scholarly journals The evolution of surgical treatment of urolithiasis: from lithotomy to combined intrarenal technologies

2021 ◽  
Vol 9 (2) ◽  
pp. 36-41
Author(s):  
Rogachikov VV ◽  
Bogorad IV ◽  
Kudryashov AV ◽  
Ignatiev DN
Keyword(s):  
Historical Review ◽  
Scientific Work ◽  
New Methods ◽  
New Concepts ◽  
History Of ◽  
Physical Impact ◽  
Near Future ◽  
Methods Of Treatment ◽  
Treatment Of Urolithiasis ◽  
Minimally Invasive Methods

Urolithiasis (hereinafter ICD) has a long thousand-year history, worldwide spread, frequent recurrence and occupies a leading place in the structure of surgical diseases of the urinary system. The development of urology as a clinical discipline is thorny and is associated with the stages of origin and formation as a science, oblivion and revival - as a modern field of surgery. The progress of technical thought, achievements of fundamental science, naturally led to the formation of urology and, in particular, surgery of urolithiasis on the basis of new concepts of operative capabilities, preoperative diagnostics, new methods of physical impact on the structure of the calculus. The creation and improvement of new low-traumatic techniques, their active and widespread introduction into practice, contributed to the displacement of open traumatic interventions used for centuries, and made it possible to successfully remove stones from the urinary tract with minimal complications. The work is devoted to the historical review of the formation of urolithiasis surgery, comparative characteristics of alternative minimally invasive methods of treatment of KSD. The scientific work reveals the modern achievements of percutaneous surgery, the history of the development of technical improvements and the possibilities of retrograde fiber-optic intrarenal technologies. The promising directions of development of antegrade and retrograde surgery of nephrolithiasis in the present and near future have been determined.

scholarly journals A brief history of antidepressant drug development: from tricyclics to beyond ketamine

2018 ◽  
Vol 30 (6) ◽  
pp. 307-322 ◽  
Author(s):  
Vitor Silva Pereira ◽  
Vinícius Antonio Hiroaki-Sato
Keyword(s):  
Antidepressant Drug ◽  
Antidepressant Drugs ◽  
Historical Review ◽  
New Wave ◽  
Glutamatergic System ◽  
Pharmacological Agents ◽  
New Era ◽  
Antidepressant Effects ◽  
History Of ◽  
Near Future

ObjectiveAlthough monoaminergic-targeted drugs have prompted great advances in the development of treatments for depression, the need for new options persists, since these drugs still have a delayed clinical effect and most patients do not respond properly to them. Recently, the observation of the antidepressant effects of ketamine brought on a new wave of studies regarding the comprehension of the neurobiology of depression and the development of new and more effective antidepressant drugs.MethodsThus, in this paper, we present a historical review of the development of monoaminergic antidepressant drugs and the role of ketamine as the introductory agent of a new era in the research of the neurobiology of depression.ResultsFirstly, we review how the pharmacological treatment for major depression started, and we point out the main drugs discovered, the researchers involved, and how the studies developed have contributed to the understanding of the neurobiology of depression. Secondly, the major problems regarding the clinical efficacy and acceptance of these drugs are discussed, and the introduction of the glutamatergic system as a target for antidepressant drugs is presented. Finally, we review how ketamine revealed itself as an exciting option towards obtaining pharmacological agents to treat depression, through the understanding of biological markers.DiscussionKetamine contributed to confirm that different targets of the glutamatergic system and neurotrophic pathways are strictly related to the neurobiology of depression. There are several antidepressant drugs based on ketamine’s mechanism of action already in the pipeline, and glutamatergic-targeted antidepressants may be on the market in the near future.

Prospects in treatment of multiple sclerosis: near future

2020 ◽  
Vol 28 (3) ◽  
pp. 377-390
Author(s):  
Gennadii E. Sheiko ◽  
Anna N. Belova ◽  
Maksim N. Kudykin
Keyword(s):  
Multiple Sclerosis ◽  
Modern Science ◽  
Therapeutic Approaches ◽  
New Methods ◽  
New Therapeutic Approaches ◽  
The Central Nervous System ◽  
Unclear Etiology ◽  
Near Future ◽  
The Given ◽  
Methods Of Treatment

Multiple sclerosis (MS) is a widespread dysimmune-neurodegenerative disease of the central nervous system of unclear etiology. Despite significant achievements in the therapy of MS, the level of progressing disability and early mortality remains alarmingly high. The main aim of the given review is to give a detailed description of new promising medical drugs for treatment of MS. In the article the data of preclinical and clinical trials are given, presumptive mechanisms of the medical drugs under development are described. Development of new therapeutic approaches in treatment of MS is of great interest in modern science. The given review highlights new methods of treatment that are now undergoing clinical trialы and will probably come to the clinical practice in the near future.

scholarly journals O Marii Skłodowskiej-Curie w 150. rocznicę urodzin

2018 ◽  
Vol 17 ◽  
pp. 501-521
Author(s):  
Alicja Rafalska-Łasocha ◽  
Keyword(s):  
Scientific Work ◽  
150Th Anniversary ◽  
New Methods ◽  
Pierre Curie ◽  
Woman Professor ◽  
History Of ◽  
Role Of Women ◽  
Scientific Achievements

