Control Group ◽  
Treatment Groups ◽  
Group 2 ◽  
Group 1

This study aims to determine the effectiveness of bitter beans peels (Parkia speciosa Hassk)  extract on creatinine and urea levels, and the effective dose of the exctract on creatinine and urea levels. This research was a laboratory experiment using 25 rats which were divided into five treatment groups, each group consisting of 5 rats. Group 1 (normal control), group 2 (negative control) were given suspension of Na-CMC, groups 3, 4, and 5 respectively given petai rind ethanolic extract doses of 300, 400 and 500 mg/kg. The results showed that petai fruit (Parkia speciosa hassk) peels extract had an effect on creatinine and urea levels of diabetes hypercholesterolemia male rats by an effective dose of 300 mg/kg which has an effect on creatinine levels by an average of 0.38 mg/dL and ureum levels by an average of 12.9 mg/dL. Keywords: petai fruit peels extract, secondary metabolite, creatinine, ureum, Streptozotocin

scholarly journals Rosmarinic acid ameliorates renal ischemia reperfusion damage in rats

2019 ◽  
Vol 9 (2) ◽  
pp. e15-e15
Author(s):  
Majid Tavafi ◽  
Hassan Ahmadvand ◽  
Ahmad Tamjidipour ◽  
Afshin Hasanvand
Keyword(s):  
Serum Creatinine ◽  
Rosmarinic Acid ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Male Rats ◽  
Control Group ◽  
Renal Vessels ◽  
Group 2 ◽  
Ischemia Induction ◽  
Group 1

Introduction: Reactive oxygen species (ROS) are the main factors in pathogenesis of renal ischemia-reperfusion (I/R) injury. Objectives: The aim of this study was to evaluate the renoprotective effect of rosmarinic acid (ROA) as an antioxidant substance against renal I/R injury. Materials and Methods: Forty male rats were divided into five groups. Group 1 control; group 2 ischemia reperfusion (I/R). Groups 3, 4 and 5 I/R treated by ROA 50, 100 and 200 mg/kg respectively. The treated groups (groups 3, 4 and 5) received ROA one hour before ischemia induction. Renal ischemia was induced by ligating of renal vessels through vascular clips. After 45 minutes of ischemia, the clips were removed to make renal recirculation (reperfusion). Twenty-four hours after the onset of reperfusion, under anesthesia blood were sampled and kidneys were removed. The serum and supernatant of renal homogenate were prepared. Serum creatinine, nitric oxide (NO) and paraoxonase (PON) were measured. The concentration of renal malondialdehyde (MDA), glutathione peroxidase (GPX), glutathione (GSH) and catalase (CAT) activity were assessed. Results: The administration of ROA, decreased serum creatinine and increased serum NO and PON compared to group 2 (P<0.05). Renal MDA, GSH, GPX and CAT activity improved significantly in animals that received ROA in comparison to group 2. Conclusion: Administration of ROA improved renal I/R injuries via inhibition of lipid peroxidation and increase of GSH, GPX, CAT, NO and PON.

scholarly journals Effect of a liquid with a negative redox potential on the indicators of blood and humoral immunity after resection thin gut

2021 ◽  
Vol 22 (3) ◽  
pp. 48-52
Author(s):  
A. A. Zheludev ◽  
Yu. A. Parhisenko
Keyword(s):  
Experimental Study ◽  
Small Intestine ◽  
Humoral Immunity ◽  
Bacterial Contamination ◽  
Male Rats ◽  
Surgical Wound ◽  
Blood Indices ◽  
Biological Substrate ◽  
Group 2 ◽  
Group 1

An experimental study was conducted to establish changes in blood indices and humoral immu1nity in rats in the postoperative period with the use of catholyte and anolyte. The experiments were carried out on 45 male rats weighing 290–320 g, which were distributed equally into 3 groups: group 1 — intact animals, group 2 and 3 — animals which underwent surgery in the amount of resection of the small intestine (1.5 cm) with anastomosis end to end.After surgery, rats used catholyte as a drink, instead of drinking water. The surgical wound was treated with anolyte. Blood and the wall of the small intestine in the anastomosis zone were used as a biological substrate. The material was studied on days 5 and 15. A study of the composition of blood and the walls of the small intestine was carried out on days 5 and 15 4. An analysis of the materials showed that the use of catholyte (a liquid with negative AFP-leads to positive changes in blood counts, humoral immunity and phagocytic activity, impaired after resection of the small intestine. The use of anolyte antiseptic (liquid with positive AFP) prevents bacterial contamination of the surgical wound. The studied parameters indicate that catholyte positively affects humoral immunity, and anolyte prevents bacterial insemination of the surgical wound.

