scholarly journals Дослідження ембріотоксичної дії препарату для зовнішнього використання «Мазь для ран» на лабораторних тваринах

2017 ◽  
Vol 19 (78) ◽  
pp. 162-166
Author(s):  
R.N. Sachuk
Keyword(s):  
Group Intervention ◽  
Intervention Group ◽  
Embryonic Mortality ◽  
Control Group ◽  
Internal Organs ◽  
Pregnant Rats ◽  
External Examination ◽  
Tea Tree ◽  
Embryotoxic Effects ◽  
Post Implantation

The results of experiments showed one of the aspects of the application safety of the new preparation «Ointment for Wounds», which is intended for external use to bovine cattle, horses, sheep, goats, swine, fur-bearing animals, rabbits, dogs and cats. The preparation formula includes essential oils of Siberian Cedar, Eucalyptus, Tea Tree, Cedar, Clove, and chlorophyllipt oil solution. Pre-clinical trial of the «Ointment for Wounds» were carried out on pregnant rats, through repeated dermal application in the period from the 1st to the 19th day of pregnancy, and it did not cause toxic effects on animals. At the autopsy post-mortem examination of the rats on the 20th day of pregnancy, the quantity of yellow bodies in the ovaries, the implantation and resorption sites in the uterus, the number of live and dead fetuses were estimated. It was defined that the gestation course in control and experimental groups of animals did not differ significantly. The pre-implantation and total embryonic mortality in the experimental group (intervention group) of rats for which «Ointment for Wounds», was used dermally proved to be lower than that of the control group, respectively, by 16.3% and 10.2%. Post-implantation mortality exceeded by 7.0% the similar indicator of the control group. Morphometry of embryos did not reveal the growth retardation of the fetuses. During the external examination, significant visible development anomalies (deformities) of the fetuses extracted from the uterus have not been observed. During the external examination, significant visible development anomalies (deformities) of the fetuses extracted from the uterus have not been observed. Investigation of the fetuses’ internal organs did not reveal defects in their development, as well as defects in the development of the bone system have not been established, that suggests that this preparation does not cause a violation in the osteogenesis processes.The skin application of «Ointment for Wounds» to rats in a dose of 0.5 g/kg in the studied period of pregnancy effects neither on the number of newborns, nor the percentage of stillborns. Parturation of the experimental does took place, as a rule, at the 23rd day of pregnancy, as well as in control group. Consequently, the drug does not cause embryotoxic effects, does not affect the parameters of preimplantation, post-implantation, general embryonic mortality and postnatal development of offspring. Further research will focus on clinical trials of the preparation in the treatment of hyperkeratosis of the dams of the cow dummy. 

scholarly journals Change of Embryotoxic Effects of Metal Citrates Depending on the Duration of Their Introduction

2021 ◽  
Vol 6 (6) ◽  
pp. 259-266
Author(s):  
I. I. Kolosova ◽  
◽  
L. Yu. Bogomolna ◽  
G. Yu. Chriss ◽  
N. N. Tereshchenko ◽  
...  
Keyword(s):  
Embryonic Mortality ◽  
Control Group ◽  
Intragastric Administration ◽  
Sterile Saline ◽  
Cadmium Compounds ◽  
Female Wistar Rats ◽  
Combined Action ◽  
Embryotoxic Effects ◽  
Experimental Group ◽  
Post Implantation