The article regards the celebrations of the 150th anniversary of the birth of Marie Sklodowska-Curie − a discoverer of polonium and radium, twice decorated with a Noble Prize, the first woman professor of the Sorbonne, who in the ranking organized by the periodical New Scientist was considered the most outstanding and inspiring scientist of all time. In her youth, many universities (among them also Polish) were closed to women, so Marie Skłodowska studied at the Sorbonne in Paris. When, after her studies, she was not accepted as an assistant at the Jagiellonian University in Kraków (Poland), Marie Skłodowska came back to Paris, married Pierre Curie and started her scientific work in his humble lab. The scientific achievements of Maria Skłodowska-Curie were a breakthrough in the history of exact sciences and the basis for the application of new methods in oncological therapies. For modern scientists she is a timeless source of inspiration and is admired not only for her scientific achievements but also for her courage in breaking barriers and helping to redefine the role of women in society and science. On November 7, 2017, we celebrated the 150th anniversary of Marie Skłodowska-Curie’s birth. In Poland and abroad many events were organized during the whole year of 2017 to commemorate her life and achievements. Some of them, as well as some aspects of Skłodowska-Curie’s life and work are described in this paper.

scholarly journals History of the treatment of persons with psychological difficulties and the abuse of their civil rights

Temida ◽  
2013 ◽  
Vol 16 (2) ◽  
pp. 33-42
Author(s):  
Nikola Petrovic ◽  
Bejan Saciri
Keyword(s):  
Civil Rights ◽  
Historical Review ◽  
Dominant Form ◽  
History Of ◽  
The Subject ◽  
Psychological Difficulties ◽  
Relationship Of ◽  
The Relationship ◽  
Methods Of Treatment ◽  
Historical Periods

Treatment of persons with psychological difficulties varied in different historical periods, but in its essence remained similar until today. It included an inhumane relationship towards these persons, involuntary treatment through torture, and isolation from society as a kind of punishment for their diversity. It was not until the late 19th century that the relationship of society towards these individuals started to improve gradually, but in the 21st century isolation of these individuals still remained the dominant form of acceptable social solution for the ?problem?, with a somewhat more humane attitude towards them and less cruel treatment. Serbia has followed the trends of treatment of the persons with psychological difficulties from the rest of Europe for centuries, but is still lagging behind the world in the introduction of new methods of treatment. Indeed the first legal solution to regulate the human rights of these people is currently in the process of implementation. The subject of this paper is the treatment of persons with psychological difficulties and the violation of their civil rights. In a subject specific context the goal of the analysis was the historical review of the treatment towards persons with psychological difficulties by doctors, other practicioners and the community in general, with reference to the current situation regarding their treatment within the psychiatric institutions, as well as the legal regulations and the protection of their civil rights.

Users behaviors: The Heritage of Digital World

2014 ◽  
Vol 13 (7) ◽  
pp. 4675-4682
Author(s):  
Atefeh Danesh Moghadam ◽  
Alireza Alagha
Keyword(s):  
Technology Development ◽  
Second Step ◽  
Information Communication ◽  
The Third ◽  
Digital World ◽  
New Concepts ◽  
Emerging Patterns ◽  
History Of ◽  
Fourth Step ◽  
Communication And Technology

In the advent of information era, not only digital world is going to expand its territories, it is going to penetrate into the traditional notions about the meaning of the words and also valorize new concepts. According to Oxford Dictionary, the word heritage is defined: The history, tradition and qualities that a country or society has had for many years and that are considered an important part of its character. In order to present how emerging patterns, as the consequences of technology development, are going to be considered as the new concept of heritage, we follow four steps. In the first step, we present the convergence of Information, Communication and Technology (ICT) and a concise history of its convergence. In the second step, we argue how convergence has culminated in emerging patterns and also has made changes in digital world. In the third step, the importance of users behaviors and its mining is surveyed. Finally, in the fourth step; we illustrate User Generated Contents (UGC) as the most prominent users behaviors in digital world.

La valorisation des prestations non-bois: particularités genevoises (essai) | Commercialization of non-wood forest services: the case of Geneva (essay)

2009 ◽  
Vol 160 (8) ◽  
pp. 232-234
Author(s):  
Patrik Fouvy
Keyword(s):  
Forest Regeneration ◽  
Biological Diversity ◽  
The State ◽  
Forest Land ◽  
Private Forests ◽  
The Public ◽  
Public Body ◽  
Provision Of Services ◽  
History Of ◽  
Near Future

The history of the forests in canton Geneva, having led to these being disconnected from productive functions, provides a symptomatic demonstration that the services provided by the forest eco-system are common goods. Having no hope of financial returns in the near future and faced with increasing social demands, the state has invested in the purchase of forest land, financed projects for forest regeneration and improvement of biological diversity and developed infrastructures for visitors. In doing this the state as a public body takes on the provision of services in the public interest. But the further funding for this and for expenses for the private forests, which must be taken into account, are not secured for the future.

