Abstract 54: The Correlation Between IgE And The Level Of Interleukin-21 In Kawasaki Disease

Purpose: It has been reported that serum level of immunoglobulin E (IgE) is increased in patients with Kawasaki disease (KD) after acute phase. However the exact mechanism of increasing IgE is yet to be revealed. We investigated whether the interleukin-21 (IL-21) could be related with the high IgE in KD. Instead of IL-4, IL-21 was focused in this study because it has been reported that its level is increased in various autoimmune vasculitis. Methods: From June 2008 to June 2010, 49 patients with KD admitted in Wonju Severance Christian Hospital and 13 controls with high fever due to unknown infection who had no history of KD were included in this study. The sera from patients and controls were collected and checked in terms of immunoglobulin E (Chemiluminescent method, Siemens, Munich, Germany) and IL-21 (ELISA, eBioscience, San Diego, USA). Results: The median age of patients with KD was 3 years of age (range: 0.4-10) and that of controls was 7 years of age (range: 1-12). The group of patients with KD was composed of 39 complete KD and 10 incomplete KD. Among patients with KD, 10 patients had coronary arterial dilatation (CAD) and 39 patients had no coronary complications. The median value of IL-21 in patients with KD was significantly increased as 466 pg/mL (range: 0-1544) while that value in controls was <62.5 pg/mL (range: 0- 825 pg/mL) ( P < 0.01). We could not find the significant correlation between the serum level of IgE and that of IL-21 in patients with KD (Spearman R=0.2, P = 0.08) though 30% of patients with KD showed increased IgE more than 100 IU/mL. In addition, our data showed no significant difference between CAD group and non CAD group in terms of serum IL-21. Conclusion: Our data showed firstly that IL-21 is increased in patients with KD. There was no significant correlation between high IgE and the level of IL-21.

Download Full-text

Bronchiolitis as a Possible Cause of Wheezing in Childhood: New Evidence

PEDIATRICS ◽

10.1542/peds.74.1.1 ◽

1984 ◽

Vol 74 (1) ◽

pp. 1-10

Author(s):

Kenneth M. McConnochie ◽

Klaus J. Roghmann ◽

Suzanne J. Klein ◽

Thomas K. Mclnery ◽

James B. MacWhinney ◽

...

Keyword(s):

Control Group ◽

Historical Cohort ◽

Practice Population ◽

Confounding Variables ◽

Significant Difference ◽

History Of ◽

Age Range ◽

New Evidence ◽

Possible Cause ◽

Allergic Manifestations

A historical cohort study was performed in order to assess the hypothesis that even mild bronchiolitis in infancy is a predictor of wheezing later in childhood. Subjects who had experienced bronchiolitis and a matched control group were compared in terms of reported wheezing 8 years later. A highly significant difference was found between the bronchiolitis group and the control group in terms of current wheezing (P < .0001, relative risk 3.24). This difference was maintained after adjusting for many potentially confounding variables including family history of allergy and other allergic manifestations in the child. Results suggested that 13.6% of a normal practice population in the age range 6 to 9 years currently wheeze, but that 44.1% of children who experienced bronchiolitis currently wheeze. Based on the incidence of bronchiolitis (4.27/100 children in their first 2 years of life) and the relative odds for wheezing derived from a logistic regression model including variables that measured passive smoking, genetic tendency to wheeze, and bronchiolitis, calculations of attributable risk suggested that wheezing in 9.4% of the population of children who currently wheeze was attributable to bronchiolitis.

Download Full-text

Job’s Syndrome With a Family History of Kawasaki Disease: A Case Presentation and Review of Literature

Disease and Diagnosis ◽

10.34172/ddj.2021.04 ◽

2021 ◽

Vol 10 (1) ◽

pp. 19-22

Author(s):

Tamar Yared ◽

Samer Mohsen

Keyword(s):