Given the increase in cadmium in the environment (air, soil, water) through modern industrial processes, the absorption of significant amounts from cigarette smoke is relevant to studying the effect of cadmium compounds on embryogenesis. The purpose of the study: experimental study and comparison of embryolethality and embryotoxicity of metal citrates depending on the duration of their intragastric administration (during 13 and 20 days of gestation). Materials and methods. The study was performed on 120 white adult female Wistar rats that weigh 170-200 g. They were divided into 6 groups due to the intragastric administration of solutions of the studied metals – rats treated with citrates: cadmium at a dose of 1.0 mg/kg – 1st group (nfemale = 20, nemb = 166); cadmium at a dose of 1.0 mg/kg and cerium (1.3 mg/kg) – 2nd group (nfemale = 20, nemb = 185); cadmium in a dose of 1.0 mg/kg and germanium (0.1 mg/kg) – 3rd group (nfemale = 20, nemb = 184); cadmium at a dose of 1.0 mg/kg and zinc (1.5 mg/kg) – 4th group (nfemale = 20, nemb = 179); cadmium at a dose of 1.0 mg/kg and nanocomposite (iodine + sulfur + selenium) at a dose of 2.0 mg/kg – 5th group (nfemale = 20, nemb = 180), 6th group – control (nfemale = 20, nemb = 212) – proportional volume of sterile saline in the same way. Females were divided into 2 subgroups of 10 animals each, depending on the duration of administration of test substances. The embryotoxic and embryolethal effects of the test substances were evaluated according to generally accepted criteria, which were calculated according to well-known formulas. Results and discussion. Cadmium compounds harm the embryogenesis of rats in the experimental groups and increase the rates of embryolethality. The most pronounced differences in these parameters concerning the control were found in animals with isolated exposure to cadmium citrate: the rates of total embryonic mortality increased by 4.0 times in both study periods of embryogenesis and 20% from the 13th to the 20th day; increased pre-implantation mortality by 6.0 times with an increase in post-implantation mortality by 3 times on the 13th day and by 15.0 times and 2.8 times on the 20th day of embryogenesis, respectively. Depending on the duration of introduction, the indicators of pre-implantation mortality increased by 25.0% with an increase in post-implantation mortality by 22.2% in the same period. The experimental group of exposure to cadmium citrate at a dose of 1.0 mg/kg recorded the lowest indicators of the number of live fetuses and intrauterine survival with the highest resorption rate studied of embryonic development. At the same time, in the groups of combined exposure to cadmium citrate with metal citrates, a decrease in the indicators of total embryonic mortality was 50.0% - 30.0%, pre-implantation mortality – 50.0% - 25.0%, post-implantation mortality – 60.0% - 44.4 % and increase in the number of fetuses per female – 12.7% - 25.3%. Conclusion. Analysis of the results shows a pronounced embryotoxic effect of cadmium citrate at a dose of 1.0 mg/kg on the processes of embryogenesis, which is a significant increase in overall embryonic mortality, preimplantation, and postimplantation mortality compared with the control group in all studied terms. In the groups of combined action of cadmium citrate with metal citrates, the data obtained indicate a decrease in the accumulation of cadmium under the influence of the studied citrates, which allows them to be considered as potential bioantagonists of cadmium citrate

The Effect of Preoperative Video Based Pain Training on Postoperative Pain and Analgesic Use in Patients Undergoing Total Knee Arthroplasty: A Non-randomized Control Group Intervention Study

2020 ◽  
pp. 105477382098336
Author(s):  
Ceyda Su Gündüz ◽  
Nurcan Çalişkan
Keyword(s):  
Total Knee Arthroplasty ◽  
Postoperative Pain ◽  
Knee Arthroplasty ◽  
Group Intervention ◽  
Intervention Study ◽  
Intervention Group ◽  
Control Group ◽  
Total Knee ◽  
Randomized Control ◽  
Analgesic Use

This non-randomized control group intervention study was conducted to determine the effect of preoperative video based pain training on postoperative pain and analgesic use in patients undergoing total knee arthroplasty. During the study, the patients in the control ( n = 40) received routine care and the patients in the intervention group ( n = 40) received video based pain training. İt was determined that the mean postoperative pain scores of the intervention group were significantly lower and their pain management was better compared to the control group ( p < .05). The intervention group was found to use significantly less paracetamol on operation day compared to the control group ( p < .05). The intervention group was determined to benefit from non-pharmacological methods more than the control group did ( p < .05). Providing video based pain training to patients undergoing total knee arthroplasty is recommended since it reduces postoperative pain levels and increases the use of non-pharmacological pain control methods.

Walking for Better Outcomes and Recovery: The Effect of WALK-FOR in Preventing Hospital-Associated Functional Decline Among Older Adults

2019 ◽  
Vol 74 (10) ◽  
pp. 1664-1670 ◽  
Author(s):  
Yaniv Cohen ◽  
Anna Zisberg ◽  
Yehudit Chayat ◽  
Nurit Gur-Yaish ◽  
Efrat Gil ◽  
...  
Keyword(s):  
Older Adults ◽  
Group Intervention ◽  
Functional Decline ◽  
Intervention Group ◽  
Control Group ◽  
Community Mobility ◽  
Steps Per Day ◽  
Quasi Experimental ◽  
Activity Survey

