Bronchiolitis as a Possible Cause of Wheezing in Childhood: New Evidence

PEDIATRICS ◽  
1984 ◽  
Vol 74 (1) ◽  
pp. 1-10
Author(s):  
Kenneth M. McConnochie ◽  
Klaus J. Roghmann ◽  
Suzanne J. Klein ◽  
Thomas K. Mclnery ◽  
James B. MacWhinney ◽  
...  
Keyword(s):  
Control Group ◽  
Historical Cohort ◽  
Practice Population ◽  
Confounding Variables ◽  
Significant Difference ◽  
History Of ◽  
Age Range ◽  
New Evidence ◽  
Possible Cause ◽  
Allergic Manifestations

A historical cohort study was performed in order to assess the hypothesis that even mild bronchiolitis in infancy is a predictor of wheezing later in childhood. Subjects who had experienced bronchiolitis and a matched control group were compared in terms of reported wheezing 8 years later. A highly significant difference was found between the bronchiolitis group and the control group in terms of current wheezing (P < .0001, relative risk 3.24). This difference was maintained after adjusting for many potentially confounding variables including family history of allergy and other allergic manifestations in the child. Results suggested that 13.6% of a normal practice population in the age range 6 to 9 years currently wheeze, but that 44.1% of children who experienced bronchiolitis currently wheeze. Based on the incidence of bronchiolitis (4.27/100 children in their first 2 years of life) and the relative odds for wheezing derived from a logistic regression model including variables that measured passive smoking, genetic tendency to wheeze, and bronchiolitis, calculations of attributable risk suggested that wheezing in 9.4% of the population of children who currently wheeze was attributable to bronchiolitis.

scholarly journals Functional state of the nasal cavity after endoscopic septoplasty

2020 ◽  
Vol 19 (3) ◽  
pp. 16-21
Author(s):  
S. A. Karpishchenko ◽  
◽  
A. N. Aleksandrov ◽  
A. E. Shakhnazarov ◽  
A. F. Fatalieva ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Nasal Cavity ◽  
Nasal Septum ◽  
Control Group ◽  
Endoscopic Techniques ◽  
Endoscopic Septoplasty ◽  
Diagnostic Measures ◽  
Significant Difference ◽  
History Of ◽  
Age Range

Septoplasty is one of the three most frequently performed operations in otorhinolaryngology. The history of the development has more than 200 years. The research and analysis of the features of different methods of this surgical treatment does not lose interest to this day. The article presents an analysis of the restoration of the functions of the nasal cavity after septoplasty. The research included 96 patients with various types of nasal septum deformities. The age range of patients ranged from 19 to 54 years. All patients had nasal septum correction under general anesthesia. Patients were divided into 2 groups. The 1st group included 64 patients who had endoscopic septoplasty. The 2nd control group consisted of 43 patients with the same pathology who underwent classical septoplasty without optical control. Dynamic observation was carried out before surgical treatment, on the 7th day, 1, 3, 6, 12 months after surgery. The aim of the research was to estimate the functional status of the mucous membrane of the nasal cavity after surgery, the time of the operation, as well as long-term postoperative complications if any. The following diagnostic measures there were: complaints, otorhinolaryngological examination by using endoscopic techniques, anterior active rhinomanometry on the Rinolan device (manufactured by Lana-Medica), measurement of mucociliary transport time using the saccharin test. Comparative analysis of groups of patients showed no significant difference in the restoration of nasal cavity functions. However, performing septoplasty using endoscopic technique reduces the time of surgery and the percentage of complications in contrast to the classical septum surgery

Breastfeeding Training through Role-Play and Effects on Mother-infant Attachment Behaviours: A Randomised Controlled Trial

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Farokh Saljughi ◽  
Mitra Savabi-Esfahani ◽  
Shahnaz Kohan ◽  
Soheila Ehsanpour
Keyword(s):  
Pregnant Women ◽  
Maternal Employment ◽  
Controlled Trial ◽  
Role Play ◽  
Intervention Group ◽  
Control Group ◽  
Maternal Behaviour ◽  
Infant Attachment ◽  
Significant Difference ◽  
History Of

