scholarly journals Functional autonomy and sarcopenia markers in women over 55 years of age

2021 ◽  
Vol 69 (4) ◽  
Author(s):  
Jhon Fredy Ramírez-Villada ◽  
Carlos Mario Arango-Paternina ◽  
Annie Tibaduiza-Romero ◽  
Leonardo Rodríguez-Perdomo ◽  
Nery Cecilia Molina Restrepo ◽  
...  
Keyword(s):  
Fat Mass ◽  
Multiple Linear Regression Model ◽  
Gait Pattern ◽  
Lower Limbs ◽  
Physically Active ◽  
Functional Autonomy ◽  
Colombian Women ◽  
Group 2 ◽  
Appendicular Mass ◽  
Group 1

Introduction: Some parameters used to diagnose sarcopenia, and functional autonomy disorders can lead to interpretation and classification errors. Objective: to analyze sarcopenia markers and their relationship with the strength and gait of physically active older women aged between 55 and 76 years. Materials & Methods: Analytical observational study conducted in 178 physically active Colombian women who were distributed in two age groups (Group 1: 55-66 years, n=98, and Group 2: 67-76 years, n=80). A multiple linear regression model was used to establish possible correlations between strength and gait indicators (dependent variables) and body composition (independent variables). Results: In group 1 (G1) the fat mass and the appendicular mass (appendicular lean/height2(kg/m2)) explained the variance of the power in the lower limbs (SJ: p= 0.001, R2 =0.56; CMJ: p =0.001, R2 =0.51; CMJAS: R2 =0.60, P= 0.001). Similar results were observed in group 2 (G2) (SJ: R2=0.32, DW=2.14; CMJ: R2 = 0.51, DW=2.38; CMJAS: R2=0.41, DW=2.56). Furthermore, fat mass explained differently the variance in G1 and G2 regarding the gait pattern (G1: p=-0.006; R2=20%; G2: p =-0.001; R2=29%).  Conclusion: The records of fat and appendicular mass allow studying negative changes in lower limb strength, and their effect on the gait pattern, as well as identifying the type of sarcopenia and functional autonomy disorders in Colombian physically active Colombian women aged 55 to 76 years.

Analysis of therapy effectiveness of deep vein thrombosis of lower limbs with warfarin and rivaroxaban in the long-term period

2020 ◽  
Author(s):  
А.А. Полянцев ◽  
Д.В. Фролов ◽  
Д.В. Линченко ◽  
Ю.В. Щелокова ◽  
Т.А. Литвинова ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Oral Anticoagulants ◽  
Lower Limbs ◽  
Prophylactic Regimen ◽  
Therapy Regimen ◽  
Vein Thrombosis ◽  
Group 2 ◽  
Deep Vein ◽  
Group 1