Family History ◽

Kawasaki Disease ◽

Immunoglobulin E ◽

Serum Antibody ◽

Primary Immunodeficiency Disease ◽

Case Presentation ◽

Job’S Syndrome ◽

History Of ◽

Job's Syndrome ◽

Probable Relation

Background: Job’s syndrome or hyper-immunoglobulin E (IgE) syndrome (HIES) is an extremely rare primary immunodeficiency disease with an approximate annual incidence of less than 1/1000000. It is characterized by recurrent cold staphylococcal infections, unusual eczematous dermatitis, severe lung infections, and extensively high concentrations of the serum antibody IgE. Case Presentation: A typical case of Job’s syndrome with a family history of Kawasaki disease is presented in this study aiming at identifying the clinical features, investigational procedures, and management strategy, as well as evaluating the role of the ear, nose, and throat specialist and highlighting the probable relation between Job’s syndrome and Kawasaki disease. Conclusions: In general, early detection with proper care can prevent the progression of Job syndrome. In addition, the initiated treatment at the first signs of infection is mandatory for preventing long-term complications. There is a probable relation between Job and Kawasaki which requires more consideration.

Download Full-text

Sarcomas Arising in Paget Disease of Bone: A Clinicopathologic Analysis of 70 Cases

Archives of Pathology & Laboratory Medicine ◽

10.5858/2007-131-942-saipdo ◽

2007 ◽

Vol 131 (6) ◽

pp. 942-946 ◽

Cited By ~ 4

Author(s):

Andrea T. Deyrup ◽

Anthony G. Montag ◽

Carrie Y. Inwards ◽

Zhiheng Xu ◽

Ronald G. Swee ◽

...

Keyword(s):

Rare Complication ◽

Clinical History ◽

Axial Skeleton ◽

Clinical Findings ◽

Paget Disease Of Bone ◽

Paget Disease ◽

Significant Difference ◽

History Of ◽

Age Range

Abstract Context.—Sarcomatous transformation is a rare complication of Paget disease of bone. Prognosis in patients with other types of sarcomas arising in bone has improved in the last several decades because of therapeutic advances. However, because of the rarity of Paget sarcoma, outcome studies in these patients are limited. Objective.—To determine whether prognosis for Paget sarcoma has improved. Design.—Seventy cases of sarcomas arising in the setting of Paget disease were collected, and the histologic and clinical findings were reviewed. Clinical follow-up was obtained in 67 cases. Results.—Sarcoma arising in Paget disease tended to arise in older men (46 men, 24 women; age range, 31–88 years; mean age, 66 years) and predominated in the axial skeleton (n = 37), especially in the pelvis. Thirty-three patients had a clinical history of Paget disease ranging in duration from 16 months to 30 years (mean, 15 years). No significant difference in incidence between monostotic (n = 33) and polyostotic (n = 36) disease was noted. Most tumors were osteosarcomas (88%). All tumors were high grade. Follow-up information was obtained in 67 of 70 cases (range of follow-up, 1–252 months). Survival ranged from 1 month to 20 years, with a 5-year survival rate of 10%. Conclusions.—Prognosis remains poor in patients with Paget sarcoma. There is no significant correlation between the number of bones involved with Paget disease or the duration of disease and development of Paget sarcoma. Poor prognosis in Paget sarcoma is unrelated to site or stage at presentation.

Download Full-text

Aspects of the life history of the Atlantic poacher, Leptagonus decagonus, in Svalbard waters

Polish Polar Research ◽

10.1515/popore-2015-0004 ◽

2015 ◽

Vol 36 (1) ◽

pp. 79-87

Author(s):

Kristin Heggland ◽

Camilla A. Meyer Ottesen ◽

Jørgen Berge

Keyword(s):

Life History ◽

Reproductive Strategies ◽

Age Distribution ◽

Gut Content ◽

Sex Distribution ◽

Male Population ◽

Female Population ◽

Significant Difference ◽

History Of ◽

Age Range

Abstract The aim of the study is to describe aspects of the life history of the Atlantic poacher (Leptagonus decagonus) obtained during early October 2010 and late September 2011 from the Hinlopen Strait, located between Nordaustlandet and the Spitsbergen Archipelago. Length was measured for 142 individuals, and 82 out of these were weighed, sexed and the age in years determined. The sex distribution in the population was 45% females and 55% males. Gut content examination revealed the domination of the mesopelagic and hyper−benthic calanoid Bradyidius similis that was recorded in 87% of the stomachs analysed. Overall there was a significant difference in size (length and weight) between the sexes, and a difference in length and weight at age between the sexes. There was no difference in age distribution between the sexes, but there was a larger age range within the male population than in the female population. The sexual dimorphism in size is likely linked to different reproductive strategies. This study represents the first data on the life history of the Atlantic poacher in Svalbard waters.