Who Is the Founder of Psychophysics and Experimental Psychology?

1999 ◽  
Vol 16 (2) ◽  
pp. 1-26
Author(s):  
Omar Khaleefa
Keyword(s):  
Visual Perception ◽  
Experimental Method ◽  
Experimental Psychology ◽  
Visual Illusion ◽  
Eleventh Century ◽  
Central Place ◽  
Psychological Explanation ◽  
Moon Illusion ◽  
New Concepts ◽  
History Of

The study is an investigation of the origins of psychophysics and experimentalpsychology. According to historians of psychology. FrancisBacon had the most crucial influence in the history of the experimentalmethod, because he emphasized the importance of induction, skepticism,quantification, and observation. The present study, however,attempts to show that Ibn al-Haytham laid the foundations of the aboveaspects of the experimental method. Furthermore, a number of historiansof psychology believe that Fechner was the founder of psychophysicswith his application “Filements of Psychophysics” in 1860.This study shows that in the eleventh century, Ibn al-Haytham made anoriginal contribution to the study of vision, wherein his psychophysicsborrowed its structure from physics and its spirit from psychology.Several aspects of visual perception were investigated by him, includingsensation (which occupies a central place in psychophysics), variationsin sensitivity, perception of colors. sensation of touch, perceptionof darkness, the psychological explanation of moon illusion, and binocularvision. This study presents five experiments by Ibn al-Haythamregarding the errors of vision, which is called in contemporary psychology“visual illusion.” These experiments have been applied andverified in Bahrain from both the physical and psychological perspectives.Finally, the study concludes that Ibn al-Haytham deserves the title“founder” of psychophysics as wellp the “founder” of experimentalpsychology. In this respect. Kitab ul-Manazir by Ibn al-Haytham.which appeared in the fmt half of the eleventh century, and not the“Elements of Psychophysics” by Fechner. which was published in thenineteenth century, marks the official “founding” of psychology,because it provides not only new concepts and theories but new methodsof measurement in psychology.

Towards a Contemporary Philosophy of Islamic Science

1990 ◽  
Vol 7 (1) ◽  
pp. 1-7
Author(s):  
Anwar Ibrahim
Keyword(s):  
Scientific Work ◽  
Single Observation ◽  
Body Of Knowledge ◽  
Stephen Hawking ◽  
The Social ◽  
History Of ◽  
Theoretical Physicist ◽  
Islamic Science ◽  
Rational Mind ◽  
Understanding Of Science

Our understanding of science itself as a body of knowledge and as asystem of analysis and research has changed over the last decades, just asover the last two centuries, or especially after the age of Enlightement inEurope, science has become more powerful, more sophisticated and complex.It is rather difficult to determine where science ends and where technologybegins. In fact there is a gmwing awareness that the physical or nam sciences,as a means of studying and understanding nature, are relying on the more“humanistic“ and cultural approaches adopted by the social sciences or thehumanities. The tradition of natural science is being challenged by newdiscoveries of the non-physical and non-natural sciences which go beyondthe physical world.Certainly research is vital for the growth and development of all sciencesthat attempt to discover and understand the “secrets” of nature. The validityof any scientific theory depends on its research and methodological premisesand even that-its proposition or theories (in the words of a leading cosmologistand theoretical physicist, Stephen Hawking) -is tentative. Hawlung says: “Anyphysical theory is always provisional, in the sense that it is only a hypothesis:you can never prove it. No matter how many times the results of experimentsagree with some theory, you can never be sure that the next time the resultwill not contradict the theory. On the other hand, you can disprove a theoryby finding even a single observation that disagrees with the predictions ofthe theory.”The history of Western science is rooted in the idea of finding the ’truth’by objectivity. Nothing can be believed until there is a scientific proof ofits existence, or until it can be logically accepted by the rational mind. Theclassical scenario of scientific work gives you an austere picture of heroicactivity, undertaken against all odds, a ceaseless effort to subjugate hostileand menacing nature, and to tame its formidable forces. Science is depicted ...

Perfektives und Imperfektives Partizip

2020 ◽  
Vol 28 ◽  
pp. 27-79
Author(s):  
Marc Brose
Keyword(s):  
Tense And Aspect ◽  
History Of Research ◽  
New Concepts ◽  
History Of ◽  
Basic Semantic

“Perfective and Imperfective Participle”: This article deals with the basic semantic opposition of the two types of Egyptian participles, jri̯ and jrr. After an extended overview of the history of research presenting the classical approaches of K. Sethe and A. H. Gardiner, who both used established terms of models of tense and aspect, and also the advanced approaches of W. Schenkel, J. P. Allen, K. Jansen-Winkeln and E. Oreál, who introduced new concepts and terminolgy and so tried to overcome the classical approaches, it is nevertheless shown that the classification of the opposition as “perfective–imperfective”, with modernized definitions in contrast to Gardiner’s, suffices to explain the entire functional range of the two types and that the advanced approaches are not necessary.

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