Введение. Влияние стандартной и альтернативных схем антикоагулянтной терапии на степень и скорость реканализации глубоких вен привлекает внимание современных исследователей. Цель исследования: сравнение эффективности терапии тромбоза глубоких вен (ТГВ) нижних конечностей варфарином и ривароксабаном в отдаленном периоде. Материалы и методы. В исследование включено 94 пациента с ТГВ нижних конечностей, которые были разделены на 2 группы в зависимости от назначенной схемы лечения. Средний возраст 50 пациентов группы 1 составил 44,0 12,6 лет, 44 больных группы 2 39,5 11,7 лет. Пациентам группы 1 был назначен варфарин, группы 2 ривароксабан в течение 6 мес после выписки. Конечная точка наблюдения 4 года. Результаты. Прием антикоагулянта ранее установленного срока прекратили 18 (36) пациентов из группы 1 и 2 (4,5) пациента из группы 2. Режим эластической компрессии в обеих группах пациенты соблюдали нерегулярно. Рецидив венозных тромбоэмболических осложнений в группе 1 отмечен в 11 (22) случаях, в группе 2 у 7 (15,9) пациентов. Отрицательная динамика ультразвукового обследования складывалась у пациентов обеих групп: у 16 пациентов группы 1 и у 9,1 группы 2 появились признаки поражения ранее неизмененных вен или окклюзия ранее проходимой вены после перенесенного тромбоза без клиники острого венозного тромбоза в анамнезе. Трофические расстройства отмечены у одного пациента группы 2 и у 1/3 пациентов группы 1 к четвертому году наблюдения. Значимые отличия между группами были получены по таким параметрам, как приверженность к лечению и степень тяжести венозной недостаточности, оцениваемая клинически, в пользу ривароксабана. Заключение. Неудовлетворительные результаты лечения при использовании стандартной схемы терапии ТГВ требуют назначения препаратов из группы новых оральных антикоагулянтов с возможным внедрением схемы профилактического приема. Introduction. Effect of standard and alternative anticoagulant therapy regimens on the degree and rapidity of deep vein recanalization attracts the attention of modern researchers. Aim: to compare the treatment effectiveness of deep vein thrombosis (DVT) of lower limbs with warfarin and rivaroxaban in the long-term period. Materials and methods. The study included 94 patients with DVT of lower limbs they were divided into 2 groups depending on the prescribed treatment regimen. The average age of 50 patients of group 1 was 44.0 12.6 years, 44 patients of group 2 39.5 11.7 years. Warfarin was prescribed to patients of group 1, rivaroxaban to patients of group 2 treatment was prescribed for 6 months after discharge. The endpoint of observation was 4 years. Results. 18 (36) patients from group 1 and 2 (4.5) patients from group 2 stopped taking the anticoagulant earlier than target date. Elastic compression treatment patients in both groups kept irregularly. Recurrence of venous thromboembolic complications in group 1 was noted in 11 (22) cases, in group 2 in 7 (15.9) patients. The negative ultrasound dynamics was observed in patients of both groups: 16 of patients in group 1 and 9.1 in group 2 had lesion signs of previously unchanged veins or occlusion of a previously passable vein after thrombosis without clinic of acute venous thrombosis. Trophic disorders were identified in 1 patient in group 2 and in 1/3 of patients in group 1 by the 4th year of observation. Significant differences between the groups were obtained in favor of rivaroxaban according to such parameters as adherence to treatment and the severity of venous insufficiency. Conclusion. Unsatisfactory results of DVT treatment with standard therapy regimen require the administration of new oral anticoagulants with the possible introduction of prophylactic regimen.

Phenotypic Spectrum of Myopathies with Recessive Anoctamin-5 Mutations

2020 ◽  
Vol 7 (4) ◽  
pp. 443-451
Author(s):  
José Vázquez ◽  
Claire Lefeuvre ◽  
Rosa Elena Escobar ◽  
Alexandra Berenice Luna Angulo ◽  
Antonio Miranda Duarte ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Pulmonary Function Tests ◽  
Lower Limbs ◽  
Manual Muscle Testing ◽  
Compound Heterozygous ◽  
Imaging Features ◽  
Muscular Weakness ◽  
Muscle Testing ◽  
Group 2 ◽  
Group 1

Background: Biallelic variants in Anoctamin 5 (ANO5) gene are causative of limb-girdle muscular dystrophy (LGMD) R12 anoctamin5-related, non-dysferlin Miyoshi-like distal myopathy (MMD3), and asymptomatic hyperCKemia. Objective: To describe clinic, histologic, genetic and imaging features, of ANO5 mutated patients. Methods: Five patients, four from France (P1, P2, P3 and P4) and one from Mexico (P5), from four families were included. P1 and P2, belonging to group 1, had normal muscle strength; Group 2, P3, P4 and P5, presented with muscular weakness. Muscle strength was measured by manual muscle testing, Medical Research Council (MRC) grades 1/5 to 5/5. Laboratory exams included serum CK levels, nerve conduction studies (NCS)/needle electromyography (EMG), pulmonary function tests, EKG and cardiac ultrasound. ANO5 molecular screening was performed with different approaches. Results: Group 1 patients showed myalgias with hyperCKemia or isolated hyperCKemia. Group 2 patients presented with limb-girdle or proximo-distal muscular weakness. Serum CK levels ranged from 897 to 5000 UI/L. Muscle biopsy analysis in P4 and P5 showed subsarcolemmal mitochondrial aggregates. Electron microscopy confirmed mitochondrial proliferation and revealed discontinuity of the sarcolemmal membrane. Muscle MRI showed asymmetrical fibro-fatty substitution predominant in the lower limbs. P1 and P2 were compound heterozygous for c.191dupA (p.Asn64Lysfs*15) and c.1898 + G>A; P3 was homozygous for the c.692G>T. (p.Gly231Val); P4 harbored a novel biallelic homozygous exons 1–7 ANO5 gene deletion, and P5 was homozygous for a c.172 C > T (p.(Arg 58 Trp)) ANO5 pathogenic variant. Conclusions: Our cohort confirms the wide clinical variability and enlarge the genetic spectrum of ANO5-related myopathies.