Abstract Background In-hospital immobility of older adults is associated with hospital-associated functional decline (HAFD). This study examined the WALK-FOR program’s effects on HAFD prevention. Methods A quasi-experimental pre-post two-group (intervention group [IG] n = 188, control group [CG] n = 189) design was applied in two hospital internal medical units. On admission, patients reported pre-hospitalization functional status, which was assessed again at discharge and 1-month follow-up. Primary outcome was decline in basic activities of daily living (BADL), using the Modified Barthel Index. Secondary outcomes were decline in instrumental ADL (Lawton’s IADL scale) and community mobility (Yale Physical Activity Survey). All participants (75.1 ± 7 years old) were cognitively intact and ambulatory at admission. The WALK-FOR included a unit-tailored mobility program utilizing patient-and-staff education with a specific mobility goal (900 steps per day), measured by accelerometer. Results Decline in BADL occurred among 33% of the CG versus 23% of the IG (p = .02) at discharge, and among 43% of the CG versus 30% in the IG (p = .01) at 1-month follow-up. Similarly, 26% of the CG versus 15% of the IG declined in community mobility at 1-month follow-up (p = .01). Adjusted for major covariates, the intervention reduced the odds of decline in BADL by 41% (p = .05) at discharge and by 49% at 1-month follow-up (p = .01), and in community mobility by 63% (p = .02). There was no significant effect of the intervention on IADL decline (p = .19). Conclusions The WALK-FOR intervention is effective in reducing HAFD.

Cluster Randomized Controlled Trial of Disability Education Module During Clinical Clerkship

2019 ◽  
Vol 58 (13) ◽  
pp. 1387-1393
Author(s):  
Jonathan D. Santoro ◽  
Emily E. Whitgob ◽  
Lynne C. Huffman
Keyword(s):  
Group Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Family Control ◽  
Time Interaction ◽  
Functional Aspects ◽  
Management Participation ◽  
Cluster Randomized ◽  
Disability Education

The effect of a randomized disability education program on medical student knowledge and attitudes concerning disability was performed. Intervention group received bedside teaching of physical examination/interview skills and case-based discussion. Twenty-three participants completed the study (control group n = 11; intervention group n = 12). Pre-clerkship, 39% of all participants reported no personal experience and 43% reported no professional experience with people with disabilities. Post-clerkship knowledge was higher for both groups; the test of group-by-time interaction was not significant. Qualitative analysis of post-clerkship attitude responses demonstrated that intervention group gave more detailed answers. Intervention group used terms representing functional aspects of disability twice as frequently as control group. Intervention group responses described long-term experience of a disability within community and family; control group responses focused on acute medical management. Participation in disability education resulted in changed attitude toward disability and better understanding of aspects of disability.

Efficacy of Integrative Body-Mind-Spirit Group Intervention for Parents of Children With Eczema: A Randomized, Wait-List Controlled Clinical Trial

2020 ◽  
Vol 30 (6) ◽  
pp. 623-632
Author(s):  
Yat-Lui Fung ◽  
Hiu-Tin Leung ◽  
Celia H. Y. Chan ◽  
Bobo H. P. Lau ◽  
Cecilia L. W. Chan
Keyword(s):  
Psychosocial Intervention ◽  
Group Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Empirical Support ◽  
Well Being ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Wait List ◽  
Reducing Stress

Objectives: This randomized controlled trial evaluated the effects of a psychosocial intervention developed based on the Integrative Body-Mind-Spirit (IBMS) model that aimed to enhance the well-being of parents of children with eczema. Methods: Ninety-one families were randomly allocated to either the six-session intervention group ( n = 48) or the wait-list control group ( n = 43) and completed the randomized trial. For both groups, a range of psychosocial outcome measures were taken before the intervention (T0), postintervention (T1), and 6 weeks after the intervention (T2). Results: Relative to the control group, the intervention group was significantly improved over time in their levels of perceived stress, depression, and a number of holistic well-being measures, including nonattachment, afflictive ideation, and general vitality. Discussion: The results provided empirical support for an IBMS-informed psychosocial intervention in reducing stress and depression and enhancing well-being among parents of children with eczema.

scholarly journals Early intervention in panic: pragmatic randomised controlled trial

2010 ◽  
Vol 196 (4) ◽  
pp. 326-331 ◽  
Author(s):  
Peter Meulenbeek ◽  
Godelief Willemse ◽  
Filip Smit ◽  
Anton van Balkom ◽  
Philip Spinhoven ◽  
...  
Keyword(s):  
Early Intervention ◽  
Panic Disorder ◽  
Group Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Self Report ◽  
Control Group ◽  
Cognitive Behavioural ◽  
Clinically Significant ◽  
Randomised Controlled