Mother-infant attachment is an intimate, lasting and satisfying relationship that leads to better cognitive, emotional and social growth of the infant. The aim of this study was to determine the effects of breastfeeding training by role-play on mother-infant attachment behaviours. This research was a randomised clinical trial (parallel design). Inclusion criteria were: no history of mental disorders; ability to read and write the Persian language to complete the questionnaire; no history of drug and tobacco intake in primigravida women. The sample comprised 100 pregnant women (in 2 groups), selected through simple random sampling at healthcare centres. The researcher reviewed prenatal care registries of selected healthcare centres and extracted the names of pregnant women in their early third trimester. The data were imported into randomisation software. The control group received routine breastfeeding training, while the intervention group received routine training together with training through role-play. The data collection tool was the Maternal Behaviour Inventory Questionnaire. Consequently 75 samples were analysed in SPSS16. Independent t-tests and chi-square tests were used to examine the difference between the two groups. Results showed that the mean score of mother-infant attachment one week after delivery was significantly higher in the intervention group in comparison to that in the control group (p<0.001). No significant difference was observed between the two groups in maternal age, age of marriage, neonatal gender, maternal employment and education, number of parity, and number of abortions (P>0.05). Since breastfeeding training through role-play could affect mother-infant attachment, it is suggested that this type of training should be provided for pregnant women to promote mother-infant attachment and exclusive breastfeeding.

scholarly journals Evaluation of depression and self-esteem in children with monosymptomatic nocturnal enuresis: A controlled trial

2014 ◽  
Vol 86 (3) ◽  
pp. 212 ◽  
Author(s):  
Orhan Koca ◽  
Mehmet Akyüz ◽  
Bilal Karaman ◽  
Zeynep Yesim Özcan ◽  
Metin Öztürk ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Nocturnal Enuresis ◽  
Depression Scale ◽  
Self Esteem ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Significant Difference ◽  
Monosymptomatic Nocturnal Enuresis ◽  
Age Range

Objectives: Nocturnal enuresis (NE) is very common and is one of the most common causes for patients to be admitted to urology, pediatrics, child psychiatry and child surgery departments. We aimed to investigate the effect on depression and self-esteem of this disorder that can cause problems on person's social development and human relations. Material and methods: 90 patients who were admitted to our clinic with complaints of nocturnal enuresis were enrolled. Investigations to rule out organic causes were performed in this group of patients. Out of them 38 children and adolescents (age range 8-18 years) with primary monosymptomatic nocturnal enuresis (PMNE) agreed to participate in the study In the same period 46 healthy children and adolescents with a similar age range without bed wetting complaint were included in the study as a control group. The age of the family, educational and socioeconomic level were questioned and Piers-Harris Children's Self-Concept Scale (PHCSCS) and Children's Depression Inventory (CDI) forms were filled out. Results: Mean age of the cases (18 females or 47.4% and 20 males or 52.6%) was 10.76 ± 3.82 years whereas mean age of controls (26 females or 56.5% and 20 males or 43.5%) was 10.89 ± 3.11 years. Depression scale was significantly higher (p = 0.001) in the case group than in the control group (10.42 ± 4.31 vs 7.09 ± 4.35). In both groups there was no statistically significant difference by age and sex in terms of depression scale (p &gt; 0.05). Conclusion: NE is widely seen as in the community and is a source of stresses either for children and for their families. When patients were admitted to physicians for treatment, a multidisciplinary approach should be offered and the necessary psychological support should be provided jointly by child psychiatrists and psychologists.

scholarly journals Effect of Eight Weeks Water Resistance Training with Dark Chocolate Supplementation on the Balance of the Elderly

2020 ◽  
Author(s):  
Maryam Mousavi ◽  
Farshad Ghazalian
Keyword(s):  
Resistance Training ◽  
Water Resistance ◽  
Training Group ◽  
The Elderly ◽  
Dark Chocolate ◽  
Control Group ◽  
Daily Lives ◽  
Significant Difference ◽  
Group Water ◽  
Age Range