scholarly journals The evaluation of health-related behaviours between the physically active and non-active women

2014 ◽  
Vol 124 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Dariusz Boguszewski ◽  
Jakub Grzegorz Adamczyk ◽  
Sylwia Kowalska ◽  
Judyta Sado-Drapała ◽  
Monika Lewandowska ◽  
...  
Keyword(s):  
Physical Activity ◽  
Positive Attitude ◽  
Healthy Lifestyle ◽  
Positive Influence ◽  
Physically Active ◽  
Medical Institutions ◽  
Health Related ◽  
The Face ◽  
Group 2 ◽  
Group 1

Abstract Introduction. In the face of the more and more general threat with civilization diseases the promotion of healthy lifestyle should be one of main activities of educational and medical institutions. Aim. The aim of the work was comparison of chosen elements of healthy lifestyle between the young physically active women and non-sports ones. Material and methods. The survey was carried out on 156 women aged 18-35 years, divided into two groups. Persons physically active were classified into Group 1 (n=72), whereas into Group 2 - non-active ones (n=84). The investigative tool was the Inventory of Health-Related Behaviours by Juczyński (where health-related behaviours were rated in four categories: proper nutrition habits, prophylaxis behaviours, and positive attitude and health practices). Differences between the data were qualified with the t-student test for independent groups; level p≤0.05 was accepted as of minimum significance. Results. The results show that physically active persons pay greater attention to healthy lifestyle than non-sports people. The general indicator of health-related behaviours was noticeably higher in Group 1 (p=0.007). Greatest differences (p=0.008) were noted within the range of nutritional habits, and the least significant ones - in positive attitude (p=0.546). Conclusion. The positive influence of the physical activity on other aspects of the healthy lifestyle has been proven. It seems legitimate to promote physical activity among women of every age

scholarly journals Laparoscopic morphological aspects and tentative explanation of the aetiopathogenesis of isolated endometriosis of the sciatic nerve: a review based on 267 patients

2021 ◽  
Vol 13 (4) ◽  
pp. 369-375
Author(s):  
M Possover
Keyword(s):  
Sciatic Nerve ◽  
Lower Limb ◽  
Neurological Disorders ◽  
Retroperitoneal Fibrosis ◽  
Lower Limbs ◽  
Foot Drop ◽  
Time Interval ◽  
Morphological Aspects ◽  
Group 2 ◽  
Group 1