Download Full-text

Comparison of Functional Balance and Probability of Falling in the Elderly with and Without a History of Falling Living in Care Centers

Journal of Sport Biomechanics ◽

10.32598/biomechanics.6.2.6 ◽

2020 ◽

Vol 6 (2) ◽

pp. 134-143

Author(s):

Seyyed Mojtaba Tabatabaiasl ◽

◽

Parisa Sedaghati ◽

Fariba Javazi ◽

◽

...

Keyword(s):

Risk Index ◽

The Elderly ◽

Test Results ◽

Statistical Population ◽

Functional Balance ◽

Normality Test ◽

Significant Difference ◽

History Of ◽

Spss Software ◽

Age Range

Objective: The purpose of this study was to compare functional balance and probability of fall in elderly with or without history of fall in care centers. Methods: The statistical population of the present study consisted of 30 elderly men and women over 60 years of two elderly nursing centers in rasht. These specimens were selected according to the inclusion criteria and exit criteria. The age range was between 60 and 74 years. Individuals (15 people)were divided into two groups of aged persons (15 persons) and with a history of land (15 people). People who had no history of eating during the last six months have been knocked down in the group without a history of land eating and people who had tripped once or more in the last six months. the evaluation of the balance and the possibility of seniors fall with tests (leaves and time of rise and departure) were carried out. SPSS software was used to analyze the data. from the shayper-vink test to be natural for data distribution, descriptive statistics were used in the form of statistics such as mean, standard deviation, median, change range and direction of data describing and in the deductive statistics section with respect to comparing the variables from independent t-test. Results: Normality test results confirmed normality of data in the variables of performance equilibrium and probability of fall there was a significant difference between functional balance index in the elderly with a history of fall or without the history of fall. there was a meaningful difference between fall risk index in the elderly with a history of fall or without the history of fall. Conclusion: according to the results of this study, individuals with no history of fall in performance balance indices and probability of fall were better than those with history of fall.

Download Full-text

Abstract 13271: Aortic Inflammation Continues in Patients With A History of Kawasaki Disease and Persistent Arterial Aneurysms

Circulation ◽

10.1161/circ.132.suppl_3.13271 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Kenji Suda ◽

Nobuhiro Tahara ◽

Akihiro Honda ◽

Tomohisa Nakamura ◽

Hironaga Yoshimoto ◽

...

Keyword(s):

Kawasaki Disease ◽

Fdg Pet ◽

Vascular Inflammation ◽

Laboratory Data ◽

Standardized Uptake Value ◽

Fdg Uptake ◽

Positron Emission ◽

Significant Difference ◽

History Of ◽

Arterial Aneurysms

Introduction: Kawasaki disease (KD) is well known vasculitis that primarily affects small to middle sized arteries such as coronary arteries and/or peripheral arteries. However, little evidence showed inflammation of large vasculature such as the aorta in patients with KD. Measurements of 18F-fluorodeoxyglucose (FDG) uptake evaluated by positron emission tomography (PET) and X-ray computed tomography (CT) could be useful to identify inflammatory activity of the vessel wall. Hypothesis: We hypothesized that aortic inflammation continues long after KD. Methods: FDG-PET/CT was performed in 19 patients with a history of KD. Of 19 patients, 11 patients still had persistent coronary and/or systemic vascular aneurysms (KD-An) and the remaining 8 revealed regression of arterial aneurysms (KD-Reg). Patients suffered from KD at 2.8 ± 3.2 years old and underwent FDG-PET at 22.2 ± 8.0 years old. FDG-PET was also performed in 5 control with age 14.1 ± 2.6 years old. Vascular inflammation was measured by blood-normalized standardized uptake value, known as a target-to-background ratio (TBR). Also demographic and laboratory data were collected. Results: Aortic FDG uptake was distinctly intense in patients with a history of KD and persistent vascular aneurysms. The Aortic TBR was significantly higher in KD-An (1.50 ± 0.30) than KD-Reg (1.11 ± 0.13, p = 0.004) or controls (1.03 ± 0.25, p=0.003). Although Control was significantly younger and had significantly lower body mass index, there was no significant correlation between these values and TBR. Also there was no significant difference in laboratory data including lipid profiles and glycemic status among 3 groups. Conclusions: Vascular inflammation of the aortic wall continues long after KD with persistent arterial aneurysms.