Introduction: Improving balance in the daily lives of the elderly plays an important role, especially in reducing their risk of falling. Therefore, the aim of the present study was to investigate the effect of eight weeks water resistance training with dark chocolate supplementation on the balance of the elderly.Methods: In this study, 38 elderly people with an age range of 73-60 years were randomly divided into four groups. Participants in groups, included water resistance training and water resistance training + dark chocolate, performed water resistance training for eight weeks. In this period, groups of dark chocolate and water resistance training + dark chocolate, consumed 6 pieces of dark chocolate 83%, 5 gr per day, and the control group did not have any training or supplementation. The stork test (flamingo) was used to assess balance. The results of covariance analysis (ANOVA) showed that there was a statistically significant difference between the four groups. Data were evaluated using Excel and SPSS-25 (p≤ 0.05). Results: The adjusted means after eliminating the effect of pre-test scores showed that the water resistance-training group had a higher mean than the other three groups and the weakest scores belonged to the control group. The results of other groups were as followed: experimental group 18.77, chocolate group 16.88, combined group (water resistance training + dark chocolate) 17.24 and control group 9.77. The results of Benferoni test showed that there was a significant difference between the water resistance training group and the control group (p = 0.006). Conclusion: According to the results of this study, it seems that eight weeks of water resistance training and dark chocolate supplementation can improve the balance and quality of life of the elderly.

scholarly journals Investigation on Glucose and levels of Zn and Cu in Sera of Iraqi Males addicted on Methamphetamine or Tramadol

2021 ◽  
Vol 3 (2) ◽  
pp. 52-63
Author(s):  
Rulla Sabah ◽  
Ahmed saad abbas Fatin F.Al-Kazazz ◽  
Salam A.H Al-Ameri
Keyword(s):  
Chronic Disease ◽  
Normal Weight ◽  
Control Group ◽  
Healthy Group ◽  
Significant Difference ◽  
Zn And Cu In ◽  
Healthy Control ◽  
Group A ◽  
Age Range ◽  
Heavy Smokers

Addiction is the most critical form of Addiction. It is a chronic disease with a potential for fatality if not treated. In this work, 180 samples of male individuals were collected in this study. They classified into three groups, groups:  G1 who were healthy control; G2 who was addicted to methamphetamine (meth); G3 who was addicted to tramadol (Tra). Each group consists of 60 heavy smokers Iraqi male individuals in the age range of 18-43 years. The results showed a highly significant increase (p<0.0001) in the level of Glucose of the two addicted groups in comparison with the healthy group. A highly significant decrease (p<0.0001) could be seen in the level of Zn of the two addicted groups G2, G3 compared to the control group, while the level of Cu of the two addicted groups were highly significant increased (p<0.0001). Also, the results showed a highly significant difference (p<0.0001) in BMI for the studied groups, G2, G3 in comparison with the control group. All addictive individuals under this study were at normal weight depending on their BMI.  

scholarly journals The Characteristics of Risk Factors in Chinese Young Women with Acute Coronary Syndrome

2020 ◽  
Author(s):  
Ruifang Liu ◽  
Fangxing Xu ◽  
Yujie Zhou ◽  
Tongku Liu
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Young Women ◽  
Early Onset ◽  
Young Female ◽  
Cardiac Insufficiency ◽  
Control Group ◽  
Significant Difference ◽  
Gynecological Diseases ◽  
History Of

Abstract Background In recent years, the prevalence rate of ACS in Chinese young women has been increasing significantly, becoming the main cause of death in young female. This study aimed to investigate the characteristics and difference of risk factors in Chinese young women with ACS and to provide references for ACS prevention and treatment. Methods A 1:1 case-control study was conducted to evaluate risk factors of 415 young female patients with ACS (ACS group) who underwent PCI treatment and 415 young female cases without ACS (control group) who were hospitalized and confirmed by coronary angiography to exclude coronary heart disease from January 2010 to August 2016. The average age of the cases in the two groups was respectively (40.77±4.02) years-old and (40.57±4.01) years-old (P> 0.05). Results The risk factors in ACS group were overweight (64.10%), hypertension (49.88%), hyperlipidemia (35.66%), diabetes (23.37%), depression or anxiety disorder (16.62%), gynecological diseases (16.39%), Hyperuricemia (15.18%), family history of early onset coronary heart disease (14.94%), hyperhomocysteinemia (11.33%), hypothyroidism(14.96%), hypercholesterolemia (8.43%) and high c-reactive protein (7.47%), and were statistically significant difference (P<0.01) compared with that of control group. The average number of risk factors per case in ACS group was significantly more than that of control groups (P<0.01). There was a statistically significant difference in the number of combined risk factors of the overweight cases compared between two groups (P<0.01). Regression analysis showed that hyperlipidemia, hyperhomocysteinemia, overweight（obesity）, high CRP, hypertension, hypothyroidism, gynecological diseases, depression or anxiety, cardiac insufficiency, hypercholesterolemia, diabetes, oral contraceptives, family history of early onset CHD, and autoimmune diseases were independent risk factors (P<0.01). The bivariate correlation analysis between CRP level and age was r= -0.158 (P<0.01). This result showed the younger ACS patient is the higher serum CRP. Conclusion The independent risk factors of ACS in young women are hyperlipidemia, hyperhomocysteinemia, overweight, high CRP, hypertension, hypothyroidism, gynecological diseases, depression or anxiety, cardiac insufficiency, hypercholesterolemia, diabetes, oral contraceptives, family history of early onset CHD, and autoimmune diseases. The co-existence of multiple risk factors is the main cause suffering from ACS in young women.