Background: Endometriosis of the sciatic nerve (ESN) is considered a rare disease. How can endometriosis develop within the sciatic nerve; a structure which has nothing in common with the uterus either anatomically or functionally, and why it occurs in the absence of any retroperitoneal/parametric endometriosis, is unknown. A better understanding of the pathophysiology of this enigmatic disease may improve its diagnosis and therapy. Materials and Methods: From a pool of 452 patients operated for ESN, only patients with “isolated” endometriosis of the sciatic nerve” confirmed at laparoscopy were included in this study. Patients with suspicion of ESN by extension from a parametric, ovarian or other intraperitoneal deeply infiltrating endometriosis were excluded from this study. Main outcome measure: All information acquired during the preoperative patient’s medical history and clinical examination were collected and compared with the morphological aspects of the disease observed by the laparoscopic treatment. Patients were classified into three groups according to the time interval between the onset of sciatic pain and the time of surgery: less than 1 year (Group 1), between 1 and 3 years (Group 2), and more than 3 years (Group 3). Results: Two hundred sixty-seven consecutive patients were included in this study. In Group 1 (n=67), 76% of the patients presented with cyclical sciatica, without sensory or motor disorders of the lower limbs. Laparoscopic exploration found in the great majority of these patients only the presence of an isolated endometrioma in the nerve itself, the size of which was proportional to the time elapsed since the onset of pain. In Group 2 (n=83), pain had become constant in 91% of the patients with neurological disorders of the lower limb (foot drop, Trendelenburg gait, atrophied muscles) in about 30% of patients. Laparoscopic examination revealed, in addition to intraneural cystic lesions, a retroperitoneal fibrosis in more than 80% of the patients. In the third group (N=117), more than 80% of the patients presented with neurological disorders of the lower limb, with, on laparoscopic examination, massive retroperitoneal fibrosis with endometriomas in the nerve and adjacent pelvic wall muscles in all patients and an infiltration of the obturator nerve in 41% of patients. Conclusions: The different morphologic aspects of ESN do not correspond to different forms of the disease, but obviously to one single disease at different stages of its evolution. ENS starts first with the development of an endometrioma within the sciatic nerve, then develops in a second step a perineural fibrosis that expands into the whole retroperitoneal space and finally involves surrounding anatomical structures. The ESN is a very particular pathology because it induces a completely new aspect on the pathogenesis of endometriosis: all hypothesis of implanted endometrial cells following retrograde menstruation, angiogenic spread, lymphogenic spread or the metaplasia theory cannot explain the pathogenesis of this disease. ESN obviously does not develop from “genital metastatic cells”. A possible hypothesis for explanation the pathogenesis of ESN, could consist in the development of endometriosis of the nerve from progenitor stem cells present within the nerve, pluripotent cells which, for an as yet unknown reason (possibly in connection with iterative inflammations and micro-damages of the nerve itself), mutate and proliferate to form endometriosis.

scholarly journals EVALUATING THE BODY RESPONSE TO A 15-MINUTE WORKOUT PROPOSED AS AN ALTERNATIVE TO GYM TRAINING DURING LOCKDOWN CAUSED BY THE COVID-19 PANDEMIC

2021 ◽  
pp. 80-85
Author(s):  
Dariusz Boguszewsk ◽  
Agata Szymańska ◽  
Justyna Wielgosz ◽  
Aleksandra Hanc ◽  
Jakub Grzegorz Adamczyk ◽  
...  
Keyword(s):  
Subjective Evaluation ◽  
Interval Training ◽  
The Body ◽  
Abdominal Muscles ◽  
High Intensity Interval Training ◽  
Physically Active ◽  
Muscle Groups ◽  
Group 2 ◽  
High Intensity Interval ◽  
Group 1

The aim of the work was to study the body reaction to high intensity interval training. The study included 92 women aged 18 to -35. People who have been engaged in organised, regular physical activity (at least twice a week) were qualified to Group 1. Group 2 were physically inactive persons. All subjects performed interval training in the Tabata formula - two 4-minute sequences. The exercise carried out in the first part is elevating the legs from the “plank” position, in the second part, the hands were elevated from the same position. The pulse rate, the Borg Scale and the VAS pain rate scale (24, 48, 72 and 96 h after exercise) were used to assess the exercise intensity. The respondents from both groups performed the training at a similar intensity: the average heart rate after workout was 131 beats per minute. The highest pain of all muscle groups (when added together) was recorded 24 hours after training. The highest pain intensity during the four days after the training concerned the back and abdominal muscles in Group 1 and the muscles of the abdomen, back and arms (front and back). The intensity of abdominal and arm muscle pain (front) was significantly higher in Group 2. The proposed 15-minute workout planned in the form of Tabata evoked similar cardiovascular reactions in both groups and a similar subjective evaluation of intensity. Individuals who were physically active before the introduction of restrictions related to the COVID-19 pandemic had less pain in the muscular system after the applied training.

Is frozen tumour-bearing autograft with concurrent vascularized fibula an alternative to the Capanna technique for the intercalary reconstruction after resection of osteosarcoma in the lower limb?