BackgroundMany people suffer from subthreshold and mild panic disorder and are at risk of developing more severe panic disorder.AimsThis study (trial registration: ISRCTN33407455) was conducted to evaluate the effectiveness of an early group intervention based on cognitive–behavioural principles to reduce panic disorder symptomatology.MethodParticipants with subthreshold or mild panic disorder were recruited from the general population and randomised to the intervention (n = 109) or a waiting-list control group (n = 108). The course was offered by 17 community mental health centres.ResultsIn the early intervention group, 43/109 (39%) participants presented with a clinically significant change on the Panic Disorder Severity Scale–Self Report (PDSS–SR) v. 17/108 (16%) in the control group (odds ratio (OR) for favourable treatment response 3.49, 95% CI 1.77–6.88, P = 0.001). The course also had a positive effect on DSM–IV panic disorder status (OR = 1.96, 95% CI=1.05–3.66, P = 0.037). The PDSS–SR symptom reduction was also substantial (between-group standardised mean difference of 0.68). The effects were maintained at 6-month follow-up.ConclusionsPeople presenting with subthreshold and mild panic disorder benefit from this brief intervention.

scholarly journals Garlic: an alternative in reducing blood glucose on diabetic patients

2020 ◽  
Vol 7 (6) ◽  
pp. 2078
Author(s):  
Putri Dafriani ◽  
Roza Marlinda ◽  
Eliza Arman ◽  
Meldafia Idaman
Keyword(s):  
Blood Sugar ◽  
Group Intervention ◽  
Blood Sugar Level ◽  
Intervention Group ◽  
Antidiabetic Drugs ◽  
Control Group ◽  
Diabetic Patients ◽  
Post Test ◽  
Quasi Experimental ◽  
Sugar Levels

Background: Diabetes mellitus (DM), a metabolic disorder characterized by an increasing of blood sugar (hyperglycemia). Medication is one of the seven pillars of diabetes managementt. Garlic (Allium sativum), an alternative herb, also has an antidiabetic effect. The purpose of this study was to investigate the effect of garlic on the blood sugar level in type 2 diabetes mellitus.Methods: This study was a quasi-experimental design with two group post-test design. The participants were DM patients who only take medication without any supplemental herbs. The respondents were divided into two group; intervention group, given antidiabetic drugs and consume garlic 3 pieces of garlic/day for 2 weeks and control group only got antidiabetic drugs. Data were collected by performing blood sugar measurement using glucose-check on all respondents using capillary blood in the fingertips. Second measurement were taken after monitoring the consumption of garlic together with drugs for two weeks. Hypothesis testing used independent T-Test test.Results: The study result found that the average of blood sugar level after administering the treatment is 240 mg/dl in the intervention group, and 284 mg/dl in control group. It can be concluded that the administration of 3 pieces of garlic combining with antidiabetic drugs for 2 weeks has not been able to reduce blood sugar levels into normal limits.Conclusions: This combination found to lowering the blood sugar levels in a significant amount compare to only drugs. The length of the therapy could consider as a significant predictor.

Efficacy of a written prayer technique on the anxiety of mothers of children with cancer

2018 ◽  
Vol 17 (1) ◽  
pp. 54-59
Author(s):  
Maryam Ahmadi ◽  
Khdije Zaree ◽  
Anoushirvan Kazemnejad Leily ◽  
Akram Sadat Sadat Hoseini
Keyword(s):  
Group Intervention ◽  
Intervention Group ◽  
Cost Effective ◽  
Practical Method ◽  
Control Group ◽  
Children With Cancer ◽  
Demographic Questionnaire ◽  
Significant Difference ◽  
Convenience Sampling ◽  
And Control

AbstractObjectiveTo investigate the effect of a written prayer technique on the anxiety of mothers of children with cancer.MethodThis clinical trial recruited 90 mothers of children with cancer admitted to the Medical Centre of Tehran. Using a convenience sampling method, we randomly assigned the participants to two groups: control (n = 45) and intervention (n = 45). Data were collected through the Spielberger's anxiety scale and a demographic questionnaire. Maternal anxiety was measured before the intervention, immediately after the three-day intervention, and five weeks after the intervention. We used a writing technique in the intervention and control groups for 20 minutes over three consecutive days. In the intervention group, participants wrote down their sincere desires and wishes that they demanded from God without any worry or stress. The control group spent 20 minutes writing their normal daily schedules; for example, feeding their children or changing their children's clothes. During the three consecutive days of intervention, we asked both groups not to worry about grammar or spelling errors. Finally, the data were analyzed using descriptive and analytical statistical methods.ResultA statistically significant difference was observed between the two groups (intervention and control mean, 34.9 ± 9.9 and 47.9 ± 16.2, respectively) relative to anxiety after the intervention (p < 0.001). After five weeks, the intervention group continued to exhibit significantly reduced anxiety compared with the control group (intervention and control mean, 34.7 ± 9.6 and 48.5 ± 16.4; p < 0.001).Significance of resultsThe written prayer technique appears to be an effective, efficient, cost-effective, and practical method for reducing anxiety in mothers of children with cancer.