Download Full-text

Comparative Study of Salivary and Serum Levels of Vitamin D in Patients with a History of High Blood Pressure and Healthy People

Journal of Molecular Biology Research ◽

10.5539/jmbr.v8n1p101 ◽

2018 ◽

Vol 8 (1) ◽

pp. 101 ◽

Cited By ~ 1

Author(s):

Hamidreza Abdolsamadi ◽

Mohammad vahedi ◽

Farnaz Fariba ◽

Alireza Soltanian ◽

Meghdad Zakavati Avval ◽

...

Keyword(s):

Blood Pressure ◽

Vitamin D ◽

Serum Level ◽

High Blood Pressure ◽

Healthy Subjects ◽

Serum Levels ◽

Vitamin D Levels ◽

Significant Difference ◽

History Of ◽

The Mean

Introduction: Vitamin D deficiency is a major public health problem. Low vitamin D levels associated with adverse health consequences such as musculoskeletal health, cognitive decline and progression of cancer and death. The lack of vitamin D associated with major risk factors for cardiovascular disease (CVD) includes hypertension is considered. The ability to assess the general health, disease and treatment outcomes through saliva as a non-invasive, inexpensive and simple method of interest is located. The aim of this study was a comparative study of salivary and serum levels of vitamin D3 in patients with a history of developing high blood pressure and a healthy person.Methods: This study was a case - control survey, in which 40 patients with high blood pressure were examined. The control group including 40 healthy subjects. Both groups were matched in terms of age and gender. After collecting samples of serum and saliva, the amount of vitamin D level samples were measured using ELISA method by electrochemiluminescence (ELC), and then analyzed the results using software SPSS 16 and statistical test including Chi Square Test, Independent-Samples, linear regression model, the Mann-Whitney Test and Spearman correlation coefficient.Results: There was no significant difference in the mean serum levels of vitamin D among patients and healthy subjects (p= 0.588). In addition, there was no significant difference in the mean salivary levels of vitamin D between patients and healthy subjects (p= 0.833). There was no significant relationship between salivary and serum level of vitamin D in healthy individuals (p= 0.095). As well as there was no significant correlation between salivary and serum level of vitamin D in patients (p= 0.5).Conclusions: This study showed that vitamin D is a measurable marker in saliva, but its analysis in saliva, may not be a reliable tool for determining the vitamin D levels.

Download Full-text

Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130058 ◽

2013 ◽

Vol 71 (7) ◽

pp. 437-441 ◽

Cited By ~ 8

Author(s):

Stella Maris Costa Castro ◽

Alfredo Damasceno ◽

Benito Pereira Damasceno ◽

Jose Paulo de Vasconcellos ◽

Fabiano Reis ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Visual Pathway ◽

Significant Difference ◽

Relapsing Remitting ◽

History Of ◽

Remission Phase ◽

Magnetic Resonance Imaging Mri ◽

Multiple Sclerosis Patients ◽

Age Range

ObjectiveIt was to investigate visual field (VF) abnormalities in a group of multiple sclerosis (MS) patients in the remission phase and the presence of magnetic resonance imaging (MRI) lesions in the optic radiations.MethodsVF was assessed in 60 participants (age range 20-51 years): 35 relapsing-remitting MS patients [20 optic neuritis (+), 15 optic neuritis (-)] and 25 controls. MRI (3-Tesla) was obtained in all patients.ResultsVisual parameters were abnormal in MS patients as compared to controls. The majority of VF defects were diffuse. All patients except one had posterior visual pathways lesions. No significant difference in lesion number, length and distribution was noted between patients with and without history of optic neuritis. One patient presented homonymous hemianopsia.ConclusionPosterior visual pathway abnormalities were found in most MS patients despite history of previous optic neuritis.