2020 ◽  
Vol 102-B (5) ◽  
pp. 646-652
Author(s):  
Yajie Lu ◽  
Haodong Zhu ◽  
Mengquan Huang ◽  
Chunlin Zhang ◽  
Guojing Chen ◽  
...  
Keyword(s):  
Lower Limbs ◽  
Fibular Graft ◽  
Musculoskeletal Tumor ◽  
Musculoskeletal Tumor Society ◽  
Tumour Bearing ◽  
Significant Difference ◽  
Vascularized Fibula ◽  
Duration Of Surgery ◽  
Group 2 ◽  
Group 1

Aims The use of frozen tumour-bearing autograft combined with a vascularized fibular graft (VFG) represents a new technique for biological reconstruction of massive bone defect. We have compared the clinical outcomes between this technique and Capanna reconstruction. Methods From June 2011 to January 2016 a retrospective study was carried out of patients with primary osteosarcoma of lower limbs who underwent combined biological intercalary reconstruction. Patients were categorized into two groups based on the reconstructive technique: frozen tumour-bearing autograft combined with concurrent VFG (Group 1) and the Capanna method (Group 2). Demographics, operating procedures, oncological outcomes, graft union, limb function, and postoperative complications were compared. Results A total of 23 patients were identified for analysis: eight in Group 1 and 15 in Group 2. There was no difference in the demographics (age, sex, and affected site) and operating procedures (resection length, duration of surgery, and blood loss) between the two groups. No significant difference was found in local recurrence in Group 1 versus Group 2 (p = 0.585). Mean union time for the frozen autograft-host junction was 8.4 months (7.0 to 11.0), significantly earlier than for the allograft-host junction in Group 2 (mean 14.1 months (10.0 to 28.0); p < 0.001). Mean Musculoskeletal Tumor Society scores in groups 1 and 2 were 90.3% (SD 7.4%) and 88.0% (SD 9.0%), respectively, with no significant statistical difference (p = 0.535). In terms of complications, infection (n = 1, 6.7%) and delayed union (n = 2, 13.3%) occurred in Group 2, but no such complications were observed in Group 1. Conclusion Frozen tumour-bearing autograft in combination with VFG can be used as an alternative to the Capanna reconstruction in properly selected patients with osteosarcoma. Cite this article: Bone Joint J 2020;102-B(5):646–652.

scholarly journals Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1226 ◽  
Author(s):  
Georgia Colleluori ◽  
Lina Aguirre ◽  
Clifford Qualls ◽  
Rui Chen ◽  
Nicola Napoli ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Estrogen Receptor Α ◽  
Best Response ◽  
Group 2 ◽  
Subcutaneous Adipose ◽  
Esr1 Expression ◽  
Estradiol Levels ◽  
Group 1

Estradiol (E2), mainly produced from Testosterone (T) in men, promotes visceral lipolysis. However, high visceral fat and hyperestrogenemia are features of obese hypogonadal (HG) men. Our study objectives are to evaluate relationships between circulating E2 and: (1) fat mass; (2) Estrogen Receptor α (ESR1) expression in subcutaneous adipose tissue; (3) changes in body fat after 6 months (M) of T therapy in HG men. Hypotheses: (1) existence of a range of circulating E2 associated with better body composition; (2) serum E2 determines tissue E2 sensitivity which affects response to T therapy. Men 40–74 years old, T < 300 (ng/dL), given T-cypionate for 6 months. Subjects were divided into 4-E2 categories: (1) <10.0; (2) 10.0–15.9; (3) 16.0–19.9; (4) ≥20.0 (pg/mL). Body composition (DXA), fat biopsies (liposuction), gene expression (qPCR), serum E2 and T (LC/MS), at baseline and 6 months. We enrolled 105 men; 90 completed the study. Group 2 had lower total and truncal fat mass (p < 0.01) but higher % lean mass (p < 0.001). ESR1 mRNA was the highest in group 1 (p = 0.01). At 6 months, group 1 had higher reduction in total (p = 0.03) and truncal (p = 0.01) fat. In conclusion, serum E2 = 10–15.9 (pg/mL) is associated with the best body composition profile in HG men; however, those with E2 < 10 (pg/mL) had the best response (greater fat loss) to T replacement possibly because of greater E2 sensitivity.

scholarly journals Effectiveness of Foot Exercise and Epsom Salt Water on Reduction of Foot Oedema among Antenatal Mothers

2021 ◽  
Author(s):  
Khevna Rameshbhai Macwan ◽  
Parasben Krunal Savaliya
Keyword(s):  
Standard Deviation ◽  
Salt Water ◽  
Mean Difference ◽  
Lower Limbs ◽  
Control Group ◽  
Cutaneous Manifestations ◽  
Significant Difference ◽  
Group 2 ◽  
Epsom Salt ◽  
Group 1