Alloreactive Natural Killer Cells Reduce Graft-Versus-Host Disease and Enhance Engraftment in Mice Bone Marrow Transplantation Model.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5180-5180
Author(s):  
Ting Liu ◽  
Chunlan Huang ◽  
Wentong Meng ◽  
Xiaoxi Lu
Keyword(s):  
Bone Marrow ◽  
Small Intestine ◽  
Nk Cells ◽  
Graft Rejection ◽  
Bone Marrow Cells ◽  
Control Group ◽  
Graft Versus Host ◽  
Group 2 ◽  
Tgf Β1 ◽  
Group 1

Abstract Bone marrow transplantation (BMT) has become an important approach to cure many hematological malignancies. Unfortunately, graft-versus-host disease (GVHD) and graft rejection are still the major drawbacks of allogeneic BMT. GVHD fundamentally depends on the interaction of donor T cells with antigen-presenting-cells (APC) and it subsequently effect T cells activation and proliferation. Natural killer (NK) cells exert a variety of immunological functions and accommodation capacity to alter the course of GVHD and graft rejection. In this study, we established a mice GVHD model and with this model explored whether NK cells could reduce GVHD and enhance engraftment. Methods:C57BL/6(H-2b) mice were as bone marrow cells donors, and BALB/c (H-2d) mice as recipients. NK cells from donors and recipients were enriched with anti-CD49b immuno-magnetic microbeads and MiniMACS separator respectively, and been reactive by culture in complete DMEM medium supplemented with recombinant human IL-2(rhIL-2). The recipients were divided into four groups: Control group 1 was treated with nothing, Control group 2 with BMT alone, Experiment group 1 with BMT plus autoreactive NK cells, and Experiment group 2 with BMT plus alloreactive NK cells. Each recipient mouse received 1×107 donor bone marrow cells and 1×107 spleen cells combination infusion after 7Gy 60Co total-body irradiation, and in Experiment groups, each mouse was infused 5×105 autoreactive NK cells (group 1)or donor activated NK cells (group 2). Results: The survival time in groups of the BMT alone, the BMT with alloreactive NK cells, and the BMT with syngeneic NK cells were 25.6±1.2 days, 33.7±1.5 days, and 19.4±1.8 days; the mortality of these three groups at Day +30 were 100%, 20%, and 100%, and the chimerism of donor cells were 51.9±3.3%, 72.9±2.47%, and 41.8±2.19% respectively. Histopathological study in liver, small intestine, and skin of the recipients received BMT alone and BMT with syngeneic NK cells showed extensive infiltration of inflammatory lymphocytes associated with cellular necrosis, and a GVHD score was 7.6±0.47 and 8.6±0.47 respectively at 4 weeks after BMT. However, the mice received BMT with alloreactive NK cells showed little infiltration of inflammatory cells with normal structure of liver, small intestine, and skin, and a GVHD scores was 2.4±0.53(P <0.01). When allogeneic NK cells reduced GVHD and enhanced engraftment, the content of host APC or DCs and host mature APC or DCs were decreased and serum TGF-β1 level were increased, and when syngeneic NK cells aggravated GVHD and reduced engraftment, the contents of host APC or DCs were not changed and host mature APC or DCs were increased and the TGF-β1 level were decreased. Conclusions:Our study suggested that alloreactive NK cells can reduce GVHD and enhance engraftment; and syngeneic reactive NK cells can aggravate GVHD and reduce engraftment. The mechanism of allogeneic NK cells reducing GVHD and enhancing engraftment is related to decreasing of host APC or DCs, and to increasing of TGF-β1 level, and in the other hand, the mechanism of syngeneic NK cells aggravating GVHD and reducing engraftment is related to increasing of host APC or DCs, and to decreasing of TGF-β1 level. Our results provide a theoretic proof of NK cells reducing GVHD and graft rejection in allogeneic BMT, especially in unrelated donor BMT, and may be related to the mismatch of Ly49-MHCIantigen.

Antiurolithiatic effect of Cymbopogon Proximus, Alhagi Maurorum, on Sulfadimidine induced urolithiasis in male New Zealand rabbits

2019 ◽  
Vol 20 (1) ◽  
pp. 12-18
Author(s):  
Sameh El-Nabtity
Keyword(s):  
New Zealand ◽  
Intramuscular Injection ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Aqueous Extracts ◽  
Blood And Urine Samples ◽  
Group 2 ◽  
New Zealand Rabbits ◽  
Group 1

The present study aimed to investigate the prophylactic effect of Cymbopogon proximus and Alhagi maurorum on Sulfadimidine induced urolithiasis in rabbits . Thirty New Zealand male rabbits were allocated into six equal groups (each of five): Group (1) was used as a negative control. Group(2) were administered sulfadimidine (200mg/kg) by intramuscular injection.Groups(3) and (4) were administered sulfadimidine(200mg/kg) by intramuscular injection and 330mg/kg of Cymbopogon proximus alcoholic and aqueous extracts respectively orally.Groups(5) and (6) were administered sulfadimidine(200mg/kg) by intramuscular injection and 400mg/kg of Alhagi maurorum alcoholic and aqueous extracts respectively orally. The period of experiment was 10 days. Blood and urine samples were collected from rabbits on the 10th day. The results recorded a significant decrease in serum creatinine, urea, uric acid and crystalluria in Cymbopogon proximus and Alhagi maurorum groups compared to sulfadimidine treated group.We conclude that Cymbopogon proximus and Alhagi maurorum have a nephroprotective and antiurolithiatic effects against sulfadimidine induced crystalluria.

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