Download Full-text

Comparison of immunoglobulin E anti-thyroid peroxidase antibodies in patients with Hashimoto thyroiditis and chronic spontaneous urticaria

Medicine and Pharmacy Reports ◽

10.15386/mpr-1598 ◽

2021 ◽

Author(s):

Songül Çildağ ◽

Çiğdem Yenisey ◽

Mustafa Ünübol ◽

Taşkın Şentürk

Keyword(s):

Hashimoto’S Thyroiditis ◽

Immunoglobulin E ◽

Chronic Spontaneous Urticaria ◽

Hashimoto's Thyroiditis ◽

Unknown Etiology ◽

Enzyme Linked Immunosorbent Assay ◽

Thyroid Peroxidase ◽

Thyroid Peroxidase Antibodies ◽

Significant Difference ◽

History Of

Background and aim. Chronic spontaneous urticaria (CSU) is a disease of unknown etiology and autoimmunity has been thought to be an etiological factor. Immunoglobulin E (IgE)-anti-thyroid peroxidase antibodies (anti-TPO) may play a role in the pathogenesis of certain cases of urticaria. The aim of this study is to investigate IgE-anti-TPO in patients with chronic spontaneous urticaria and in patients with Hashimoto’s thyroiditis. Methods. A total of 175 -subjects were included in this study. 59 patients had chronic spontaneous urticaria without history of Hashimoto’s thyroiditis, while 58 patients had Hashimoto’s thyroiditis without history of urticaria. The control group consisted of 58 participants without history of Hashimoto’s thyroiditis and urticaria. Serum IgE-anti-TPO levels were analyzed by site-directed IgE capture Enzyme-Linked Immunosorbent Assay technique. We used this technique by modifying it. Results. IgE-anti-TPO antibodies were detected in all three groups and in all subjects. There was no significant difference between the three groups in terms of IgE-anti-TPO levels. Although total IgE and IgE-anti-TPO levels were higher in the IgG-anti-TPO positive chronic spontaneous urticaria, there was no significant difference. Conclusions. IgE-anti-TPO antibodies do not play a pathogenic role in the majority of patients with chronic spontaneous urticaria.

Download Full-text

Low- versus high-concentration intravenous immunoglobulin for children with Kawasaki disease in the acute phase

10.21203/rs.3.rs-859793/v1 ◽

2021 ◽

Author(s):

Takanori Suzuki ◽

Nobuaki Michihata ◽

Tetsushi Yoshikawa ◽

Kazuyoshi Saito ◽

Hiroki Matsui ◽

...

Keyword(s):

Kawasaki Disease ◽

Propensity Score ◽

Confidence Interval ◽

Intravenous Immunoglobulin ◽

Acute Phase ◽

Instrumental Variable ◽

Risk Difference ◽

High Concentration ◽

Ivig Resistance ◽

Significant Difference

Abstract Purpose: Few studies have compared the effects of low-concentration (5%) and high-concentration (10%) intravenous immunoglobulin (IVIG) preparations for patients with Kawasaki disease (KD) in the acute phase. The purpose of this study was to compare outcomes between low- and high-concentration IVIG preparations in children with KD, using a national inpatient database in Japan.Method: We used the Diagnostic Procedure Combination database to identify patients with KD treated with IVIG from April 2012 to March 2020. We identified those receiving high- and low-concentration IVIG preparations as an initial treatment. The outcomes included the proportions of patients with coronary artery abnormalities (CAAs) and IVIG resistance, length of stay, and medical costs. Propensity score-matched analyses were conducted to compare the outcomes between the two groups. Instrumental variable analyses were performed to confirm the results.Result: We identified 48,046 patients with KD and created 4:1 propensity score-matched pairs between the low- and high-concentration IVIG groups. There was a significant difference in the percentage with IVIG resistance between the two groups (20.6% vs 24.1%; risk difference, 3.5% [95% confidence interval, 2.3-4.7]; p < 0.001). However, there was no significant difference in CAAs (1.6% vs 1.6%; risk difference, 0.013% [95% confidence interval, −0.34 to 0.37]; p = 0.953). The instrumental variable analyses showed similar results.Conclusions: The proportion of CAAs did not differ significantly between those receiving low- and high-concentration IVIG. To confirm the results of this study, prospective studies adjusting for duration of IVIG administration and duration of observation are needed.

Download Full-text