Introduction: Pregnancy is a very special time for both woman and her partner. Physiological lower leg oedema is one of the cutaneous manifestations of pregnancy. The weight increase during pregnancy and effect of gravity, slows down the blood circulation at lower limbs, thus leading to accumulation of fluids in that region. It is envisioned that about 75% of women suffer this excessive accumulation of fluid around the legs and ankles during pregnancy. Aim: This study was conducted to evaluate the effect of foot exercise and Epsom salt water on reduction of foot oedema among the antenatal mothers at selected hospitals of Kheda district. Materials and Methods: This was a Quasi experimental study, conducted from January 17, 2020 to March 18, 2020 at Dr ND Desai Hospital and Medical College, Nadiad, Gujarat, on forty antenatal mothers having foot oedema, selected from selected hospitals of Kheda district by purposive non probability sampling techniques. The total sample of 40 mothers was randomly allocated to group 1 (n=20 of foot exercise) and group 2 (n=20 of Epsom salt water). Foot oedema level assessment was done using tools of data collection for both groups which include performa of demographic variables and Modified Standardised Erin oedema scale. Results: Amongst the total study subjects, maximum 11 (55%) of those in group 2 were from 18-24 years of age while those in group 1. Oedema score analysis pre-interventionally, showed moderate score in 18 (90%) of subjects in group 1 and 9 (45%) of subjects in group 2. Severe score presented by 2 (10%) subjects in group 1 and 11 (55%) subjects in group 2. Post interventionally, none of the subjects in Group 1 and Group 2 showed moderate and severe oedema. All gave the score of 0, trace or mild oedema.There was statistically significant difference found in level of foot oedema in group 1 and group 2 which shows that mean difference of group 1 was 2.2 and Standard Deviation 0.51 and for control group mean difference was 2.95 and Standard Deviation 0.68. The calculated value of Mann-Whitney test was group 1 (3) and group 2 (1.49). Among them the level of foot oedema reduced 55% in group 1 (foot exercise) whereas in group 2 (Epsom salt water) it reduced 73.75%. Conclusion: Epsom salt water is more effective then foot exerciseon reduction of foot oedema among the antenatalmothers.

scholarly journals Costo-Efectividad De Exploración De Miembros Pélvicos Para Prevenir Pie Diabético

2016 ◽  
Vol 12 (24) ◽  
pp. 137
Author(s):  
Reyes-Chávez Prishila Danae ◽  
Villarreal-Ríos Enrique ◽  
Martínez-Martínez Martha Leticia ◽  
Velázquez-Tlapanco Jorge ◽  
Camacho-Calderón Nicolás ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Diabetic Foot ◽  
Average Cost ◽  
Cost Of Care ◽  
Lower Limbs ◽  
Laboratory Studies ◽  
Total Cost ◽  
Group 2 ◽  
Clinical Records ◽  
Group 1

Diabetic neuropathy is a common and frequent complication of DM2. It is the main risk factor for ulcer and amputation of lower limbs. The risk of developing ulcer foot is 12 -25%. In the first level of care medical, history and physical examination of the patient with DM2 is performed to determine the appropriate treatment. Objective: Determine the costeffectiveness of the exploration of pelvic limbs to prevent diabetic foot. Materials and Methods: Cost-effectiveness design. Clinical records of patients with DM2. Sample calculation with the formula of percentages of two populations. Group 1, complete scan of pelvic limbs (n=15) and Group 2 with incomplete examination of lower limbs (n=40). Sociodemographic variables, health characteristics, type and number of laboratory studies requested, type and quantity of drugs prescribed were analyzed. The effectiveness was evaluated as absence of data from diabetic foot in five years follow- up. The cost of care was estimated with the profile of use and unit cost. Statistical analysis averages, percentages and cost-effectiveness. Results: The total cost in group 1 was $7,203.24 and $4,909.03 in 2. Group 1, the total cost in laboratory studies was $5,863.44, $ 187.62 in drugs and average cost of $ 1,152.18 in consultation; while in the 2, laboratory it was $ 3,596.76 , $ 186.24 medicines and average cost of consultation $ 1,126.03. The effectiveness for $ 5,000.00 in group 1 corresponds to $ 37.00 and in the group 2 to $79.75. Conclusions: It was no scanning showed that full pelvic limbs and timely detection of diabetic foot out cost-effective.