The Effect of Crystal Dependence on Brain Activity Related to the Perception of Pleasure Using fMRI

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Ali Yoonessi ◽  
Seyed Amir Hossein Batouli ◽  
Iman Ahmadnezhad ◽  
Hamid Soltanian-zadeh
Keyword(s):  
Case Control Study ◽  
Brain Activity ◽  
Economic Status ◽  
Smoking History ◽  
Control Group ◽  
Human Society ◽  
Significant Difference ◽  
History Of ◽  
The Brain ◽  
Control Study

Background: Addiction is currently one of the problems of human society. Drug abuse is one of the most important issues in the field of addiction. Methamphetamine (crystal) is one of the drugs that has been abused in recent decades. Methods: In this case-control study, 10 individuals aged 20 to 40 years old with at least 2 years of experience of methamphetamine consumption without any history of drug use or other stimulants from clients and drug withdrawal centers in Tehran City, and 10 healthy volunteers were selected. Age, social status, and economic status of addicts were included in the fMRI apparatus, and 90 selected pleasurable, non-pleasurable, and neutral images (IAPS) were displayed by the projector through an event-related method. The playback time of each photo was 3 s, and after this process, the person outside the device, without the time limit selected the enjoyable and unpleasant images. Results: The results showed that there was no significant difference between the groups in terms of age, alcohol use, and smoking history (P < 0.05). There was no significant difference in terms of the age at first use between members of the methamphetamine-dependent group. Also, the methamphetamine-dependent group showed more brain activity in their pre-center and post-center gyrus than the normal (control) group. Conclusions: According to the results obtained in this study, in general, it can be concluded that there are some areas in the brain of addicts that are activated when watching pleasant photos, while these areas are not active in the brains of normal people.

Abstract 54: The Correlation Between IgE And The Level Of Interleukin-21 In Kawasaki Disease

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Hae-Yong Lee
Keyword(s):  
Kawasaki Disease ◽  
Serum Level ◽  
Acute Phase ◽  
Immunoglobulin E ◽  
Significant Difference ◽  
History Of ◽  
Interleukin 21 ◽  
Christian Hospital ◽  
Age Range ◽  
Chemiluminescent Method

Purpose: It has been reported that serum level of immunoglobulin E (IgE) is increased in patients with Kawasaki disease (KD) after acute phase. However the exact mechanism of increasing IgE is yet to be revealed. We investigated whether the interleukin-21 (IL-21) could be related with the high IgE in KD. Instead of IL-4, IL-21 was focused in this study because it has been reported that its level is increased in various autoimmune vasculitis. Methods: From June 2008 to June 2010, 49 patients with KD admitted in Wonju Severance Christian Hospital and 13 controls with high fever due to unknown infection who had no history of KD were included in this study. The sera from patients and controls were collected and checked in terms of immunoglobulin E (Chemiluminescent method, Siemens, Munich, Germany) and IL-21 (ELISA, eBioscience, San Diego, USA). Results: The median age of patients with KD was 3 years of age (range: 0.4-10) and that of controls was 7 years of age (range: 1-12). The group of patients with KD was composed of 39 complete KD and 10 incomplete KD. Among patients with KD, 10 patients had coronary arterial dilatation (CAD) and 39 patients had no coronary complications. The median value of IL-21 in patients with KD was significantly increased as 466 pg/mL (range: 0-1544) while that value in controls was <62.5 pg/mL (range: 0- 825 pg/mL) ( P < 0.01). We could not find the significant correlation between the serum level of IgE and that of IL-21 in patients with KD (Spearman R=0.2, P = 0.08) though 30% of patients with KD showed increased IgE more than 100 IU/mL. In addition, our data showed no significant difference between CAD group and non CAD group in terms of serum IL-21. Conclusion: Our data showed firstly that IL-21 is increased in patients with KD. There was no significant correlation between high IgE and the level of IL-21.