Effectiveness of a psychoeducational group intervention in patients with mild/moderate depression in primary care (PC): randomized controlled trial

2011 ◽  
Vol 26 (S2) ◽  
pp. 616-616 ◽  
Author(s):  
R. Casañas ◽  
R. Catalan ◽  
M. Casas ◽  
A. Raya ◽  
E.M. Fernandez ◽  
...  
Keyword(s):  
Primary Care ◽  
Depressive Symptoms ◽  
Group Intervention ◽  
Intervention Group ◽  
Control Group ◽  
Medical Illness ◽  
Mild Depression ◽  
Psychoeducational Group ◽  
Moderate Depression ◽  
The Impact

BackgroundDue to the high prevalence of depressive symptoms in PC (Ayuso, 2001) is relevant to know the impact of the psychoeducation in the management of these symptoms to decrease the prevalence in the PC population.ObjectiveTo compare the effectiveness of a psychoeducational group intervention in patients with mild/moderate depression in PC.Methods242 participants older than 20 years with ICD-10 mild/moderate depression were recruited through nurse/general practice in 12 urban primary health care centers in Barcelona city. Randomization was realised by means of a computer program. Exclusion criteria: severe mental disorder, major depressive disorder, use of secondary mental health services and acute medical illness. The intervention group (IG) received a psycoeducational group program (12 weekly 1,5h sessions) leads by two nurses. The program was an adaptation of Coping With Depression (CWD) (Lewinsohn, 1989). The control group (CG) received TAU. Outcome measures: Sociodemographic, BDI and EuroQol-5D questionnaires pre-post intervention.Results232 patients were included, IG (n = 121) and CG (n = 112), of whom 86 patients had mild depression (BDI≤ 18) and 146 moderate depression (BDI≥ 19). The sample characteristics were as follow: 90% women with mean age of 53,27 (SD = 12,72)The intervention was associated with significant improvements in BDI (t(230) =-2.25; p = 0.025). Separately analyze the sample: Patients with mild depression: (t(83) =-2.52; p = 0.014).Patients with moderate depression: (t(141) =-2.62; p = 0.010). Posttest results show that this intervention has statistically significant effect on depressive symptoms in overall sample and in mild/moderate depression separately.ConclusionsThe psychoeducational intervention is effective treatment in both mild and moderate depressive symptoms in primary care.

A Prospective Intervention in Patients with Complicated Grief

2017 ◽  
Vol 41 (S1) ◽  
pp. s781-s781
Author(s):  
M. Pinheiro ◽  
N. Carvalho ◽  
D. Mendes ◽  
J. Rocha
Keyword(s):  
Narrative Therapy ◽  
Group Intervention ◽  
Therapy Group ◽  
Intervention Group ◽  
Complicated Grief ◽  
Depression Scale ◽  
Special Treatment ◽  
Control Group ◽  
Depression Symptoms ◽  
Significant Difference

IntroductionMost reactions to grief are adaptive. However, there is the possibility that some individuals present a complicated grief disorder, where there is a pathological intensification of symptoms lasting more than 6 months, deserving special treatment.Objectives/aimsEvaluate the effectiveness of two types of intervention in complicated grief: group intervention (GI) and cognitive-narrative (CN) therapy.MethodsPatients in a complicated grief process were selected (n = 70), and distributed in three groups: cognitive–narrative therapy group (CNTG), group intervention group (GIG) and a control group (CG). Inclusion criteria: adults, with a reference to mourning situation, with personal meaning, for over six months and results in ICG ≥30points (cutoff). The Inventory of Complicated Grief (ICG), the Center for epidemiologic studies depression scale (CES-D) and the trauma questionnaire (ICD-11) were used. Follow-up was performed 3 months after the end of each intervention. Data analysis was performed using the statistical package from social sciences (SPSS 20).ResultsWith respect to complicated grief symptoms (CGx) and depression symptoms (Dx) there were statistically significant differences between the CNTG and the CG, but not with the GIG. There was no statistically significant effect in post-traumatic symptoms (PTx), even though both interventions had a slight decrease. When the CNTG and the GIG were directly compared, there was only a statistically significant difference between PTx.ConclusionsIn our single center cohort, CNTG was a more effective intervention in complicated grief patients for CGx and Dx reduction. For PTx, no intervention was superior. Larger multi-center studies are needed to validate these results.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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