scholarly journals CHARACTERISTICS OF PURULONECROTIC LESIONS IN COVID-19 PATIENTS

2021 ◽  
pp. 19-26
Author(s):  
A.N. Belyaev ◽  
I.S. Pol'kina
Keyword(s):  
Social Life ◽  
Inflammatory Diseases ◽  
Lower Extremities ◽  
Limb Ischemia ◽  
Lower Limbs ◽  
Limb Amputation ◽  
Acute Limb Ischemia ◽  
Arterial Embolism ◽  
Group 2 ◽  
Group 1

The COVID-19 pandemic has changed not only our social life, but also the course of many diseases, including purulent-inflammatory diseases of the lower extremities. The aim of the paper is to assess the influence of COVID-19 on purulonecrotic lesions of the lower extremities. Materials and Methods. We analyzed the results of treatment of 65 patients with purulonecrotic lesions of the lower extremities. All the patients were divided into 2 groups: Group 1 – 32 Non-COVID-19 patients, Group 2 – 33 COVID-19 patients. We studied laboratory blood parameters, hemostatic systems, performed lungs computed tomography (CT), and color-coded duplex scanning (CDS) of veins. Results. COVID-19 is more likely to affect patients aged 60–69 (51.5 %) and females (66.7 %). In Group 2 the level of leukocytes was higher than in Group 1 (11.2×109 and 13.9 109, respectively, p<0.05). Patients in both groups showed a tendency to hypercoagulability during anticoagulant therapy. In Group 2 patients, the percentage of transfemoral amputations was higher than in Group 1 patients (58 % and 18.8 % respectively). Arterial embolism of the lower limbs in Group 2 was observed in 6 % of patients. There were no deaths in Group 1, but in Group 2 mortality rate was 33.3 %. Conclusion. COVID-19 increases the number of arterial and venous thrombosis, often complicated by acute limb ischemia. Ischemic purulonecrotic processes complicated by COVID-19 are more severe, often lead to major limb amputation and are an important aggravating factor leading to death. Key words: COVID-19, purulonecrotic complications, coagulation, amputation. Пандемия COVID-19 не только внесла коррективы в социальную жизнь, но и изменила течение многих заболеваний, в т.ч. и гнойно-воспалительных поражений нижних конечностей. Цель. Оценить влияние коронавирусной инфекции на течение гнойно-некротических поражений нижних конечностей. Материалы и методы. Проведен анализ результатов лечения 65 больных с гнойно-некротическими поражениями нижних конечностей. Пациенты были разделены на 2 группы: 1-я группа – 32 больных без COVID-19, 2-я группа – 33 больных с COVID-19. Исследовались лабораторные показатели крови, системы гемостаза, проводились компьютерная томография легких, цветное дуплексное сканирование вен, анализировались результаты лечения. Результаты. COVID-19 чаще поражаются пациенты в возрасте 60–69 лет (51,5 %) и лица женского пола (66,7 %). У больных 2-й группы уровень лейкоцитов был выше, чем в 1-й группе (11,2×109/л и 13,9 ×109/л соответственно, р<0,05). На фоне антикоагулянтной терапии у больных обеих групп отмечалась тенденция к гиперкоагуляции. У больных 2-й группы ампутации на уровне бедра достигли 58 %, что более чем в 2 раза больше, чем у больных 1-й группы (18,8 %). Тромбоэмболии артерий конечностей во 2-й группе составили 6 %. Летальности в первой группе не было, во 2-й группе – 33,3 %. Выводы. Коронавирусная инфекция способствует возрастанию количества артериальных и венозных тромбозов, нередко осложняющихся острой ишемией конечностей. Ишемические гнойно-некротические процессы на фоне COVID-19 имеют более тяжелое течение, часто приводят к высокой ампутации конечности и являются важным отягощающим фактором, приводящим к летальному исходу. Ключевые слова: COVID-19, гнойно-некротические осложнения, коагуляция, ампутация.

Sign in / Sign up

Export Citation Format

Share Document