scholarly journals Ophthalmologic Manifestations and Retinal Findings in Children with Down Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Adem Ugurlu ◽  
Emre Altinkurt
Keyword(s):  
Down Syndrome ◽  
Control Group ◽  
Healthy Children ◽  
Fiber Layer ◽  
Children With Down Syndrome ◽  
Department Of Ophthalmology ◽  
Significant Difference ◽  
Snellen Chart ◽  
Ophthalmologic Examination ◽  
Age Range

Purpose. To evaluate ocular findings in children with Down syndrome and to compare with the healthy children group. Methods. The study patients were divided into two groups as the diagnosed Down syndrome group and the control group. The study was designed as a prospective and single-center study in Istanbul University Faculty of Medicine Department of Ophthalmology. The study included 93 patients in the age range from 7 to 18 years, who applied to the ophthalmology department of our clinic in the period from July 2017 to June 2018. The study included the patients allocated into the control group and the Down syndrome patients allocated into the patient group, containing 49 and 44 participants, respectively. All patients underwent complete ophthalmologic examination with biomicroscopy. Autorefractometer measurements were performed in all patients, and the best corrected visual acuity (BCVA) was determined with the use of the Snellen chart. All patients underwent spectral domain optical coherence tomography (SD-OCT) measurements for central foveal retinal (CRT), subfoveal choroidal (CCT), and peripapillary retinal nerve fiber layer (pRNFL) thicknesses. Results. The average CRT was 241.2 ± 25.7 microns in Down syndrome group and 219.4 ± 21.1 microns in the control group. There was a statistically significant difference between the groups in regards to CRT (p<0.001). The average pRNFL values were 123.1 ± 15.4 microns in the Down syndrome group and 102.2 ± 8.7 microns in the control group (p<0.001). Conclusions. In the subjects with Down syndrome, the incidence of lens opacities, strabismus, and amblyopia was higher than the control group. CRT and pRNFL were thicker in the Down syndrome group than in control group. This may represent retinal developmental changes in the patients with Down syndrome.

scholarly journals Low detection rate of advanced neoplasia within 5 years after polypectomy of small serrated adenoma

2019 ◽  
Vol 95 (1122) ◽  
pp. 187-192 ◽  
Author(s):  
Duochen Jin ◽  
Hailong Cao ◽  
Bikash Kumar Shah ◽  
Danfeng Chen ◽  
Yujie Zhang ◽  
...  
Keyword(s):  
Control Group ◽  
Case Group ◽  
Surveillance Colonoscopy ◽  
Surveillance Period ◽  
Serrated Adenoma ◽  
Advanced Neoplasia ◽  
Significant Difference ◽  
Negative Findings ◽  
History Of ◽  
Low Prevalence

AimPatients with small serrated adenomas (SAs) (<10 mm) often undergo surveillance colonoscopy before the routine recommended time. We aimed to determine the appropriate surveillance intervals following polypectomy of small SAs for symptomatic patients.MethodWe retrospectively reviewed the data of 638 patients, including 122 cases and 516 controls. Subjects in the case group had small SAs at baseline colonoscopy, including sessile SA/polyps and traditional SAs, while subjects in the control group had negative findings. All patients underwent at least one surveillance colonoscopy during the following 5 years.ResultsThere was no significant difference in the incidence rate of advanced neoplasia between the two groups over a 5-year duration (3.6% vs 2.6%, p=0.455). Moreover, both groups also showed a low prevalence of SA formation over 1–5 years (3.6% vs 1.0%, p=0.145). Patients with baseline SA tended to undergo the first surveillance colonoscopy earlier than those without adenoma (≤1 year vs 1 to ≤3 years). Seventy-one (11.1%) of the total included subjects underwent inadequate initial colonoscopy, and 30 (42.3%) underwent early surveillance of adenoma formation within 1 year. Patients with a family history of colorectal cancer (OR 4.69, 95% CI 1.48 to 14.71, p=0.017) or inadequate baseline colonoscopy (OR 3.17, 95% CI 1.202 to 8.409, p=0.035) were at a higher risk of metachronous adenoma formation during the surveillance period.ConclusionPatients with small SAs at baseline gain little benefit from follow-up of colonoscopy within 5 years after complete polypectomy.

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